Latest studies
- Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase 1 study to evaluate the dose, safety and tolerability of a radionuclide therapy (Radspherin®) in patients with platinum sensitive recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma with peritoneal carcinomatosis following complete surgical resection
This study is testing a new treatment called Radspherin® for women with certain types of ovarian, fallopian tube, or peritoneal cancer that has come back. It's looking at the right dose and how safe it is after surgery.
Platinum Sensitive Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma With Peritoneal CarcinomatosisNorway - AuthorisedTherapeutic exploratory (Phase II)
A Randomized Open-Label, Parallel-Group, Phase 2, 2-Arm Study to Investigate the Pharmacokinetic Profiles of Midazolam Subcutaneous Injection Compared with Midazolam Intravenous Injection in Adult Male and Female Terminally Ill Patients
This study compares two ways of giving a medicine called midazolam to people with difficult symptoms at the end of their lives. It looks at how the body handles the medicine when given as an injection under the skin versus directly into a vein.
Terminal illness requiring palliative care, with indications for parenteral midazolam administration for symptom management (e.g., anxiety, restlessness, agitation, and dyspnea).Norway - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-Label, Long-Term Safety Extension Study Evaluating the Safety and Tolerability of the Fixed-Dose Combination of Obeticholic Acid and Bezafibrate in Subjects with Primary Biliary Cholangitis
This study looks at a new drug combination for Primary Biliary Cholangitis (PBC). It checks if mixing two existing medicines, Obeticholic Acid and Bezafibrate, helps liver health over a long time. Researchers want to see how safe and effective this combination is for patients.
Primary Biliary Cholangitis (PBC)Norway - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
LeukemiaNorway - Enrolling by invitationNA
Optical Coherence Tomography in Acute Vessel Evaluation
This study compares two ways to help people having a heart attack: one uses standard X-rays, the other uses a special camera called OCT. We want to see if the OCT camera leads to better results for patients.
Ischemic Heart DiseaseIschemic Coronary Artery DiseaseACS (Acute Coronary Syndrome)Norway - Ongoing, recruitingTherapeutic exploratory (Phase II)
EORTC 2120-HNCG: Radiotherapy plus xevinapant or placebo in older patients with locally advanced head and neck squamous cell carcinoma: a randomized phase II study (Ravina)
This study looks at a new drug, xevinapant, given with radiotherapy for older patients with advanced head and neck cancer. We want to see if this combination helps more people live longer without their cancer coming back. It's a Phase II study, meaning we're testing its effectiveness and safety.
Squamous cell carcinoma of head and neckNorway - AuthorisedTherapeutic use (Phase IV)
Exploring the Psychoactive Effects of Paracetamol: A parallel group, basic science, double blind, two armed study, to investigate potential emotional and cognitive effects of paracetamol (tablet form) compared to a placebo (tablet form) in healthy male and female participants between ages 18 and 30.
This study is looking into how paracetamol might affect our feelings and thinking. We want to see if healthy adults aged 18-30 feel differently or think differently after taking paracetamol compared to a dummy pill. It’s a carefully designed study to understand more about this common painkiller.
Healthy adults aged 18-30.Norway - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyNorway - Active not recruitingPHASE2
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
This study looks at a new drug, tulisokibart, for people with a lung condition called interstitial lung disease (ILD) linked to scleroderma. We want to see if it's safe and helps improve the condition.
Diffuse Cutaneous Systemic SclerosisInterstitial Lung DiseaseNorway - Active not recruitingPHASE3
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
This study looks at treating muscle-invasive bladder cancer. It compares standard chemotherapy with chemotherapy plus a new immunotherapy drug called nivolumab, given before and after surgery. The aim is to see if adding nivolumab helps more people.
Urinary Bladder NeoplasmsMuscle-Invasive Bladder CancerNorway - Ongoing, recruitingTherapeutic use (Phase IV)
CALCIGRAN FORTE AND DOSING OF IMMUNOSUPPRESSIVE DRUGS IN KIDNEY TRANSPLANT RECIPIENTS
This study is looking at how a common calcium supplement, Calcigran Forte, affects the levels of medicines taken by people who have had a kidney transplant. We want to make sure these important drugs work as well as they should.
Kidney transplantationNorway - RecruitingPHASE2
A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)
This study is looking into a new medicine, calderasib, to treat certain advanced cancers. Researchers want to see if it can shrink these cancers, either alone or with another medicine called cetuximab, in people whose cancers have a specific genetic change (KRAS G12C mutation).
Neoplasm MalignantNorway - RecruitingPHASE3
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
This study looks at a new treatment called Pumitamig for advanced non-small cell lung cancer that hasn't been treated before. It compares Pumitamig to an existing treatment, Pembrolizumab, in people whose cancer cells have a high level of a specific marker called PD-L1.
Non-Small Cell Lung Cancer (NSCLC)Norway - RecruitingPHASE2, PHASE3
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
This study is testing a new medicine, elenestinib, for a rare blood condition called indolent systemic mastocytosis. It compares the new medicine to a dummy pill (placebo) to see if it helps reduce symptoms that current treatments aren't fully controlling.
Indolent Systemic MastocytosisSmoldering Systemic MastocytosisNorway - Active not recruitingPHASE3
A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
This study is looking into a new combination of medicines for people in the UK with multiple myeloma that has come back or not responded to previous treatments. It compares a new medicine combination with a standard one to see if the new option works better.
Relapsed or Refractory Multiple MyelomaNorway - Active not recruitingPHASE3
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
This study compares two drug combinations – camizestrant with palbociclib, and anastrozole with palbociclib – for advanced breast cancer. It's for patients whose cancer has specific hormone features and hasn't yet been treated for its advanced stage. The goal is to find a better first treatment.
ER-Positive HER2-Negative Breast CancerNorway - RecruitingPHASE3
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)
This study compares a new treatment, AZD0120, with standard treatments for multiple myeloma that has come back or isn't responding well. It aims to see if the new medicine works better and is safe for patients.
Relapsed Refractory Multiple MyelomaNorway - RecruitingPHASE3
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
This study is looking at a new medicine called sacituzumab govitecan (SG) for people with a type of lung cancer called extensive stage small cell lung cancer (ES-SCLC) that has been treated before. We want to see if SG works better than standard treatments to help people live longer.
Extensive Stage Small Cell Lung Cancer (ES-SCLC)Norway - Active not recruiting
The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
The SPECTRUM Study is looking at how well a new eye medicine called aflibercept 8 mg works for vision problems caused by wet AMD or diabetic macular oedema. Researchers will collect information from patients who are already prescribed this medicine by their doctor.
Visual ImpairmentNeovascular Age-related Macular Degeneration (nAMD)Diabetic Macula Edema (DME)Norway - Active not recruitingPHASE3
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
This study is testing a new medicine, tulisokibart, for people with moderate to severe ulcerative colitis. It aims to see if the medicine can help people feel better and stay in remission, compared to a dummy medicine, both in the short and long term.
Ulcerative ColitisNorway - Active not recruitingPHASE3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
This study compares a new treatment called Sacituzumab Tirumotecan with standard care for recurrent or metastatic cervical cancer. It aims to see if the new treatment improves how long people live when current treatments aren't enough.
Cervical CancerNorway - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-0616 in Adults With Heterozygous Familial Hypercholesterolemia
This study is testing a new tablet, MK-0616, for adults with a condition called Heterozygous Familial Hypercholesterolemia (HeFH). We want to see if it lowers 'bad' cholesterol (LDL-C) and if it's safe to use. Half the people will get the new tablet, and half will get a dummy tablet.
Heterozygous Familial Hypercholesterolemia (HeFH)Norway - Enrolling by invitationPHASE3
A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia
This study looks at a medicine called fostamatinib for a type of anaemia called warm antibody autoimmune haemolytic anaemia (wAIHA). It wants to check how safe it is over a long time for people who have already taken part in a related study.
Warm Antibody Autoimmune Hemolytic AnemiaNorway - RecruitingPHASE3
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for children and teenagers aged 2 to 17 with moderately to severely active Crohn's disease. It checks how well the medicine works after a year in those who responded early on.
Crohn's DiseaseNorway - Active not recruitingNA
STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
This study looks at the best way to fix a torn knee ligament (ACL) in young, active people. It compares different ways of surgery and materials used to help prevent future re-injury and improve long-term knee health.
Anterior Cruciate Ligament InjuryAnterior Cruciate Ligament ReconstructionJoint InstabilityNorway - AuthorisedTherapeutic confirmatory (Phase III)
HELIOS: An Open-Label, Long-Term Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants with Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP).
This study is looking at a new medicine called Bitopertin for people with rare conditions called Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP). It aims to check if the medicine is safe, if people can tolerate it well, and if it helps them spend more time in sunlight without pain.
X-Linked Protoporphyria (XLP)Erythropoietic Protoporphyria (EPP)Norway - Active not recruitingPHASE3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.
GlioblastomaGBMBrain Neoplasms, Adult, MalignantBrain TumorNorway - Active not recruitingPHASE3
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
This study looks at a new medicine called survodutide for people who are overweight or obese. It checks if survodutide helps with heart health problems. Participants take the medicine weekly for up to 2 years, alongside diet and exercise advice.
ObesityNorway - Active not recruitingPHASE2
Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma
This study is looking for new ways to treat advanced melanoma, a type of skin cancer. It's testing combinations of new medicines (LXH254, LTT462) with existing ones (Trametinib, Ribociclib) in people whose melanoma has progressed after previous treatments. The goal is to see how well these new combinations work and if they are safe.
MelanomaNorway - Ongoing, recruitingTherapeutic exploratory (Phase II)
Does human skeletal muscle possess an epigenetic memory of testosterone
This study looks at how testosterone might affect muscle memory in men, especially in relation to ageing and muscle weakness. It compares testosterone to a dummy treatment, with and without exercise, to see changes in muscle size and strength.
Healthy aging, Sarcopenia, Anabolic resistance, Anti-DopingNorway - RecruitingPHASE1, PHASE2
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
This study is testing a new medicine called pirtobrutinib for people with Immune Thrombocytopenia (ITP). It aims to see how safe it is, what side effects it might cause, and if it helps improve blood platelet counts.
Immune Thrombocytopenia (ITP)Norway - RecruitingPHASE2, PHASE3
Visugromab in Cachexia International Trial
This study looks at a new drug called visugromab for people with certain cancers and severe weight loss (cachexia). It checks if the drug helps with weight gain, appetite, and movement. Researchers also want to know about any side effects. It's compared to a dummy treatment.
Cancer-associated CachexiaNorway - AuthorisedTherapeutic confirmatory (Phase III)
A multicenter, multinational, randomized, double-blind, placebo-controlled Phase 3, maintenance study to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active Crohn’s disease
This study is looking at a new medicine called duvakitug for people with moderate to severe Crohn's disease. Researchers want to see if it helps keep the disease under control and is safe to use. It's a phase 3 study, meaning many people will take part.
Immune system diseasesNorway - Active not recruiting
Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)
This study looks at how a medicine called filgotinib works for people with ulcerative colitis in everyday life. Researchers want to see if it helps with symptoms, improves quality of life, and if it's safe for people with moderate to severe disease.
Ulcerative ColitisNorway - Ongoing, recruitingTherapeutic use (Phase IV)
Immunosuppressive drug bioequivalence in kidney transplant recipients – Prograf and CellCept
This study looks at how well different versions of medicines (Prograf and CellCept) used after a kidney transplant are absorbed by the body. It helps make sure new versions work just as well as existing ones to protect your new kidney.
Organ transplantationNorway - Recruiting
Biology of Juvenile Myoclonic Epilepsy
This study aims to find the genetic causes of Juvenile Myoclonic Epilepsy (JME). Researchers are collecting blood samples and health information from people with JME and comparing them to people who don't have it. Finding these causes could lead to better understandings and new treatments for JME.
Juvenile Myoclonic EpilepsyNorway - RecruitingPHASE3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.
Ulcerative ColitisUlcerative Colitis ChronicInflammatory Bowel DiseasesCrohn's DiseaseNorway - RecruitingNA
The Dragon PLC Trial (DRAGON-PLC)
This study looks at a new way to prepare people with certain liver cancers for surgery. It compares a standard procedure (PVE) with a new one (PVE + HVE) to see if more people can have life-saving surgery and live longer.
Primary Liver CancerHepatocellular Carcinoma (HCC)CholangiocarcinomaNorway - RecruitingPHASE3
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
This study is looking at a new medicine called INCB161734, given alongside standard chemotherapy, for advanced pancreatic cancer with a specific genetic change (KRAS G12D). It aims to see if this combination works better and is safe for people who haven't had treatment for their advanced cancer.
Solid TumorsNorway - Recruiting
Cerebellar Mutism Syndrome Study
This study looks at why some children develop Cerebellar Mutism Syndrome (CMS) after brain surgery for a tumour. CMS causes speech problems and other issues. Researchers hope to understand its causes, how it progresses, and the best ways to treat it for better patient care.
Infratentorial NeoplasmsMutismNorway - AuthorisedTherapeutic exploratory (Phase II)
A multicenter randomized double-blinded controlled phase 2 study evaluating the efficacy of valganciclovir as add-on therapy in glioblastoma patients
This study looks at whether adding a drug called valganciclovir to standard treatment can help people with a type of brain tumour called glioblastoma live longer. Doctors are comparing it to a dummy pill to see if it makes a difference.
Glioblstoma WHO grade IVNorway - Recruiting
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
This study, called IRONMAN, is collecting information from men with advanced prostate cancer across many countries, including the UK. It aims to understand treatments, how they vary, and what helps men live longer and have a better quality of life.
Prostate CancerNorway - Ongoing, recruitingTherapeutic confirmatory (Phase III)
HD21 for advanced stages - Treatment optimization trial in the first-line treatment of advanced stage Hodgkin lymphoma; comparison of 4-6 cycles of escalated BEACOPP with 4-6 cycles of BrECADD
This study compares two common treatments for advanced Hodgkin lymphoma (a type of cancer). It looks at how well they work, their side effects, and their impact on quality of life, especially for older patients.
Advanced Stage of Hodgkin LymphomaNorway - Ongoing, recruitingTherapeutic exploratory (Phase II)
Tenofovir Alafenamide Fumarate and Epstein-Barr virus activity in people with MS – The TAF-MS study
This study, called TAF-MS, is looking into how a medicine called Tenofovir Alafenamide Fumarate (TAF) affects the Epstein-Barr virus (EBV) in people with Multiple Sclerosis (MS). Researchers want to see if this treatment can help reduce EBV activity, which may be linked to MS.
Multiple sclerosisNorway - Active not recruitingNA
Invest-CTO PCI Trial
This study looks at a new two-step procedure for serious blockages in heart arteries called CTOs. Doctors want to see if planning two shorter procedures, instead of one long one, is safer, works better, and is a better experience for patients.
Chronic Total Occlusion of Coronary ArteryAngina PectorisQuality of LifePROMNorway - RecruitingPHASE2, PHASE3
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
This study keeps an eye on people who have had a special treatment called gene-modified T-cell therapy for cancer. It aims to check their health and how well the treatment worked over a long time, making sure it's safe and effective.
NeoplasmsNorway - RecruitingPHASE3
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
This study investigates if a drug called baricitinib can protect the body's insulin-making cells in children and adults newly diagnosed with type 1 diabetes. It aims to see if preserving these cells helps manage the condition better.
Diabetes Mellitus, Type 1Norway - RecruitingPHASE3
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
This study offers ongoing treatment with pelacarsen for people who have finished a previous trial for heart disease. It aims to check the long-term safety of the medicine, which helps lower a type of cholesterol called Lp(a).
Cardiovascular Disease and Lipoprotein(a)Norway - Active not recruitingPHASE3
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
This study is looking at a medicine called semaglutide for a liver condition called non-alcoholic steatohepatitis (NASH). Participants will receive either semaglutide or a dummy medicine. It's a long study, lasting about 5 years, with regular clinic visits.
Non-alcoholic SteatohepatitisNorway - RecruitingPHASE3
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
This study is looking into whether a medicine called baricitinib can delay Type 1 Diabetes in children and adults who are at a high risk of developing it. It's a key step in preventing the condition.
Diabetes Mellitus, Type 1Norway