Latest studies
- RecruitingPHASE4
Is ICG Imaging Safe and Accurate to Predict Testicular Torsion?
This study looks at a new, quick way to tell if a boy with sudden testicle pain has testicular torsion. This problem needs urgent surgery. We want to see if this new test can help avoid unnecessary operations for children while making sure no serious cases are missed.
Torsion TestisScrotum DiseaseUnited Kingdom - RecruitingNA
Improving CRT Outcome With Non-Invasive Cardiac Mapping
This study looks at a new way to place a special device (CRT) for people with heart failure. It compares standard placement with a new method using a special mapping system to see if it improves how well the treatment works.
Heart Failure With Reduced Ejection FractionUnited Kingdom - Active not recruitingNA
Does Screening With the Galleri Test in the NHS Reduce the Likelihood of a Late-stage Cancer Diagnosis in an Asymptomatic Population? A Randomised Clinical Trial
This study is looking at a new blood test called the Galleri test. It aims to see if using this test with usual NHS care can help find many types of cancer earlier in people aged 50-77 who don't have symptoms. Finding cancer early often makes it easier to treat.
CancerUnited Kingdom - Active not recruitingPHASE2
A Clinical Trial to Evaluate Safety of Vosoritide in At-risk Infants With Achondroplasia
This study is testing a medicine called vosoritide for babies up to one year old with achondroplasia. We want to see if it's safe and helps improve a tricky neck problem often seen in achondroplasia, especially in babies who might need surgery.
AchondroplasiaUnited Kingdom - Active not recruitingPHASE2
KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer
This study is testing if a very diluted version of a common chemical, hydrogen peroxide, can make radiotherapy work better for large breast cancer lumps. It involves injecting this special gel into the cancer twice a week during a standard course of radiotherapy. Early results from Japan have been promising.
Breast CancerUnited Kingdom - Active not recruitingNA
Pediatric Expansion Study of the Sentio System
This study is looking at how a hearing system, called Sentio, works for children aged 3 to 11. It's already used by adults and older children, and this research aims to check its safety and how well it helps younger children hear better.
Hearing Loss, ConductiveHearing Loss, MixedSingle Sided DeafnessUnited Kingdom - Recruiting
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
This study is gathering important information about a rare kidney disease called atypical Hemolytic-Uremic Syndrome (aHUS). It looks at how the disease progresses and how safe new treatments like eculizumab and ravulizumab are for patients of all ages.
Atypical Hemolytic-Uremic SyndromeUnited Kingdom - Active not recruitingNA
Prehabilitation and RecOVERy From Surgery for Breast Cancer Study
This study looks into whether a supported exercise programme before and after breast cancer surgery helps women recover better. It aims to see if exercising before treatment, called 'prehabilitation', can make a difference to confidence and activity levels after surgery, and if starting exercise soon after surgery is practical.
ExerciseBreast Neoplasm FemaleUnited Kingdom - Active not recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
This study compares an intensive weight loss programme, including special diets and support, with standard NHS weight management for adults with severe obesity. It aims to see which works best for health and cost.
ObesityUnited Kingdom - Active not recruitingPHASE3
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
This study looks at a new drug, zanidatamab, combined with chemotherapy, and sometimes another drug called tislelizumab. It aims to see if this treatment works better and is safer than standard chemotherapy for advanced stomach and gullet cancers that have HER2.
Gastric NeoplasmsGastroesophageal AdenocarcinomaEsophageal AdenocarcinomaUnited Kingdom - RecruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
Heart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection FractionObesityUnited Kingdom - Not yet recruitingNA
Time and Cost-implications of Intraoral Scans Vs Alginate Impressions
This study compares two ways to take dental impressions for braces: traditional molds and digital scans. Researchers want to find out which method takes less time for patients and costs less for dental practices. This helps improve orthodontic care.
Alginate ImpressionIntraoral ScannerTimeCostUnited Kingdom - Active not recruiting
The Effect of Continuous Positive Airway Therapy on the Blood Pressure in Sleepy vs Non-sleepy Patients With Obstructive Sleep Apnea
This study looks at how treating sleep apnea affects blood pressure. We want to see if the treatment works differently for people who feel very sleepy compared to those who don't. We're using information from past studies to find out more.
Obstructive Sleep ApneaUnited Kingdom - Active not recruitingPHASE1
Study of the Effect of Rifampicin on the Pharmacokinetics (PK) of Multiple Doses of Cediranib in Patients With Solid Tumours
This study looks at how your body handles a new cancer drug called cediranib when you also take a common medicine called rifampicin. It helps researchers understand how these drugs work together in patients with advanced solid tumours, aiming for safer and more effective treatments.
Solid TumorsUnited Kingdom - Active not recruitingPHASE4
OM-85 in Paediatric Recurrent Respiratory Tract Infections With Wheezing Lower Respiratory Illness
This study looks at a medicine called OM-85 to see if it can help young children, aged 6 months to 5 years, who get lots of chest infections and wheezing. We want to know if it's safe and effective at reducing how often they get ill.
Respiratory Tract InfectionsWheezing Lower Respiratory IllnessUnited Kingdom - RecruitingPHASE3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
This study looks at a new medicine, abelacimab, for people with an irregular heartbeat (atrial fibrillation) who can't take usual blood thinners. It compares abelacimab to a dummy medicine to see if it can prevent strokes.
Atrial Fibrillation (AF)United Kingdom - Active not recruitingPHASE2
Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options
This study is testing a new weekly drug called rezafungin for adults with a serious lung infection called Chronic Pulmonary Aspergillosis (CPA). It's for people who haven't found other treatments effective or can't take them. We want to see if it's safe and helps improve their health over six months.
Chronic Pulmonary AspergillosisUnited Kingdom - Not yet recruiting
Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment
This study looks at retinal detachment, a serious eye condition. We want to understand why some people develop further problems after surgery and how to spot them earlier. This could help doctors predict who might need extra care and improve future treatments.
Retinal Detachment RhegmatogenousProliferative VitreoretinopathyProliferative Vitreoretinopathy in Rhegmatogenous Retinal DetachmentUnited Kingdom - Active not recruitingPHASE1
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
This study looks at a new drug called XL092 for advanced solid tumours like kidney, breast, prostate, or bowel cancer. Researchers are testing it alone and with other drugs (Atezolizumab, Avelumab) to see if it's safe, how it works, and if it can help slow down or shrink tumours.
Neoplasm MalignantRenal Cell CarcinomaHormone Receptor Positive Breast CarcinomaMetastatic Castration-resistant Prostate CancerUnited Kingdom - RecruitingPHASE1, PHASE2
A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
This study is testing a new medicine, AZD4512, for people with a type of blood cancer called B-cell non-Hodgkin lymphoma that has come back or not responded to past treatments. It looks at how safe and effective the medicine is, sometimes on its own, and sometimes with other cancer drugs.
B-cell Non-Hodgkin LymphomaUnited Kingdom - RecruitingPHASE2
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
This study is testing a new medicine, GSK4532990, for people aged 18-70 with liver damage caused by alcohol. We want to see if it's safe and if it helps the liver. Some people will get the medicine, others a dummy pill.
Liver Diseases, AlcoholicUnited Kingdom - RecruitingPHASE2
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
This study is testing a new medicine, ensifentrine, for people with a lung condition called non-cystic fibrosis bronchiectasis. We want to see if it helps reduce flare-ups, improve breathing, and make people feel better, compared to a dummy medicine.
Non-cystic Fibrosis BronchiectasisUnited Kingdom - RecruitingPHASE1
First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors
This study is testing a new experimental medicine, CDR404, for hard-to-treat solid cancers that have a specific marker called MAGE-A4. It's the first time CDR404 is being used in people, and doctors want to see if it's safe and if it can help fight the cancer.
Select Advanced Solid TumorsUnited Kingdom - Not yet recruitingNA
Mechanistic Study of Anti-Platelet Therapy in Atherosclerosis
This study looks at how common heart medications, aspirin and clopidogrel, affect small blood cell clumps in people with hardening of the arteries. It aims to see if these medicines can reduce these clumps, which are linked to heart problems, especially in those showing no symptoms.
Peripheral Arterial DiseaseSilent AtherosclerosisUnited Kingdom - RecruitingNA
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
This study looks at how a new weight loss medicine, Tirzepatide, affects high blood pressure in young adults who are overweight or obese. We want to see if losing weight can help lower blood pressure more effectively than usual care.
HypertensionObesity & OverweightUnited Kingdom - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
LeukemiaUnited Kingdom - RecruitingPHASE3
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
This study is testing a new medicine, volrustomig, for people with a type of head and neck cancer that hasn't spread and wasn't removed by surgery. It aims to see if volrustomig helps prevent the cancer from coming back after standard treatment like chemotherapy and radiotherapy.
Locally Advanced Head and Neck Squamous Cell CarcinomaUnited Kingdom - RecruitingNA
Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.
This study compares two common surgeries to reconnect your gut after removing most of your large bowel for Ulcerative Colitis. It aims to see which one, an ileal pouch or an ileorectal anastomosis, offers the best quality of life, satisfaction, and fewer complications for patients in the UK.
Ulcerative ColitisInflammatory Bowel DiseasesIleostomy - StomaUnited Kingdom - Enrolling by invitationNA
Optical Coherence Tomography in Acute Vessel Evaluation
This study compares two ways to help people having a heart attack: one uses standard X-rays, the other uses a special camera called OCT. We want to see if the OCT camera leads to better results for patients.
Ischemic Heart DiseaseIschemic Coronary Artery DiseaseACS (Acute Coronary Syndrome)United Kingdom - RecruitingPHASE2
Methods of T Cell Depletion Trial (MoTD)
This study compares different ways to prevent a complication called GvHD after stem cell transplants for various blood cancers. It's looking for the best treatment plan to help patients recover well, using common medicines like Thymoglobulin, Cyclophosphamide, Cyclosporine, Sirolimus, and Mycophenolate Mofetil.
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaChronic Myelomonocytic LeukemiaMyelodysplastic SyndromesUnited Kingdom - RecruitingPhase I/II
Testing a novel home-based approach for strengthening motor pathways
This study is looking for people with hand weakness from a spinal cord injury. We're testing a new home device that uses small electrical pulses and hand movements to help strengthen the brain-hand connection. We hope this will improve hand function.
Individuals who have had a cervical spinal cord injury which resulted in hand weaknessUnited Kingdom - Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
This study is gathering information on a rare genetic condition called LAL Deficiency. It aims to understand the disease better and improve care for affected individuals, from babies to adults. It's a worldwide effort to collect health data over time.
Lysosomal Acid Lipase DeficiencyCholesterol Ester Storage DiseaseWolman DiseaseAcid Cholesteryl Ester Hydrolase Deficiency, Type 2United Kingdom - Recruiting
Fatigue and brain function in young people after brain injury
This study looks at why young people who have had a brain injury often feel very tired and have trouble thinking clearly. We want to understand what causes this fatigue and how it affects their daily lives, as well as explore links to sleep, brain activity, and memory.
Cognitive fatigue in children and young people (CYP) with acquired brain injury (ABI)United Kingdom - Recruiting
Understanding why cancer immunotherapy helps some people but causes side effects in others
This study looks at why immunotherapy for cancer works for some people but causes side effects in others. By studying samples from patients, researchers hope to improve treatment and reduce side effects for future patients. It's an observational study, meaning your treatment won't change.
Psychosocial oncology and survivorshipUnited Kingdom - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyUnited Kingdom - RecruitingNA
Investigating the Glycaemic and Satiating Capacity of PulseOn® Enriched Foods
This study looks at how special crackers, made with a new type of pulse flour called PulseOn, affect your blood sugar and how full you feel after breakfast. We also check how much you eat at lunch. We hope to find out if these crackers could help manage appetite.
Glycaemic ResponseAppetitive BehaviorEnergy IntakeUnited Kingdom - Enrolling by invitationNA
Assessment of Visual Function and Optics in Intraocular Lenses
This study looks at how well different replacement lenses work after cataract surgery. We want to understand what makes them effective and how they can be even better in the future to give you the best possible vision.
CataractUnited Kingdom - Active not recruitingPHASE2
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
This study looks at a new drug, tulisokibart, for people with a lung condition called interstitial lung disease (ILD) linked to scleroderma. We want to see if it's safe and helps improve the condition.
Diffuse Cutaneous Systemic SclerosisInterstitial Lung DiseaseUnited Kingdom - RecruitingPHASE2
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
This study looks at new treatments for stomach or food pipe cancer that can be removed by surgery. It aims to see how safe and effective these new drugs or drug combinations are before and after the operation.
Gastroesophageal AdenocarcinomaUnited Kingdom - Active not recruitingPHASE3
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
This study is testing a new medicine, selumetinib, for adults with a condition called Neurofibromatosis Type 1 (NF1). It focuses on people who have painful, non-removable growths called plexiform neurofibromas. We want to see if this medicine can help reduce symptoms and safely shrink these growths.
Neurofibromatosis 1Plexiform Neurofibroma (PN)United Kingdom - Active not recruitingPHASE3
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
This study looks at a medicine called atezolizumab for people with a type of bladder cancer that has spread into the muscle. It checks if this medicine, given after surgery, can stop the cancer from coming back in those who show signs of tiny cancer cells in their blood.
Muscle-invasive Bladder CancerUnited Kingdom - Recruiting
FAD - Food for ADHD and Depression
This study, called FAD, explores if diet and coaching can improve ADHD symptoms and related low mood. Adults with ADHD and depression symptoms will follow a guided diet for 16 weeks to see if it helps more than another dietary approach. It aims to find new ways to support people.
ADHD and related depression symptomsUnited Kingdom - RecruitingNA
Children's Health, Respiratory Inflammation and Short-term Air Pollution
This study looks at how air pollution affects children's breathing during sports and lessons. We want to see if being active in areas with more pollution is harder on children's lungs compared to resting. It involves children aged 7-11 from London schools.
Asthma AcuteRespiratoryUnited Kingdom - Recruiting
Intimate lives matter: sex, relationships and the Care Act
This study aims to improve how social workers support autistic people and those with learning disabilities in their relationships. It will create tools and training for social workers, helping them discuss sex and relationships during care assessments to reduce loneliness and improve well-being.
Support for autistic people and people with learning disabilities around sex and relationshipsUnited Kingdom - Active not recruitingPHASE3
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
This study looks at treating muscle-invasive bladder cancer. It compares standard chemotherapy with chemotherapy plus a new immunotherapy drug called nivolumab, given before and after surgery. The aim is to see if adding nivolumab helps more people.
Urinary Bladder NeoplasmsMuscle-Invasive Bladder CancerUnited Kingdom - Recruiting
Use of forum theatre in service design and patient decision aids
This study looks at using a special type of theatre to help design better maternity services. It aims to improve how pregnant people make important decisions about their birth, especially for things like larger babies. We want to make sure everyone gets the right support.
Decision-making in maternity care, specifically informed choice for birth planning (e.g. large-for-gestational-age pregnancies), and optimisation of healthcare service design using forum theatreUnited Kingdom - Not yet recruiting
The SAFE study: Exploring a new support package for autistic children and their families
This study, called SAFE, explores a new support programme for autistic children aged 3-16 and their families. It aims to see if SAFE improves family mental health and coping compared to usual care, and if it's suitable and affordable for the NHS.
Diagnosis of autism; if other diagnoses are present (e.g., ADHD, OCD, ED), autism must be the primary diagnosisUnited Kingdom - RecruitingNA
Probiotic Intake and Perimenopausal Psychological Assessments
This study looks at how a special probiotic might help women in perimenopause with their emotions and thinking skills, like memory and focus. Researchers will check changes in mood, memory, and gut bacteria.
Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive PerturbationsPerimenopausePerimenopause-Related DepressionPerimenopausal WomenUnited Kingdom - Recruiting
The Imperial College comprehensive study of people with chronic damage to small blood vessels in the brain to define underlying mechanisms
This study from Imperial College London looks at people with small vessel disease in the brain. It aims to understand why this condition happens and how it affects people, hoping to find new ways to treat it. It involves reviewing medical records, interviews, and some simple tests.
Cerebral small vessel diseaseUnited Kingdom - Recruiting
Respiratory-swallow training in head and neck cancer
This study aims to develop and test a new breathing and swallowing exercise programme for head and neck cancer patients in the UK. Many people find swallowing difficult after treatment, and this programme hopes to offer a simpler, more accessible way to help improve it.
Swallow training in head and neck cancerUnited Kingdom