Latest studies
- Recruiting
Can a digital self-help tool, created together with autistic people, support them in managing headaches?
Headaches are common in autistic people, but most health apps are not built with their needs in mind. This UK study works alongside autistic people to adapt a headache self-help app. Researchers want to see if the new app is easy, practical, and helpful to use in daily life.
Self reported persistent or chronic headache in autistic individualsIreland - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
MyelofibrosisAnemiaIreland - Completed
Multi-centre European study of major infectious disease syndromes (MERMAIDS) – Acute respiratory infections
This study looks at acute chest and throat infections to understand why some people get much sicker than others. Researchers from the University of Oxford are collecting blood and swab samples from adults treated at GP surgeries or hospitals to help develop better, more personalised treatments for future infections.
Acute respiratory infectionsIreland - CompletedNot Applicable
Evaluating the use of a lower blood pressure target to guide drug treatment in critically ill children with low blood pressure
This UK study looks at critically ill children in intensive care who have low blood pressure. Doctors want to see if aiming for a slightly lower, safe blood pressure target reduces the amount of strong medicine needed. This could help children recover better and avoid unwanted side effects from intensive treatments.
Critically ill children with hypotensionIreland - Completed
Vitamin D and lifestyle Intervention for gestational diabetes mellitus (GDM) prevention
This study looks at ways to prevent gestational diabetes, which is high blood sugar during pregnancy. Researchers are testing whether vitamin D supplements, healthy eating advice, regular physical activity, or combinations of these can help pregnant women with a higher body mass index stay healthy throughout their pregnancy.
Gestational diabetesIreland - RecruitingPhase III
Tranexamic acid (and Desmopressin) for very early bleeds in the brain
This clinical trial tests whether an affordable medicine called tranexamic acid can stop bleeding in the brain after a stroke. Doctors want to see if giving this injection quickly in the emergency room helps people survive with less long-term disability, improving recovery and everyday life six months later.
Hyperacute primary intracerebral haemorrhage (stroke)Ireland - Completed
Add-Aspirin: the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.
The Add-Aspirin study looks at whether taking everyday aspirin can stop cancer from coming back after standard treatment. Adults with early-stage breast cancer and other common tumours take either a low dose of aspirin, a higher dose, or a dummy tablet to see if it helps them live longer, healthier lives.
CancerIreland - CompletedPhase III
MyeChild 01: Treating children with acute myeloid leukaemia
MyeChild 01 is a clinical trial for children and young people with acute myeloid leukaemia (AML). It tests whether adding a targeted drug called gemtuzumab ozogamicin to standard chemotherapy helps clear leukaemia cells more effectively and safely. It also looks at the best chemotherapy combinations before a stem cell transplant.
Acute myeloid leukaemiaIreland - Completed
The SENSE-Cog Randomised Controlled Trial (RCT): Comparing individualised sensory intervention to standard care to improve quality of life in people with dementia and their companions
This trial looks at whether personalised support for hearing and sight loss improves daily life for people with dementia and their carers. Half of participants receive free hearing aids or glasses with home visits from a therapist, while the other half receive standard care and advice.
DementiaIreland - Completed
A multi-site observational study looking at the risk factors associated with tooth sensitivity, receding gums and tooth wear
This study looks into why adults develop sensitive teeth, receding gums, and worn tooth enamel. Researchers are studying how diet, brushing, and lifestyle affect oral health across Europe. Taking part is simple: it involves completing a short lifestyle survey and having a gentle mouth check-up during a single dental appointment.
Dentine hypersensitivity Tooth wear Recession Clinical loss of attachment Oral hygiene habits Dietary habitsIreland - Completed
Assessing the efficacy of emotion-focused therapy in the treatment of depression, anxiety and related disorders
This clinical trial looks at whether a talking therapy called Emotion-Focused Therapy can help adults with depression, anxiety, OCD, or trauma. Researchers want to see if one single therapy approach can successfully treat people who experience one or more of these common mental health challenges at the same time.
Depression and anxiety and related disorders (such as obsessive-compulsive disorders and trauma/stressor related disorders).Ireland - CompletedPhase IV
Real world health outcomes in people with cystic fibrosis after initiation of a new combination treatment
This study looks at how new combination medicines help people with cystic fibrosis in everyday life. Researchers across the UK and Ireland are following children and adults aged six and older for up to seven years to see how these treatments improve health and daily living over time.
Cystic fibrosisIreland - AuthorisedTherapeutic confirmatory (Phase III)
An Open-Label, Phase 3 Study to Evaluate the Efficacy and Safety of Salanersen (BIIB115) in Participants Aged 15-60 Years With Spinal Muscular Atrophy Who Are Either Treatment-Naïve or Have Previously Been Treated With Risdiplam
This phase 3 study tests an investigational medicine called salanersen (BIIB115) for people aged 15 to 60 with spinal muscular atrophy (SMA). Researchers want to see if it helps improve physical movement, arm strength, and walking ability over time in people new to treatment or previously treated with risdiplam.
Spinal Muscular AtrophyIreland - AuthorisedPhase III and phase IV (Integrated)
4TAZPower: A Phase 3b/4, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Trial to Evaluate the Efficacy and Safety of Daily Subcutaneous Injections of Elamipretide in Patients with Genetically Confirmed Barth Syndrome
This study tests whether a medicine called elamipretide can help men with Barth syndrome. Researchers want to see if daily injections under the skin can improve physical strength, walking ability, and day-to-day energy over 72 weeks, compared to an inactive dummy injection known as a placebo.
Barth SyndromeIreland - AuthorisedTherapeutic confirmatory (Phase III)
A Randomized, Open-Label Phase 3 Study of Azenosertib Versus Investigator’s Choice of Chemotherapy in Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression
This study is testing a new targeted cancer drug called azenosertib. It is for women with advanced ovarian, fallopian tube, or peritoneal cancer that has returned after standard platinum chemotherapy. Researchers want to see if azenosertib works better than standard chemotherapy options at keeping the cancer under control.
High-Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal CancerIreland - AuthorisedTherapeutic exploratory (Phase II)
HOVON 168: Epcoritamab in Addition to R-Mini-CHOP Compared to R-Mini-CHOP in Elderly, Frail or Unfit Patients with Diffuse Large B-cell Lymphoma
This study looks at a new drug combination for older or frail adults with diffuse large B-cell lymphoma, a type of blood cancer. Researchers want to see if adding an antibody drug called epcoritamab to standard, gentler chemotherapy helps clear the cancer better and keeps people well for longer.
Diffuse large B-cell lymphoma (DLBCL)Ireland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease
This clinical trial is testing a new tablet called mitapivat for adults with sickle cell disease. Researchers want to find out if taking mitapivat every day for one year can safely reduce or stop the need for blood transfusions by helping red blood cells stay healthy for longer.
Anemia in subjects with sickle cell disease (SCD)Ireland - RecruitingTherapeutic confirmatory (Phase III)
ATHENA (A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)
This study looks at two medicines, rucaparib and nivolumab, for women with advanced ovarian, fallopian tube, or primary peritoneal cancer. It aims to see if using these drugs after standard chemotherapy helps keep the cancer away for longer compared to dummy treatments, known as placebos.
Ovarian epithelialcancer, Malignant peritonealneoplasm, advanced (FIGO stage III-IV), high-grade epithelial ovarian, fallopiantube, or primary peritoneal cancer (who responded to front-lineIreland - RecruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older With Active Idiopathic Inflammatory Myopathy
This clinical trial is testing a new injection called efgartigimod for adults with inflammatory muscle disease (myositis). Researchers want to see if the medicine can safely reduce muscle inflammation, improve strength, and help people lower their daily steroid dose compared to a dummy treatment over 52 weeks.
Active Idiopathic Inflammatory Myopathy (IIM)Ireland - RecruitingTherapeutic exploratory (Phase II)
A Phase 2, Multi-Center, Randomized, Double-Blind, Controlled Trial Evaluating the Safety and Efficacy of ENV-101 in Patients with Lung Fibrosis (WHISTLE-PF Trial)
The WHISTLE-PF study looks at an experimental tablet called ENV-101 (taladegib) for idiopathic pulmonary fibrosis (IPF). Researchers want to see if this treatment helps protect lung function and improves daily symptoms like coughing, breathlessness, and tiredness over 24 weeks compared to a dummy tablet (placebo).
idiopathic pulmonary fibrosisIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Orally Administered Deucrictibant Extended-release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults with Hereditary Angioedema
This clinical trial is testing a new daily tablet called deucrictibant for adults with hereditary angioedema (HAE). Researchers want to find out if taking this tablet can safely prevent painful swelling attacks. Participants will take either the study tablet or an inactive dummy pill for 24 weeks.
Hereditary AngioedemaIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial with Open-Label Extension to Evaluate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Patients with Primary Sjögren’s Disease
This study tests whether a medicine called efgartigimod can help adults with primary Sjögren’s disease. Researchers want to see if regular injections under the skin can ease symptoms like joint pain, dry eyes, and dry mouth, and lower overall body inflammation compared with a dummy treatment (placebo).
Primary Sjögren’s DiseaseIreland - RecruitingTherapeutic confirmatory (Phase III)
BRISOTE: A Multicentre, Randomised, Double-blind, Parallel Group, Active-Controlled, Phase 3b Study to Evaluate the Efficacy and Safety of Benralizumab 30 mg SC in Eosinophilic Asthma Patients Uncontrolled on Medium-Dose Inhaled Corticosteroid Plus Long-acting β2 Agonist
This clinical trial is testing whether an injection called benralizumab can help adults with severe eosinophilic asthma. Researchers want to see if adding this medicine to standard daily inhalers reduces asthma attacks and improves everyday breathing over 48 weeks compared to standard inhaler treatments alone.
Eosinophilic AsthmaIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Global Study to Evaluate the Efficacy and Safety of Intravenous AOC 1001 for the Treatment of Myotonic Dystrophy Type 1
This phase 3 clinical trial is testing a new medicine called AOC 1001 for adults with myotonic dystrophy type 1. Researchers want to see if the medicine, given through a vein drip, helps improve muscle stiffness in the hands, increases strength, and improves daily life over 54 weeks.
Myotonic Dystrophy Type 1Ireland - RecruitingTherapeutic confirmatory (Phase III)
A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System™ Kit, in Subjects with Hypertension
This clinical trial is testing a new keyhole treatment called the Peregrine System for high blood pressure. The procedure aims to calm overactive nerves near the kidneys. Researchers want to see if this safely lowers blood pressure over several months compared to a dummy procedure.
HypertensionIreland - RecruitingTherapeutic confirmatory (Phase III)
A multi-center, randomized, double-blind, placebo controlled, parallel-group Phase IIIb study evaluating the effect of inclisiran on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of non-obstructive coronary artery disease without previous cardiovascular events (VICTORION-PLAQUE)
This study looks at a cholesterol-lowering injection called inclisiran. Researchers want to see if adding inclisiran to standard daily statin tablets can stop or shrink fatty build-up in the heart's arteries. It is for adults with early heart disease who have never had a heart attack or stroke.
Non-obstructive Coronary Artery DiseaseIreland - AuthorisedPhase I and Phase II (Integrated)- Other
ROSETTA RCC-208: A Phase 1/2 Open-label, Multi-center, Randomized Study of Pumitamig Alone or in Combination with Ipilimumab or Cabozantinib in Participants with Advanced Renal Cell Carcinoma (RCC)
This study is testing an experimental medicine called pumitamig for adults with advanced kidney cancer. Doctors want to see how safe it is on its own or alongside other cancer drugs, and whether it can help shrink tumours or stop the cancer from getting worse.
Advanced Renal Cell CarcinomaIreland - AuthorisedTherapeutic exploratory (Phase II)
C6461010 - An Interventional, Open-Label, Phase 2 Study to Investigate the Safety and Efficacy of PF-08634404 Monotherapy or in Combination in Adult Participants with Early-Stage Resectable or Locally Advanced Unresectable Non-Small Cell Lung Cancer
This study is testing a new cancer medicine called PF-08634404. Researchers want to see how safe and effective it is when given on its own or with standard chemotherapy for adults with non-small cell lung cancer, either before surgery or when surgery is not an option.
Early-Stage Resectable or Locally Advanced Unresectable Non-Small Cell Lung CancerIreland - AuthorisedPhase III and phase IV (Integrated)
A Phase 3b/4, Multicenter, Parallel-Group, Double-Blind, Placebo-Controlled, Two-Arm, Long-Term Study to Evaluate the Safety and Efficacy of Saroglitazar Magnesium on Clinical Outcomes in Participants with Primary Biliary Cholangitis (PBC)
This study is looking at a medicine called saroglitazar magnesium for people living with primary biliary cholangitis (PBC). Researchers want to see if this daily tablet can protect the liver from long-term damage, reduce extreme tiredness, and lower the risk of serious complications or needing a liver transplant.
Primary Biliary Cholangitis (PBC)Ireland - RecruitingTherapeutic confirmatory (Phase III)
APOLLO: A Randomized, Double-Blind, Placebo-Controlled Study of Bitopertin to Evaluate the Efficacy, Safety, and Tolerability in Participants with Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)
The APOLLO study is testing a new daily tablet called bitopertin for adults with EPP or XLP. These rare conditions cause severe skin pain in sunlight. Researchers want to see if bitopertin can reduce this pain and allow people to spend more time outdoors safely over six months.
X-Linked Protoporphyria (XLP), Erythropoietic Protoporphyria (EPP)Ireland - RecruitingHuman Pharmacology (Phase I)- First administration to humans
A multi-part, adaptive, Phase 1, first time in human study in healthy participants and participants with atopic dermatitis (AD) to assess the safety, tolerability, pharmacokinetics (PK) of single ascending (SAD), multiple ascending doses (MAD) and selected dose of SYX-5219 (AD Participants)
This early-stage study tests a new medicine called SYX-5219 for the first time in humans. Researchers want to see if it is safe, how well the body handles it, and how it behaves. The study includes both healthy adults and adults living with atopic dermatitis (eczema).
Atopic DermatitisIreland - AuthorisedTherapeutic confirmatory (Phase III)
IM0271016: An Open-label, Multi-center, Long-term Extension Study to Evaluate the Long-term Safety and Tolerability of Admilparant in Participants with Pulmonary Fibrosis
This study looks at the long-term safety of a medicine called admilparant for people with pulmonary fibrosis. Researchers want to see how well the body handles the treatment over time, tracking any side effects and checking heart health and blood tests to make sure it is safe to use.
Progressive pulmonary fibrosis and Idiopathic pulmonary fibrosisIreland - RecruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized Study of Relatlimab plus Nivolumab in Combination with Chemotherapy vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
This study looks at a new drug combination for advanced non-small cell lung cancer. Researchers are testing whether adding a modern immunotherapy medicine called relatlimab to standard immunotherapy and chemotherapy works better and is safe for adults who have not yet had treatment for their advanced cancer.
Non small Cell Lung cancer, Non Small Cell Lung Cancer, Non Small Cell Lung Cancer, Non Small Cell Lung CancerIreland - RecruitingTherapeutic exploratory (Phase II)
PaTcH Trial: A phase 2 study to explore primary and emerging resistance mechanisms in patients with metastatic refractory Pancreatic cancer treated with Trametinib and Hydrochloroquine.
The PaTcH trial is testing whether combining two medications, trametinib and hydroxychloroquine, can help control advanced pancreatic cancer. It is designed for adults whose cancer has spread and no longer responds to standard treatments. Researchers want to see if these tablets can keep tumours stable for at least 12 weeks.
Metastatic refractory Pancreatic CancerIreland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blinded Study to Evaluate the Safety and Efficacy of Salanersen (BIIB115) After Onasemnogene Abeparvovec Treatment in Infants with Genetically Diagnosed Spinal Muscular Atrophy
This study tests a medicine called salanersen for babies with spinal muscular atrophy (SMA) who have already received gene therapy. Doctors want to see if salanersen is safe and whether it can give extra support to help infants build muscle strength, sit, crawl, and walk.
Spinal Muscular AtrophyIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Niraparib Maintenance Treatment in Patients with Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
This study looks at a new drug called niraparib to see if it can help women with advanced ovarian cancer stay well longer after their first round of chemotherapy. It compares niraparib to a dummy pill to find out how effective and safe it is.
Homologous recombination deficiency advanced ovarian cancerIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease
This study is looking at a medicine called ozanimod for people with Crohn's disease that is moderate to severe. It wants to see how well the medicine helps reduce their symptoms and improve their gut health over a long period. Researchers will also check how it affects COVID-19 antibody levels.
Moderately to Severely Active Crohn's DiseaseIreland - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Phase 3, Double-Blind Study of Chemoradiotherapy With or Without Pembrolizumab for the Treatment of High-risk, Locally Advanced Cervical Cancer (KEYNOTE-A18 / ENGOT-cx11/GOG-3047)
This study is testing a new treatment combination for locally advanced cervical cancer. It compares standard chemotherapy and radiation with the same treatment plus a new drug, pembrolizumab (Keytruda), to see if it helps patients live longer and stops the cancer from growing.
Locally Advanced Cervical CancerIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, multicenter, open-label, randomized study to evaluate the efficacy and safety of fedratinib compared to best available therapy in subjects with DIPSS - intermediate or high-risk primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis and previously treated with ruxolitinib
This study is comparing a new medicine, fedratinib, with other common treatments for people with a type of bone marrow disorder called myelofibrosis. It's for patients whose myelofibrosis has been treated before with another drug called ruxolitinib. We want to see how well fedratinib shrinks the spleen.
Primary myelofibrosis, post-polycythemia vera myelofibrosis , or post-essential thrombocythemia myelofibrosisIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blind Study of Tiragolumab Plus Atezolizumab Compared with Placebo Plus Atezolizumab in Participants with Completely Resected Stage IIB, IIIA, or Select IIIB, PD-L1 Positive, Non-Small Cell Lung Cancer who have received Adjuvant Platinum-Based Chemotherapy
This study looks at a new treatment for people with a certain type of lung cancer that has been removed by surgery. It compares two medicines, Tiragolumab and Atezolizumab, against Atezolizumab alone, to see if the new combination can help prevent the cancer from coming back.
Non-Small Cell Lung CancerIreland - RecruitingTherapeutic use (Phase IV)
Daily versus alternate day oral iron supplementation for the treatment of iron deficiency anaemia in pregnancy (IronMother)
This study is looking at the best way to give iron supplements to pregnant women who have too little iron (iron deficiency anaemia). We want to find out if taking iron every day or every other day works better to improve their iron levels and how they feel, while keeping side effects low.
Iron deficiency anaemia in pregnancyIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind clinical study of pembrolizumab (MK-3475) plus chemotherapy versus placebo plus chemotherapy as first-line treatment in participants with HER2 negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (KEYNOTE-859)
This study is testing a new medicine, pembrolizumab (Keytruda), alongside standard chemotherapy for advanced stomach or food pipe cancer. It aims to see if this combination helps people live longer compared to chemotherapy alone, especially for cancers that don’t have too much of a protein called HER2.
Gastric and gastric esophageal junction (GEJ) adenocarcinomaIreland - RecruitingTherapeutic confirmatory (Phase III)
An Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of ZYN002 Administered as a Transdermal Gel to Children, Adolescents and Young Adults with Fragile X Syndrome
This study looks at the long-term safety of a CBD gel for children, teenagers, and young adults with Fragile X Syndrome. It also checks if the gel helps with common symptoms like irritability and social difficulties over time.
Fragile X Syndrome (FXS)Ireland - RecruitingTherapeutic confirmatory (Phase III)
ATLAS-OLE: An Open-label, Long-term Safety and Efficacy Study of Fitusiran in Patients with Hemophilia A or B, with or without Inhibitory Antibodies to Factor VIII or IX
This study is testing a new medicine, fitusiran, for people with haemophilia A or B. It wants to see how safe and effective it is over a long time, especially in stopping bleeding. Doctors are looking at side effects and how it improves daily life.
Hemophilia A or Hemophilia BIreland - RecruitingTherapeutic exploratory (Phase II)
A Phase 2 Study of Tremelimumab (Day 1 only), Durvalumab (MEDI4736) and Trans-arterial catheter chemoembolization (TACE)in patients with advanced Hepatocellular Carcinoma (HCC)
This study is looking at a new combination of medicines and a treatment called TACE for people with advanced liver cancer. It aims to see if this combination can stop the cancer from growing for at least 6 months and if it's safe.
Advanced Hepatocellular Carcinoma (HCC)Ireland - RecruitingTherapeutic confirmatory (Phase III)
A 52-week, randomised, double-blind, double-dummy, parallel group, multi-centre, non-inferiority study assessing exacerbation rate, additional measures of asthma control and safety in adult and adolescent severe asthmatic participants with an eosinophilic phenotype treated with GSK3511294 (depemokimab) compared with mepolizumab or benralizumab
This study looks at a new medicine called depemokimab for severe asthma with high eosinophils. It compares it to existing treatments like mepolizumab and benralizumab over a year to see if it's just as good at preventing asthma attacks and improving control.
Severe asthma with an eosinophilic phenotypeIreland - RecruitingTherapeutic exploratory (Phase II)
A phase II, randomized, open-label study to assess the efficacy, safety, and pharmacokinetics (PK) of maintenance cabozantinib (XL184) plus best supportive care (BSC) versus BSC in children, adolescents and young adults (AYA) with unresectable residual osteosarcoma either at diagnosis or at first relapse after standard treatment.
This study looks at a new medicine called cabozantinib for young people with a type of bone cancer called osteosarcoma. It compares cabozantinib plus supportive care with supportive care alone to see if it helps stop the cancer from growing.
Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults, OsteosarcomaIreland - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Crossover Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Attacks in Adolescents and Adults with Hereditary Angioedema.
This study is testing a new soft capsule medicine for people with Hereditary Angioedema (HAE) to quickly stop attacks. It compares the new medicine, called deucrictibant, with a dummy capsule (placebo) and another existing medicine to see how fast it relieves symptoms.
Hereditary AngioedemaIreland - RecruitingTherapeutic exploratory (Phase II)
REFRaME-O1: A Phase 2/3 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) versus Investigator’s Choice (IC) Chemotherapy in Women with Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing Folate Receptor Alpha (FOLR1)
This study is for women with advanced ovarian (or related) cancer that has come back and isn't responding to platinum-based chemotherapy. Researchers are comparing a new treatment called Luveltamab Tazevibulin with standard chemotherapy to see if it works better and is safe.
Advanced Epithelial Ovarian Cancer (including Fallopian Tube or Primary Peritoneal cancers)Ireland - RecruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of AMX0035 Versus Placebo for 48-week Treatment of Adult Patients with Amyotrophic Lateral Sclerosis (ALS)
This study is testing a new medicine, AMX0035, for people with Motor Neurone Disease (ALS). It aims to see if the medicine can slow down the disease's progression over 48 weeks, compared to a dummy medicine.
Amyotrophic Lateral Sclerosis (ALS)Ireland