Latest studies
- CompletedNot Applicable
Finding out the genetic cause of Juvenile Myoclonic Epilepsy
This study aims to find the genetic causes of Juvenile Myoclonic Epilepsy (JME). Researchers are comparing DNA and brainwave tests (EEGs) from people with JME to people without epilepsy. The goal is to better understand JME, potentially helping scientists develop more targeted and personalised treatments in the future.
People with a diagnosis of Juvenile Myoclonic EpilepsyWales - Completed
Supervised Pulmonary Hypertension Exercise REhabilitation (SPHERe) trial
The SPHERe trial looks at whether an online, home-based exercise and support programme can help people living with pulmonary hypertension. Participants complete eight weeks of guided home exercise with specialist online support. Researchers want to see if this safely improves fitness, eases breathlessness, and boosts day-to-day quality of life.
Pulmonary hypertensionWales - CompletedPhase III
A trial of rivastigmine to prevent falls in Parkinson's
Parkinson’s disease can affect balance and walking, leading to frequent falls. This UK clinical study is testing whether a skin patch containing a medicine called rivastigmine can improve steadiness and prevent falls. Around 600 people with Parkinson's will use either the real medicine patch or a dummy patch for one year.
Parkinson's DiseaseWales - Completed
Can patients with residual cancer after chemotherapy for early breast cancer be identified with multiple ultrasound-guided biopsies?
This study looks at whether ultrasound-guided needle biopsies can reliably check for remaining breast cancer after chemotherapy. For some people, chemotherapy clears the cancer completely. Researchers want to see if precise biopsies can confirm this, which could help doctors discover if surgery might safely be avoided in the future.
Breast cancerWales - CompletedPhase II
A randomised, double blind, placebo-controlled study of RAD001 (Everolimus) in the treatment of neurocognitive problems in tuberous sclerosis
This UK study tests whether a medicine called everolimus can improve memory and everyday thinking skills in people with tuberous sclerosis. Participants take daily tablets for six months while having regular check-ups and memory tests to see if the treatment helps with common brain-related symptoms of the condition.
Tuberous sclerosisWales - Completed
Programme on Adherence to Medication (PAM) randomised controlled trial
Around 9.5 million people in England and Wales take medicines for high blood pressure, but many miss doses. The PAM study explores whether a quick chat with a practice nurse, followed by helpful text messages or an app, helps people remember their medicines and keep their blood pressure under control.
Supporting medication adherence in patients prescribed treatment for hypertensionWales - RecruitingPhase II
A clinical trial to explore the potential of ondansetron for treating hallucinations in people with Parkinson’s disease
Visual hallucinations are common in Parkinson's disease, but current medications can cause serious side effects. This UK clinical trial tests ondansetron, an established anti-sickness medication, to see if it safely and effectively reduces hallucinations. The study aims to provide a safer, affordable treatment option through the NHS.
Parkinson's hallucinationsWales - Completed
VITDALIZE UK: Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency
This study looks at whether giving high-dose vitamin D to very sick adults in intensive care helps them recover better. Around seven in ten critically ill patients have low vitamin D levels. Researchers want to see if replacing this vitamin improves survival rates and shortens time spent in hospital.
Vitamin D deficiencyWales - CompletedPhase I
A platform trial investigating new combinations of therapies in patients with relapsed multiple myeloma
The ProMMise study is testing a new drug called belantamab mafodotin (belamaf) for people with multiple myeloma that has returned after prior treatment. Researchers want to find out how safe and effective it is, both on its own and when combined with standard myeloma medicines.
Multiple myelomaWales - Completed
A study to evaluate diagnostic tests used at the point of care for improving antibiotic prescribing for patients with respiratory tract infections in primary care in Europe
Antibiotics treat bacterial infections, but taking them when not needed makes them less effective over time. This European study checks whether rapid clinic tests can help GPs decide if patients with coughs or sore throats truly need antibiotics, safely cutting down unnecessary prescriptions without harming patient recovery.
Community-acquired acute respiratory tract infectionWales - CompletedNot Applicable
Can we predict which patients with psoriatic arthritis will respond to treatment using precision medicine?
This UK study looks at whether a simple blood test can help doctors choose the best biologic medicine for people with psoriatic arthritis. By checking specific immune cells before treatment starts, researchers hope to match each person to the right drug first time, helping relieve joint pain and swelling much faster.
Arthritis that affects some people with the skin condition psoriasisWales - Completed
Smoking, nicotine and pregnancy 2 trial
This study looks at whether extra text messages, a website, and a leaflet can help pregnant women stick with nicotine replacement therapy (NRT). The aim is to see if this extra support helps more women successfully quit smoking during pregnancy alongside their regular NHS stop smoking care.
Adherence to nicotine replacement therapy during pregnancyWales - CompletedNot Applicable
The iHOLDS Trial: High Or Low Dose Syntocinon for induction of labour
Around one in three first-time mothers have their labour started artificially (induced). Many need a hormone drip called oxytocin. This UK study compares the standard dose of oxytocin with a higher dose to see if it safely helps women give birth vaginally and reduces the need for an unplanned caesarean section.
Induction of labourWales - RecruitingPhase II/III
A trial assessing preoperative chemotherapy in patients with locally advanced but operable colon cancer
The FOxTROT trials look at whether giving bowel cancer treatments, such as chemotherapy or immunotherapy, before surgery helps shrink tumours and stops cancer returning. The study tests this approach in people of different ages, fitness levels, and tumour types to see who benefits the most.
Locally advanced but operable colon cancerWales - RecruitingNot Applicable
Trial of local anaesthetic nerve blocks for hip fracture pain relief in prehospital care, compared to usual care (morphine), given by paramedics
Breaking a hip is painful and common in older adults. Paramedics usually give strong painkillers like morphine, which can cause unpleasant side effects. This UK study explores whether trained paramedics giving a targeted numbing injection directly into the hip offers safer, more effective pain relief before a patient reaches hospital.
Pain relief of patients with hip fracture in prehospital careWales - Completed
A trial comparing the effectiveness of an online sleep behavioural intervention versus standard care in children with rolandic epilepsy
This UK study tests whether an online sleep programme can help children with epilepsy sleep better. Children aged 4 to 12 who have sleep issues take part completely from home. Half use an online sleep programme alongside standard care, while half continue with their usual NHS care alone.
Sleep quality in children with rolandic epilepsyWales - Completed
A feasibility study of a digital self-management physiotherapy intervention for individuals with musculoskeletal pain
Musculoskeletal pain affects millions in the UK. This study tests TRAK-MSK, a new website offering video consultations with physiotherapists and tailored exercise videos. Researchers want to see if this online support helps adults with ongoing back, leg, or arm pain manage symptoms at home better than usual NHS care.
Musculoskeletal painWales - Completed
Remote rehabilitation after intensive care
Leaving intensive care can be tough, leaving people physically weak and emotionally drained. This UK study tests a six-week online rehabilitation programme designed to help people recover at home. Researchers want to see if regular remote support, gentle exercises, and recovery advice improve quality of life compared to standard NHS care.
Any condition requiring admission to intensive care and 48 hours of invasive mechanical ventilationWales - Completed
Adaptation and implementation of health Qigong and Tai Chi exercises on quality of life and physical functioning in patients with atrial fibrillation: a feasibility study
This study looks at whether gentle online Tai Chi and Qigong classes can help people with atrial fibrillation (an irregular heartbeat). Researchers want to see if patients enjoy these slow, home-based exercises, find them easy to do, and feel benefits to their everyday wellbeing and physical health.
Tai Chi and Qigong for patients with atrial fibrillation.Wales - CompletedNot Applicable
Investigating the use of lenzilumab for acute graft versus host disease (when transplanted stem cells attack the body’s cells)
This UK clinical trial is testing a new drug called lenzilumab for acute graft versus host disease (GvHD). GvHD happens when transplanted donor cells attack the patient's body. Researchers want to see if adding lenzilumab to standard steroid treatment is safe and helps patients who have a higher risk of severe illness.
Graft versus host disease following allogeneic stem cell transplantationWales - Completed
AFTER – Ankle fracture treatment: enhancing rehabilitation trial
The AFTER study explores the best way to help people aged 50 and over recover from a broken ankle. It compares doing exercises at home using a guide and website against having four to six one-to-one sessions with an NHS physiotherapist, to see which approach works best.
Ankle fractureWales - CompletedPhase II
A comparison of response to treatment in patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes taking ASTX727 versus best supportive care
This UK clinical trial is testing a new tablet called ASTX727 for adults with rare bone marrow cancers called MDS/MPN overlap syndromes. Researchers want to find out if taking this tablet at home works better at managing the condition and improving quality of life than standard supportive hospital care.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap SyndromesWales - Completed
To determine if critically ill patients with acute respiratory failure treated with carbocisteine, hypertonic saline, or both, experience increased hydration of airway mucus.
This study looks at whether medicines called carbocisteine and hypertonic saline help clear thick phlegm from the lungs of critically ill patients on breathing machines. By testing small mucus samples, researchers hope to see how these treatments work to help patients recover and breathe on their own sooner.
Critically ill patients with acute respiratory failure (ARF)Wales - CompletedPhase II
A clinical trial adding Sativex (a cannabis-based medicine) to standard treatment, temozolomide, to find out if it is beneficial for patients whose glioblastoma brain tumour has returned after treatment
The ARISTOCRAT trial is testing whether adding a cannabis-based mouth spray called Sativex to standard chemotherapy (temozolomide) helps people whose glioblastoma brain tumour has returned. Researchers want to see if combining these treatments slows tumour growth, helps patients live longer, and improves day-to-day quality of life.
Glioblastoma multiformeWales - Completed
A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer
This UK clinical trial compares two forms of radiotherapy for throat cancer: standard radiotherapy and proton beam therapy. Researchers want to find out if proton therapy causes fewer long-term side effects, such as speech and swallowing problems, while working just as well to treat the cancer alongside chemotherapy.
Oropharyngeal cancerWales - CompletedPhase IV
Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis
Bacterial vaginosis (BV) is a common vaginal condition usually treated with antibiotics. This UK study compares standard antibiotics with dequalinium chloride, an antiseptic tablet placed in the vagina. Researchers want to find out if this alternative works just as well, without harming healthy bacteria or causing antibiotic resistance.
Bacterial vaginosisWales - Recruiting
Cerebrospinal fluid shunting or dural venous sinus stenting to preserve vision in idiopathic intracranial hypertension (IIH Intervention)
Idiopathic intracranial hypertension (IIH) causes high pressure around the brain that can threaten your sight. This UK study compares two standard operations: inserting a small drainage tube (shunt) or a tiny mesh tube (stent). The aim is to discover which treatment best protects your vision and helps the NHS.
Idiopathic intracranial hypertensionWales - Completed
The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care
Premature babies fed through a tube often have their stomach contents checked regularly to see how they digest milk. The neoGASTRIC study looks at whether stopping these routine checks helps premature babies reach full milk feeds more quickly and safely. It compares two standard care approaches already used in hospitals.
Preterm birthWales - Recruiting
Treating people with a lung collapse (pneumothorax) without inserting a needle into the chest. Is it safe and effective?
This UK clinical trial is looking at whether a collapsed lung can heal safely on its own without needing a chest drain. Researchers want to see if simply resting and being monitored allows patients aged 16 to 50 to recover well at home, avoiding invasive hospital procedures.
Primary spontaneous pneumothoraxWales - Completed
Barriers and facilitators to deprescribing antithrombotic therapy in advanced cancer patients: A qualitative interview study of patients’, companions’ and clinicians’ experiences and perspectives
This study looks at how people with advanced cancer feel about taking blood-thinning medicines. Researchers want to understand patients' and carers' views on whether and when to stop these treatments. Taking part involves a single 30 to 60-minute interview. The findings will help build a new decision-making app for future patients.
Cancer and deprescribing antithrombotic therapy at end-of-lifeWales - Completed
Investigating methods of measuring visual field sensitivity in glaucoma
Glaucoma causes gradual loss of side vision. Current clinic tests for this were designed over 40 years ago. This study explores new and better ways to test peripheral vision. Researchers in Cardiff, London, and Northern Ireland are welcoming both people with glaucoma and healthy volunteers aged 40 and older.
Investigating peripheral visual sensitivity in people with glaucoma and normally-sighted individualsWales - RecruitingPhase III
The neurocognitive benefits of proton beam therapy for patients with oligodendroglioma
The APPROACH study compares two forms of radiotherapy for adults with a brain tumour called oligodendroglioma. Researchers want to find out whether advanced proton beam therapy protects memory and thinking skills better than standard radiotherapy, while keeping the tumour under control, helping doctors choose the best treatment for future patients.
Brain cancer, oligodendrogliomaWales - RecruitingPhase II
Assessing if stopping and starting standard of care medication for later stage melanoma can reduce the body's resistance to the treatment
This clinical trial tests a new way of taking standard medicines for advanced skin cancer (melanoma). Instead of taking pills every day, some patients take planned breaks guided by regular blood tests. Researchers want to see if pausing and restarting treatment stops cancer cells from becoming resistant, helping the medicine work longer.
Cutaneous melanomaWales - Completed
Effectiveness of a maternity improvement programme to reduce excess bleeding and need for transfusion after childbirth: the Obstetric Bleeding Study UK (OBS UK)
Heavy bleeding is a common complication after giving birth. The OBS UK study tests a new maternity care package across 36 NHS hospitals to help staff spot and treat heavy bleeding faster. By measuring blood loss accurately and acting early, researchers hope to reduce blood transfusions and improve safety.
Obstetric bleedingWales - CompletedNot Applicable
Ambulatory ECG monitor versus standard care in acute unexplained syncope (sudden loss of consciousness also known as blackout or fainting)
Fainting and sudden blackouts are common reasons people visit hospital, but finding the cause can be tricky once you feel better. This UK trial tests whether wearing a small, stick-on heart monitor for two weeks helps doctors spot hidden heart rhythm problems faster than standard NHS care alone.
Early diagnosis of patients presenting to Emergency Departments with undiagnosed syncope (blackouts).Wales - RecruitingPhase III
Investigating the clinical and cost-effectiveness of two different drugs (amiodarone and beta blockers) to treat patients with new-onset atrial fibrillation whilst in the intensive care unit
This UK study looks at two standard NHS medicines for an irregular heartbeat that can start during a stay in intensive care. Researchers want to find out whether drugs called beta-blockers or a drug called amiodarone work best to return the heart to a normal rhythm safely.
New onset atrial fibrillation (NOAF)Wales - CompletedPhase III
Pain relief after instrumented spinal surgery trial
Having lower back surgery can cause significant pain, which can slow down recovery. The PRAISE study compares three different ways to relieve pain after spinal surgery: standard pain tablets and drips, a targeted spinal injection, or a nerve block in the back muscles, to see which helps patients heal best.
Patients scheduled for elective, posterior lumbar-instrumented spinal surgery +/- decompression.Wales - Completed
The 3P Study: Optimisation and feasibility of Triple P parenting programme for remote delivery
The 3P Study looks at delivering the popular Triple P parenting programme online using video calls compared to in-person groups. Researchers want to see if remote sessions work well, help families manage child behaviour, and offer good value for money to guide future family support programmes across the UK.
Positive parenting for parents/caregivers of children aged 0-12 years old.Wales - Recruiting
CONNECT: using electronic devices (e.g. smartphones, smartwatches) to predict relapse of psychosis
The CONNECT study explores whether everyday smartwatches and mobile phones can help spot early warning signs of a psychosis relapse. By monitoring daily activity, sleep, and brief mood check-ins over 12 months, researchers hope to help NHS teams step in earlier to keep people well.
PsychosisWales - Recruiting
Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) in the management of cancers of the bowel, ovary and stomach: a randomised controlled trial of efficacy in peritoneal metastases
This UK clinical trial is testing a new way to deliver chemotherapy called PIPAC for people whose bowel, ovarian, or stomach cancer has spread to the lining of the abdomen. It aims to see if spraying chemotherapy directly into the tummy during keyhole surgery works better than standard chemotherapy alone.
Colorectal, ovarian and stomach cancer with peritoneal metastasisWales - RecruitingPhase II
EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis (EXPERTS-ALS)
EXPERTS-ALS is a UK clinical trial testing whether existing, widely used medications can help slow down amyotrophic lateral sclerosis (ALS). Researchers check blood samples for a nerve protein called NFL to see if a drug protects nerve cells. There is no dummy pill, so every participant receives an active treatment.
Amyotrophic lateral sclerosis (ALS)Wales - RecruitingPhase III
MiTiGate trial: Is Botox more effective than lidocaine and treatment as usual in myalgia temporomandibular disorder (TMD)?
The MiTiGate trial looks at treatments for ongoing jaw muscle pain (M-TMD). Researchers are comparing standard daily pain tablets (amitriptyline or gabapentin) with injections of either Botox or a numbing medicine called lidocaine. The aim is to find out which option provides the safest, most effective, and best-value relief.
Myalgia temporomandibular disorder (M TMD)Wales - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseWales - Completed
Developing a checklist to allow accurate diagnosis of vulval lichen sclerosus
This UK study tests a simple checklist to help doctors diagnose vulval lichen sclerosus more quickly and accurately. Researchers want to see if this new tool helps non-specialists spot the skin condition sooner. Women aged 18 and over attending a specialist clinic for vulval symptoms can take part during one appointment.
Vulval lichen sclerosusWales - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaWales - Recruiting
Randomised evaluation of rehabilitation after acute proximal humerus (shoulder) fracture: the REACH study
The REACH study looks at the best way to help adults recover from a broken shoulder that does not need surgery. It compares doing exercises at home using a guidebook and videos against attending regular hospital physiotherapy appointments, to see if home recovery works just as well.
Proximal humerus fractureWales - RecruitingNot Applicable
A randomised, double-blind, parallel group, placebo controlled, trial of Bactek for the prevention of lower respiratory tract infections in preterm infants
Premature babies often get chest infections that can cause lasting lung damage. This UK clinical trial tests Bactek, an oral spray made of harmless, heat-treated bacteria. It aims to train babies' natural immune systems to fight off bugs and cut down on GP visits and hospital admissions.
Respiratory outcomes after premature birth including lower respiratory tract infections and wheeze.Wales - Recruiting
Personalised exercise rehabilitation for people with multiple long-term conditions: Main Trial
This UK study tests whether a personalised exercise programme, called PERFORM, helps people living with two or more long-term health conditions. Researchers want to see if tailored exercise improves fitness, quality of life, and day-to-day well-being compared to standard NHS care.
Multiple long-term conditionsWales - Recruiting
Operative or non-surgical treatment of Perthes’ disease
Perthes’ disease affects the hip joint in children, causing the top of the thigh bone to soften and flatten. This UK study compares two usual NHS treatments: physiotherapy and guided exercises without surgery, versus an operation to realign the hip bone. The aim is to see which approach works best.
Perthes’ diseaseWales - Recruiting
INITIATE: Increased mobility in hospital after hip fracture
Breaking a hip can severely affect an older person's independence. The INITIATE trial is exploring whether encouraging patients to move around more on the hospital ward after hip surgery helps them recover faster, return home sooner, and stay living independently. It is open to adults aged 60 and older.
Mobility in hospital after hip fractureWales