Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-Label, Long-Term Safety Extension Study Evaluating the Safety and Tolerability of the Fixed-Dose Combination of Obeticholic Acid and Bezafibrate in Subjects with Primary Biliary Cholangitis
This study looks at a new drug combination for Primary Biliary Cholangitis (PBC). It checks if mixing two existing medicines, Obeticholic Acid and Bezafibrate, helps liver health over a long time. Researchers want to see how safe and effective this combination is for patients.
Primary Biliary Cholangitis (PBC)Lithuania - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 14-week, multicentre, double-blind, randomised, placebo-controlled phase II study with an 8-week treatment period to assess the efficacy and tolerability of a fixed dose of BH-200 (250 mg BID) in outpatients with Major Depressive Disorder (MDD)
This study looks at a new medicine called BH-200 for adults with severe depression. It compares BH-200 to a dummy pill to see if it helps improve mood and daily life better, and if it's safe.
Major Depressive DisorderLithuania - Active not recruitingPHASE3
Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis
This study is testing a new medicine, ianalumab, for adults with active lupus nephritis. It compares ianalumab given every 4 or 12 weeks to a dummy medicine, alongside standard treatments, to see if it's safe and effective.
Lupus NephritisLithuania - RecruitingPHASE3
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
This study is looking at a new medicine called Etelcalcetide for children aged 2-17 with kidney disease who are on dialysis. It aims to see if the medicine works well and is safe for a condition called secondary hyperparathyroidism.
Secondary HyperparathyroidismLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
(22153) Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of Aflibercept 8 mg in Macular Edema Secondary to Retinal Vein Occlusion
This study looks at a new version of Eylea (a medicine for eye problems) to see if it's safe and works well for people with blurry vision caused by fluid build-up at the back of their eye. It compares the new version to the standard treatment.
Macular edema secondary to retinal vein occlusionLithuania - Active not recruitingPHASE3
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
This study is testing a new medicine, tulisokibart, for people with moderate to severe ulcerative colitis. It aims to see if the medicine can help people feel better and stay in remission, compared to a dummy medicine, both in the short and long term.
Ulcerative ColitisLithuania - Active not recruitingPHASE3
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
This study is looking at a new medicine called frexalimab for people aged 18-55 with certain types of Multiple Sclerosis (MS). It compares frexalimab to an existing MS medicine, teriflunomide, to see how well it stops MS relapses and if it's safe.
Multiple SclerosisLithuania - Active not recruitingPHASE3
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
This study aims to see if adding the drug pembrolizumab to standard chemotherapy before and after surgery helps people with early-stage non-small cell lung cancer live longer and prevent the cancer from returning. It's a large study comparing this new approach with chemotherapy alone.
Non-small Cell Lung CancerLithuania - Enrolling by invitationPHASE3
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
This study looks at a new medicine called efgartigimod for people with certain muscle conditions like myositis. It's for adults who were in a previous study, to see if the medicine is safe and helpful over a long time.
MyositisActive Idiopathic Inflammatory MyopathyDermatomyositisPolymyositisLithuania - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
This study is looking into a new medication called remibrutinib for people with a type of multiple sclerosis (MS) called Secondary Progressive MS (SPMS). It will check if the medicine is safe and helps slow down the disease.
Secondary Progressive Multiple Sclerosis (SPMS)Lithuania - Recruiting
FeetSee Thermal Images Collection Protocol in Diabetes Patients
This study uses a special camera called FeetSee to take pictures of people's feet at home. It's for adults with diabetes who have had a foot ulcer and nerve damage. The goal is to see if finding 'hot spots' on the feet can help prevent new ulcers.
Diabetic Foot UlcerLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A pivotal, multicentre, randomised, open-label, parallel-group trial on contraceptive efficacy, safety and tolerability of LVDS (Levonorgestrel Vaginal Delivery System) during 9 cycles in comparison with Desogestrel tablets 0.075 mg.
This study compares a new vaginal ring delivery system for contraception with a commonly used birth control pill. It aims to see how well each prevents pregnancy and how safe and tolerable they are for women.
Prevention of pregnancyLithuania - RecruitingPHASE3
Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation
This study looks at adding a new medicine, revumenib, to standard chemotherapy for people with a specific type of newly diagnosed acute myeloid leukaemia (AML) with a particular gene change (NPM1 mutation). It aims to see if this combination works better and is safe.
Acute Myeloid LeukemiasLithuania - RecruitingNA
Keep On Keep Up Bladder Health: Co-creating and Testing a Self-management Technological Solution for Ageing Well
This study is developing a new online program called KOKU Bladder to help people aged 50 and over manage bladder issues like urinary incontinence. We want to see if this easy-to-use digital tool can improve bladder health and well-being.
Urinary Incontinence in Old AgeLithuania - AuthorisedTherapeutic confirmatory (Phase III)
A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, maintenance study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Crohn’s disease
This study is looking at a new medicine called duvakitug for people with moderate to severe Crohn's disease. Researchers want to see if it helps keep the disease under control and is safe to use. It's a phase 3 study, meaning many people will take part.
Immune system diseasesLithuania - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, multicenter, open-label extension study to evaluate the long-term safety, tolerability, and efficacy of subcutaneous sonelokimab in participants with psoriatic arthritis (PsA)
This study looks at a new medicine called sonelokimab for psoriatic arthritis. It checks how safe and helpful the medicine is over a long time for people who have already tried it in another study. Doctors will monitor side effects and overall health.
psoriatic arthritis (PsA)Lithuania - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Randomized, Open-Label, Active-Control Study of REGN9933, a Factor XI Monoclonal Antibody, for Prevention of Venous Thromboembolism after Elective, Unilateral, Total Knee Arthroplasty
This study is testing a new medicine called REGN9933 to see if it can prevent blood clots after knee replacement surgery. Blood clots can be serious, so finding good ways to prevent them is important. We're comparing REGN9933 to other common clot-preventing medicines.
Thromboembolic diseaseLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
This study is comparing a new medication called Andexanet Alfa to usual care. It's for patients who are taking blood thinners (like apixaban, rivaroxaban, or edoxaban) and need urgent surgery. The aim is to see if Andexanet Alfa helps stop bleeding during their operation.
Reversal of anticoagulation effect in patients on a FXa inhibitor (apixaban, rivaroxaban, or edoxaban) who require urgent surgery or procedure, and who have a major risk of bleeding.Lithuania - Recruiting
Post COVID-19 Condition
This study looks at how many people get Long COVID and what might lead to it. It follows adults who have recovered from COVID-19 to understand the long-lasting health effects. The goal is to learn why some people continue to feel unwell months after having the virus.
COVID-19Lithuania - Recruiting
Cerebellar Mutism Syndrome Study
This study looks at why some children develop Cerebellar Mutism Syndrome (CMS) after brain surgery for a tumour. CMS causes speech problems and other issues. Researchers hope to understand its causes, how it progresses, and the best ways to treat it for better patient care.
Infratentorial NeoplasmsMutismLithuania - Active not recruitingPHASE3
A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.
This study is looking at a new way to give risankizumab, a medicine for Crohn's disease, as an injection under the skin. It aims to see how well it works and if it's safe for adults with moderate to severe Crohn's disease.
Crohn's DiseaseLithuania - Active not recruitingPHASE3
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
This study is testing a new medicine, inclisiran, to see if it can prevent serious heart problems like heart attacks and strokes in people who are at high risk but haven't had one before. They are comparing it to a dummy medicine.
Primary Prevention of Atherosclerotic Cardiovascular DiseaseLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study is testing a new inhaled medicine, saralutinib, for people with pulmonary arterial hypertension (PAH). Researchers want to see if it helps patients walk further in six minutes and improves their health compared to a dummy inhaler.
Pulmonary Arterial HypertensionLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multi-regional, Double-blind, Double-dummy Parallel-group, Placebo and Allopurinol-controlled Phase 3 Study to Assess the Efficacy and Safety of Tigulixostat in Gout Patients with Hyperuricemia
This study is testing a new medicine, Tigulixostat, for people with gout and high uric acid. Researchers want to see if it lowers uric acid levels as well as current treatments and if it's safe to use. It compares Tigulixostat to a common gout medicine, Allopurinol, and a dummy pill.
Gout with hyperuricemiaLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, multicenter phase III study to evaluate the efficacy and safety of ABX464 once daily for induction treatment in subjects with moderately to severely active ulcerative colitis
This study is testing a new medicine, ABX464, for people with moderate to severe ulcerative colitis. Researchers want to see if it helps improve the gut lining and reduces symptoms after 8 weeks, and if it's safe to use.
Moderately to severely active ulcerative colitisLithuania - RecruitingPHASE3
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
This study is for people with wet macular degeneration, a common eye condition. It's testing a new, single injection treatment (4D-150) against a standard treatment (Eylea) to see if it can help improve or maintain vision. The goal is to find a longer-lasting solution.
Neovascular Age-Related Macular Degeneration (nAMD)Lithuania - Active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
Ulcerative ColitisLithuania - Active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
Breast CancerLithuania - Ongoing, recruitingTherapeutic exploratory (Phase II)
First-line treatment with osimertinib in EGFR-mutated non-small cell lung cancer, coupled to extensive translational studies (The FIOL-study)
This study looks at a medicine called osimertinib (also known as Tagrisso) for a type of lung cancer with a specific gene change (EGFR mutation). We want to see how well it shrinks tumours and helps people live longer, while also checking if it's safe.
EGFR-mutated non-small cell lung cancerLithuania - RecruitingPHASE2, PHASE3
A Study of Efgartigimod IV in Participants From 12 Years to Less Than 18 Years of Age With Chronic Immune Thrombocytopenia (ITP)
This study is looking into a new medicine called efgartigimod for young people aged 12 to 17 with a blood condition called chronic ITP. The aim is to find the best dose to help increase their platelet count and manage their condition.
Immune Thrombocytopenia (ITP)ITP - Immune ThrombocytopeniaITPImmune Thrombocytopenic PurpuraLithuania - Active not recruitingPHASE3
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
This study is looking at a new medicine called vutrisiran for people with a heart condition called transthyretin amyloidosis (ATTR) cardiomyopathy. It aims to see if the medicine can help improve the condition and if it's safe compared to a dummy treatment.
Transthyretin Amyloidosis (ATTR) With CardiomyopathyLithuania - Active not recruitingPHASE3
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
This study looks at new ways to treat advanced lung cancer that can't be removed by surgery. It combines standard chemotherapy and radiation with newer drugs, pembrolizumab and olaparib, to see if they can improve survival compared to current treatments.
Lung NeoplasmsCarcinoma, Non-Small-Cell LungLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A multicentre, single arm trial on contraceptive efficacy, safety and tolerability of LVDS (Levonorgestrel Vaginal Delivery System) during 13 cycles.
This study is testing a new vaginal ring for contraception (birth control). Researchers want to see how well it prevents pregnancy in women aged 18-35. They will also check if it's safe and if women find it easy to use over 13 monthly cycles.
Prevention of pregnancyLithuania - RecruitingPHASE3
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
This study is testing a new drug called finerenone for people hospitalised with heart failure. We want to see if it's safe and effective for patients whose hearts can still pump blood fairly well, to improve their health and quality of life.
Heart FailureAcute Heart FailureLithuania - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A comparative bioavailability of reformulated ibuprofen 2% and 4% oral suspensions (Berlin Chemie AG) and reference ibuprofen (Nurofen®) 200 mg/5 ml oral suspension in healthy male and female adult subjects under fasting conditions: an open-label, randomized, single-dose, three-period, three-treatment, three-sequence crossover study
This study compares how quickly and how much ibuprofen from two new liquid medications gets into the body compared to a common ibuprofen syrup. It's for healthy adults and helps ensure new medicines work the same way as existing ones.
In this study will be no subjects involved with any specific medicalcondition or diseaseLithuania - Active not recruitingPHASE3
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
This study is testing a new medicine called olpasiran to see if it can help people with heart disease and high levels of a specific fat in their blood, called Lp(a). We want to find out if olpasiran can lower the risk of heart attacks and other heart problems.
Atherosclerotic Cardiovascular DiseaseLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
(19767 OCEANIC-AF) A multicenter, international, randomized, active comparator-controlled, double-blind, double-dummy, parallel-group, 2-arm, Phase 3 study to compare the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) with apixaban for the prevention of stroke or systemic embolism in male and female participants aged 18 years and older with atrial fibrillation at risk for stroke
This study is testing a new medication called asundexian against a standard treatment (apixaban) to see how well it prevents strokes or serious blood clots in people with atrial fibrillation, a type of irregular heartbeat. It's also looking at how safe the new drug is.
Prevention of stroke or systemic embolism in atrial fibrillationLithuania - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Reducing Supraphysiologic Glucocorticoid Use in Adult Subjects with Classic Congenital Adrenal Hyperplasia
This study is looking into a new medication called Tildacerfont for adults with a condition called classic congenital adrenal hyperplasia. It aims to see if Tildacerfont can help reduce the amount of steroid medicine (like hydrocortisone or prednisolone) people need to take.
Classic Congenital Adrenal HyperplasiaLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multi-center, Double-blind, Placebo-controlled Phase 3 Study of Bemarituzumab plus Chemotherapy versus Placebo plus Chemotherapy in Subjects with Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b Overexpression FORTITUDE-101)
This study looks at a new drug, bemarituzumab, for advanced stomach or gullet cancer that hasn't been treated before. It aims to see if adding bemarituzumab to standard chemotherapy helps people live longer and improves their quality of life compared to chemotherapy alone.
Previously Untreated Advanced Gastric or Gastroesophageal JunctionCancer with FGFR2b overexpressionLithuania - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess how radium-223 moves through the patients with prostate cancer receiving radium-223 dichloride treatment.
This study looks at how a medicine called radium-223 moves through the bodies of men with prostate cancer who are receiving this treatment. It helps doctors understand how the drug works and is processed by the body.
Prostate cancerLithuania - RecruitingPHASE4
HOPE Against Cancer Recurrence in HCC
This study looks at a new way to prepare donor livers for transplant to help prevent cancer recurrence. It compares cooling livers with a special oxygen-rich fluid to the usual cooling method, hoping to reduce the chance of liver cancer coming back after transplant.
Liver TransplantationHCCOncological OutcomesLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, parallel-group study to assess the efficacy, safety, and tolerability of dexpramipexole administered orally for 52 weeks in participants with severe eosinophilic asthma (EXHALE-3)
This study looks at a new medicine called dexpramipexole for severe asthma. It wants to see if the medicine can reduce asthma flare-ups and improve breathing over 52 weeks. Researchers will compare it to a dummy medicine to see if it works and is safe.
Severe eosinophilic asthmaLithuania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety, and tolerability of intravenous ganaxolone added to standard of care in refractory status epilepticus
This study is testing a new medicine, ganaxolone, for a severe type of epilepsy called refractory status epilepticus. It's a late-stage trial comparing ganaxolone to a dummy medicine to see if it can stop seizures quickly and safely when other treatments haven't worked.
Refractory Status Epilepticus (RSE)Lithuania - RecruitingPHASE3
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
This study looks at a medicine called vedolizumab for children and teenagers with moderate to severe Crohn's disease. It aims to see if the medicine can make their symptoms better and heal inflammation in their gut.
Crohn's Disease (CD)Lithuania - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Pharmacokinetics (PK) study to compare GME751 (proposed pembrolizumab biosimilar) and United States (US)-licensed and European Union (EU)-approved Keytruda®in participants with stage Ⅱ and Ⅲ skin cancer requiring adjuvant treatment (therapy applied after initial treatment of cancer to suppress the regrowth of tumor) with pembrolizumab.
This study is looking at a new medicine, GME751, which is very similar to an existing cancer drug called Keytruda (pembrolizumab). It's for people with certain stages of skin cancer (melanoma) who need treatment after their initial cancer care. We want to see how GME751 works in the body compared to Keytruda.
MelanomaLithuania - Active not recruitingNA
Evaluate the Safety and Performance of the AccuCinch® Ventricular Repair System - The CorCinch-EU Study
This study is testing a new device, the AccuCinch® system, for people with severe heart failure. It aims to see how safe and effective it is at improving heart function and symptoms, especially for those whose heart is enlarged and not pumping well.
Heart FailureCardiomyopathiesLithuania - Active not recruitingPHASE3
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
This study is comparing two medicines, milvexian and apixaban, for people with an irregular heartbeat called atrial fibrillation. We want to see if milvexian is just as good as apixaban at stopping serious problems like strokes, which can happen with this condition.
Atrial FibrillationLithuania - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Single-Arm, Multicentre Study Investigating the Pharmacokinetics, Pharmacodynamics, Efficacy and Safety of Teverelix DP, a Gonadotropin-releasing Hormone (GnRH) Antagonist, in Participants with Advanced Prostate Cancer
This study looks at a new drug, Teverelix, for men with advanced prostate cancer. We want to see how well it lowers testosterone, a hormone that can make prostate cancer grow, and if it's safe to use.
Advanced prostate cancerLithuania - RecruitingPHASE3
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
This study looks at the long-term safety and effectiveness of a cancer drug called pembrolizumab (and related treatments) for people with advanced cancers. It's for patients who are already receiving these treatments in other studies and want to continue.
Solid TumorsHematologic MalignanciesLithuania - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
Diabetes Mellitus, Type 2HypertensionCardiovascular DiseasesLithuania