Latest studies
- RecruitingPHASE1
Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer
This study looks at a new drug, BNT116, for advanced lung cancer. It explores if BNT116 is safe, how much to give, and how well it works when used alone or with other treatments for different types of non-small cell lung cancer.
Non-Small Cell Lung CancerUnited Kingdom - RecruitingPHASE1, PHASE2
Halting Ornithine Transcarbamylase Deficiency With Recombinant AAV in ChildrEn
This study is testing a new gene therapy for children with a rare liver condition called Ornithine Transcarbamylase Deficiency (OTCD). It aims to help their livers produce a missing enzyme, reduce harmful ammonia build-up, and potentially act as a 'bridge' to a liver transplant, improving their health.
Ornithine Transcarbamylase DeficiencyUnited Kingdom - RecruitingNA
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
This study looks at new ways to find prostate cancer using MRI scans and biopsies. Researchers want to see if a shorter, simpler MRI is as good as the usual one, and if guiding biopsies with a computer is better than relying on a doctor’s eye.
Prostate CancerAdenocarcinomaProstatic NeoplasmsProstatic DiseasesUnited Kingdom - Active not recruiting
Surgically Induced Neurological Deficits in Glioblastomas (SIND Study)
This study looks at how brain surgery for glioblastoma affects your vision, thinking, and daily life. Researchers use scans and tests before and after surgery to understand how changes in the brain link to your well-being.
GlioblastomaUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
This study is looking into a new medication called remibrutinib for people with a type of multiple sclerosis (MS) called Secondary Progressive MS (SPMS). It will check if the medicine is safe and helps slow down the disease.
Secondary Progressive Multiple Sclerosis (SPMS)United Kingdom - RecruitingNA
Somatic Tracking for Tinnitus
This study looks at how a special type of meditation, called mindfulness, can help people with tinnitus. It aims to see if focusing on your body and breath can make tinnitus less bothersome and improve how you feel about it.
TinnitusUnited Kingdom - Recruiting
Placental Biology in Health and Disease
This study looks at tiny particles from the placenta called 'EVs' to understand pregnancy problems like pre-eclampsia and gestational diabetes. Researchers hope to find new ways to detect and treat these conditions early to help mums and babies.
Pre-eclampsiaGestational Diabetes Mellitus (GDM)Fetal Growth Restriction (FGR)Pregnancy Induced Hypertension (PIH)United Kingdom - RecruitingPHASE2
Long-Term Safety, Tolerability and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria
This study looks at a new drug, OMS906, for a rare blood condition called Paroxysmal Nocturnal Hemoglobinuria (PNH). It checks how safe it is, if people can tolerate it, and if it helps over a long time. Patients get the drug through an IV every eight weeks.
Paroxysmal Nocturnal HemoglobinuriaUnited Kingdom - Active not recruitingPHASE2
Seal, Stopping Eczema and Allergy Study
This study is for babies under 12 weeks old with early eczema. It compares special skin creams and treatments to standard care to see if they can reduce eczema and prevent food allergies. We want to find the best ways to keep young skin healthy.
Eczema, InfantileEczemaAtopic Dermatitis EczemaAtopic DermatitisUnited Kingdom - RecruitingPHASE2
Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL
This study is testing a new medicine called Surovatamig for adults with certain types of B-cell non-Hodgkin lymphoma that has returned or not responded to previous treatments. It aims to see how well it works and if it's safe.
B-cell Non-Hodgkin LymphomaFollicular Lymphoma (FL)Large B-Cell Lymphoma (LBCL)United Kingdom - Enrolling by invitationNA
Conventional Endoscopic Techniques Versus EndoRotor® System for Necrosectomy of Walled of Necrosis
This study compares a new device, the EndoRotor, with standard methods for clearing infected fluid collections in the pancreas. It aims to find out if the new device is better for treating a condition called 'walled off necrosis' in people with severe pancreatitis.
Acute PancreatitisNecrosis; Pancreas, Acute (Infectious)United Kingdom - Recruiting
Examining Scottish Chiropractic Professional Identity Using Chiropractic Professional Identity Scales
This study is surveying Scottish chiropractors to understand their professional identity, using a questionnaire. Researchers hope to identify influences like age and education to strengthen the profession in Scotland and Europe, potentially improving patient care and professional satisfaction.
Professional Identity FormationUnited Kingdom - Active not recruitingPHASE2, PHASE3
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen
This study is looking for people with HIV-1 who are currently on a complex treatment plan. It compares a new two-drug combination, bictegravir and lenacapavir, with their current treatment to see if it's a simpler and effective option.
HIV-1-infectionUnited Kingdom - Not yet recruitingNA
Effects of a Brown Seaweed Tart Cherry Blend in Mild-moderate Hypertension
This study is looking at whether a blend of brown seaweed and tart cherry can help people with slightly high blood pressure. These natural ingredients are thought to have good effects on the heart and blood vessels, and researchers want to see if they can reduce blood pressure without needing traditional medicines.
HypertensionUnited Kingdom - Active not recruiting
Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies?
This study looks at tiny germs in the vagina of women carrying twins. We want to see if these germs are linked to twin babies being born too early. The goal is to find ways to predict and prevent early births in twin pregnancies.
Preterm BirthPreterm LaborMultiple; Pregnancy, ComplicatedTwin Dichorionic Diamniotic PlacentaUnited Kingdom - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs
This study is testing a new medicine, Debio 4126, for people with acromegaly, a hormone disorder, who are already taking similar treatments. We want to see if Debio 4126 can help keep their hormone levels stable compared to a dummy drug.
AcromegalyUnited Kingdom - Recruiting
Vercise™ DBS Dystonia Prospective Study
This study looks at how well a device called Vercise Deep Brain Stimulation (DBS) works for people with dystonia. It aims to see if it helps with symptoms and improves daily life. The study monitors how patients do in real-life situations after having the device implanted.
DystoniaUnited Kingdom - Active not recruiting
Predicting Incidental Gallbladder Cancer
This study aims to find out if we can predict who might have an unexpected gallbladder cancer during routine surgery. We'll look at patient information to create a scoring system to help doctors decide if a removed gallbladder needs extra checks, potentially avoiding unnecessary tests.
Gallbladder CancerUnited Kingdom - RecruitingPHASE3
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
This study looks at whether adding chemotherapy before surgery helps people with certain types of retroperitoneal sarcoma live longer without their cancer coming back. It compares surgery alone to chemotherapy followed by surgery.
Retroperitoneal SarcomaLiposarcomaLeiomyosarcomaUnited Kingdom - Active not recruitingNA
Brief ES for Recovery of Autonomic Function in CES
This study looks at using gentle electrical stimulation during or after emergency back surgery for a condition called cauda equina syndrome. It aims to see if this stimulation can help people recover better control of their bladder, bowels, and sexual function.
Cauda Equina SyndromeUnited Kingdom - Active not recruitingPHASE3
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
This study is testing a new medicine, AR1001, for people in the early stages of Alzheimer's disease. We want to see if it's safe and helps improve or slow down symptoms compared to a dummy medicine.
Alzheimer DiseaseUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
This study is looking at a new medicine called AZ-3102 for children and young people with rare conditions like Niemann-Pick Type C, GM1 Gangliosidosis, or GM2 Gangliosidosis. It aims to see if the medicine is safe and if it helps improve their health over 18 months.
Niemann-Pick Type C DiseaseGM1 GangliosidosisGM2 GangliosidosisUnited Kingdom - RecruitingNA
Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction
This study looks at how hormones, age, and sex affect weight loss from dieting. We want to understand why some people find it harder to lose weight and how diet affects women's health to help fight obesity.
Overweight and Obese AdultsHealthyUnited Kingdom - Recruiting
Low Stable Pressure Pneumoperitoneum in Colorectal Surgery (CROSS STUDY)
This study looks at using a special low-pressure method during keyhole bowel surgery for conditions like cancer. The aim is to help patients recover faster, spend less time in hospital, and experience less pain after their operation.
Colorectal SurgeryBenign or Malignant Rectal or Colon TumorsUnited Kingdom - Recruiting
IONA Longitudinal Cohort Study
The IONA study in Scotland is looking at how memory and thinking decline. Researchers are collecting health, lifestyle, and genetic information from people over 50. The goal is to better understand dementia and eventually help develop new treatments for conditions like Alzheimer's disease.
Alzheimer DiseaseDementiaUnited Kingdom - Active not recruitingNA
Changing Outcomes Through Achievement Emails in COPD Using Routine Healthcare Audits
This study looks at how emails sent to GP practices can help improve prescriptions for people with COPD. It tests if personalised emails or simple notification emails work better to help doctors follow national guidelines for lung medication.
COPD (Chronic Obstructive Pulmonary Disease)United Kingdom - Active not recruitingPHASE2
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
This study looks at a new treatment called patritumab deruxtecan for people with an advanced type of lung cancer that has a specific genetic change (EGFR mutation). It's for those who have already tried other standard treatments that are no longer working.
Non-Small Cell Lung Cancer MetastaticNon-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor ReceptorUnited Kingdom - Active not recruitingPHASE3
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
This study looks at a new medicine called Seladelpar for Primary Biliary Cholangitis (PBC). It's a long-term study to see how safe and effective it is over time. Participants will have taken Seladelpar in a previous study.
Primary Biliary CirrhosisUnited Kingdom - RecruitingNA
Lymphatic Mapping Of Oropharyngeal Cancer
This study is checking a new way to find if throat cancer has spread to lymph glands in the neck. It aims to improve decisions about treatment, potentially preventing unnecessary procedures or missed cancer, by using a special imaging technique during surgery.
Oropharyngeal CancerUnited Kingdom - RecruitingPHASE3
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
This study is looking at a new medicine called sacituzumab govitecan (SG) for people with a type of lung cancer called extensive stage small cell lung cancer (ES-SCLC) that has been treated before. We want to see if SG works better than standard treatments to help people live longer.
Extensive Stage Small Cell Lung Cancer (ES-SCLC)United Kingdom - RecruitingPHASE3
Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD
This study looks at a new medicine, pelacarsen, for people with heart and circulation problems and high levels of a specific fat called Lp(a). It aims to see if it's safe and effective when used alongside another medicine, inclisiran.
Atherosclerotic Cardiovascular Disease (ASCVD)United Kingdom - RecruitingPHASE3
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
This study is looking at two new drug combinations for adults newly diagnosed with Chronic Lymphocytic Leukemia (CLL). It compares sonrotoclax plus zanubrutinib with venetoclax plus acalabrutinib to see which is more effective and safer for treating this type of blood cancer.
Chronic Lymphocytic LeukemiaUnited Kingdom - Active not recruitingPHASE3
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
This study looks at a new drug, astegolimab, for people with COPD who have flare-ups often. It compares the new drug to a dummy treatment (placebo) to see if it's safe and helps improve their breathing and reduce flare-ups.
Chronic Obstructive Pulmonary Disease (COPD)United Kingdom - Active not recruitingPHASE1
A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants
This study is testing a new medicine, GSK4528287, for bowel conditions like ulcerative colitis for the very first time in people. We want to see if it's safe, how the body handles it, and if it works as expected. We'll start with small doses in healthy volunteers.
Colitis, UlcerativeUnited Kingdom - RecruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
This study is testing a new medicine, PF-07328948, for adults with heart failure. We want to see if it's safe and helps improve symptoms when taken alongside existing treatments. Volunteers will take the medicine or a dummy pill for 36 weeks.
Heart FailureUnited Kingdom - RecruitingPHASE2
A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome
This study is testing a new drug, acalabrutinib, alongside the usual treatment (CHOP-R) for Richter's Syndrome. It aims to see if this combination improves outcomes for people recently diagnosed with this aggressive blood cancer.
Richter SyndromeUnited Kingdom - Recruiting
Longitudinal Early-onset Alzheimer's Disease Study Protocol
This study looks at how early-onset Alzheimer's disease develops over time. It compares people with this condition to those without it, gathering information on memory, brain scans, and other health markers to better understand the disease.
Early Onset Alzheimer DiseaseAlzheimer DiseaseMild Cognitive ImpairmentUnited Kingdom - Active not recruitingPHASE3
Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa
This study is looking at a new medicine called ALXN1850 for children with a rare bone condition called hypophosphatasia (HPP). It compares ALXN1850 with a current treatment, asfotase alfa, to see if it's safe and works well for children who have already been using asfotase alfa.
HypophosphatasiaUnited Kingdom - Recruiting
Neonatal Infection Surveillance Database
This project, called NeonIN, collects information about serious infections in newborn babies across many UK hospitals. It helps doctors understand how common these infections are, what causes them, and how best to treat them by gathering data in a secure online system.
Neonatal InfectionUnited Kingdom - Enrolling by invitation
Psychiatry Research and Motherhood at 6 to 8 (PRAM-P@6to8)
This study looks at how a mother's mental health problems during and after pregnancy might affect her child's development, especially their stress responses, between the ages of 6 and 8. It also considers other family factors.
Perinatal PsychiatryUnited Kingdom - Active not recruitingNA
PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG
This study compares two ways to fix blocked heart arteries in people who have had bypass surgery. Researchers are looking at whether fixing the original artery or the bypass graft works better in the long run for patients with coronary artery disease.
Coronary Artery DiseaseUnited Kingdom - Active not recruitingPHASE3
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
This study looks at a new medicine called concizumab for haemophilia A or B with inhibitors. It aims to see if it can prevent bleeding and is safe. Some people will get the new medicine straight away, others later, all through daily injections at home.
Haemophilia A With InhibitorsHaemophilia B With InhibitorsUnited Kingdom - Active not recruitingPHASE3
Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome
This study is testing a nasal spray called carbetocin for people with Prader-Willi syndrome (PWS) who have a strong urge to eat. It aims to see if the spray can help reduce this feeling of constant hunger. Participants will use either the real spray or a dummy spray for 12 weeks.
Hyperphagia in Prader-Willi SyndromeUnited Kingdom - RecruitingPHASE2
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
This study is looking into a new treatment called VHB937 for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps with memory and daily activities. It involves taking the treatment or a dummy pill and having regular check-ups.
Alzheimer's DiseaseUnited Kingdom - Active not recruitingPHASE2
Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01
This study is testing new combinations of treatments for head and neck cancer that has come back or spread. It compares two new drugs plus chemotherapy against one new drug plus chemotherapy. The aim is to find safer and more effective ways to treat this type of cancer.
Head and Neck Squamous Cell CarcinomaUnited Kingdom - RecruitingNA
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
This study is testing a new smartphone device called AliveCor 12-lead ECG. It aims to see if this device can accurately detect heart attacks (STEMI and NSTEMI) in people with chest pain, just as well as the standard ECG machines used in hospitals.
Myocardial InfarctionIschemiaMyocardial IschemiaHeart DiseasesUnited Kingdom - RecruitingPHASE2
A Clinical Trial to Evaluate Efficacy and Safety of Navepegritide in Adolescents (12 - 18 Years of Age) With Achondroplasia.
This study is looking at a new medicine called navepegritide for teenagers aged 12 to 18 with achondroplasia. We want to see if it helps them grow and if it's safe. It's compared to a dummy medicine over 52 weeks.
AchondroplasiaUnited Kingdom - RecruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
This study is looking into a new medicine, PF-07275315, for people with moderate to severe asthma who struggle with breathing. We want to see if it's safe and helps improve their daily life.
AsthmaUnited Kingdom - RecruitingPHASE2, PHASE3
A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
This study looks for better ways to treat B-cell non-Hodgkin Lymphoma (B-NHL) in children and young people when initial treatments haven't worked or the cancer has returned. It tests new medicines to see if they are safe and effective, aiming to improve chances of recovery.
B-cell Non Hodgkin LymphomaUnited Kingdom - Active not recruitingPHASE3
Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects
This study looks at the long-term safety and effects of a drug called ALZ-801 for people with early Alzheimer's disease who have a specific genetic make-up (APOE4/4). It's an ongoing study where all participants receive the active drug. The aim is to see how well it works and if it's safe over a longer period.
Early Alzheimer's DiseaseUnited Kingdom