Latest studies
- RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseSaudi Arabia - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseSaudi Arabia - Active not recruitingPHASE3
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called lutikizumab for people aged 12 and over with moderate to severe hidradenitis suppurativa (HS). It compares the new medicine to a dummy treatment (placebo) to see if it helps reduce HS symptoms and is safe.
Hidradenitis SuppurativaSaudi Arabia - Active not recruitingPHASE3
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
This study is looking at a new medicine called romosozumab for children and teenagers aged 5-17 with Osteogenesis Imperfecta (brittle bone disease). It wants to see if romosozumab is better than existing bisphosphonate medicines at preventing broken bones and improving bone strength over 12 months.
Osteogenesis ImperfectaSaudi Arabia - RecruitingPHASE3
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
This study looks at a new combination treatment, Sigvotatug Vedotin plus pembrolizumab, for a type of lung cancer where a protein called PD-L1 is high. We want to see if this combination works better than pembrolizumab alone to help patients.
Non-Small Cell Lung CancerCarcinoma, Non-Small-Cell LungCarcinoma, Non-Small-Cell Lung (NSCLC)Saudi Arabia - Active not recruiting
Micra Transcatheter Pacing System Post-Approval Registry
This study is looking at how a tiny pacemaker, the Micra Transcatheter Pacing System, works in everyday life after it's been approved. It's for people who need this type of pacemaker due to a slow heart rate (bradycardia) to check its safety and how well it works over time.
BradycardiaSaudi Arabia - RecruitingPHASE3
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
This study looks at a new medicine called Tozorakimab. We want to see if it can help people in hospital with lung infections who need extra oxygen. The goal is to stop them from getting sicker, like needing a breathing machine, or even dying.
Viral Lung Infection and Acute Respiratory FailureSaudi Arabia - Recruiting
Product Surveillance Registry
This study keeps track of how well Medtronic medical devices, like those for heart problems or other conditions, work in real life. It aims to make sure these devices are safe and effective for patients.
Cardiac Rhythm DisordersUrological DisordersNeurological DisordersCardiovascular DisordersSaudi Arabia - RecruitingPHASE3
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
This study looks at how best to treat a type of cancer called germ cell tumours in children and adults. It compares simply watching the tumour after surgery with different chemotherapy treatments to see which works best and causes fewer side effects.
Childhood Extracranial Germ Cell TumorExtragonadal Embryonal CarcinomaGerm Cell TumorMalignant Germ Cell TumorSaudi Arabia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
This study looks at a new drug, Giredestrant, combined with an existing treatment called Phesgo, for advanced breast cancer. It aims to see if this new combination is safe and works better than Phesgo alone for people with specific types of breast cancer.
Locally Advanced or Metastatic Breast CancerSaudi Arabia - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
Diabetes Mellitus, Type 2HypertensionCardiovascular DiseasesSaudi Arabia - Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Gaucher disease over time, whether or not they are receiving treatment. There's also a sub-study for pregnant women with Gaucher disease to see how their pregnancies and babies' health progress. It helps doctors learn more about the condition.
Gaucher DiseaseCerebroside Lipidosis SyndromeGlucocerebrosidase Deficiency DiseaseGlucosylceramide Beta-Glucosidase Deficiency DiseaseSaudi Arabia - RecruitingNA
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
This study looks at treating hip fractures quickly in older patients who also have heart problems. It compares fast surgery to usual care to see if it reduces deaths within 90 days, and also checks other important health outcomes.
Hip FracturesMyocardial InjurySaudi Arabia - RecruitingNA
Platform of Randomized Adaptive Clinical Trials in Critical Illness
This study, called PRACTICAL, looks at new ways to help critically ill patients with severe breathing problems. It tests different treatments like breathing machine settings and other therapies to find the safest and most effective options for improving recovery and survival.
Respiratory InsufficiencyExtracorporeal Membrane Oxygenation ComplicationMechanical Ventilation Pressure HighSaudi Arabia - Recruiting
An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis
This study looks at how well a medicine called risankizumab works long-term for people with psoriatic arthritis, compared to other treatments. It will help doctors understand how people use and benefit from this medicine in real life.
Psoriatic ArthritisSaudi Arabia - RecruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
Heart FailureSaudi Arabia - Active not recruitingPHASE2
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma
This study looks at a new cell therapy called JNJ-68284528 for people with multiple myeloma. It aims to see how well it works in clearing up any remaining cancer cells after treatment.
Multiple MyelomaSaudi Arabia - RecruitingPHASE3
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
This study compares a new treatment called BMS-986393 with standard medicines for adults with multiple myeloma that has come back or not responded to previous treatment, including lenalidomide. We want to see if the new medicine works better and is safe.
Relapsed or Refractory Multiple Myeloma (RRMM)Saudi Arabia - Not yet recruiting
An International Multicenter Study on Transcatheter Device Closure of Perimembranous Ventricular Septal Defects
This study looks at how well a procedure works to close a hole in the heart called a PmVSD. It gathers information from many hospitals to see how different devices perform in children and adults, focusing on safety and how patients recover.
Perimembranous Ventricular Septal DefectSaudi Arabia - Active not recruiting
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
This study looks at how well certain eye medicines from Roche work for conditions like wet macular degeneration and diabetic eye disease in real patients. It's about understanding long-term results and why doctors choose specific treatments, without changing how patients are usually cared for.
Neovascular Age-related Macular DegenerationDiabetic Macular EdemaRetinal Vein OcclusionBranch Retinal Vein OcclusionSaudi Arabia - RecruitingPHASE3
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
This study is testing a new medicine, Etavopivat, for sickle cell disease and thalassaemia. It looks at how safe and effective the treatment is over a long period for people already benefiting from it in previous studies. The goal is to improve oxygen delivery in the body.
Sickle Cell DiseaseThalassemiaSaudi Arabia - Active not recruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.
This study looks at a new drug, baxdrostat, combined with an existing one, dapagliflozin, for adults with chronic kidney disease and high blood pressure. It aims to see if this combination can slow down kidney disease progression safely.
Chronic Kidney Disease and HypertensionSaudi Arabia - Active not recruitingPHASE3
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
This study looks at a new drug, upadacitinib, for moderate to severe Hidradenitis Suppurativa (HS). It's for adults and teenagers whose HS hasn't improved with other treatments. We'll check if it's safe and helps reduce HS symptoms.
Hidradenitis SuppurativaSaudi Arabia - RecruitingPHASE3
A Gaucher Disease Gene Therapy Trial With FLT201
This study is testing a new gene therapy called FLT201 for adults with Gaucher disease type 1. It aims to see if patients can stop their current treatment after receiving FLT201 while remaining well. This is the final stage of testing before it might become available.
Gaucher Disease Type 1Saudi Arabia - RecruitingPHASE3
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
This study looks at a new combination of drugs, adagrasib, pembrolizumab, and chemotherapy, for people with a specific type of advanced non-small cell lung cancer (NSCLC) that hasn't been treated before and has a KRAS G12C gene change.
Carcinoma, Non-Small-Cell LungSaudi Arabia - Active not recruitingPHASE4
STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
This study looks at how a weekly injection, semaglutide, helps teenagers aged 12-15 with obesity to lose weight and keep it off. All participants will receive the treatment for at least three years, aiming to understand its effectiveness for weight management.
ObesitySaudi Arabia - RecruitingPHASE3
Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia
This study looks at a new drug called blinatumomab for babies under one year old with a specific type of leukaemia (blood cancer). The aim is to make treatments better for these tiny patients by adding blinatumomab to their usual care. It's a key step in finding more effective ways to fight this illness.
Acute Lymphoblastic LeukemiaMixed Phenotype Acute LeukemiaSaudi Arabia - Active not recruitingPHASE3
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
This study is testing a new medicine, povetacicept, for adults with a kidney condition called IgA Nephropathy. We want to see if it can help reduce protein in the urine and protect kidney function compared to a dummy medicine.
Immunoglobulin A NephropathySaudi Arabia - Recruiting
A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
This study looks at how a new PNH treatment, pegcetacoplan, works in real life. It aims to see how effective and safe it is for patients with Paroxysmal Nocturnal Hemoglobinuria over several years.
Paroxysmal Nocturnal HemoglobinuriaSaudi Arabia - Active not recruitingPHASE3
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
This study looks at new drug combinations for multiple myeloma that has come back or isn't responding to previous treatments. It compares different ways of combining talquetamab with other medicines to see which works best for people who have already tried certain common myeloma drugs.
Multiple MyelomaSaudi Arabia - Active not recruitingPHASE3
A Study to Determine the Effect of Triheptanoin Compared With Even-Chain MCT on MCEs in Pediatric Patients With LC-FAOD
This study is looking at how well two different oils, triheptanoin and MCT oil, can help children and teenagers with a rare genetic condition called LC-FAOD. Researchers want to see if one oil is better at preventing serious health problems.
Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)Saudi Arabia - Active not recruitingPHASE3
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
This study looks at a new, higher dose of macitentan (75mg) for people with pulmonary arterial hypertension (PAH). Researchers want to see if this dose is better than the current 10mg dose at preventing serious health problems or death related to PAH.
Pulmonary Arterial HypertensionSaudi Arabia - Recruiting
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
This study looks at how well a stomach-shrinking procedure called Endoscopic Sleeve Gastroplasty (ESG) helps people lose weight and keep it off for five years or more. It aims to understand the long-term success of this treatment for obesity.
Obesity and Obesity-related Medical ConditionsWeight LossSaudi Arabia - Active not recruitingNA
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
This study looks at different ways to care for unconscious patients after a sudden heart stop. It tests varying levels of calming medicine, body temperature control, and blood pressure targets to see what helps patients recover best and survive longer.
Cardiac Arrest With Successful ResuscitationHypoxia, BrainSaudi Arabia - Active not recruitingPHASE3
ENERGY 2: Evaluation of the Efficacy and Safety of INZ-701 in Infants With ENPP1 Deficiency
This study, called ENERGY 2, is looking at a new medicine called INZ-701 for babies with a rare genetic condition called ENPP1 Deficiency. Researchers want to see if the medicine is safe and helps improve the health of these babies.
Ectonucleotide Pyrophosphatase/phosphodiesterase1 DeficiencyAutosomal Recessive Hypophosphatemic RicketsGeneralized Arterial Calcification of Infancy 1Saudi Arabia - RecruitingPHASE3
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
This study is looking into the long-term safety and effectiveness of an inhaled medicine called seralutinib for adults with pulmonary arterial hypertension (PAH). Participants have already tried seralutinib in an earlier study and will continue to take it.
Pulmonary Arterial HypertensionSaudi Arabia - RecruitingPHASE3
A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B
This study is testing a new medicine, marstacimab, for children and teenagers aged 1 to 17 with haemophilia A or B. It aims to see if the medicine can safely and effectively reduce bleeding episodes when given as a weekly injection under the skin.
Hemophilia AHemophilia BSaudi Arabia - RecruitingPHASE3
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
This study looks at a new medicine called survodutide for adults with a liver condition called NASH or MASH and scarring (cirrhosis). Participants will get either the medicine or a dummy treatment, along with diet and exercise advice, to see if it helps their liver.
Metabolic Dysfunction Associated SteatohepatitisSaudi Arabia - RecruitingPHASE3
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
This study looks at a long-term treatment called nerandomilast for people with pulmonary fibrosis. It's for those who've used it in a past study. We'll see how safe and effective it is over time, checking if it helps lung function and slows down the disease.
Idiopathic Pulmonary FibrosisProgressive Pulmonary FibrosisSaudi Arabia - Active not recruitingPHASE3
A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis
This study looks at a new drug, BIIB017, for children and teenagers with a type of multiple sclerosis (MS) called relapsing-remitting MS. It checks if the drug is safe, well-tolerated, and how well it works over time. Researchers are also studying how the body handles the drug.
Multiple Sclerosis, Relapsing-RemittingSaudi Arabia - RecruitingPHASE3
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia
This study looks at a medicine called omaveloxolone (SKYCLARYS®) for children and teenagers aged 2 to 15 with Friedreich’s Ataxia. It aims to see how well it works and if it's safe, as it's currently only approved for adults.
Friedreich AtaxiaSaudi Arabia - RecruitingPHASE4
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
This study looks at a new treatment called dupilumab for people aged 40-85 with a severe lung condition called COPD. It aims to see if the treatment reduces lung inflammation and improves breathing and quality of life.
Chronic Obstructive Pulmonary DiseaseSaudi Arabia - Recruiting
Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance
This study is looking at how a special medical device, called the GORE® TAG® Conformable Thoracic Stent Graft, works over a long time (up to 10 years). It helps doctors understand if this device, used to fix problems in a large blood vessel near the heart, continues to be a good and safe treatment option for people.
Vascular DiseaseDissectionDissection Aortic AneurysmDissection of AortaSaudi Arabia - RecruitingPHASE3
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
This study looks at a new medicine called etavopivat for people with sickle cell disease. It aims to see if it reduces painful crises, organ damage, and tiredness, and improves exercise. Participants will get either the medicine or a dummy pill.
Sickle Cell DiseaseSaudi Arabia - Active not recruiting
An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis
This study looks at the long-term safety of a medicine called Abatacept for children and teenagers with a type of arthritis called Juvenile Idiopathic Arthritis (JIA). Researchers want to see how safe it is over time, especially regarding serious infections, other immune problems, and cancer.
Juvenile Idiopathic ArthritisSaudi Arabia - RecruitingPHASE3
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
This study looks at a new treatment called VX-880 for people with Type 1 diabetes. We want to see if it's safe, if people can tolerate it well, and if it helps those who often have severe low blood sugar and don't realise it.
Diabetes Mellitus, Type 1Impaired Hypoglycemic AwarenessSevere HypoglycemiaSaudi Arabia - RecruitingPHASE3
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
This study looks at a new medicine called roxadustat for children and teenagers with kidney disease and low red blood cells (anemia). It's a pill, hoping to be a new way to treat this condition instead of injections.
Chronic Kidney DiseaseRenal AnemiaSaudi Arabia - RecruitingPHASE3
A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia
This study is testing a new medicine, atumelnant, for adults with a condition called congenital adrenal hyperplasia (CAH). It aims to see if the medicine is safe, works well, and how the body handles it.
Congenital Adrenal HyperplasiaClassic Congenital Adrenal HyperplasiaSaudi Arabia - Active not recruitingPHASE3
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
This study is testing a new drug called frexalimab for people with a type of multiple sclerosis (MS) called non-relapsing secondary progressive MS (nrSPMS). Researchers want to see if it can slow down MS progression and if it's safe. It's compared to a dummy drug (placebo).
Multiple SclerosisSaudi Arabia - Active not recruitingPHASE3
A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease
This study is testing a new medication called guselkumab for people with Crohn's disease who have problems with fistulas around the back passage. It aims to see how well the medication works and if it's safe compared to a dummy treatment.
Fistulizing Crohns DiseasePerianal Crohns DiseaseSaudi Arabia