Latest studies
- RecruitingNot Applicable
Vagus nerve stimulation for epilepsy in children and adults: assessment of longer term clinical and cost effectiveness in a randomised controlled trial
This study looks at how well a treatment called Vagus Nerve Stimulation (VNS) works for children and adults with epilepsy that hasn't responded to other medicines. We want to understand its long-term benefits and if it helps people with learning difficulties.
EpilepsyWales - Recruiting
A-PATH: A path towards healing and support for older women
This study, A-PATH, aims to create better support for women aged 60-74 in England and Wales who have experienced domestic abuse. It will adapt an existing programme to suit their unique needs, helping them on their path to healing and recovery.
Domestic abuseWales - Recruiting
Moves Different: Boxing to reduce youth offending
This study looks at whether a six-month boxing programme can help young people, aged 13-18, at risk of crime or violence in England and Wales. It compares boxing to a gym membership to see if it improves behaviour and reduces offending.
Involvement in youth violence and crime (youth offending risk). The study targets adolescents who have one or more recognised risk factors for involvement in violence, offending, or related antisocial behaviour, and evaluates whether a structured boxing programme reduces offending and improves socio-emotional and behavioural outcomes.Wales - Completed
Feasibility randomised controlled trial of Spring PGD, a digital guided therapy for prolonged grief disorder
This study tests a new online therapy called Spring PGD for people experiencing prolonged grief after losing a loved one. It compares starting therapy straight away with waiting 11 weeks. The aim is to see if this digital tool, guided by a therapist, can help those struggling with long-lasting grief.
Prolonged Grief Disorder (PGD)Wales - CompletedNot Specified
Ultra-long-term EEG monitoring in people with intellectual disabilities
This study looks at a new tiny device, called SubQ, that fits under the skin on your head. It helps track brain activity in people with learning disabilities and epilepsy, aiming to better understand and manage seizures without needing hospital stays. It also checks if it's safe and improves quality of life.
Epilepsy and intellectual disabilityWales - CompletedNot Specified
Evaluation of N-Tidal in primary care COPD diagnosis
The CORMORANT study is testing a new device called N-Tidal to see if it can help doctors diagnose a lung condition called COPD more easily and accurately in GP practices. This could lead to quicker treatment and better care for patients.
Chronic Obstructive Pulmonary DiseaseWales - Recruiting
Genicular embolisation for knee osteoarthritis
This study explores a new treatment called genicular artery embolisation (GAE) for ongoing knee pain from osteoarthritis. It aims to see if blocking small blood vessels in the knee can reduce pain for people who haven't found relief from other treatments but aren't ready for surgery.
Knee osteoarthritisWales - Recruiting
Digital skin surveillance of healthcare workers in the NHS
This study looks at how digital photos and questionnaires can help spot hand rashes (dermatitis) early in NHS staff. It aims to find better ways to check for and manage this common skin problem, especially for those who wash their hands a lot at work.
Occupational hand dermatitisWales - Recruiting
Drug-coated balloon (Sequent Please Neo) vs drug-eluting stent treatment for acute ST-elevation myocardial infarction: a randomised trial
This study compares two ways to treat a heart attack: a special balloon (drug-coated balloon) or a small tube (drug-eluting stent). Both aim to keep the heart artery open. We want to see if the balloon treatment is just as good, or even better, over several years.
Acute ST-elevation myocardial infarctionWales - Recruiting
Glycaemic control in labour with diabetes (GILD Trial)
The GILD study explores the best way to manage blood sugar during labour for people with diabetes in pregnancy. It compares strict monitoring to a more relaxed approach to see what's safer and more comfortable for mothers and babies. Your participation could help improve care for many.
Glycaemic control in labour with diabetesWales - Completed
A study testing the effects of a stress-resilience training programme on the well-being of graduate-entry medical students
This study tested a program called Enhanced Stress-Resilience Training (ESRT) for medical students at Swansea University. It aimed to see if this program could help them manage stress, build resilience, and feel better equipped to handle the pressures of medical school.
Psychological stress, burnout, and anxiety among medical students, with a focus on prevention and early intervention to enhance resilience, emotion regulation, and psychological flexibilityWales - Recruiting
An evaluation of multidimensional therapy versus treatment as usual for young people, aged 10-17 years, who use drugs
This study looks at a new type of family therapy, called MDFT, for young people aged 10-17 in Bristol and Newport who are struggling with drug use. It compares MDFT to usual support services to see which works best.
Substance use treatment for young people who offend or at risk of offendingWales - Recruiting
DRAGON: Are reusable surgical drapes and gowns as good as disposable surgical drapes and gowns at increasing days alive and at home after surgery?
This study compares reusable and disposable surgical drapes and gowns to see if reusable options are just as safe and effective, aiming to make operations more environmentally friendly. It's part of a bigger effort to reduce the NHS's carbon footprint.
Patients (adults) undergoing elective or emergency surgery with at least one incision ≥5 cm in adults and a clean-contaminated, contaminated or dirty wound, in NHS hospitals where there is equipoise to use either disposable or reusable drapes and gowns.Wales - CompletedPhase I
Phase I Trial: 36676 (P2-101-301P)
This early-stage study is looking at a new treatment. We don't have all the details yet because the information will be published later. It's for adults aged 18 to 55.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.Wales - Recruiting
Using digital technology to support people living with obesity
This study looks at a new digital tool called W8Buddy to help people manage their weight. It compares this online support to usual NHS weight management services to see if it helps more people get the care they need for obesity.
Class 2 obesity (BMI ≥35 kg/m²) with at least one medical complication (e.g., prediabetes, type 2 diabetes [T2DM]); or patients with obesity class 3 (BMI ≥40 kg/m2), without any complications.Wales - Completed
Sex workers evaluate reporting violence
This study looks at how National Ugly Mugs (NUM), a service for sex workers, helps improve safety and mental health. It explores how NUM's alerts and support services work to prevent violence and assist survivors, with sex workers closely involved in the research.
Violence prevention and survivor support for and by sex workersWales - Recruiting
Safety and autonomy for everyone at Home. Understanding safety, risks and harm-benefit balances arising from home-based care.
This study wants to make care at home safer for older people. Researchers will review existing information and talk to care workers and people receiving care to understand how to improve home care and find out what works best. It aims to help make home care better for everyone.
Care received at home, focusing on older adults (>60 years old).Wales - RecruitingPhase III
Evaluation of intravenous therapy (i.e. injection into the vein) in asthma
This study looks at which injection works best for children and young people with severe asthma attacks. Doctors want to find out if aminophylline, magnesium sulphate, or salbutamol is the most effective and acceptable treatment to help them breathe better.
Severe acute asthmaWales - Recruiting
PCN-CRP: a programme for improving the prediction and prevention of preterm birth and women’s experience of care
This study aims to understand and prevent premature births. It's collecting health information from pregnant women at risk, combining it with other studies to find better ways to predict, stop, and improve care around early births for families in the future.
Prediction and prevention of preterm birthWales - Recruiting
Better conversations with primary progressive aphasia and other rare dementias: speech and language therapy to keep families together
This study looks into speech therapy for people with rare types of dementia like primary progressive aphasia. It aims to improve conversations for them and their families, making daily life easier and more connected.
People with dementia and their familiesWales - CompletedPhase I
Anchored muscle cells for incontinence
This study aims to help women with bowel leakage after childbirth. We're testing a new treatment where your own muscle cells are grown and injected to repair anal sphincter muscles. This first-stage study checks if it's safe and how it affects your symptoms.
Faecal incontinence (FI) in women with obstetric anal sphincter injuryWales - RecruitingPhase IV
Anti-depressants for depression in Huntington's disease
This study looks at treating depression in people with Huntington's Disease. It investigates if a common antidepressant, Sertraline, can help, and how best to measure its effects. Understanding this could improve life for those with HD.
Antidepressant treatment for depression in individuals with a confirmed genetic diagnosis of Huntington's Disease.Wales - Recruiting
Preventing miscarriage through platform testing of multiple novel interventions
This study looks at whether taking omega-3 (DHA) supplements can help prevent miscarriage in women who have had two or more miscarriages. Researchers want to see if different doses of DHA can increase the chance of a baby being born healthy and later in pregnancy.
Medical condition: Miscarriage Medical condition in lay language: Miscarriage Therapeutic areas: Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]Wales - Recruiting
Description and study of the steroid Metabolome in mucinous ovarian cancer
This study looks at new ways to find and monitor a very rare type of ovarian cancer called mucinous ovarian cancer. Researchers are checking if urine tests can help doctors diagnose the disease and see how well treatments are working, by looking for specific substances in urine.
Mucinous ovarian cancer, mucinous appendiceal and pseudomyxoma peritonei cancer.Wales - Recruiting
Care of people at the end of their lives in the rural and coastal communities of the South West Peninsula of England
This study aims to improve end-of-life care in rural and coastal areas of Devon, Cornwall, and Somerset. It involves talking to patients, families, and professionals to understand current care and find ways to make it better for everyone involved.
People at the end of life, family members and professionalsWales - Recruiting
Fix or replace enhancing distal humerus fracture outcomes
This study compares two common surgeries for broken elbows in people over 60: elbow replacement or fixing the break with plates and screws. It aims to find which treatment works best to help people recover and use their arm normally again.
Intra-articular fracture of the distal humerus AO type B or CWales - Recruiting
Balancing "bad" and "good" immune cells: testing a novel method for monitoring an immunosuppression strategy in people with Type 1 diabetes
This study is testing a new way to quickly check if treatments for Type 1 diabetes are working. It involves two medicines to help balance immune cells and aims to find better ways to stop the body from attacking insulin-producing cells.
Type 1 diabetesWales - Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthWales - Recruiting
Enhancing care for delirium in palliative care units
This study aims to improve care for acute confusion (delirium) in hospices across the UK. We're testing new ways to help hospices follow guidelines better, hoping to reduce delirium and improve life quality for patients and their families.
DeliriumWales - Recruiting
Pelvic floor muscle exercises plus pessary for treatment of prolapse versus pelvic floor muscle exercises alone
This study looks at combining pelvic floor exercises with a vaginal pessary for women with pelvic organ prolapse. It wants to see if this combined approach works better at reducing symptoms than just doing the exercises alone, helping to improve women's daily lives.
Pelvic organ prolapseWales - CompletedPhase I
A study to investigate the safety, tolerability, and concentration in the blood of different dose strengths of ENX-102 in healthy volunteers
This study is testing a new medicine, ENX-102, to see how safe it is and how much of it gets into the blood at different doses. It's for healthy adults and could help people with conditions like epilepsy or anxiety in the future.
Epilepsy, anxiety, spasticity or other CNS disordersWales - Recruiting
Falls in stroke survivors
This study looks at a new programme, called SAF, to help stroke survivors avoid falls after leaving hospital. It compares SAF with usual care to see if it reduces falls over 12 months. SAF involves a checklist and action plan to manage fall risks.
StrokeWales - RecruitingPhase III
A trial of treatments to slow progression of Parkinson's disease
This study looks for new ways to slow down Parkinson's disease, a common and growing condition. It tests known medicines, telmisartan and terazosin, to see if they can help manage symptoms and stop the disease from getting worse. It's a key step in finding better treatments.
Parkinson’s disease (PD)Wales - CompletedPhase II
Exploratory effect of long-term Verapamil therapy in adults with Type 1 diabetes mellitus (Ver-A-Long)
This study looks at whether a blood pressure medicine called Verapamil can help adults with Type 1 diabetes. It explores if taking it long-term helps the body make more insulin and checks its safety. This is for people already in a related Verapamil study.
Type 1 DiabetesWales - RecruitingPhase III
Through knee amputation compared to above knee amputation
This study compares two types of leg amputation: through-knee and above-knee. It aims to find out which one leads to a better quality of life and easier recovery for patients who need this surgery, helping doctors make the best choices in the future.
Major lower limb amputationWales - Completed
Exploring the effects of a natural seaweed supplement on digestion, health, and well-being
This study looks at a natural seaweed supplement called fucoidan. We want to see if it can help young adults (18-35) with their digestion, general health, and how they feel overall. It's a remote study, and you'd take capsules for 28 days.
Gut health and overall well-beingWales - Completed
Trial of isometric exercise to lower blood pressure
This study looks at a simple wall-squat exercise to help lower blood pressure in people with high readings. It aims to see if doing these short exercises at home can make a real difference, building on earlier promising results.
Stage 1 and 2 hypertensionWales - Completed
Taste acceptance of fluoride varnish on autistic patients
This study looks at how autistic children aged 3-15 react to the taste of different fluoride varnishes used to prevent tooth decay. We want to find out which flavours they accept best to make dental visits easier and improve their dental health.
Preventive dental care in autistic childrenWales - RecruitingPhase IV
Optimising the use of azithromycin antibiotic to reduce Bronchiectasis flare-ups
This study looks at whether people with a lung condition called bronchiectasis can safely stop taking azithromycin, an antibiotic, after their condition has settled down. We want to see if stopping the medicine still keeps flare-ups away and improves their quality of life.
Medical condition: Bronchiectasis Medical condition in lay language: Bronchiectasis Therapeutic areas: Diseases [C] - Respiratory Tract Diseases [C08]Wales - Completed
Can silver diamine fluoride (SDF) reduce the impact on young children of waiting for dental care?
This study looks at whether a treatment called silver diamine fluoride (SDF) can help young children with tooth decay who are waiting for dental surgery. It aims to see if SDF can reduce pain and infection while they wait, making their experience better.
Dental cariesWales - RecruitingNot Specified
Developing genetic tests to diagnose, monitor and guide treatment decisions for children and young people whose cancer has returned
This study looks at the genes in children and young people whose cancer has come back or not responded to treatment. We compare genes in healthy cells with cancer cells to find changes. This helps doctors personalise treatments and find new ways to fight cancer based on genetic information.
Relapsed/refractory solid tumours (including lymphomas) or leukaemiaWales - Recruiting
Reconstruction after advanced pelvic cancer surgery
This study looks at how repairing the body after major cancer surgery in the pelvis affects a person's life. It compares different ways of reconstruction to see which works best for quality of life, complications, and costs.
Advanced pelvic cancersWales - RecruitingNot Applicable
A study to find out whether gradually stopping brace treatment or stopping it all at once is better for babies with hip dysplasia
This study looks at the best way to stop wearing a hip brace for babies with hip problems. We want to see if removing it all at once or slowly over time is better. It's for babies who have already improved with the brace.
The strategy for discontinuing Pavlik harness treatment in infants under 6 months with Developmental Dysplasia of the Hip (DDH) following successful Pavlik harness use.Wales - Completed
Development of guidelines for treating patients with cancer-related blockages in the upper urinary tract
This study aims to create clear guidelines for doctors treating cancer patients who have blockages in their urinary tubes. These blockages can cause serious problems, and currently, there aren't agreed-upon ways to treat them. Experts will share their knowledge to help improve patient care.
Clinical guidelines for the management of malignant upper urinary tract obstruction (MUUTO), in cancer patients.Wales - Completed
Understanding the role of community pharmacy in the support of people with long COVID
This study looks at how local chemists (community pharmacies) can better support people in the UK living with "long COVID." Researchers will talk to people with long COVID and pharmacy staff to create a useful online training course for pharmacists to help them understand and assist those with ongoing symptoms.
Long COVIDWales - RecruitingPhase IV
DEsogestrel for Bleeding on the Implant (DEBI)
This study looks at treating annoying bleeding caused by the contraceptive implant. We're comparing two hormonal treatments, desogestrel and the combined pill, to see which works best to settle periods and offer a safer, easier option for implant users.
Self-reported problem bleeding on the contraceptive implantWales - Recruiting
The effect of a therapeutic nature-based intervention on stress in people with mental ill-health
This study looks at how nature-based activities might help reduce stress for adults with mental health challenges. Participants will join weekly outdoor sessions and complete questionnaires to see if these activities improve their well-being.
Reduction in stress in those with self-reported moderate-to-high perceived stress levelsWales - Completed
An evaluation of a cognitive-behavioural intervention for medical students
This study looks at a special support program called Thumos for UK medical students. It aims to help them cope with stress, feel more confident, and reduce burnout and depression during their clinical placements. We want to see if Thumos works better than usual support.
Improvement of psychological resilience in UK medical studentsWales - Completed
Testing the feasibility and acceptability of a novel therapeutic for depression: the CURED trial
This study, called CURED, is testing a new self-help approach for depression. It looks at whether this new treatment is practical and helpful for adults with depression. It involves weekly online sessions and aims to improve mood and understanding.
Clinical depressionWales - RecruitingPhase III
Treatment to prevent the narrowing of the oesophagus in a condition called oesophageal atresia (a disorder present at birth in which the oesophagus, the tube that carries food from the mouth to the stomach, does not develop properly)
This study looks at whether a common medicine given to babies after surgery for a birth condition called oesophageal atresia (OA) really helps. It aims to find out if giving this medicine routinely prevents problems like narrowing of the food pipe and if it has any downsides.
Infants born with oesophageal artesia (OA) with distal-oesophageal fistula (TOF) who have undergone primary repairWales