Latest studies
- Recruiting
Balancing "bad" and "good" immune cells: testing a novel method for monitoring an immunosuppression strategy in people with Type 1 diabetes
This study is testing a new way to quickly check if treatments for Type 1 diabetes are working. It involves two medicines to help balance immune cells and aims to find better ways to stop the body from attacking insulin-producing cells.
Type 1 diabetesWales - Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthWales - Recruiting
Enhancing care for delirium in palliative care units
This study aims to improve care for acute confusion (delirium) in hospices across the UK. We're testing new ways to help hospices follow guidelines better, hoping to reduce delirium and improve life quality for patients and their families.
DeliriumWales - Recruiting
Pelvic floor muscle exercises plus pessary for treatment of prolapse versus pelvic floor muscle exercises alone
This study looks at combining pelvic floor exercises with a vaginal pessary for women with pelvic organ prolapse. It wants to see if this combined approach works better at reducing symptoms than just doing the exercises alone, helping to improve women's daily lives.
Pelvic organ prolapseWales - CompletedPhase I
A study to investigate the safety, tolerability, and concentration in the blood of different dose strengths of ENX-102 in healthy volunteers
This study is testing a new medicine, ENX-102, to see how safe it is and how much of it gets into the blood at different doses. It's for healthy adults and could help people with conditions like epilepsy or anxiety in the future.
Epilepsy, anxiety, spasticity or other CNS disordersWales - Recruiting
Falls in stroke survivors
This study looks at a new programme, called SAF, to help stroke survivors avoid falls after leaving hospital. It compares SAF with usual care to see if it reduces falls over 12 months. SAF involves a checklist and action plan to manage fall risks.
StrokeWales - RecruitingPhase III
Through knee amputation compared to above knee amputation
This study compares two types of leg amputation: through-knee and above-knee. It aims to find out which one leads to a better quality of life and easier recovery for patients who need this surgery, helping doctors make the best choices in the future.
Major lower limb amputationWales - RecruitingPhase III
A trial of treatments to slow progression of Parkinson's disease
This study looks for new ways to slow down Parkinson's disease, a common and growing condition. It tests known medicines, telmisartan and terazosin, to see if they can help manage symptoms and stop the disease from getting worse. It's a key step in finding better treatments.
Parkinson’s disease (PD)Wales - CompletedPhase II
Exploratory effect of long-term Verapamil therapy in adults with Type 1 diabetes mellitus (Ver-A-Long)
This study looks at whether a blood pressure medicine called Verapamil can help adults with Type 1 diabetes. It explores if taking it long-term helps the body make more insulin and checks its safety. This is for people already in a related Verapamil study.
Type 1 DiabetesWales - Completed
Exploring the effects of a natural seaweed supplement on digestion, health, and well-being
This study looks at a natural seaweed supplement called fucoidan. We want to see if it can help young adults (18-35) with their digestion, general health, and how they feel overall. It's a remote study, and you'd take capsules for 28 days.
Gut health and overall well-beingWales - Completed
Trial of isometric exercise to lower blood pressure
This study looks at a simple wall-squat exercise to help lower blood pressure in people with high readings. It aims to see if doing these short exercises at home can make a real difference, building on earlier promising results.
Stage 1 and 2 hypertensionWales - Completed
Taste acceptance of fluoride varnish on autistic patients
This study looks at how autistic children aged 3-15 react to the taste of different fluoride varnishes used to prevent tooth decay. We want to find out which flavours they accept best to make dental visits easier and improve their dental health.
Preventive dental care in autistic childrenWales - RecruitingPhase IV
Optimising the use of azithromycin antibiotic to reduce Bronchiectasis flare-ups
This study looks at whether people with a lung condition called bronchiectasis can safely stop taking azithromycin, an antibiotic, after their condition has settled down. We want to see if stopping the medicine still keeps flare-ups away and improves their quality of life.
Medical condition: Bronchiectasis Medical condition in lay language: Bronchiectasis Therapeutic areas: Diseases [C] - Respiratory Tract Diseases [C08]Wales - Completed
Can silver diamine fluoride (SDF) reduce the impact on young children of waiting for dental care?
This study looks at whether a treatment called silver diamine fluoride (SDF) can help young children with tooth decay who are waiting for dental surgery. It aims to see if SDF can reduce pain and infection while they wait, making their experience better.
Dental cariesWales - Recruiting
Fix or replace enhancing distal humerus fracture outcomes
This study compares two common surgeries for broken elbows in people over 60: elbow replacement or fixing the break with plates and screws. It aims to find which treatment works best to help people recover and use their arm normally again.
Intra-articular fracture of the distal humerus AO type B or CWales - RecruitingNot Specified
Developing genetic tests to diagnose, monitor and guide treatment decisions for children and young people whose cancer has returned
This study looks at the genes in children and young people whose cancer has come back or not responded to treatment. We compare genes in healthy cells with cancer cells to find changes. This helps doctors personalise treatments and find new ways to fight cancer based on genetic information.
Relapsed/refractory solid tumours (including lymphomas) or leukaemiaWales - Recruiting
Reconstruction after advanced pelvic cancer surgery
This study looks at how repairing the body after major cancer surgery in the pelvis affects a person's life. It compares different ways of reconstruction to see which works best for quality of life, complications, and costs.
Advanced pelvic cancersWales - RecruitingNot Applicable
A study to find out whether gradually stopping brace treatment or stopping it all at once is better for babies with hip dysplasia
This study looks at the best way to stop wearing a hip brace for babies with hip problems. We want to see if removing it all at once or slowly over time is better. It's for babies who have already improved with the brace.
The strategy for discontinuing Pavlik harness treatment in infants under 6 months with Developmental Dysplasia of the Hip (DDH) following successful Pavlik harness use.Wales - Completed
Understanding the role of community pharmacy in the support of people with long COVID
This study looks at how local chemists (community pharmacies) can better support people in the UK living with "long COVID." Researchers will talk to people with long COVID and pharmacy staff to create a useful online training course for pharmacists to help them understand and assist those with ongoing symptoms.
Long COVIDWales - RecruitingPhase IV
DEsogestrel for Bleeding on the Implant (DEBI)
This study looks at treating annoying bleeding caused by the contraceptive implant. We're comparing two hormonal treatments, desogestrel and the combined pill, to see which works best to settle periods and offer a safer, easier option for implant users.
Self-reported problem bleeding on the contraceptive implantWales - Recruiting
The effect of a therapeutic nature-based intervention on stress in people with mental ill-health
This study looks at how nature-based activities might help reduce stress for adults with mental health challenges. Participants will join weekly outdoor sessions and complete questionnaires to see if these activities improve their well-being.
Reduction in stress in those with self-reported moderate-to-high perceived stress levelsWales - Completed
An evaluation of a cognitive-behavioural intervention for medical students
This study looks at a special support program called Thumos for UK medical students. It aims to help them cope with stress, feel more confident, and reduce burnout and depression during their clinical placements. We want to see if Thumos works better than usual support.
Improvement of psychological resilience in UK medical studentsWales - Completed
Development of guidelines for treating patients with cancer-related blockages in the upper urinary tract
This study aims to create clear guidelines for doctors treating cancer patients who have blockages in their urinary tubes. These blockages can cause serious problems, and currently, there aren't agreed-upon ways to treat them. Experts will share their knowledge to help improve patient care.
Clinical guidelines for the management of malignant upper urinary tract obstruction (MUUTO), in cancer patients.Wales - Completed
Testing the feasibility and acceptability of a novel therapeutic for depression: the CURED trial
This study, called CURED, is testing a new self-help approach for depression. It looks at whether this new treatment is practical and helpful for adults with depression. It involves weekly online sessions and aims to improve mood and understanding.
Clinical depressionWales - RecruitingPhase III
Treatment to prevent the narrowing of the oesophagus in a condition called oesophageal atresia (a disorder present at birth in which the oesophagus, the tube that carries food from the mouth to the stomach, does not develop properly)
This study looks at whether a common medicine given to babies after surgery for a birth condition called oesophageal atresia (OA) really helps. It aims to find out if giving this medicine routinely prevents problems like narrowing of the food pipe and if it has any downsides.
Infants born with oesophageal artesia (OA) with distal-oesophageal fistula (TOF) who have undergone primary repairWales - CompletedPhase II
Evaluation of a smartphone app to support low mood and worry in female armed forces veterans in Great Britain
This study looks at a smartphone app to help female UK military veterans with low mood and worry. It's online and checks if a larger study might work. Participants use the app daily for six weeks, with some getting the special app and others a simple meditation app.
Mild to moderate depression and anxietyWales - Recruiting
Mentalization-based therapy for individuals with probable complex post-traumatic stress disorder
This study looks into a new talking therapy called Mentalization-Based Treatment - Trauma Focused (MT-TF) for adults with Complex Post-Traumatic Stress Disorder (CPTSD). It compares MT-TF to usual care to see if it helps reduce symptoms and improve well-being.
Complex post-traumatic stress disorder (CPTSD)Wales - Completed
Pre-birth assessments for women who use substances in pregnancy
This study looks at how pregnant women who use alcohol or drugs are assessed before their baby is born by social services. We want to understand what women and social workers think about this process to make it better and more supportive for families.
Substance use/treatment for substance use in pregnancy in women who undergo pre-birth assessments with Children's ServicesWales - RecruitingNot Specified
Improving access to kidney transplantation
This study looks at new ways to help people with kidney failure get a kidney transplant from a living donor. We're testing if extra support from nurses, including home visits, can increase the chances of a successful transplant. It aims to improve fairness in who receives these life-changing operations.
Living-donor kidney transplantationWales - Recruiting
Could giving someone who smokes help to quit through a financial advice service make them more likely to quit than someone who does not get any support?
This study looks at whether people trying to quit smoking, who are also getting financial advice, are more likely to stop if offered extra support like vapes and counselling, compared to those who don't get any extra help from the study.
Tobacco addictionWales - Recruiting
A study exploring whether urgently required medication can be remotely issued from the REMEDY medicine machine in rural communities
This study explores if a 'medication vending machine' called REMEDY can help people in rural Wales get urgent medicines when local pharmacies are closed. It aims to make it easier to get medicines quickly after a phone call with a doctor.
Access to urgently required medication during the Out of Hours period following a telephone consultation with a primary care serviceWales - Recruiting
How treatments affect people recently diagnosed with follicular lymphoma. A study over time
This study looks at how treatments affect people newly diagnosed with follicular lymphoma. It will collect information during your usual hospital visits, helping us understand the illness better and hopefully improve future care for patients in the UK and worldwide. You won't have extra tests or treatments.
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissueWales - Recruiting
Supermarket voluntary price promotion ban: a public health study
This study looks at what happens when two UK supermarkets stop using special offers on unhealthy foods. Researchers want to see how this affects what people buy, their health, and the businesses involved. It aims to understand if stopping these deals helps people eat better.
The main focus of this work is the prevention of obesity and risk of chronic non-communicable diseases through reduction of consumption of high fat salt sugar foods.Wales - Completed
Understanding corridor care in UK emergency departments
This study looks at how many patients are cared for in places like hospital corridors when emergency departments are busy. It wants to understand who these patients are and why they're there, to help improve emergency care across the UK.
UK Emergency Department use of escalation areasWales - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionWales - Recruiting
A study of Sensore: continuous pressure monitoring for wheelchair users
This study looks at how easy and useful a system called Sensore is for wheelchair users. Sensore helps show when pressure builds up, so people know when to change position. Researchers want to see if people can use it in their daily lives to help manage pressure ulcers.
Usability and acceptability of a continuous pressure monitoring system for pressure ulcer risk management in adult wheelchair users and their carers and healthcare professionals.Wales - RecruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
BronchiectasisWales - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaWales - CompletedPhase I
Phase I Trial: 36414 (SUDO-550-102)
This early-stage study is looking for healthy women aged 18-55 to help test a new medicine or treatment. The full details are not yet public, but it's an important step in making sure new healthcare options are safe and effective.
N/A - healthy volunteersWales - Recruiting
Timing of nutrition in emergency laparotomy
This study looks at the best time to give special liquid food directly into a vein to adults having urgent belly surgery. It aims to see if starting this feeding early helps reduce problems and speeds up recovery after the operation.
Hospital complications in adults undergoing emergency laparotomyWales - Recruiting
A study of home-use brain stimulation to treat bipolar depression
This study looks at whether a home-use device using mild electrical current can help people with bipolar depression. It aims to see if it's effective, safe, and easy to use at home, compared to a dummy treatment.
Bipolar Disorder; Mental healthWales - Recruiting
Comparing large chest drains with small chest drains to explore the best treatments for chest injury
This study compares two types of tubes, small and large, used to drain air or blood from the chest after an injury. It aims to find out which one works best and is safer for patients, and if it could save the NHS money.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Emergency Medicine; Health Category: Injuries and accidents, Respiratory; Disease/Condition: Injuries to the thoraxWales - Recruiting
Evaluating The Skill Mill programme to lower violence and offending in young people
This study looks at 'The Skill Mill' programme, which gives young people aged 16-18 with a past offending history a 6-month paid job. The aim is to see if this helps reduce re-offending and improves their life skills and job prospects. It's funded by the Youth Endowment Fund.
Prevention of re-offending by young people with an offending history with one or multiple convictions of any type of offenceWales - Recruiting
Pharmacogenetics to avoid loss of hearing UK
This study uses a quick genetic test to protect newborn babies from hearing loss. Some babies given a common antibiotic, gentamicin, can become deaf if they have a certain gene. This test identifies those babies quickly so they can receive a safer treatment. It's being tested across the UK.
Use of a genetic test to detect the m.1555A>G variant associated with aminoglycoside-induced hearing loss in neonatal care unitsWales - RecruitingPhase IV
Digital multi-component intervention to improve the care of older people living with diabetes and chronic kidney disease
This study looks at whether computer reminders can help GPs give better care to older people with kidney problems caused by diabetes. The aim is to slow down kidney damage and improve health for people in the UK. Researchers will test a digital tool in GP practices.
Diabetic kidney disease (DKD)Wales - Recruiting
Investigating the use of a breathing device in older people with broken ribs
This study looks at a breathing device for older people with broken ribs. It aims to see if an incentive spirometer can help prevent chest infections and other problems, making recovery smoother after a rib injury.
Rib fracturesWales - CompletedPhase I
Phase 1 Trial: 36342 (DT-101/102)
This is a very early stage clinical trial, called a Phase 1 study, looking into a new treatment marked as DT-101/102. The aim is to understand how safe the treatment is and if it has any side effects. Full details about it will be shared later, after the study finishes.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.Wales - Completed
Evaluating CBT Bytesize: a mixed-methods feasibility trial of a blended digital CBT intervention for adolescent anxiety and low mood
This study tested a new digital programme called CBT Bytesize for young people aged 11-17 with anxiety. It combines online learning with therapist support to see if it helps reduce anxiety and is easy to use.
Anxiety disorders in children and young peopleWales - CompletedPhase I
A 2-part study to investigate the safety, tolerability and effect of MB272 in healthy volunteers
This study, called MB272, looked at a new drug (GS-0272) in healthy volunteers. It checked if the drug was safe, how well people tolerated it, and how it acted in the body when given in different ways and doses. The goal was to gather early information about this potential new medicine.
Healthy volunteersWales - Completed
Evaluating the feasibility of a samba percussion intervention for people with Parkinson’s disease
This study looks at a fun samba drumming activity for people with Parkinson's disease. It wants to see if weekly drumming sessions can help with movement, thinking, and mood. The aim is to check if a future, bigger study would be possible.
Parkinson's diseaseWales