Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax in combination with Azacitidine after allogeneic Stem Cell Transplantation in Subjects with Acute Myeloid Leukemia (AML) (VIALE-T)
This study looks at new ways to treat acute myeloid leukaemia (AML) after a stem cell transplant. It combines two medicines, venetoclax and azacitidine, to see if they are safe and help people live longer and healthier lives after their transplant.
Acute Myeloid LeukaemiaCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
This study is comparing a new medication called Andexanet Alfa to usual care. It's for patients who are taking blood thinners (like apixaban, rivaroxaban, or edoxaban) and need urgent surgery. The aim is to see if Andexanet Alfa helps stop bleeding during their operation.
Reversal of anticoagulation effect in patients on a FXa inhibitor (apixabanrivaroxabanor edoxaban) who require urgent surgery or procedureand who have a major risk of bleeding.Czechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
Multicenter, double-blind, randomized, placebo-controlled, dose-response trial with the full-spectrum Cannabis Extract VER-01 in patients with chronic non-specific low back pain
This study is testing a new cannabis-based medicine, VER-01, for people with ongoing lower back pain. It will compare VER-01 to a dummy pill (placebo) to see if it helps reduce pain when other pain medicines haven't worked or can't be used. We want to know if it's safe and effective.
For the treatment of patients with chronic non-specific low back pain when drug treatment is indicated and previous optimised treatments with non-opioid analgesics have not led to sufficient pain relief or were unsuitable due to contraindications or intolerance.Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity and type 2 diabetes. We want to see if it helps with weight loss and is safe to use over about 1.5 years, compared to a dummy medicine.
ObesityDiabetes mellitus type IICzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
J3E-MC-EZDB: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3540378 in Adults with Worsening Chronic Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called LY3540378 for people with a type of heart failure where the heart struggles to relax properly. Researchers want to see if this new medicine can help improve how the heart works and if it's safe to use.
Heart Failure with Preserved Ejection FractionHeart FailureCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb, Multicenter, Randomized, Parallel-group, Double- blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AZD0780 in Participants with Dyslipidemia
This study looks at a new medicine called AZD0780 for people with high cholesterol. We want to see if it safely lowers bad cholesterol and other fats in the blood, which can help prevent heart problems. Participants will take the medicine or a dummy pill.
Dyslipidemia Dyslipidemias are alterations to the plasma lipid profile associated often with clinical condition. A common form of dyslipidemia is Hypercholesterolemia due to high level of LDL-cholesterolwhich is a major risk factor for Cardiovascular Disease (CVD)such as Ischemic Heart Disease and Ischemic Stroke. CVD is a leading cause of global mortality and a contributor to disability.Czechia - Ongoing, recruitingTherapeutic use (Phase IV)
I4V-MC-JAJA (RA-BRIDGE): A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
This study looks at how safe and effective a medicine called baricitinib is for people with rheumatoid arthritis, compared to other common treatments. It will see how long it takes for a blood clot to happen. This is a long-term study that will last over five years.
Rheumatoid ArthritisCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Open-Label, Multicenter, Phase II Study of Multiple Doses of RO7247669 in Participants with Previously Untreated Unresectable or Metastatic Melanoma
This study is testing a new medicine called RO7247669 for advanced skin cancer (melanoma) that has spread or can't be removed by surgery. It's an early-stage trial looking at how safe the medicine is and if it can help slow down or stop the cancer from growing.
Unresectable or Metastatic MelanomaCzechia - Ongoing, recruitingPhase III and phase IV (Integrated)
A phase 3b, interventional, adaptive, clinical trial to evaluate the efficacy and safety of tralokinumab 300 mg every second week monotherapy compared with placebo in subjects with moderate-to-severe atopic hand eczema who are candidates for systemic therapy (ADHAND)
This study is looking into a new treatment called tralokinumab for adults with moderate to severe eczema on their hands. It wants to see how well it works and if it's safe compared to a dummy treatment. The goal is to see if the medicine can clear up or significantly improve hand eczema in a few months.
Atopic dermatitis and moderate-to severe atopic hand eczemaCzechia - Ongoing, recruitingPhase II and Phase III (Integrated)
A two-part randomized, double-blind, placebo-controlled multicenter dose ranging and confirmatory study to assess the safety and efficacy of VAY736 in autoimmune hepatitis patients with incomplete response to or intolerance of standard therapy (AMBER)
This study is looking into a new treatment, VAY736, for adults with a liver condition called autoimmune hepatitis. It aims to see if VAY736 is safe and helps improve liver blood tests for people whose current treatments aren't working well or cause side effects.
Autoimmune hepatitisCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
Rheumatoid arthritisCzechia - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study is looking into a new medicine, efgartigimod, for people with bullous pemphigoid (BP). It compares efgartigimod to a dummy drug (placebo) to see if it can help patients achieve clear skin without needing steroid tablets for a long time.
Bullous Pemphigoid (BP)Czechia - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A single-dose, randomized, two-period, two-sequence, crossover pilot bioequivalence study on formulations containing rivaroxaban and acetylsalicylic acid in healthy volunteers under fasting conditions.
This study is looking at how two common medicines, rivaroxaban and aspirin, work in the body when they're taken together. We want to see if a new combined medication gives the same amount of each medicine as taking them separately. It's for healthy volunteers.
increased blood clottingCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
This study is looking into a new tablet called brensocatib for adults with long-term sinus problems that don't involve growths (nasal polyps). It wants to see if this new medicine can help reduce symptoms like stuffy nose and improve how people feel, compared to a dummy pill.
Chronic Rhinosinusitis without Nasal Polyps (CRSsNP)Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma
This study looks at a new combination of medicines (A+AVD) compared to a standard treatment (ABVD) for advanced Hodgkin Lymphoma. It aims to see if the new combination can better control the cancer and help people live longer.
Advanced Classical Hodgkin LymphomaCzechia - Ongoing, recruitingPhase III and phase IV (Integrated)
MEMENTO-A Phase 3b/4 Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy to assess the impact on Myocardial Structure with Cardiac Magnetic Resonance Imaging (CMR)
This study is looking at a new medicine called mavacamten for adults with a heart condition called obstructive hypertrophic cardiomyopathy (HCM). It aims to see if the medicine can reduce the thickness of the heart walls and the size of the heart's upper chambers.
Symptomatic Obstructive Hypertrophic CardiomyopathyCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Multicenter, Phase 3 Study of Venetoclax and Azacitidine as Maintenance Therapy for Patients with Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M)
This study is looking at two medicines, venetoclax and azacitidine, to see if they can help people with a type of blood cancer called acute myeloid leukemia (AML) stay well after their first round of treatment. It's a key stage of research to check their safety and how well they work.
Acute Myeloid Leukemia in First RemissionCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy with Nivolumab + Relatlimab Fixed-dose Combination versus Nivolumab Monotherapy after Complete Resection of Stage III-IV Melanoma
This study looks at a new combination treatment for advanced melanoma that has been removed by surgery. It compares two drugs given together (nivolumab and relatlimab) against nivolumab alone, to see if the combination can help prevent the cancer from coming back.
Participants with completely resected Stage III or Stage IV melanomaCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeCzechia - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Dose escalation trial of BNT152+153 in patients with cancer
This early-stage study is testing a new treatment called BNT152+153 for different types of advanced cancer. Researchers want to find a safe dose and see how it affects the body for the first time in people. It's for adults whose cancer has spread or cannot be removed by surgery.
Various solid tumors that are metastatic or unresectableCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A parallel-group, prevention, Phase III, modified double-blind, 2-arm, study to investigate the immunogenicity and describe the safety of a quadrivalent meningococcal conjugate vaccine (MenACYW conjugate vaccine) compared with Nimenrix® when administered in a 1+1 schedule in healthy infants and toddlers at 6 and 12 months of age
This study is looking at a new vaccine to protect babies and young children from meningococcal disease. We are comparing how well this new vaccine works and its safety compared to a current vaccine, Nimenrix, in healthy infants and toddlers in the UK.
Healthy volunteers (Meningococcal infection)Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A multi-centre, single arm, open-label extension study to evaluate the long-term safety of GSK3511294 (Depemokimab) in adult and adolescent participants with severe asthma with an eosinophilic phenotype from studies 206713 or 213744
This study looks at the long-term safety of a new medicine, GSK3511294 (Depemokimab), for adults and teenagers with severe asthma. Participants have already taken part in earlier studies of this medicine. We'll check for side effects and how their asthma is doing over a year.
Severe asthma with an eosinophilic phenotypeCzechia - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
An Adaptive, Open-Label, Dose-Finding, Phase 1/2 Study Investigating the Safety, Pharmacokinetics, and Clinical Activity of Rilzabrutinib (PRN1008), an Oral BTK Inhibitor, in Patients with Relapsed Immune Thrombocytopenia
This study is testing a new oral medicine, Rilzabrutinib, for adults with a blood condition called Immune Thrombocytopenia (ITP). It aims to see if the medicine is safe, how much to give, and if it helps increase platelet counts to reduce bleeding.
Immune ThrombocytopeniaCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Baxdrostat in Participants with Uncontrolled Hypertension on Two or More Medications including Participants with Resistant Hypertension
This study is testing a new drug called Baxdrostat for people whose high blood pressure isn't controlled by their current medicines. It aims to see if Baxdrostat helps lower blood pressure and if it's safe to use, compared to a dummy pill.
Uncontrolled hypertension (uTHN) defined as blood pressure that remains higher than goal levels despite patients being treated with 2 anti-hypertensive agentsincluding a diuretic. Resistant hypertension (rHTN) defined as blood pressure that remains higher than goal levels despite the use of at least 3 anti hypertensive drugs of different classes at maximum tolerated doseincluding a diuretic.Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)
This study is looking at a new tablet, semaglutide, to see if it can help people with early Alzheimer's disease. Researchers want to know if it's safe and if it can slow down changes in memory and thinking over about two years.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
J2P-MC-LXBD: A Phase 2, Randomized, Double-Blind, Placebo Controlled, Dose-Ranging Study to Evaluate LY3556050 in Adult Participants With Diabetic Peripheral Neuropathic Pain
This study is testing a new medicine, LY3556050, for adults who have pain from diabetes nerve damage. It's a key step to see if the medicine can help reduce pain, compared to a dummy pill, to find the best dose.
Diabetic Peripheral NeuropathyCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 1b/3 Study of Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab Alone in Subjects With Previously Untreated Advanced Gastric and Gastroesophageal Junction Cancer With FGFR2b Overexpression (FORTITUDE-102)
This study is for people with advanced stomach or gut cancer that has a specific genetic marker called FGFR2b. It tests a new drug, bemarituzumab, combined with usual treatments (chemotherapy and nivolumab) to see if it works better than usual treatments alone.
Gastric and Gastroesophageal Junction Cancer With FGFR2b OverexpressionCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multi-center, Double-blind, Placebo-controlled Phase 3 Study of Bemarituzumab plus Chemotherapy versus Placebo plus Chemotherapy in Subjects with Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b Overexpression FORTITUDE-101)
This study looks at a new drug, bemarituzumab, for advanced stomach or gullet cancer that hasn't been treated before. It aims to see if adding bemarituzumab to standard chemotherapy helps people live longer and improves their quality of life compared to chemotherapy alone.
Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b overexpressionCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, 2-arm Phase III study to assess efficacy and safety of xevinapant and radiotherapy compared to placebo and radiotherapy for demonstrating improvement of disease-free survival in participants with resected squamous cell carcinoma of the head and neck, who are at high-risk for relapse and are ineligible for high-dose cisplatin
This study looks at a new medicine called xevinapant, given with radiotherapy, for people who have had surgery for head and neck cancer. It compares this treatment to radiotherapy with a dummy medicine, to see if xevinapant helps prevent the cancer from coming back.
Resected squamous cell carcinoma of the head and neckCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients with Chronic Lymphocytic Leukemia (“PRO-SID” study).
This study is testing a new medicine called Panzyga to see if it can help prevent serious infections in people with a type of blood cancer called chronic lymphocytic leukaemia (CLL). It wants to find out if taking Panzyga reduces how often these infections happen.
Primary infection prophylaxis in patients with chronic lymphocytic leukemia (CLL) and secondary hypogammaglobulinemia.Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multi-Center, Open Label Extension Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys with Duchenne Muscular Dystrophy (DMD)
This study is looking at a medicine called Viltolarsen for boys with Duchenne Muscular Dystrophy (DMD) who can still walk. It aims to check if the medicine is safe and if it helps them. This is an ongoing study where participants who have been in previous trials can continue with the treatment.
Duchenne Muscular Dystrophy (DMD)Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Multicenter, Double-Blind, Placebo- and Active Comparator-Controlled Study With a Randomized Withdrawal and Retreatment Period to Evaluate the Efficacy, Safety, and Tolerability of TAK-279 in Subjects With Moderate-to-Severe Plaque Psoriasis
This study is testing a new medicine, ZASOCITINIB (also called TAK-279), for people with moderate to severe plaque psoriasis. It compares the new medicine to existing treatments like Otezla and a dummy pill (placebo) to see how well it works and if it's safe.
Moderate to Severe Plaque PsoriasisCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
This study is looking at a new medicine called Tozorakimab for people with COPD. It aims to see if it can reduce severe flare-ups and if it's safe. Participants will be compared to those taking a dummy medicine.
Chronic Obstructive Pulmonary Disease (COPD)Czechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Dose Finding study to evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of GSK1070806 SC injection in adult participants with Moderate to Severe Atopic Dermatitis
This study is testing a new medicine, GSK1070806, for adults with moderate to severe eczema (atopic dermatitis). We want to see how well it works, if it's safe, and what dose is best. Participants will get either the new medicine or a dummy medicine by injection.
DermatitisAtopicCzechia - Ongoing, recruitingPhase II and Phase III (Integrated)
A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 (bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF)
This study is looking at a new medicine called bexotegrast for idiopathic pulmonary fibrosis (IPF). It aims to see if the medicine can help improve lung function and slow down the disease, and if it's safe to use. Some participants will receive the medicine, and others a dummy pill.
Idiopathic pulmonary fibrosis (IPF)Czechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A participant - and investigator-blinded, randomized, placebo-controlled, multicenter, platform study to investigate efficacy, safety, and tolerability of various single treatments in patients with idiopathic pulmonary fibrosis
This study is looking into new treatments for Idiopathic Pulmonary Fibrosis (IPF). It compares a new medicine, LTP001, with a dummy pill (placebo) to see if it can slow down the lung disease and improve how people feel, checking for safety and side effects along the way.
Idiopathic pulmonary fibrosisCzechia - Ongoing, recruitingPhase II and Phase III (Integrated)
IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH)
This study is looking into a new treatment, AV-101, for Pulmonary Arterial Hypertension (PAH), a condition affecting the lungs and heart. It aims to see if the treatment is safe and effective by comparing it to a dummy medicine.
Pulmonary Arterial Hypertension (PAH)Czechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A multi-center, randomized, placebo- and active-controlled, parallel-group, 24-week proof of concept and dose-finding study to evaluate efficacy, safety, and tolerability of XXB750 in patients with heart failure
This study is looking into a new medication called XXB750 for people with heart failure. It hopes to see how well it works, what dose is best, and if it's safe compared to a dummy treatment or existing medicines.
Heart FailureCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Valbenazine as Adjunctive Treatment in Subjects with Schizophrenia
This study is looking at a new medicine called Valbenazine for people with schizophrenia. It aims to see if adding Valbenazine to existing treatments helps reduce symptoms and improve daily life over 10 weeks. Some people will get the medicine, others a dummy pill.
SchizophreniaCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
(22423 NIRVANA) A randomized, parallel-group treatment, Phase 2, double-blind pilot study to investigate the efficacy and safety of elinzanetant compared with placebo for treatment of sleep disturbances associated with menopause
This study is testing a new medicine, elinzanetant, for women experiencing sleep problems during menopause. Researchers want to see if it helps improve sleep and if it's safe compared to a dummy pill.
Sleep disturbances associated with menopauseCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer
This study is looking at new ways to treat bladder cancer that has spread or can't be removed with surgery. It compares a new combination of medicines with standard chemotherapy to see which works best at helping people live longer. Participants will be randomly assigned to different treatment groups.
Untreated Unresectable or Metastatic Urothelial CancerCzechia - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A randomized, open-label, single dose, cross-over study to evaluate the drug-drug interaction between Proscar 5 mg, film-coated tablets and Cialis 5 mg film-coated tablets when co-administered versus the administration of each product alone in healthy volunteers under fasting conditions. Study no. FIN-TAD-DDI-03-24
This study looks at how two common medicines, Proscar and Cialis, work when taken together compared to taking them separately. It helps understand if they affect each other in healthy men. It's a very early stage study.
healthy male subjectsCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
IMPAHCT-FUL: A Long-Term Extension, Multi-Center Safety Study of AV-101 in Subjects With Pulmonary Arterial Hypertension (PAH) Who Have Completed Study AV-101-002
This study looks at the long-term safety of a new medicine, AV-101, for people with pulmonary arterial hypertension (PAH). It's for those who have already tried AV-101 in a previous study and aims to learn more about how well it's tolerated over time.
Pulmonary Arterial Hypertension (PAH)Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, parallel-group study to assess the efficacy, safety, and tolerability of dexpramipexole administered orally for 52 weeks in participants with severe eosinophilic asthma (EXHALE-3)
This study looks at a new medicine called dexpramipexole for severe asthma. It wants to see if the medicine can reduce asthma flare-ups and improve breathing over 52 weeks. Researchers will compare it to a dummy medicine to see if it works and is safe.
Severe eosinophilic asthmaCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo in Subjects with Resected Esophageal, or Gastroesophageal Junction Cancer
This study looks at whether a drug called Nivolumab can help prevent cancer from coming back in people who have had surgery for oesophageal or stomach cancer. It compares Nivolumab to a dummy drug to see if it improves the time patients live without their cancer returning.
Subjects with resected adenocarcinoma or squamous cell carcinoma esophageal or gastroesophageal junction cancerCzechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® pMDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (LOGOS)
This study is looking at new inhalers for adults with asthma that isn't well-controlled. It aims to see if a new combination inhaler works better than current ones to improve breathing and reduce asthma attacks.
Severe and inadequately controlled asthmaCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of ANB032 in the Treatment of Subjects with Moderate to Severe Atopic Dermatitis
This study is testing a new medicine, ANB032, for people with moderate to severe eczema (atopic dermatitis). We want to see if it makes skin better and if it's safe to use, compared to a dummy treatment.
Atopic DermatitisCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
(14308) Randomized, double-blind, placebo-controlled, parallel-group, multi-center study to evaluate the hemodynamic effects of Riociguat (BAY 63-2521) as well as safety and kinetics in patients with pulmonary hypertension associated with left ventricular systolic dysfunction.
This study is looking at a new medicine called Riociguat for people with high blood pressure in the lungs due to a weak heart. It aims to see if the drug can lower this pressure and improve heart function, comparing it to a dummy pill.
Patients symptomatic with pulmonary hypertension associated with left ventricular systolic dysfunction (PH-sLVD)Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF ORAL OZANIMOD AS MAINTENANCE THERAPY FOR MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE
This study is looking into a new medication called Ozanimod for people with moderately to severely active Crohn's disease. Researchers want to see if it can help keep symptoms under control and reduce inflammation in the gut over time.
Moderately to Severely Active Crohn's DiseaseCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicentre, Randomised, Double-blind, Placebo-controlled, Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Combination Compared to Zibotentan Monotherapy as well as Zibotentan/Dapagliflozin and Zibotentan Monotherapy Compared to Placebo in Participants with Cirrhosis
This study is looking at how safe new drug combinations (Zibotentan with Dapagliflozin, or Zibotentan on its own) are for people with liver scarring (cirrhosis). Researchers want to see if these treatments help manage fluid build-up in the body, compared to a dummy pill.
Cirrhosis of the liver is a condition in which the liver is scarred and damagedCzechia