Latest studies
- Enrolling by invitationNA
Pain-at-Work Toolkit (Definitive Trial)
This study is testing an online toolkit to help people in the UK manage long-term pain at work. It aims to boost confidence, provide support, and improve their work experience so they can stay in their jobs.
Chronic PainPain, ChronicUnited Kingdom - Active not recruitingNA
Case Series of Infants With Anterior Ankyloglossia Being Treated by the Sublingual Neonatal Incision Platform Device
This study looks at a new tool for treating tongue-tie in babies. It aims to see if this special device can safely and effectively help babies with this condition, which can affect feeding.
AnkyloglossiaUnited Kingdom - RecruitingNA
Challenging the Endocannabinoid System in Sleep Restricted Healthy Volunteers to Modulate Physiological Arousal (CANISLEEP) Study
This study looks at how cannabis-based products (THC, CBD) affect healthy people who are feeling stressed from lack of sleep. It wants to understand if these products can help with the body's stress response when sleep is restricted.
Healthy VolunteerUnited Kingdom - RecruitingPHASE2
A Phase 2a Efficacy, Safety, Tolerability, and PK Study of SYT-510 in Participants With Generalized Anxiety Disorder
This study is testing a new medicine called SYT-510 for people with Generalised Anxiety Disorder (GAD). It's a short study looking at how safe and effective a single dose of SYT-510 is compared to a dummy pill.
Generalized Anxiety DisorderUnited Kingdom - RecruitingPHASE3
Global Trial in APG2575 for Patients With CLL/SLL
This study is looking into a new treatment called lisaftoclax for people with a type of blood cancer called CLL/SLL. It compares adding lisaftoclax to an existing BTK inhibitor treatment versus just using the BTK inhibitor alone, for patients who have already been on BTK inhibitors.
CLL/SLLUnited Kingdom - Not yet recruitingPHASE4
Evaluation of the Impact of Oral Ivermectin on Musca Sorbens Flies, Putative Vector of Trachoma
This study looks at how a medicine called ivermectin, given to people, might stop flies from growing in their poo. These flies can spread an eye infection called trachoma, especially to children. Researchers want to see if the medicine passed out in poo is strong enough to kill the flies.
Survival of Flies Developing in Faecal SamplesUnited Kingdom - RecruitingPHASE3
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
This study is looking at a new medicine called KAI-9531. It aims to see if weekly injections of this medicine can help people who are overweight or obese, and have other health issues related to their weight, lose weight. We want to know if it's safe and effective.
ObesityOverweightUnited Kingdom - RecruitingPHASE3
A Gaucher Disease Gene Therapy Trial With FLT201
This study is testing a new gene therapy called FLT201 for adults with Gaucher disease type 1. It aims to see if patients can stop their current treatment after receiving FLT201 while remaining well. This is the final stage of testing before it might become available.
Gaucher Disease Type 1United Kingdom - Not yet recruitingNA
Glycaemic Response of Arabic Bread
This study is looking at how different types of Arabic bread, made with chickpea, pea, or lentil flour, affect blood sugar levels. They want to see if these breads can help keep blood sugar more steady compared to regular wheat bread in people who are overweight or have obesity.
OverweightObesityGlycaemic ResponseUnited Kingdom - RecruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
Non-small Cell Lung CancerHistiocytic NeoplasmHistiocytosisBRAF Gene MutationUnited Kingdom - RecruitingPHASE2
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
This study is looking into a new drug, AZD8965, for people with Idiopathic Pulmonary Fibrosis (IPF). It aims to see if different doses of this drug are safe and effective, compared to a dummy drug, for people with IPF, including those already on other treatments.
Idiopathic Pulmonary Fibrosis (IPF)United Kingdom - Enrolling by invitationPHASE3
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
This study looks at a new drug, LP352, for children and adults with a type of epilepsy called Developmental and Epileopathic Encephalopathy (DEE). It checks how safe and effective the drug is over a longer period for those who have already started treatment in previous studies.
Developmental and Epileptic EncephalopathyUnited Kingdom - RecruitingNA
Exercise to Improve Outcomes in Pancreatic Cancer
This study looks at a special exercise program for people having surgery for pancreatic cancer. It aims to see if exercising before, during, and after surgery helps with recovery and makes it easier to start other treatments. It's the first step to see if this program can work.
Pancreas Adenocarcinoma (MSI-H)DeconditioningUnited Kingdom - RecruitingPHASE2
Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions
This study is testing a new medicine, AHB-137, for people with long-term hepatitis B. It aims to see how well it works and if it's safe when added to their current treatment. It's for adults already taking medicine for hepatitis B.
Hepatitis B, ChronicUnited Kingdom - RecruitingPHASE1
Development of a Controlled Human Infection Model for Assessment of SARS-CoV-2 Omicron Subvariants
This study is looking into how a specific type of COVID-19 (Omicron EG.5.1) affects healthy, vaccinated adults. Volunteers will be given a small amount of the virus in their nose to help scientists understand the infection and immune response, and to test future vaccines and treatments.
SARS-CoV-2 (COVID-19)United Kingdom - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
This study looks at the long-term safety of a treatment called astegolimab for people with a lung condition called COPD. It's for people who have already taken part in previous studies of this drug.
Chronic Obstructive Pulmonary DiseaseUnited Kingdom - Active not recruitingPHASE3
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
This study is looking into the long-term effects and safety of a medicine called mirikizumab for people with Crohn's disease. Participants have already taken part in a related study, and this new study will help us understand how the medicine works over a longer period.
Crohn's DiseaseUnited Kingdom - RecruitingPHASE3
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
This study is testing a drug called pridopidine for people with Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neurone Disease. We want to see if pridopidine can slow down how ALS progresses and if it's safe to use. Participants will take the drug or a dummy pill daily.
Amyotrophic Lateral SclerosisUnited Kingdom - RecruitingPHASE2, PHASE3
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
This study is testing a new medicine, CSL300, for adults with advanced kidney disease on dialysis. It aims to see if CSL300 can improve heart health and is safe, especially for those with existing heart conditions or diabetes.
End Stage Kidney DiseaseUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseUnited Kingdom - Active not recruitingPHASE3
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
This study looks at a new medicine called risankizumab for Crohn's disease. We're checking how well it works and if it's safe for people who have already started treatment. It's like a follow-up to see how different doses work and how people feel over time.
Crohn's DiseaseUnited Kingdom - RecruitingPHASE3
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
This study is looking for better ways to treat advanced kidney cancer that has come back after earlier treatment. Researchers want to see if a new combination of medicines, belzutifan and zanzalintinib, works better than a standard medicine, cabozantinib, at shrinking the cancer.
Renal Cell CarcinomaUnited Kingdom - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseUnited Kingdom - RecruitingPHASE3
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
This study is testing a new drug, rilvegostomig, against a standard treatment, pembrolizumab, for advanced lung cancer. It's for people whose cancer has spread and has high levels of a specific marker called PD-L1. The aim is to see which treatment works better and is safer.
Carcinoma, Non-Small Cell LungUnited Kingdom - Active not recruiting
Post Market Registry for GORE® TAG® Thoracic Branch Endoprosthesis
This study looks at how a special device called the GORE® TAG® Thoracic Branch Endoprosthesis works in real patients with problems in their main body artery (aorta). We want to see how safe and effective it is for conditions like aneurysms, which are dangerous bulges.
AneurysmDissection, AorticTAA Thoracoabdominal Aortic AneurysmThoracic Aortic AneurysmUnited Kingdom - RecruitingPHASE3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
This study is for people with advanced bowel cancer that has spread and has a specific gene change called KRAS p.G12C. It compares a new combination of treatments to standard treatment to see if it can better stop the cancer from growing.
Metastatic Colorectal CancerUnited Kingdom - RecruitingPHASE2
Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients
This study is testing a new medicine, SAT-3247, for boys aged 7-9 with Duchenne muscular dystrophy. We want to find the best dose, see if it's safe, and check if it helps. Some boys will get the real medicine, others a dummy medicine.
Duchenne Muscular DystrophyDuchenneDMDNeuromuscular DiseasesUnited Kingdom - RecruitingPHASE2, PHASE3
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine, icotrokinra, for people in the UK with moderately to severely active Crohn's disease. Researchers want to see if it helps reduce symptoms and if it's safe to use, compared to a dummy medicine.
Crohn DiseaseUnited Kingdom - RecruitingPHASE3
A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer
This study compares a new treatment, TAR-210, with standard chemotherapy for high-risk bladder cancer that hasn't spread to the muscle. It aims to see which treatment best prevents the cancer from returning or getting worse.
Non-Muscle Invasive Bladder NeoplasmsUnited Kingdom - RecruitingPHASE3
Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
This study looks at new drug combinations for advanced breast cancer. It compares saruparib and camizestrant with common existing treatments to see which works best for people with specific genetic changes (BRCA1, BRCA2, or PALB2m) in their cancer.
Advanced Breast CancerUnited Kingdom - RecruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
CancerUnited Kingdom - Active not recruitingPHASE3
Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
This study compares two treatments, risankizumab and ustekinumab, for adults with moderate to severe Crohn's disease. Researchers want to see which treatment works best to reduce Crohn's symptoms. Both treatments are given initially by IV, then by injection.
Crohn's Disease (CD)United Kingdom - RecruitingPHASE3
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
This study is testing a new drug, Telisotuzumab Vedotin, against a standard treatment, Docetaxel, for advanced non-small cell lung cancer. It aims to see if the new drug works better and is safe for adults who have already had treatment.
Non Small Cell Lung CancerUnited Kingdom - Active not recruitingPHASE3
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
This study looks at a new medicine called upadacitinib for adults with Crohn's disease. It checks how well it works and if it's safe over a long time for people who have already started treatment in previous studies. The aim is to see if it can help manage Crohn's.
Crohn's DiseaseUnited Kingdom - Active not recruitingPHASE3
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called lutikizumab for people aged 12 and over with moderate to severe hidradenitis suppurativa (HS). It compares the new medicine to a dummy treatment (placebo) to see if it helps reduce HS symptoms and is safe.
Hidradenitis SuppurativaUnited Kingdom - Active not recruitingPHASE3
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
This study compares a new medicine, upadacitinib, with a sugar pill (placebo) and an existing medicine, adalimumab, for adults with rheumatoid arthritis. It looks at how well these treatments work and if they are safe when methotrexate isn't enough on its own.
Rheumatoid ArthritisUnited Kingdom - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
Ulcerative ColitisUnited Kingdom - Recruiting
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This study looks at how well a special scan, called PET-CT, works on removed cancer tissue. It compares these scans with lab results and patient health over time to see if this technology can improve cancer care and treatment decisions.
Prostate CancersBreast CancerHead and Neck CancerCancerUnited Kingdom - Active not recruitingNA
Multicenter Study to Evaluate the Clinical Outcome of the OmniTaper EV Implant in Single Tooth Restorations
This study tests a new titanium dental implant, the OmniTaper EV, for replacing single missing teeth. It aims to check its safety and effectiveness. The study involves regular dental visits over five and a half years at clinics in the UK and Europe.
Jaw, EdentulousUnited Kingdom - RecruitingPHASE2
FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis
The FARGO trial is investigating if a 'healthy gut bacteria transplant' (Faecal Microbiota Transplant, or FMT) can help people in the UK with the liver condition Primary Sclerosing Cholangitis (PSC) who also have Inflammatory Bowel Disease (IBD). Half of the participants will receive FMT, and the other half a dummy treatment, to see if it improves their condition.
Primary Sclerosing CholangitisInflammatory Bowel DiseasesUnited Kingdom - Active not recruitingPHASE4
Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients
This study looks at whether a medicine called semaglutide (Wegovy®), along with healthy eating and exercise, can help people who have gained weight from certain mental health medications. It aims to reduce weight gain linked to antipsychotic treatment.
Obesity and Obesity-related Medical ConditionsPsychiatric DisordersUnited Kingdom - Active not recruitingPHASE2
A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)
This study is testing a new medicine called tarlatamab for people with a type of lung cancer called Small Cell Lung Cancer (SCLC) that has come back or not responded to previous treatments. It aims to see how safe and effective the new medicine is.
Relapsed/Refractory Small Cell Lung CancerUnited Kingdom - Active not recruiting
Gestational Diabetes Monitoring and Management
This study looks at information from pregnant women with gestational diabetes to predict potential problems for mum and baby, and to work out the best way to monitor blood sugar. It uses existing data to help improve care and reduce the number of blood tests needed.
Gestational DiabetesPregnancy ComplicationsPregnancy in DiabeticPregnancy, High RiskUnited Kingdom - Active not recruitingPHASE3
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
This study is looking at a new treatment called Tarlatamab for advanced small cell lung cancer that has come back after earlier treatment. We want to see if Tarlatamab helps people live longer compared to standard chemotherapy.
Small Cell Lung Cancer (SCLC)United Kingdom - Active not recruitingPHASE3
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
This study is looking at a new medicine called romosozumab for children and teenagers aged 5-17 with Osteogenesis Imperfecta (brittle bone disease). It wants to see if romosozumab is better than existing bisphosphonate medicines at preventing broken bones and improving bone strength over 12 months.
Osteogenesis ImperfectaUnited Kingdom - RecruitingPHASE3
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
This study looks at a new combination treatment, Sigvotatug Vedotin plus pembrolizumab, for a type of lung cancer where a protein called PD-L1 is high. We want to see if this combination works better than pembrolizumab alone to help patients.
Non-Small Cell Lung CancerCarcinoma, Non-Small-Cell LungCarcinoma, Non-Small-Cell Lung (NSCLC)United Kingdom - Active not recruitingPHASE2
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
This study looks at a new treatment called RP1, by itself and with another drug called nivolumab. It's for people with certain advanced cancers like lung cancer, some skin cancers, and specific solid tumours that haven't responded well to previous treatments.
Non-Small Cell Lung Cancer (NSCLC)Microsatellite Instability-High (MSI-H)Non-melanoma Skin Cancer (NMSC)Cutaneous MelanomaUnited Kingdom - Active not recruitingPHASE3
A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
This study looks at a new drug, apalutamide, combined with standard hormone therapy for men with high-risk prostate cancer before and after surgery. It aims to see if this combination helps shrink the cancer more and prevents it from spreading, compared to hormone therapy alone.
Prostatic NeoplasmsUnited Kingdom - Recruiting
Natural History of Wilson Disease
This study aims to better understand Wilson Disease, a rare genetic condition where too much copper builds up in the body. Researchers want to find the best ways to diagnose it and check if treatments are working. By collecting information from patients, they hope to improve future care.
Wilson DiseaseUnited Kingdom - Enrolling by invitationPHASE2
Extension Study of Infigratinib in Children With Achondroplasia (ACH)
This study looks at a medicine called Infigratinib for children and teenagers aged 3-18 with achondroplasia, a type of dwarfism. It's an ongoing study to check the medicine's safety, how well it works, and its long-term effects on growth and quality of life.
AchondroplasiaUnited Kingdom