Latest studies
- RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
This study is looking into a new medication called remibrutinib for people with a type of multiple sclerosis (MS) called Secondary Progressive MS (SPMS). It will check if the medicine is safe and helps slow down the disease.
Secondary Progressive Multiple Sclerosis (SPMS)France - RecruitingPHASE2
Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL
This study is testing a new medicine called Surovatamig for adults with certain types of B-cell non-Hodgkin lymphoma that has returned or not responded to previous treatments. It aims to see how well it works and if it's safe.
B-cell Non-Hodgkin LymphomaFollicular Lymphoma (FL)Large B-Cell Lymphoma (LBCL)France - Authorised (with conditions)Phase II and Phase III (Integrated)
C5351004 - A Phase 2/3 Randomized, Multicenter Study of Osivelotor Administered Orally to Participants with Sickle Cell Disease and an Open-Label Pharmacokinetics Study in Pediatric Participants with Sickle Cell Disease
This study is testing a new oral medicine, osivelotor, for adults with sickle cell disease. It aims to see how well it works to increase healthy blood cells and reduce pain crises, and how safe it is compared to a dummy pill.
Sickle Cell DiseaseFrance - Active not recruitingPHASE2, PHASE3
Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen
This study is looking for people with HIV-1 who are currently on a complex treatment plan. It compares a new two-drug combination, bictegravir and lenacapavir, with their current treatment to see if it's a simpler and effective option.
HIV-1-infectionFrance - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs
This study is testing a new medicine, Debio 4126, for people with acromegaly, a hormone disorder, who are already taking similar treatments. We want to see if Debio 4126 can help keep their hormone levels stable compared to a dummy drug.
AcromegalyFrance - RecruitingPHASE3
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
This study looks at whether adding chemotherapy before surgery helps people with certain types of retroperitoneal sarcoma live longer without their cancer coming back. It compares surgery alone to chemotherapy followed by surgery.
Retroperitoneal SarcomaLiposarcomaLeiomyosarcomaFrance - Active not recruitingPHASE3
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
This study is testing a new medicine, AR1001, for people in the early stages of Alzheimer's disease. We want to see if it's safe and helps improve or slow down symptoms compared to a dummy medicine.
Alzheimer DiseaseFrance - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
This study is looking at a new medicine called AZ-3102 for children and young people with rare conditions like Niemann-Pick Type C, GM1 Gangliosidosis, or GM2 Gangliosidosis. It aims to see if the medicine is safe and if it helps improve their health over 18 months.
Niemann-Pick Type C DiseaseGM1 GangliosidosisGM2 GangliosidosisFrance - Recruiting
Low Stable Pressure Pneumoperitoneum in Colorectal Surgery (CROSS STUDY)
This study looks at using a special low-pressure method during keyhole bowel surgery for conditions like cancer. The aim is to help patients recover faster, spend less time in hospital, and experience less pain after their operation.
Colorectal SurgeryBenign or Malignant Rectal or Colon TumorsFrance - Active not recruitingPHASE2
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
This study looks at a new treatment called patritumab deruxtecan for people with an advanced type of lung cancer that has a specific genetic change (EGFR mutation). It's for those who have already tried other standard treatments that are no longer working.
Non-Small Cell Lung Cancer MetastaticNon-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor ReceptorFrance - Active not recruitingPHASE3
Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)
This study looks at a new medicine called Seladelpar for Primary Biliary Cholangitis (PBC). It's a long-term study to see how safe and effective it is over time. Participants will have taken Seladelpar in a previous study.
Primary Biliary CirrhosisFrance - RecruitingPHASE3
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
This study is looking at a new medicine called sacituzumab govitecan (SG) for people with a type of lung cancer called extensive stage small cell lung cancer (ES-SCLC) that has been treated before. We want to see if SG works better than standard treatments to help people live longer.
Extensive Stage Small Cell Lung Cancer (ES-SCLC)France - RecruitingPHASE3
Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD
This study looks at a new medicine, pelacarsen, for people with heart and circulation problems and high levels of a specific fat called Lp(a). It aims to see if it's safe and effective when used alongside another medicine, inclisiran.
Atherosclerotic Cardiovascular Disease (ASCVD)France - RecruitingPHASE3
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
This study is looking at two new drug combinations for adults newly diagnosed with Chronic Lymphocytic Leukemia (CLL). It compares sonrotoclax plus zanubrutinib with venetoclax plus acalabrutinib to see which is more effective and safer for treating this type of blood cancer.
Chronic Lymphocytic LeukemiaFrance - Active not recruitingPHASE3
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
This study looks at a new drug, astegolimab, for people with COPD who have flare-ups often. It compares the new drug to a dummy treatment (placebo) to see if it's safe and helps improve their breathing and reduce flare-ups.
Chronic Obstructive Pulmonary Disease (COPD)France - RecruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
This study is testing a new medicine, PF-07328948, for adults with heart failure. We want to see if it's safe and helps improve symptoms when taken alongside existing treatments. Volunteers will take the medicine or a dummy pill for 36 weeks.
Heart FailureFrance - Active not recruitingPHASE3
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
This study looks at a new medicine called concizumab for haemophilia A or B with inhibitors. It aims to see if it can prevent bleeding and is safe. Some people will get the new medicine straight away, others later, all through daily injections at home.
Haemophilia A With InhibitorsHaemophilia B With InhibitorsFrance - Active not recruitingPHASE3
Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome
This study is testing a nasal spray called carbetocin for people with Prader-Willi syndrome (PWS) who have a strong urge to eat. It aims to see if the spray can help reduce this feeling of constant hunger. Participants will use either the real spray or a dummy spray for 12 weeks.
Hyperphagia in Prader-Willi SyndromeFrance - RecruitingPHASE2
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
This study is looking into a new treatment called VHB937 for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps with memory and daily activities. It involves taking the treatment or a dummy pill and having regular check-ups.
Alzheimer's DiseaseFrance - Active not recruitingPHASE2
Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01
This study is testing new combinations of treatments for head and neck cancer that has come back or spread. It compares two new drugs plus chemotherapy against one new drug plus chemotherapy. The aim is to find safer and more effective ways to treat this type of cancer.
Head and Neck Squamous Cell CarcinomaFrance - RecruitingPHASE2
A Clinical Trial to Evaluate Efficacy and Safety of Navepegritide in Adolescents (12 - 18 Years of Age) With Achondroplasia.
This study is looking at a new medicine called navepegritide for teenagers aged 12 to 18 with achondroplasia. We want to see if it helps them grow and if it's safe. It's compared to a dummy medicine over 52 weeks.
AchondroplasiaFrance - RecruitingPHASE2
ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
This study is for people with HER2-positive breast cancer that has spread. It's testing a new drug called evorpacept alongside standard treatments like trastuzumab and chemotherapy. Researchers want to see if this combination is safe and helps people whose cancer has grown despite previous treatments.
Breast Cancer, MetastaticFrance - Recruiting
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
This study, HDClarity, aims to gather fluid samples from people with Huntington's disease to find better ways to treat it. By studying blood and spinal fluid, researchers hope to understand the disease better and develop new medicines.
Huntington's DiseaseFrance - RecruitingPHASE1
Study of KM-023 in Healthy Volunteers and Patients With Olmsted Syndrome.
This study is testing a new medicine, KM-023, for Olmsted Syndrome. It first checks safety in healthy people, then looks at effects and safety in patients. It also studies how the body handles the medicine and how it affects the skin.
Olmsted SyndromeFrance - Active not recruitingPHASE3
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)
This study compares a new drug combination (Lurbinectedin and Doxorubicin) against Doxorubicin alone for people with advanced leiomyosarcoma, a rare type of cancer. It aims to see if the combination can keep the cancer from growing for longer.
LeiomyosarcomaFrance - RecruitingPHASE2
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
This study, called WISPer, is testing a new medicine called MTX-463 for Idiopathic Pulmonary Fibrosis (IPF). It's comparing MTX-463 to a dummy medicine (placebo) to see if it's safe and effective for people with this lung condition.
Idiopathic Pulmonary FibrosisFrance - Active not recruitingPHASE2
A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
This study looks at new ways to treat a type of bladder cancer that hasn't responded to usual treatments. It tests two medicines, TAR-200 and cetrelimab, alone or together, for people who can't or don't want major surgery.
Urinary Bladder NeoplasmsFrance - Active not recruitingPHASE2
Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
This study looks at a new type of treatment called afamitresgene autoleucel for advanced synovial sarcoma or myxoid liposarcoma. It aims to see how well it works and if it's safe for people who have specific genetic markers.
Synovial SarcomaMyxoid LiposarcomaFrance - Recruiting
A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials
This study looks at how well new treatments called teclistamab and talquetamab work for people in the UK with a specific type of blood cancer called multiple myeloma, when these treatments are given outside of formal clinical trials. It's about understanding real-world results.
Relapsed/Refractory Multiple Myeloma (RRMM)France - RecruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
Solid TumorsAdvanced CancerRenal CancerGastric CancerFrance - Active not recruitingPHASE3
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
This study is looking into a new combination treatment for a type of breast cancer called triple-negative breast cancer (TNBC) that has spread or is advanced. It combines a new drug, Capivasertib, with a common chemotherapy, Paclitaxel, to see if it works better than just Paclitaxel alone.
Triple Negative Breast NeoplasmsFrance - RecruitingNA
PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)
This study looks at whether regular brain scans alone are as good as scans plus radiation therapy for people with small cell lung cancer. It aims to see if avoiding radiation therapy can improve quality of life and brain health without making outcomes worse.
Limited Stage Small Cell Lung CancerExtensive-stage Small-cell Lung CancerFrance - Active not recruitingPHASE2
Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)
This study is testing a new medicine called sevasemten (also known as EDG-5506) for adults with Becker muscular dystrophy. It wants to see if the medicine is safe and if it helps people. Early parts of the study are now full, but one large part, GRAND CANYON, has also finished taking new participants.
Becker Muscular DystrophyFrance - RecruitingPHASE3
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
This study looks at a new medicine called ziltivekimab for people with heart failure and inflammation. It aims to see if monthly injections of ziltivekimab can help, compared to a dummy medicine, over a few years.
Heart FailureFrance - RecruitingPHASE3
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
This study looks at new ways to treat advanced squamous non-small cell lung cancer. It combines standard treatment (Pembrolizumab, Carboplatin, Paclitaxel/Nab-paclitaxel) with a new drug, sac-TMT, to see if it helps people live longer.
Non-small Cell Lung CancerNSCLCFrance - RecruitingPHASE2, PHASE3
A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
This study is looking at a new medicine called R-DXd for certain types of advanced ovarian, primary peritoneal, or fallopian tube cancer that haven't responded well to platinum chemotherapy. It aims to find out if R-DXd is safe and effective.
Solid CancerFrance - Active not recruitingPHASE3
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
This study aims to see if adding the drug pembrolizumab to standard chemotherapy before and after surgery helps people with early-stage non-small cell lung cancer live longer and prevent the cancer from returning. It's a large study comparing this new approach with chemotherapy alone.
Non-small Cell Lung CancerFrance - Active not recruitingPHASE1
Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)
This study tests a new medicine called zongertinib for advanced cancers with changes in the HER2 gene. It aims to find the right dose and see if it can shrink tumours, especially in non-small cell lung cancer.
Neoplasm MetastasisNon-Small Cell Lung CancerFrance - RecruitingPHASE2
An Extension Study of Subjects Who Received an Avalyn Inhaled Antifibrotic Agent (SAIL)
This study is for people who were in a previous study with an inhaled medicine called AP01 for lung scarring (pulmonary fibrosis). It’s an extension to see how the medicine works over a longer time, using an inhaler twice a day.
Progressive Pulmonary FibrosisIdiopathic Pulmonary Fibrosis (IPF)France - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
This study is looking at a medicine called emicizumab for babies up to 12 months old with severe haemophilia A. It aims to see how well it works, if it's safe, and how the body handles it, to help prevent bleeding episodes.
Severe Hemophilia AFrance - Active not recruitingPHASE3
Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation
This study looks at a new drug (AG-120) combined with a standard treatment (azacitidine) for adults newly diagnosed with a specific type of acute myeloid leukaemia (AML) that has a particular gene change (IDH1 mutation). It compares this combination to azacitidine alone to see if it works better.
Newly Diagnosed Acute Myeloid Leukemia (AML)Untreated AMLAML Arising From Myelodysplastic Syndrome (MDS)Leukemia, Myeloid, AcuteFrance - RecruitingPHASE2
Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)
This study looks at a new medicine called sotatercept for a specific type of high blood pressure in the lungs (Cpc-PH) linked to heart failure. It's for people who were in a previous study to see how the medicine works long-term and if it's safe.
Hypertension, PulmonaryFrance - RecruitingPHASE2
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
This study is looking at a new medicine called iptacopan for people with active lupus nephritis, a kidney problem caused by lupus. It aims to see how well it works and if it's safe when added to standard treatments.
Lupus NephritisFrance - Active not recruitingPHASE1
Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung Cancer
This study looks at a new drug, Amivantamab, alone or with other treatments, for certain types of advanced lung cancer. We want to find the safest and most effective dose, and see how well it works.
Non-Small-Cell Lung CancerFrance - Active not recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (PATHFNDR-2)
This study is testing a new medicine, paltusotine, for people with acromegaly, a rare condition causing too much growth hormone. It's a pill being compared to a dummy pill to see if it's safe and helps improve symptoms.
AcromegalyFrance - Active not recruitingPHASE1, PHASE2
A Clinical Trial Evaluating TG4050 in Head and Neck Cancer
This study is testing a new treatment called TG4050 for a type of head and neck cancer. It's looking at how safe and effective the treatment is in patients who have already had their main cancer treated.
Squamous Cell Carcinoma of Head and NeckFrance - Active not recruiting
A Prospective, Non-interventional, Multinational, Observational Study With Isatuximab in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM)
This study looks at how a medicine called isatuximab works for people in the UK with a type of blood cancer called multiple myeloma that has come back or not responded to previous treatments. It checks how well it works and if it's safe in real-world settings.
Plasma Cell MyelomaFrance - RecruitingPHASE2, PHASE3
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
This study looks at switching from one existing medicine, Bulevirtide, to a new one, Brelovitug, for people with long-term Hepatitis D. Researchers want to see if the new medicine is safe and works better.
Chronic Hepatitis DFrance - RecruitingPHASE2, PHASE3
Phase 2/3 Study of KPL-387 in Recurrent Pericarditis
This study is testing a new medicine, KPL-387, for people with recurrent pericarditis, a condition causing chest pain and inflammation around the heart. We want to see if it's safe and helps reduce symptoms and prevent the problem from coming back.
PericarditisPericarditis AcuteRecurrent PericarditisFrance - Recruiting
Fabry Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Fabry disease over time, including pregnant women. It helps doctors better understand the disease and improve care, without giving any new treatments. It's about observing, not experimenting.
Fabry DiseaseFrance