Latest studies
- Completed
A study testing the safety and practicality of infecting healthy UK adults with malaria to understand how the parasite grows and how the body responds
Researchers in Oxford are studying a type of malaria that can hide in the liver and return months later. In this closely monitored trial, healthy adult volunteers are safely infected through mosquito bites, treated promptly with tablets, and tracked to help develop future vaccines and cure relapsing malaria.
Specialty: Infection, Primary sub-specialty: Tropical Medicine; Health Category: InfectionUnited Kingdom - Completed
Randomised control trial of the Child and Adolescent to Parent Violence and Abuse (CAPVA) programme run by RISE Mutual Community Interest Company (CIC)
This study tests a support programme for families experiencing child and adolescent to parent violence and abuse (CAPVA). It aims to find out whether teaching parents calm, non-violent strategies helps reduce aggression and improves family life compared to the standard support usually offered by local services.
Reduction and/or amelioration in CAPVA behaviours.United Kingdom - Completed
Developing a novel, food-based intervention to improve nutritional health and ageing in older South Asian and Black African and Caribbean communities living in the UK – co-produced research project
This study explores how traditional diets and cultural foods can support healthy ageing. Researchers are working directly with older South Asian, Black African, and Black Caribbean adults across the UK. By listening to lived experiences, the team aims to create practical, culturally relevant nutrition guidance to help communities stay healthier for longer.
Dietary practices in older adults from diverse communitiesUnited Kingdom - Recruiting
Getting recovery from head and neck cancer right after neck dissection
This study looks at whether a specialised physiotherapy programme helps people recover better after neck surgery for head and neck cancer. Researchers want to see if extra exercises and advice improve shoulder movement, reduce pain, and boost quality of life compared to standard NHS care.
Rehabilitation after neck dissection for head and neck cancerUnited Kingdom - Recruiting
Improving stroke diagnosis: A study using blood tests and clinical information to quickly identify stroke types in suspected stroke patients
When someone has a stroke, doctors need to know quickly whether it is caused by a bleed or a clot. This UK study tests a simple finger-prick blood test called the LVOne test. It aims to help emergency teams identify the stroke type faster so patients receive the right treatment sooner.
Differentiation of intracerebral hemorrhage (ICH) and large vessel occlusion (LVO) from other suspected stroke cases in adult patients presenting with stroke-like symptoms.United Kingdom - RecruitingNot Applicable
Diabetic foot ulcer infection prevention study
Diabetic foot ulcers can easily become infected, leading to serious medical complications. This UK study looks at whether a special wound dressing called Cutimed Sorbact can help stop infections before they start. Researchers are comparing this dressing alongside routine NHS wound care against standard care alone over 12 weeks.
Non-infected superficial diabetes-related foot ulcersUnited Kingdom - Recruiting
reMOte DEntal tReatment planniNg study- MODERN study
The MODERN study looks at whether specialist children's dentists can safely plan dental operations from photos and routine X-rays. Tooth decay is common, and some children need general anaesthetic for treatment. Researchers want to see if remote planning works well, helping more families access specialist NHS dental care closer to home.
Children/young person aged 4-16 who are treatment planned for a dental general anaesthetic (DGA)United Kingdom - Recruiting
Testing SpeechMate as a speech support system for public speaking and challenging conversations
Researchers at the University of Oxford are testing a new system called SpeechMate. It uses smart glasses and special headphones to guide speech during presentations and conversations. The study wants to see how well this digital tool supports adults who stutter, adults with apraxia of speech, and typically fluent speakers.
Speech production during public speaking and semi-structured conversation, including developmental stuttering, apraxia of speech, and typically fluent speech.United Kingdom - Recruiting
An online group programme to support weight management in adults who have severe obesity
This UK study looks at whether an online group programme called PROGROUP-Online can help adults with severe obesity manage their weight. Running over six months, it tests whether remote video sessions with health professionals are practical and supportive for patients referred to specialist NHS weight services.
Obesity and other hyperalimentationUnited Kingdom - Completed
Physical activity patterns after knee arthroplasty: recovery of physical activity after knee replacement surgery
This study looks at how physical activity changes before and after knee replacement surgery. Researchers want to study movement data that people already tracked on their smartwatches, fitness bands, or smartphones. The goal is to help future patients know what kind of recovery and mobility to expect after surgery.
MusculoskeletalUnited Kingdom - Recruiting
ImMUnologiCal memOry to reSpirAtory viraL infection in the airways
This UK study looks at how our lungs and nose remember and fight off common respiratory viruses, like flu, RSV, and COVID-19. Researchers want to understand airway immunity in adults aged 18 to 85 who recently had a viral infection, helping scientists design better protective vaccines in the future.
Duration of natural and hybrid immunity in response to various viruses, including SARS-CoV-2, RSV, and influenza in the nose and airwaysUnited Kingdom - Recruiting
A feasibility study of a combined mental health and neurodevelopmental assessment for young people in crisis services
This study tests a new approach for young people aged 12 to 17 in mental health crisis. It combines urgent mental health support with a quick assessment for conditions like autism and ADHD. The goal is to see if this combined check helps teens get the right support much faster.
Neurodivergence. Mental health, suicidality, self harmUnited Kingdom - Not yet recruiting
BOOST-3: Boosting baby communication and play
The BOOST-3 study looks at whether a gentle video-feedback play programme helps parents with mental health difficulties bond with their babies. Mothers and birthing parents receive either video-guided play sessions alongside usual NHS care, or usual care alone. The goal is to build parenting confidence and support baby development.
Perinatal mental illnessUnited Kingdom - Completed
Communication confidence for post-stroke aphasia
Having a stroke can make it hard to find the right words, which can knock your confidence. This UK study explores whether a type of talking therapy called cognitive behavioural therapy (CBT) can help people with post-stroke speech difficulties feel more confident when talking and taking part in everyday life.
Post-stroke aphasiaUnited Kingdom - Not yet recruitingPhase III
A study to see if fluoxetine will help reduce the symptoms of problematic sexual arousal in adult men serving a prison sentence when compared with a placebo (dummy) drug
This study tests whether a daily medicine called fluoxetine can help men in prison manage distressing, out-of-control sexual urges. Researchers will compare fluoxetine with a dummy pill over six months to see if it is safe, effective, and helps improve everyday wellbeing.
Problematic sexual arousalUnited Kingdom - RecruitingPhase III
Oral versus intramuscular glucocorticoids in rheumatoid arthritis
The LEADER trial looks at the best way to give short-term steroid treatment to people with rheumatoid arthritis. It compares steroid tablets against a single injection into the muscle, testing both higher and lower doses to find out which option provides the best relief with the fewest side effects.
Rheumatoid arthritisUnited Kingdom - Recruiting
Plant Your Health: a randomised controlled trial comparing vegan, vegetarian and omnivorous diets in younger to middle-aged adults with overweight or obesity
The 'Plant Your Health' trial investigates how changing to a vegan or vegetarian diet affects heart health. Researchers want to see if cutting out meat or animal products for one year lowers 'bad' cholesterol in adults carrying extra weight, compared with sticking to a regular diet that includes meat.
Overweight and obesity and associated cardiometabolic risk factors in adultsUnited Kingdom - RecruitingPhase IV
The 3TR-PARTNER-RA study: Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with early Rheumatoid Arthritis (symptoms <12 months) predictive of response to biologic drug treatments?
This UK clinical study investigates whether testing a tiny sample of joint tissue can help doctors choose the most effective treatment for early rheumatoid arthritis. Researchers want to see if specific biological markers can predict whether a modern medicine called abatacept works well for newly diagnosed patients.
Rheumatoid arthritisUnited Kingdom - RecruitingPhase II
NOVEL: A Clinical Trial of the Oxygen-carrying Substance NanO2 to Protect the Brain after Stroke
This UK clinical trial tests a new medicine called NanO2 for people who have had a severe stroke caused by a blood clot. NanO2 carries extra oxygen to brain tissue to keep it alive while doctors work to open the blocked blood vessel and restore normal blood flow.
Large vessel occlusion strokeUnited Kingdom - Recruiting
Exacerbation prevention in patients with both chronic obstructive pulmonary disease and obstructive sleep apnoea
This UK clinical study tests whether using a nighttime breathing machine (PAP therapy) helps people with both chronic obstructive pulmonary disease (COPD) and sleep apnoea. Researchers want to see if treating sleep apnoea can reduce chest flare-ups, keep people out of hospital, and improve everyday quality of life.
RespiratoryUnited Kingdom - Completed
Transforming outcome & experience for patients with hypoglycaemia
Low blood sugar (hypoglycaemia) can leave people with type 1 diabetes feeling drained and foggy, even after blood sugar levels recover. This UK study tests a new recovery drink called FLO23011 against standard glucose gel. Researchers want to see if it helps people feel better and recover their energy faster.
Recovery from non-severe hypoglycaemia in adults with type 1 diabetes using insulin therapy.United Kingdom - Recruiting
Developing a brain health programme for people with Mild Cognitive Impairment to reduce dementia risk
This study tests a new brain health programme for adults aged 50 to 90 with mild memory problems. It aims to support memory, mood, and daily wellbeing to reduce the risk of dementia. Participants attend small group sessions at the Bristol Brain Centre and complete simple memory checks and surveys.
A confirmed mild cognitive disorder conferring elevated risk of future dementia progression, including Mild Cognitive Impairment (MCI) and Subjective Cognitive Impairment (SCI)United Kingdom - Recruiting
Online arm-crank exercise programme for people with spinal cord injury (SCI)
This UK study tests whether a 12-week home workout programme using an arm bike is practical for people with spinal cord injuries. Participants join online group sessions over Zoom three times a week to help boost upper body fitness, strength, and overall wellbeing safely from home.
Spinal cord injuryUnited Kingdom - Recruiting
A study to evaluate whether power assisted exercise can help people living with stroke to improve their mobility and fitness
This UK study tests whether special motorised exercise machines can help stroke survivors improve their fitness and movement. Participants attend two seated exercise sessions a week for eight weeks in Sheffield. The machines give gentle support to help make moving easier, safer, and more comfortable after a stroke.
StrokeUnited Kingdom - Recruiting
Co-development of a web-app for young people with attention deficit hyperactivity disorder
Researchers in the UK are developing a new web app to support young people aged 16 to 30 who have ADHD or are waiting for an assessment. By testing the app in friendly workshops, participants help design useful tools and trusted information to improve everyday life and future NHS care.
Attention deficit hyperactivity disorder (ADHD)United Kingdom - CompletedPhase I
CAR T cells to fight acute myeloid leukaemia
This Phase I clinical trial tests a new cell therapy called BE-CAR33 for children and teenagers with acute myeloid leukaemia that has returned. Researchers use modified donor immune cells to clear out cancer cells before a planned stem cell transplant, aiming to keep the leukaemia from coming back.
Paediatric relapsed CAR33+ acute myeloid leukaemiaUnited Kingdom - Recruiting
Investigating the impact of kefir on metabolic syndrome subjects in an inpatient setting
This study looks at how kefir, a fermented milk drink, affects gut health in people with metabolic syndrome. Researchers want to see if beneficial bacteria in kefir can improve digestion and health markers. Participants will stay in a London hospital for two separate four-day visits to test kefir against a dummy drink.
Metabolic syndromeUnited Kingdom - Recruiting
Tissue and therapy assignment in cancers of unknown primary
Doctors diagnose Cancer of Unknown Primary (CUP) when cancer has spread, but they cannot find where it began. This Sussex-based study tests tumour samples already collected during routine care. Researchers use genetic tests and artificial intelligence (AI) to try to find the original cancer and discover better treatments for future patients.
Cancers of unknown primary (CUP)United Kingdom - Recruiting
A feasibility study of an online support programme to help South Asian people newly diagnosed with rheumatoid arthritis manage their condition
This study tests 'Apni Jung', a free online support programme for South Asian adults newly diagnosed with rheumatoid arthritis. Available in Hindi, Punjabi, and Urdu, it helps people understand and manage joint pain in daily life alongside their usual NHS care, testing if this approach works well for a larger future trial.
Rheumatoid arthritis (RA)United Kingdom - Completed
Investigating the role of dietary probiotics on athletic performance and health
Researchers at Nottingham Trent University are investigating whether taking daily friendly gut bacteria (probiotics) helps runners recover faster and perform better. Healthy, active men aged 20 to 40 will take either a probiotic or a dummy capsule for two weeks to see if it improves energy use and running times.
Exercise performance and metabolismUnited Kingdom - CompletedPhase I
Deferred Registration: Quotient Sciences Code: QSC303709
This is an early-stage Phase 1 clinical trial run by Quotient Sciences in the UK. The study is testing the safety of a potential new medicine in healthy male volunteers aged 30 to 65. Specific details about the medicine are temporarily confidential and will be published once initial testing finishes.
Healthy volunteersUnited Kingdom - RecruitingPhase I
Deferred registration: Phase I Trial: MAC code 'MAC215'
MAC215 is an early-stage (Phase 1) clinical study for adults aged 50 to 85. The UK Health Research Authority has agreed that specific study details can remain private for now. Full information about the treatment and health condition will be published after the study has ended.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry date.United Kingdom - Completed
A pilot study evaluating two continuous glucose monitoring education strategies for adults with type 2 diabetes in primary care
This UK pilot study tests two different ways of teaching people with type 2 diabetes how to use continuous glucose monitors. The monitors are small sensors worn on the skin. Researchers want to see how these tools help adults not using insulin understand their blood sugar levels better.
Type 2 diabetesUnited Kingdom - CompletedPhase I
Deferred Registration: Quotient Sciences Code: QSC303955
This is an early-stage Phase 1 clinical trial for healthy adults aged 18 to 55. It tests the safety of a new medicine. Detailed information about the drug is currently kept confidential under official UK research rules, but it will be made public once this initial stage finishes.
Healthy volunteersUnited Kingdom - Recruiting
Finding kidney disease sooner in communities most at risk
Chronic kidney disease often develops without any symptoms, particularly affecting people of African heritage. This study offers quick, free kidney checks in local community spaces like churches and community centres. Researchers want to see if peer-led testing helps find kidney problems earlier so people can get timely support and care.
Chronic Kidney DiseaseUnited Kingdom - CompletedNot Applicable
A trial to test the use of HIV drugs to treat neurofibromatosis type 2 (NF2) related tumours
This UK study tests whether two common HIV medications, lopinavir and ritonavir, can reach and slow down non-cancerous skin tumours in adults with NF2-related schwannomatosis. Researchers want to see if these tablets get absorbed into tumour tissue and could become a helpful future treatment option.
NF2-related schwannomatosis (formerly Neurofibromatosis Type II) (NF2)United Kingdom - RecruitingPhase III
Additional treatment for improving severe colitis
This UK trial tests whether adding a medicine called upadacitinib to standard steroid treatment helps people admitted to hospital with a severe flare-up of ulcerative colitis. Researchers want to see if this combination calms gut inflammation faster and reduces the need for emergency bowel surgery or other strong medicines.
Acute severe ulcerative colitisUnited Kingdom - CompletedPhase IV
An assessment of the acceptability and practicality of using Janus kinase inhibitors to treat palmoplantar pustulosis
Palmoplantar pustulosis (PPP) causes painful, pus-filled blisters on the hands and feet. This UK trial looks at whether a daily tablet called upadacitinib is an acceptable and practical treatment. Researchers want to see if patients find the medicine and monitoring manageable before planning a larger national clinical trial.
Palmoplantar pustulosisUnited Kingdom - CompletedPhase I
Deferred registration: Fortrea code 780279
This is an early-stage (Phase 1) clinical trial involving babies under one year of age, run by research organisation Fortrea. Full medical details about the condition and treatment are currently delayed with permission from the UK Health Research Authority. Complete study information will be made public once this delay ends.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry dateUnited Kingdom - Completed
Investigating the clinical and cost-effectiveness of children’s early self-care support in children with neurodisability
This UK study tests a programme called CHESS, which helps young children with disabilities learn everyday skills like eating, dressing, and washing. Researchers want to find out if CHESS works better and provides better value for money than the usual care NHS therapists currently provide.
Investigating the clinical and cost-effectiveness of self-care support in children with neurodisabilityUnited Kingdom - Recruiting
Can a digital self-help tool, created together with autistic people, support them in managing headaches?
Headaches are common in autistic people, but most health apps are not built with their needs in mind. This UK study works alongside autistic people to adapt a headache self-help app. Researchers want to see if the new app is easy, practical, and helpful to use in daily life.
Self reported persistent or chronic headache in autistic individualsUnited Kingdom - Completed
MOVE SMART – a feasibility study in patients with psoriasis
The MOVE SMART study looks at whether breaking up sitting time can help people with psoriasis. Sitting for long periods can harm health and increase heart risks. This 24-week home study tests if regular, two-minute movement breaks improve skin symptoms, heart health, and general well-being without needing hospital visits.
PsoriasisUnited Kingdom - CompletedNot Applicable
Assessment of the impact on chemotherapy decision-making and cost effectiveness of the integration of the digital biomarker test OncoProg into early stage colon cancer treatment pathways
This UK study tests a new computer tool called OncoProg for early-stage bowel cancer. The test examines tumour samples already removed during surgery. It helps doctors work out whether chemotherapy is truly needed, aiming to save patients from unnecessary side effects while making sure those who need treatment receive it.
Cancer: Stage II (T3/T4 ) or stage IIIA (T1-3N1) colorectal carcinoma (histological diagnosis)United Kingdom - CompletedPhase I
Developing a vaccine against Bundibugyo ebolavirus
Researchers in Oxford are testing a new vaccine against Bundibugyo Ebola, a rare but dangerous virus. The study is checking how safe the vaccine is in 50 healthy adults aged 18 to 55. Volunteers will receive the jab and attend regular check-ups over one year to monitor their health.
Bundibugyo ebolavirusUnited Kingdom - Recruiting
Care Confidence in Action
Arranging and paying for your own social care can feel overwhelming. "Care Confidence in Action" is a UK study exploring how to help older adults and carers use a helpful online care guide. Researchers want to learn how local services can best support people who are funding their own care choices.
Care decisionsUnited Kingdom - RecruitingPhase II
A study to evaluate the tolerability and the effects on the immune system of a tetanus and diphtheria vaccine which does not need any cold chain distribution or storage
This study tests a new tetanus and diphtheria booster vaccine that does not need to be kept in a fridge. Researchers want to see if it is just as safe and produces the same immune protection as an existing booster in healthy adults aged between 18 and 60.
Tetanus and diphtheria preventative vaccinationUnited Kingdom - Not yet recruitingPhase I
Deferred Registration: Quotient Sciences Code: QSC302324
This is an early-stage Phase 1 clinical trial for healthy volunteers, run by Quotient Sciences in the UK. Full details about the study medicine are temporarily withheld under standard UK research rules. The study aims to test how a new treatment behaves safely inside the human body.
This is a phase I trial in healthy volunteers only and qualifies for an automatic deferral. The full details will be added to the trial record on or before the deferral expiry dateUnited Kingdom - CompletedPhase II
Tranexamic acid to prevent anastomotic leak after rectal cancer surgery
This study looks at whether a medicine called tranexamic acid can stop bowel joins from leaking after rectal cancer surgery. During surgery, doctors place a soft tube to give either the medicine or sterile water directly into the back passage for three days to see if it aids healing.
Anastomotic leak; rectal cancer surgeryUnited Kingdom - Recruiting
Hypoglycemia in type 1 diabetes
This study looks at ways to help adults with type 1 diabetes who no longer feel warning signs when their blood sugar drops too low. Researchers are testing whether automated insulin devices, specialised education courses, or a combination of both can help people avoid dangerous low blood sugar episodes.
Type 1 diabetes with impaired awareness of hypoglycemiaUnited Kingdom - Recruiting
Experiences of feeling exceptional: preliminary testing of a new therapy for treating harmful grandiose delusions
This study tests a new talking therapy for people who have strong, ongoing beliefs that they have special powers, wealth, or a unique identity. Researchers at Oxford want to see if 16 weekly sessions with a psychologist can help people live meaningful lives while reducing harm and personal distress.
Treating persistent harmful grandiose delusions in patients attending NHS mental health services for the treatment of affective or non-affective psychosis.United Kingdom