Latest studies
- Active not recruitingPHASE3
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
This study is looking into a new combination treatment for a type of breast cancer called triple-negative breast cancer (TNBC) that has spread or is advanced. It combines a new drug, Capivasertib, with a common chemotherapy, Paclitaxel, to see if it works better than just Paclitaxel alone.
Triple Negative Breast NeoplasmsSaudi Arabia - Recruiting
Fabry Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Fabry disease over time, including pregnant women. It helps doctors better understand the disease and improve care, without giving any new treatments. It's about observing, not experimenting.
Fabry DiseaseSaudi Arabia - Active not recruiting
A Prospective, Non-interventional, Multinational, Observational Study With Isatuximab in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM)
This study looks at how a medicine called isatuximab works for people in the UK with a type of blood cancer called multiple myeloma that has come back or not responded to previous treatments. It checks how well it works and if it's safe in real-world settings.
Plasma Cell MyelomaSaudi Arabia - Active not recruitingPHASE2, PHASE3
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
This study is looking at a new medicine called mitapivat for sickle cell disease. It aims to find the right dose and see if it helps increase healthy red blood cells and reduce painful crises.
Sickle Cell DiseaseSaudi Arabia - Enrolling by invitation
Registry of Patients With Hypophosphatasia
This study is gathering information over a long time about people in the UK and other countries who have a rare bone condition called Hypophosphatasia (HPP). It aims to understand how HPP affects people of all ages and how they respond to treatment.
Hypophosphatasia (HPP)Saudi Arabia - RecruitingPHASE3
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease
This study is looking into a new medication, rilzabrutinib, for adults with a condition called IgG4-related disease. It compares the medication to a dummy pill to see if it's safe and helps control the disease over 52 weeks.
Immunoglobulin G4 Related DiseaseSaudi Arabia - Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
This study is gathering information on a rare genetic condition called LAL Deficiency. It aims to understand the disease better and improve care for affected individuals, from babies to adults. It's a worldwide effort to collect health data over time.
Lysosomal Acid Lipase DeficiencyCholesterol Ester Storage DiseaseWolman DiseaseAcid Cholesteryl Ester Hydrolase Deficiency, Type 2Saudi Arabia - Active not recruitingNA
CHAMPION-AF Clinical Trial
This study compares a small heart device (WATCHMAN FLX) with standard blood-thinning medicines (such as DOACs) for people with an irregular heartbeat called atrial fibrillation. It aims to see if the device can prevent strokes just as well as the medicines.
Atrial FibrillationStrokeBleedingSaudi Arabia - Active not recruitingPHASE3
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
This study is comparing a new medication called remibrutinib with an existing treatment, teriflunomide, for people with relapsing multiple sclerosis (RMS). It aims to see how well remibrutinib works and if it's safe to use in managing RMS symptoms.
Relapsing Multiple SclerosisSaudi Arabia - Active not recruitingPHASE3
The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency
The ENERGY 3 Study is looking at a new treatment called INZ-701 for children aged 1-12 with a rare genetic condition called ENPP1 Deficiency. This study wants to see how well INZ-701 works and if it's safe compared to usual care.
Ectonucleotide Pyrophosphatase/Phosphodiesterase1 DeficiencyAutosomal Recessive Hypophosphatemic RicketsGeneralized Arterial Calcification of InfancySaudi Arabia - RecruitingPHASE4
Asciminib Roll-over Study
This study is for people who have already been taking a medicine called asciminib (or similar drugs) in a Novartis study for a type of blood cancer called CML. It allows them to keep taking the medicine if their doctor thinks it's still helping them.
Chronic Myelogenous LeukemiaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveSaudi Arabia - Enrolling by invitationPHASE2, PHASE3
Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
This study looks at a medicine called amlitelimab for moderate to severe eczema in people who've already tried it in other studies. We want to see how safe and effective it is over a long time, and if it continues to help.
Dermatitis AtopicSaudi Arabia - Active not recruitingNA
SyncAV Post-Market Trial
This study looks at a special heart device for people with heart failure. We're testing if a new setting, called SyncAV ON, helps the device work better and improve the heart's function more than the usual settings.
Congestive Heart FailureSaudi Arabia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseSaudi Arabia - Recruiting
Pompe Disease Registry Protocol
This registry tracks people with Pompe disease globally. It helps us understand the condition better, how it changes over time, and the effects of treatments. The goal is to improve care for everyone with Pompe disease.
Glycogen Storage Disease Type IIPompe DiseaseSaudi Arabia - Active not recruiting
A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health
This 4-year study looks at how well Elocta medicine helps people with haemophilia A keep their joints healthy. It observes patients already using Elocta in their daily lives to see its long-term effects on preventing joint problems.
Hemophilia ASaudi Arabia - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseSaudi Arabia - Recruiting
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
This study looks at how well a stomach-shrinking procedure called Endoscopic Sleeve Gastroplasty (ESG) helps people lose weight and keep it off for five years or more. It aims to understand the long-term success of this treatment for obesity.
Obesity and Obesity-related Medical ConditionsWeight LossSaudi Arabia - Enrolling by invitationPHASE3
A Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)
This study looks at a new treatment called pegtibatinase for Homocystinuria (HCU) in people aged 5 to 65. It's a long-term study to see how safe and effective the treatment is over time, especially for those already in other related studies.
HomocystinuriaSaudi Arabia - RecruitingPHASE3
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
This study looks at a new medicine called survodutide for adults with a liver condition called NASH or MASH and scarring (cirrhosis). Participants will get either the medicine or a dummy treatment, along with diet and exercise advice, to see if it helps their liver.
Metabolic Dysfunction Associated SteatohepatitisSaudi Arabia - RecruitingPHASE2
Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus
This study looks at a medicine called difelikefalin for teenagers (12-17) on dialysis who have very itchy skin from kidney disease. It checks if the medicine is safe and how much gets into their blood. We hope to find a new way to help young people with this problem.
PruritusChronic Kidney DiseasesSaudi Arabia - RecruitingPHASE3
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
This study looks at a new treatment called VX-880 for people with Type 1 diabetes. We want to see if it's safe, if people can tolerate it well, and if it helps those who often have severe low blood sugar and don't realise it.
Diabetes Mellitus, Type 1Impaired Hypoglycemic AwarenessSevere HypoglycemiaSaudi Arabia - RecruitingPHASE3
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
This study looks at a new medicine, Baxdrostat, combined with an existing one, Dapagliflozin, for people with long-term kidney disease and high blood pressure. It aims to see if this combination can help protect the kidneys and heart better than Dapagliflozin alone.
Chronic Kidney Disease and HypertensionSaudi Arabia - RecruitingPHASE3
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
This study looks at a new medicine called Tozorakimab. We want to see if it can help people in hospital with lung infections who need extra oxygen. The goal is to stop them from getting sicker, like needing a breathing machine, or even dying.
Viral Lung Infection and Acute Respiratory FailureSaudi Arabia - RecruitingPHASE2
Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA
This study looks at a new treatment called rapcabtagene autoleucel for severe forms of a condition called ANCA-Associated Vasculitis (AAV), specifically GPA and MPA. It aims to see how well it works and if it's safe compared to current treatments.
ANCA Associated Vasculitis (AAV)Saudi Arabia - RecruitingPHASE2
Phase 2 Study of Rapcabtagene Autoleucel in Myositis
This study is testing a new cell therapy called rapcabtagene autoleucel for severe inflammatory muscle diseases (myositis). It aims to see if it's safe and helps people whose current treatments aren't working well.
Idiopathic Inflammatory MyopathiesSaudi Arabia - RecruitingPHASE3
A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B
This study is testing a new medicine, marstacimab, for children and teenagers aged 1 to 17 with haemophilia A or B. It aims to see if the medicine can safely and effectively reduce bleeding episodes when given as a weekly injection under the skin.
Hemophilia AHemophilia BSaudi Arabia - Active not recruiting
The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
The SPECTRUM Study is looking at how well a new eye medicine called aflibercept 8 mg works for vision problems caused by wet AMD or diabetic macular oedema. Researchers will collect information from patients who are already prescribed this medicine by their doctor.
Visual ImpairmentNeovascular Age-related Macular Degeneration (nAMD)Diabetic Macula Edema (DME)Saudi Arabia - Active not recruitingPHASE3
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called lutikizumab for people aged 12 and over with moderate to severe hidradenitis suppurativa (HS). It compares the new medicine to a dummy treatment (placebo) to see if it helps reduce HS symptoms and is safe.
Hidradenitis SuppurativaSaudi Arabia - RecruitingPHASE3
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
This study looks at new drug combinations for multiple myeloma that has come back or isn't responding to previous treatments. It compares different ways of combining talquetamab with other medicines to see which works best for people who have already tried certain common myeloma drugs.
Multiple MyelomaSaudi Arabia - Active not recruitingNA
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
This study looks at different ways to care for unconscious patients after a sudden heart stop. It tests varying levels of calming medicine, body temperature control, and blood pressure targets to see what helps patients recover best and survive longer.
Cardiac Arrest With Successful ResuscitationHypoxia, BrainSaudi Arabia - Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Gaucher disease over time, whether or not they are receiving treatment. There's also a sub-study for pregnant women with Gaucher disease to see how their pregnancies and babies' health progress. It helps doctors learn more about the condition.
Gaucher DiseaseCerebroside Lipidosis SyndromeGlucocerebrosidase Deficiency DiseaseGlucosylceramide Beta-Glucosidase Deficiency DiseaseSaudi Arabia - Active not recruiting
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
This study looks at how well certain eye medicines from Roche work for conditions like wet macular degeneration and diabetic eye disease in real patients. It's about understanding long-term results and why doctors choose specific treatments, without changing how patients are usually cared for.
Neovascular Age-related Macular DegenerationDiabetic Macular EdemaRetinal Vein OcclusionBranch Retinal Vein OcclusionSaudi Arabia - RecruitingPHASE3
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
This study looks at how best to treat a type of cancer called germ cell tumours in children and adults. It compares simply watching the tumour after surgery with different chemotherapy treatments to see which works best and causes fewer side effects.
Childhood Extracranial Germ Cell TumorExtragonadal Embryonal CarcinomaGerm Cell TumorMalignant Germ Cell TumorSaudi Arabia - Active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Atrial FibrillationSaudi Arabia - Active not recruiting
Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD
This study looks at how well a medicine called inclisiran works for people with high cholesterol and helps prevent heart problems. We want to see if it lowers bad cholesterol and if people stick to taking it as part of their usual care.
Primary HypercholesterolemiaMixed DyslipidemiaSaudi Arabia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
This study looks at a new drug, Giredestrant, combined with an existing treatment called Phesgo, for advanced breast cancer. It aims to see if this new combination is safe and works better than Phesgo alone for people with specific types of breast cancer.
Locally Advanced or Metastatic Breast CancerSaudi Arabia - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)
This study looked at a new drug, mitapivat, for people aged 18 and over with a type of blood disorder called thalassemia that doesn't need regular blood transfusions. It aimed to see if mitapivat could help reduce anaemia compared to a dummy pill.
Non-Transfusion-dependent Alpha-ThalassemiaNon-Transfusion-dependent Beta-ThalassemiaSaudi Arabia - Active not recruitingPHASE3
A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
This study looks at a new weekly medicine, somapacitan, for children who need help growing. It compares it to Norditropin®, a daily medicine already used. The study includes children born small, or with Turner, Noonan syndrome, or unexplained short stature, over up to 5.5 years.
SGA, Turner Syndrome, Noonan Syndrome, ISSSaudi Arabia - Recruiting
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
This study looks at people who have a stroke while taking blood thinners for an irregular heartbeat. It aims to understand why this happens and what treatments work best afterwards to prevent another stroke. Researchers will collect information from medical records and follow some patients over time.
Ischemic StrokeOral AnticoagulationAtrial Fibrillation (AF)Outcome AssessmentSaudi Arabia - Active not recruitingPHASE3
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
This study looks at a new drug, trastuzumab deruxtecan, for advanced breast cancer that is HER2-low and hormone receptor positive. We want to see if it works better and is safer than standard chemotherapy for people whose cancer has progressed after other treatments.
Advanced or Metastatic Breast CancerSaudi Arabia - RecruitingPHASE3
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia
This study looks at a medicine called omaveloxolone (SKYCLARYS®) for children and teenagers aged 2 to 15 with Friedreich’s Ataxia. It aims to see how well it works and if it's safe, as it's currently only approved for adults.
Friedreich AtaxiaSaudi Arabia - Active not recruitingPHASE3
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
This study is testing a new medicine, povetacicept, for adults with a kidney condition called IgA Nephropathy. We want to see if it can help reduce protein in the urine and protect kidney function compared to a dummy medicine.
Immunoglobulin A NephropathySaudi Arabia - Active not recruitingPHASE3
A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis
This study is testing a new medicine called efgartigimod for people with a type of Myasthenia Gravis (MG). It checks how well it works and if it's safe compared to a dummy medicine. Some people will then get the new medicine openly.
Generalized Myasthenia GravisgMGMyasthenia Gravis, GeneralizedMyasthenia GravisSaudi Arabia - Active not recruiting
A Study to Learn How Men With Advanced Prostate Cancer Respond to Treatment With Darolutamide and Hormone Therapy, With or Without Chemotherapy, in Real-world Medical Practice
This study looks at how men with advanced prostate cancer respond to darolutamide and hormone therapy, sometimes with chemotherapy, in real-world settings. It aims to understand treatment effectiveness, safety, and patient experiences to help improve care.
Metastatic Hormone-Sensitive Prostate CancerSaudi Arabia - Recruiting
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
This study looks at how a new scoring system helps doctors decide the best treatment for broken bones in the back caused by osteoporosis. It compares how well patients do when doctors follow the score's advice versus when they choose a different path.
Osteoporotic FracturesOsteoporosisSaudi Arabia - RecruitingPHASE3
A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment
This study is looking at a new medicine called pegtibatinase for people aged 12-65 with a rare condition called Homocystinuria (HCU). It aims to see if the drug is effective and safe compared to a dummy treatment.
HomocystinuriaSaudi Arabia - Active not recruitingPHASE3
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
This study looks at new treatments for HER2-positive breast cancer that has spread. It compares an experimental drug, trastuzumab deruxtecan (T-DXd), alone or with another drug, pertuzumab, to standard care, to see if they work better and are safe.
Breast Cancer; HER2-positive; MetastaticSaudi Arabia - Active not recruitingPHASE3
A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease
This study is testing a new medication called guselkumab for people with Crohn's disease who have problems with fistulas around the back passage. It aims to see how well the medication works and if it's safe compared to a dummy treatment.
Fistulizing Crohns DiseasePerianal Crohns DiseaseSaudi Arabia - Active not recruitingPHASE3
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
This study is looking into the long-term safety and effectiveness of an inhaled medicine called seralutinib for adults with pulmonary arterial hypertension (PAH). Participants have already tried seralutinib in an earlier study and will continue to take it.
Pulmonary Arterial HypertensionSaudi Arabia