Latest studies
- Active not recruitingPHASE3
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
This study looks at the long-term safety of a treatment called astegolimab for people with a lung condition called COPD. It's for people who have already taken part in previous studies of this drug.
Chronic Obstructive Pulmonary DiseaseDenmark - Active not recruitingPHASE3
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
This study is looking into the long-term effects and safety of a medicine called mirikizumab for people with Crohn's disease. Participants have already taken part in a related study, and this new study will help us understand how the medicine works over a longer period.
Crohn's DiseaseDenmark - RecruitingPHASE2, PHASE3
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
This study is testing a new medicine, CSL300, for adults with advanced kidney disease on dialysis. It aims to see if CSL300 can improve heart health and is safe, especially for those with existing heart conditions or diabetes.
End Stage Kidney DiseaseDenmark - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseDenmark - Active not recruitingPHASE3
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
This study looks at a new medicine called risankizumab for Crohn's disease. We're checking how well it works and if it's safe for people who have already started treatment. It's like a follow-up to see how different doses work and how people feel over time.
Crohn's DiseaseDenmark - RecruitingPHASE3
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
This study is looking for better ways to treat advanced kidney cancer that has come back after earlier treatment. Researchers want to see if a new combination of medicines, belzutifan and zanzalintinib, works better than a standard medicine, cabozantinib, at shrinking the cancer.
Renal Cell CarcinomaDenmark - Active not recruiting
Post Market Registry for GORE® TAG® Thoracic Branch Endoprosthesis
This study looks at how a special device called the GORE® TAG® Thoracic Branch Endoprosthesis works in real patients with problems in their main body artery (aorta). We want to see how safe and effective it is for conditions like aneurysms, which are dangerous bulges.
AneurysmDissection, AorticTAA Thoracoabdominal Aortic AneurysmThoracic Aortic AneurysmDenmark - RecruitingPHASE3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
This study is for people with advanced bowel cancer that has spread and has a specific gene change called KRAS p.G12C. It compares a new combination of treatments to standard treatment to see if it can better stop the cancer from growing.
Metastatic Colorectal CancerDenmark - RecruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
CancerDenmark - RecruitingPHASE3
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
This study is testing a new drug, Telisotuzumab Vedotin, against a standard treatment, Docetaxel, for advanced non-small cell lung cancer. It aims to see if the new drug works better and is safe for adults who have already had treatment.
Non Small Cell Lung CancerDenmark - Active not recruitingPHASE3
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
This study looks at a new medicine called upadacitinib for adults with Crohn's disease. It checks how well it works and if it's safe over a long time for people who have already started treatment in previous studies. The aim is to see if it can help manage Crohn's.
Crohn's DiseaseDenmark - Active not recruitingPHASE3
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called lutikizumab for people aged 12 and over with moderate to severe hidradenitis suppurativa (HS). It compares the new medicine to a dummy treatment (placebo) to see if it helps reduce HS symptoms and is safe.
Hidradenitis SuppurativaDenmark - Active not recruitingPHASE3
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
This study compares a new medicine, upadacitinib, with a sugar pill (placebo) and an existing medicine, adalimumab, for adults with rheumatoid arthritis. It looks at how well these treatments work and if they are safe when methotrexate isn't enough on its own.
Rheumatoid ArthritisDenmark - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
Ulcerative ColitisDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) with a History of Exacerbations (PROSPERO)
This study is testing a new medicine called Tozorakimab for people with severe COPD. It aims to see if Tozorakimab can reduce flare-ups and is safe to use long-term, compared to a dummy medicine.
Chronic Obstructive Pulmonary Disease (COPD)Denmark - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2b/3 Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-1654 in Healthy Pre-Term and Full-Term Infants
This study is looking at a new medicine, MK-1654, to help protect babies from a common chest infection called RSV. It will check if the medicine works well and if it's safe for both premature and full-term babies.
Prevention of RSVDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Plethysmography with acetylcholin and carbacholin – A clinical method study
This study is looking at a condition where blood vessels don't work properly. It involves using special eye drops, usually given during eye surgery, to see how they affect blood flow in the forearm. Researchers are trying to find better ways to measure how well blood vessels are working.
Vascular dysfunctionDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
The Intertransverse Process Block - Single or Multiple Injection? A randomised, procedure related, blinded crossover trial in healthy volunteers
This study is looking at a pain-relief method called an 'Intertransverse Process Block' in healthy men. Researchers are comparing one injection to multiple injections to see which works better for numbing areas of the chest. It's about finding the best way to help with pain, especially after breast cancer surgery.
The ITP block is primarily used for pain amelioration after breast cancer surgery.Denmark - Ongoing, recruitingTherapeutic use (Phase IV)
A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs. Standard-Dose Quadrivalent Influenza Vaccine in Older Adults
This study is looking at whether a high-dose flu vaccine works better than the standard flu vaccine for older adults. It aims to see if the high-dose vaccine helps prevent hospital stays due to flu or pneumonia.
Prevention of influenza infection in older adultsDenmark - Ongoing, recruitingPhase III and phase IV (Integrated)
A study in healthy volunteers to improve methods for detection of GHB in drug rape victims
This study looks for better ways to detect the drug GHB in people, especially if it's used to harm someone. Researchers want to find new clues in blood, pee, and hair to show when someone has taken GHB, even days later. This could help victims and investigations.
IntoxicationDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. -AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
This study looks at how morphine, a painkiller, works in people with obesity and sleep apnoea compared to healthy volunteers. We want to understand if these conditions change how the body handles morphine to make sure it's used safely and effectively.
Obesity andObstructive Sleep apnoeaDenmark - Ongoing, recruitingPhase II and Phase III (Integrated)
Thiamine against chronic rheumatoid arthritis fatigue
This study looks at whether a high dose of vitamin B1 (thiamine) can help reduce tiredness in people with rheumatoid arthritis. We want to see if fatigue levels change after four weeks of treatment.
Rheumatoid ArthritisDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Pan-European proof-of-concept study comparing Decentralised Clinical Trial (DCT) and hybrid approaches to conventional clinical trial approaches in patients with Type 2 diabetes mellitus treated with Toujeo®
This study is looking at new ways to run clinical trials for people with Type 2 diabetes who use Toujeo insulin. It compares traditional trial methods with more flexible approaches to see which works best for patients.
Type 2 diabetes mellitus (T2DM)Denmark - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1 Study of the SHP2 Inhibitor BBP-398 (formerly known as IACS-15509) in combination with the KRAS-G12C Inhibitor Sotorasib in Patients with Advanced Solid Tumors and a KRAS-G12C Mutation
This study is testing a new combination of two medicines for people with advanced cancers that have a specific genetic change (called KRAS-G12C). One medicine is new (BBP-398), and it's being given with an existing one (sotorasib) to see if they work better together.
Advanced or metastatic solid tumors with a KRAS-G12C mutation, Advanced or metastatic non-small cell lung cancer (NSCLC) with a KRAS-G12C mutation and who are KRAS-G12Ci naïveDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, 24-week, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety and Tolerability of Rocatinlimab (AMG 451) Monotherapy in Adult Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon)
This study is looking at a new medicine called Rocatinlimab for adults with moderate to severe eczema. We want to see if it helps improve skin, reduce itching, and is safe over 24 weeks compared to a dummy medicine.
Atopic DermatitisDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Efficacy of Remimazolam with Fentanyl versus Midazolam with Fentanyl for sedation in screening colonoscopy: A randomized controlled study
This study compares two different medicine combinations, Remimazolam with Fentanyl versus Midazolam with Fentanyl, used to help patients relax during a colonoscopy. Researchers want to see which combination allows patients to recover faster and leave the hospital sooner after the procedure.
Screening patientsDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
ISIS 678354-CS9: A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) in Patients with Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), or with Severe Hypertriglyceridemia
This study is testing a new medicine, Olezarsen, for people with high 'triglycerides' (a type of fat in the blood) and heart problems. It aims to see if the medicine can lower these fats and is safe to use.
Hypertriglyceridemia, Cardiovascular Diseases, AtherosclerosisDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)
This study is testing a new medicine, AZD3427, for people with heart failure and high blood pressure in the lungs caused by heart problems. We want to see if it improves how the heart and lungs work together.
Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, parallel-group, double-blind, placebo-controlled, multicenter Phase III trial to evaluate efficacy and safety of secukinumab administered subcutaneously versus placebo, in combination with a glucocorticoid taper regimen, in patients with polymyalgia rheumatica (PMR)
This study is testing a new medicine, secukinumab, for polymyalgia rheumatica (PMR). It compares secukinumab with a dummy treatment (placebo) alongside a common steroid medicine to see if it helps reduce symptoms and allows people to use less steroid medicine.
Polymyalgia RheumaticaDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, placebo controlled, investigator and participant-blinded study, investigating safety, tolerability and efficacy of RHH646 in participants with knee osteoarthritis
This study is looking at a new medicine called RHH646 for people with knee osteoarthritis. Researchers want to see if it's safe, if people can tolerate it well, and if it helps by checking changes in knee cartilage over 52 weeks.
Knee OsteoarthritisDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 1/Phase 2 Study to Evaluate the Safety and Tolerability of MK-1088 as Monotherapy and in Combination with Pembrolizumab in Participants with Advanced Solid Tumors
This study is testing a new cancer medicine, MK-1088, sometimes with an existing medicine called Pembrolizumab (Keytruda). We want to find out if it's safe for people with advanced solid tumours and how well it's tolerated. It's an early-stage study focusing on safety.
Treatment of advanced/metastatic solid tumorsDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ASTEGOLIMAB IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
This study is testing a new medicine, astegolimab, for people with a lung condition called COPD. It wants to see if this medicine can help reduce flare-ups (exacerbations) of COPD and if it's safe to use. You might get the new medicine or a dummy medicine.
Chronic Obstructive Pulmonary Disease (COPD)Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
This study is testing a new eye treatment called JNJ-81201887 for a condition called Geographic Atrophy (GA). GA is a serious eye problem linked to ageing that can cause blurry vision. Researchers want to see if this new treatment can slow down the worsening of GA.
Geographic AtrophyDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3b Study to Evaluate the Duration of Effect of Bimatoprost SR in Participants with Open-Angle Glaucoma or Ocular Hypertension
This study looks at how long a special eye drop called Bimatoprost SR works for people with glaucoma or high eye pressure. It helps us understand if it keeps working over time to protect your eyesight.
Open-Angle Glaucoma, Ocular HypertensionDenmark - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Rapid intravenous infusion of 10 and 22 degrees Celcius Ringer's lactate in healthy volunteers and its effects on circulation and hemostasis - a randomized crossover trial
This study looks at how quickly giving fluid by drip affects healthy volunteers. We're comparing cool fluid (10°C) with room temperature fluid (22°C) to see how it changes blood pressure and other body functions. It's a small, early-stage study.
Hemodynamic parameters is to be investigated -- comparing cold fluids 10 degrees celsius to room temperature 22 degrees celsiusDenmark - Active not recruitingPHASE2
A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)
This study is testing a new medicine called tarlatamab for people with a type of lung cancer called Small Cell Lung Cancer (SCLC) that has come back or not responded to previous treatments. It aims to see how safe and effective the new medicine is.
Relapsed/Refractory Small Cell Lung CancerDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Long-term Safety Extension Study of Mavacamten (MYK-461) in Adults with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICKHCM (MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE)
This study looks at the long-term safety of a medicine called mavacamten for adults with a heart condition called hypertrophic cardiomyopathy. It follows people who have already taken part in previous studies of this medicine.
Hypertrophic cardiomyopathyDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
(22267) A parallel-group, randomized, prospective, interventional, double-blind, multicenter global Phase 3 study to investigate the efficacy and safety of finerenone versus placebo, in addition to standard of care, in participants with chronic kidney disease and type 1 diabetes
This study is looking into a new medication called finerenone for people with long-term kidney disease caused by type 1 diabetes. We want to see if it works better than a dummy medicine (placebo) to slow down kidney damage over 6 months, alongside their usual care.
Chronic kidney disease associated with type 1 diabetes mellitusDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-label, Non-randomized, Phase 3 Study to Evaluate the Efficacy and Safety of Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to Fenfluramine.
This study is testing a new medicine, Soticlestat, for people aged 18 and over with severe epilepsy called Dravet Syndrome or Lennox-Gastaut Syndrome. It's to see if it helps reduce seizures and if it's safe, especially for those who have previously taken another epilepsy medicine called Fenfluramine.
Dravet Syndrome/Lennox-Gastaut SyndromeDenmark - Active not recruitingPHASE3
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
This study is looking at a new treatment called Tarlatamab for advanced small cell lung cancer that has come back after earlier treatment. We want to see if Tarlatamab helps people live longer compared to standard chemotherapy.
Small Cell Lung Cancer (SCLC)Denmark - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2a Open-Label, Dose-Escalation, Multicenter, First in-Human, Consecutive-Cohort, Clinical Trial of BI 1910, a Monoclonal Antibody to Tumor Necrosis Factor Receptor 2 (TNFR2), as a Single Agent and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors
This study is testing a new drug, BI 1910, for people with advanced cancers. It will check how safe the drug is, what side effects it causes, and how much of it the body can handle, both on its own and when given with another cancer drug.
Advanced solid tumorsDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Multicenter Study of Subcutaneous Daratumumab Versus Active Monitoring in Subjects with High-risk Smoldering Multiple Myeloma
This study looks at a new drug called daratumumab to see if it can stop a high-risk precancerous blood condition, called smouldering multiple myeloma, from turning into a more serious cancer. It compares the drug to close observation to see which approach works best.
Precancerous form of blood cancer in the bone marrowDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind Study to Evaluate Perioperative Pembrolizumab (MK-3475) + Neoadjuvant Chemotherapy versus Perioperative Placebo + Neoadjuvant Chemotherapy in Cisplatin-eligible Participants with Muscle-invasive Bladder Cancer (KEYNOTE-866)
This study is testing if adding a new drug, pembrolizumab (Keytruda), to standard chemotherapy before and after surgery can help people with a type of bladder cancer. Researchers want to see if this combination works better than chemotherapy alone to keep the cancer away.
Cis-eligible Muscle-invasive bladder cancer.Denmark - Active not recruitingPHASE3
An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
This study looks at a new treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread. It compares this new treatment alongside standard care to standard care alone, aiming to see if it helps patients live longer without their cancer getting worse.
Prostatic NeoplasmsDenmark - RecruitingNA
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
This study compares an intensive diet and lifestyle programme with weight-loss surgery for adults with severe obesity. We want to see which method works best and is safest, to help improve future treatment options.
ObesityDenmark - Active not recruitingPHASE3
Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy.
This study is testing a new combination treatment for advanced bowel cancer. It compares a new medicine (S95005) with an existing one (capecitabine), both given with bevacizumab. The aim is to see if the new combination works better for patients who can't have intensive chemotherapy.
Metastatic Colorectal CancerDenmark - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy
This study looks at two different daily pill combinations for adults newly diagnosed with HIV. It compares a two-drug treatment with a three-drug treatment to see which is safer and works better for controlling the virus.
HIVHIV InfectionsDenmark - Active not recruitingPHASE3
A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)
This study looks at a new personalised treatment, Intismeran Autogene, combined with Pembrolizumab for high-risk melanoma. It aims to see if this combination can stop cancer from coming back better than Pembrolizumab alone after surgery, focusing on safety and effectiveness.
MelanomaDenmark - Active not recruiting
Micra Transcatheter Pacing System Post-Approval Registry
This study is looking at how a tiny pacemaker, the Micra Transcatheter Pacing System, works in everyday life after it's been approved. It's for people who need this type of pacemaker due to a slow heart rate (bradycardia) to check its safety and how well it works over time.
BradycardiaDenmark - Active not recruitingPHASE2
To Assess Efficacy and Safety of Batoclimab in Adult Participants With Active CIDP
This study is testing a new drug called batoclimab for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see how well it works and if it's safe compared to a dummy drug.
Chronic Inflammatory Demyelinating PolyneuropathyDenmark