Latest studies
- RecruitingNA
Whey Protein and Adaptogenic Supplementation in Physically Active Males
This study looks at how whey protein, with or without a natural boost called ashwagandha, affects strength, recovery, and well-being in active men. If you're a fit male aged 18-45, you could help researchers understand if these supplements can improve your fitness journey.
Sports Nutritional SciencesSports NutritionRecoveryRecovery Following ExerciseUnited Kingdom - Active not recruitingNA
AI-enhanced LF-MRI in Epilepsy
This study is looking at a new, more affordable MRI scan for people with epilepsy. It uses a lower-strength MRI machine and artificial intelligence to see if it can diagnose epilepsy as well as the standard, more expensive scans. We want to help more people get the right diagnosis, especially in areas where advanced scans are hard to find.
EpilepsyUnited Kingdom - Active not recruiting
Demographics, Clinical Characteristics and Outcomes in Resected Non-Small Cell Lung Cancer Patients Receiving Immunotherapy in Europe and Canada
This study looks at existing medical records of people in Europe and Canada with a type of lung cancer called non-small cell lung cancer (NSCLC) who had surgery. It helps us understand how a treatment called immunotherapy is used before or after their operation, and how they got on.
Non-Small Cell Lung CancerUnited Kingdom - Not yet recruitingNA
Psychosocial Support for Nitrous Oxide Misuse
This study offers a new support program for young people struggling with laughing gas (nitrous oxide) use, which can harm nerves. It aims to help with emotional and social challenges, testing if the program works well to improve well-being and reduce reliance on laughing gas.
Brief Psychosocial InterventionUnited Kingdom - Recruiting
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
This study looks at a special treatment for liver cancer or cancer that has spread to the liver. It's called PVE/HVE and aims to help the liver grow bigger before surgery. Researchers are gathering information from many hospitals to see how well it works and if it's safe.
Liver CancerLiver MetastasesUnited Kingdom - Recruiting
Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance
This study looks at how well different kidney dialysis methods (haemodialysis and haemodiafiltration) clear waste products, how patients feel, and managing fluid. Researchers compare how much fluid is filtered and how different salt levels in the dialysis fluid affect fluid balance.
HaemodiafiltrationHaemodialysisPatient Reported Outcome MeasurementsNutritionUnited Kingdom - RecruitingPHASE2
A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis
This study is testing a new medicine, Povetacicept, for people aged 18 to 80 with a type of muscle weakness called generalized myasthenia gravis (gMG). Researchers want to see how the medicine works in the body and if it's safe to use.
Myasthenia Gravis, GeneralizedUnited Kingdom - RecruitingPHASE1
First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors
This study is testing a new drug, GSK5533524, for advanced cancers. Researchers want to find a safe dose, check for side effects, and see if it can shrink tumours or slow their growth in adults who have tried other treatments.
NeoplasmsUnited Kingdom - Not yet recruitingPHASE1, PHASE2
Investigating the Combination of Bexmarilimab and Nivolumab in Solid Tumours, Melanoma and NSCLC
This study looks at combining two drugs, bexmarilimab and nivolumab, for advanced skin and lung cancers. It aims to find a safe dose and see if this combination can help when previous immunotherapy stopped working.
Melanoma (Skin Cancer)Non Small Cell Lung CancerSolid Tumor in Advanced StageUnited Kingdom - RecruitingPHASE1, PHASE2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
This study is testing a new drug called Etentamig for adults with multiple myeloma, a type of blood cancer. Researchers want to see if it's safe and effective when given alone or with other common treatments to help manage the disease.
Multiple MyelomaUnited Kingdom - RecruitingPHASE3
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
This study looks at a new medicine called Tozorakimab. We want to see if it can help people in hospital with lung infections who need extra oxygen. The goal is to stop them from getting sicker, like needing a breathing machine, or even dying.
Viral Lung Infection and Acute Respiratory FailureUnited Kingdom - Active not recruitingPHASE1
Study of INCB123667 in Subjects With Advanced Solid Tumors
This study is testing a new drug, INCB123667, for people with advanced solid tumours. It will look at how safe the drug is, how it's used with other treatments, and if it could help shrink tumours. It's an early-stage study.
Solid TumorsUnited Kingdom - RecruitingPHASE3
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
This study is looking at a new medicine called brenipatide for people with moderate to severe alcohol use disorder. It compares brenipatide to a dummy medicine (placebo) to see if it's safe and effective in helping people cut down or stop drinking.
Alcohol Use DisorderUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)
This study looks at a new drug, Nizubaglustat, for Niemann-Pick Type C (NPC) disease in children and young people. It aims to see if the drug can help with movement problems and if it's safe, compared to a dummy pill.
Niemann-Pick Type C DiseaseUnited Kingdom - RecruitingPHASE3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
This study is looking at a new drug, Saruparib, for men with high-risk prostate cancer and a faulty BRCA gene. It aims to see if adding Saruparib to standard treatments can help prevent the cancer from spreading.
Prostate CancerUnited Kingdom - Active not recruitingPHASE2
Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine
This study is for adults with bronchiectasis who were in a previous trial with the medicine BI 1291583. It aims to see if this medicine helps long-term and how well people tolerate it. Participants take tablets daily and visit the clinic regularly.
BronchiectasisUnited Kingdom - RecruitingPHASE3
Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib
This study is for people who have already taken part in certain Incyte povorcitinib trials for Hidradenitis Suppurativa (HS) and found the treatment helpful. It allows them to continue receiving the study drug if their doctor agrees it's safe and beneficial.
Hidradenitis Suppurativa (HS)United Kingdom - RecruitingPHASE3
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemotherapy
This study looks at a new medicine called obrixtamig for advanced small cell lung cancer. It compares obrixtamig plus standard treatment against standard treatment alone to see if it helps people live longer. It also tests a device to measure a cancer marker.
Small Cell Lung Cancer (SCLC)Extensive-stage Small Cell Lung Cancer (ES-SCLC)United Kingdom - RecruitingPHASE2, PHASE3
Visugromab in Cachexia International Trial
This study looks at a new drug called visugromab for people with certain cancers and severe weight loss (cachexia). It checks if the drug helps with weight gain, appetite, and movement. Researchers also want to know about any side effects. It's compared to a dummy treatment.
Cancer-associated CachexiaUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
This study is looking at a new medicine called AZ-3102 for children and young people with rare conditions like Niemann-Pick Type C, GM1 Gangliosidosis, or GM2 Gangliosidosis. It aims to see if the medicine is safe and if it helps improve their health over 18 months.
Niemann-Pick Type C DiseaseGM1 GangliosidosisGM2 GangliosidosisUnited Kingdom - Recruiting
Metagenomics for Ocular Inflammation
This study uses a special test called 'metagenomic sequencing' to find hidden infections in people with eye inflammation. Current tests often miss these. By finding the infection, doctors hope to offer better, more targeted treatments and improve our understanding of this condition.
UveitisAqueous HumorInfectionUnited Kingdom - RecruitingPHASE1, PHASE2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
This study is testing a new medicine, LTP001, to see if it's safe and how it works in healthy people. Then, it will study people with a lung condition called Pulmonary Arterial Hypertension (PAH) to see if it helps them and if it's safe.
Healthy Volunteers, Pulmonary Arterial HypertensionUnited Kingdom - Active not recruitingPHASE3
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
This study looks at the best treatment for women with a common type of early breast cancer. It compares hormone therapy alone against hormone therapy plus chemotherapy, using a special test to help decide which is best for each woman.
Breast AdenocarcinomaHormone Receptor PositiveStage IA Breast Cancer AJCC v7Stage IB Breast Cancer AJCC v7United Kingdom - RecruitingNA
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
This study looks at the best time to treat a heart condition called aortic stenosis in people who don't have symptoms. It compares early surgery or a keyhole procedure to careful monitoring, to see which approach leads to better health and is more cost-effective.
Aortic StenosisUnited Kingdom - RecruitingPHASE2
Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients
This study is testing a new medicine, SAT-3247, for boys aged 7-9 with Duchenne muscular dystrophy. We want to find the best dose, see if it's safe, and check if it helps. Some boys will get the real medicine, others a dummy medicine.
Duchenne Muscular DystrophyDuchenneDMDNeuromuscular DiseasesUnited Kingdom - RecruitingPHASE2, PHASE3
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
This study looks at a new treatment called CABA-201 for conditions that cause muscle weakness and inflammation, like dermatomyositis. It aims to see how safe and effective this treatment is for adults and children whose condition hasn't improved with usual care.
Idiopathic Inflammatory MyopathyDermatomyositisAnti-Synthetase SyndromeImmune-Mediated Necrotizing MyopathyUnited Kingdom - RecruitingPHASE1, PHASE2
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
This study is testing two new treatments, BNT323 and BNT327, for advanced breast cancer. It aims to find the safest and most effective dose when used together, and to see if this combination helps patients with different types of breast cancer.
Locally Advanced Breast CancerUnresectable Breast CarcinomaMetastatic Breast CancerUnited Kingdom - RecruitingPHASE3
Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC
This study is testing a new drug, neladalkib, for people with a common type of lung cancer (NSCLC) that's ALK-positive. It's comparing neladalkib to a standard treatment, alectinib, to see if neladalkib works better at stopping the cancer from growing.
Non-small Cell Lung CancerAnaplastic Lymphoma Kinase-positiveUnited Kingdom - Recruiting
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
This study looks at standard treatments for people with severe lupus that hasn't responded well to usual medicines. Researchers want to understand how effective and safe these treatments are for patients, including those with kidney involvement.
Systemic Lupus Erythematosus (SLE)United Kingdom - Active not recruitingPHASE3
A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
This study is testing a new combination of medicines with chemotherapy for some upper gut cancers that have spread and can't be removed by surgery. It aims to see if the new combination works better than current treatments.
Advanced Upper Gastrointestinal Tract AdenocarcinomaUnited Kingdom - Active not recruitingPHASE3
Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC
This study looks at a new drug, selumetinib, combined with standard chemotherapy (docetaxel) for a specific type of advanced lung cancer. It aims to see if this combination works better than chemotherapy alone for patients whose cancer has the KRAS gene mutation.
Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IVUnited Kingdom - RecruitingPHASE3
Study of Oral Upadacitinib and Subcutaneous/Intravenous Tocilizumab to Evaluate Change in Disease Activity, Adverse Events and How Drug Moves Through the Body of Pediatric and Adolescent Participants With Active Systemic Juvenile Idiopathic Arthritis.
This study looks at new treatments for a severe type of childhood arthritis called Systemic Juvenile Idiopathic Arthritis (sJIA). It compares upadacitinib with an existing treatment, tocilizumab, to see how well they work and if they cause any side effects in children aged 1 to 17.
Juvenile Idiopathic ArthritisUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata
This study looks at a daily tablet called upadacitinib for severe alopecia areata, a condition where your immune system attacks hair follicles, causing hair loss. It aims to see how safe and effective it is for teenagers and adults.
Alopecia AreataUnited Kingdom - RecruitingPHASE3
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
This study looks at a new drug, upadacitinib, for moderate to severe Hidradenitis Suppurativa (HS). It's for adults and teenagers whose HS hasn't improved with other treatments. We'll check if it's safe and helps reduce HS symptoms.
Hidradenitis SuppurativaUnited Kingdom - RecruitingPHASE3
Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer
This study is looking at a new combination of medicines for a type of lung cancer that has spread or can’t be removed by surgery. It compares a drug called trastuzumab deruxtecan plus pembrolizumab to standard chemotherapy plus pembrolizumab.
Non-small Cell Lung CancerUnited Kingdom - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis
This study is looking at a new medicine called AZ-3102 for children and young people with GM1 or GM2 gangliosidosis. Researchers want to see if it's safe and helps improve balance and movement problems. Some people will get the medicine, others will get a dummy pill.
Gangliosidoses, GM2Gangliosidosis, GM1United Kingdom - RecruitingPHASE3
A Study of Brenipatide in Participants With Alcohol Use Disorder
This study is looking into a new medication called brenipatide for people with alcohol use disorder. It aims to see if it's safe and helps people reduce or stop their drinking, compared to a dummy treatment.
Alcohol Use DisorderUnited Kingdom - RecruitingPHASE2
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
This study looks at whether a new medicine, BI 764198, can help adults and teenagers with certain kidney problems. It compares the new medicine to a dummy pill to see if it reduces protein in the urine and improves kidney health.
Proteinuric Kidney DiseasesUnited Kingdom - RecruitingPHASE3
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
This study is looking at a new treatment (BNT323) for women with advanced womb cancer that has come back. It compares BNT323 to standard chemotherapy to see if it works better at shrinking tumours and keeping the cancer from growing.
Endometrial CancerUnited Kingdom - Enrolling by invitationPHASE3
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
This study looks at a new medicine called efgartigimod for people with certain muscle conditions like myositis. It's for adults who were in a previous study, to see if the medicine is safe and helpful over a long time.
MyositisActive Idiopathic Inflammatory MyopathyDermatomyositisPolymyositisUnited Kingdom - RecruitingPHASE3
The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)
This study looks at a new drug, 177Lu-TLX591, for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapy. It compares this new drug combined with standard treatments to standard treatments alone.
Metastatic Castration-resistant Prostate CancerUnited Kingdom - RecruitingPHASE3
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
This study is looking into a new drug, AZD5335, for women with advanced ovarian cancer that has become resistant to usual chemotherapy. It compares AZD5335 to existing treatments to see if it works better at controlling the cancer's growth.
Epithelial Ovarian CancerUnited Kingdom - RecruitingPHASE2
A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic Sclerosis
This study is testing a new medicine, efgartigimod, for adults with systemic sclerosis. It aims to see if the medicine helps improve symptoms and if it's safe, compared to a dummy medicine. We're looking for people to join for about 15 months.
Systemic Sclerosis (SSc)United Kingdom - Active not recruitingPHASE3
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
This study looks at a new way to give a lung cancer medicine called pembrolizumab. It compares giving it through a drip in your arm (IV) versus a new injection under the skin (SC) for people with advanced non-small cell lung cancer. Researchers want to see how the injection works.
Lung CancerNon-Small Cell Lung CancerUnited Kingdom - Recruiting
EXtubation Related Complications - the EXTUBE Study (EXTUBE)
This study looks at issues that can happen when breathing tubes are removed after surgery or critical illness. Researchers want to understand why these problems happen and how medical teams can improve this common procedure to make it safer for everyone.
ExtubationUnited Kingdom - RecruitingPHASE2, PHASE3
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
This study is for people with a type of head and neck cancer linked to HPV16. It compares a new treatment (BNT113 plus pembrolizumab) with pembrolizumab alone to see if the new combination is safe and works better.
Unresectable Head and Neck Squamous Cell CarcinomaMetastatic Head and Neck CancerRecurrent Head and Neck CancerUnited Kingdom - RecruitingPHASE3
A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP
This study compares a new medicine, empasiprubart, with standard IVIg treatment for adults with CIDP. It looks at how well they work and if they are safe. Participants will receive one of these treatments, or a dummy treatment, for several months.
Chronic Inflammatory Demyelinating PolyneuropathyCIDPCIDP - Chronic Inflammatory Demyelinating PolyneuropathyUnited Kingdom - Active not recruitingPHASE2
A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
This study looks at new treatments for advanced stomach or gullet cancer. It combines a new drug, ABBV-400, with existing chemotherapy and another new drug, Budigalimab. We want to find the safest and most effective dose and see how well it works.
Locally Advanced Unresectable or Metastatic Gastric AdenocarcinomaGastroesophageal Junction AdenocarcinomaEsophageal AdenocarcinomaUnited Kingdom - RecruitingPHASE2
Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis
This study is testing a new medicine, PIPE-791, for a lung condition called Idiopathic Pulmonary Fibrosis (IPF). We want to see how well it works, if it's safe, and if people can tolerate it. It's a phase 2 study, meaning we're still in the early stages of testing.
Idiopathic Pulmonary FibrosisUnited Kingdom - Active not recruitingNA
Portico Next Generation Approval Study
This study is testing a new replacement heart valve, called Portico™ NG, for people with severe aortic stenosis who are very sick or at high risk for surgery. It aims to make sure the new valve is safe and works well to improve their heart condition.
Symptomatic Severe Aortic StenosisUnited Kingdom