Latest studies
- Completed
A study to evaluate diagnostic tests used at the point of care for improving antibiotic prescribing for patients with respiratory tract infections in primary care in Europe
Antibiotics treat bacterial infections, but taking them when not needed makes them less effective over time. This European study checks whether rapid clinic tests can help GPs decide if patients with coughs or sore throats truly need antibiotics, safely cutting down unnecessary prescriptions without harming patient recovery.
Community-acquired acute respiratory tract infectionPoland - CompletedPhase I/II
Platform study Kaleidoscope: A Phase 1/2 Open-label Platform Study to Evaluate the Safety and Efficacy of Multiple Amivantamab-based Therapeutic Combinations in Participants with Advanced, Unresectable Lung Cancer (LC) ISA1 METalmark (now closed in UK): A phase I/II open-label platform study to evaluate the safety and efficacy of multiple amivantamab-based therapeutic combinations in participants with advanced, unresectable lung cancer ISA2 Polydamas: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Cetrelimab Combination Therapy in Metastatic Non-small Cell Lung Cancer ISA3 SwalloWTail: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Docetaxel Combination Therapy in Metastatic Non-small Cell Lung Cancer
This clinical trial tests new combination treatments for advanced non-small cell lung cancer that has spread. Researchers are checking whether combining a targeted drug called amivantamab with other cancer medicines is safe and helps slow cancer growth. Two study branches are currently open for adults at specialist UK cancer hospitals.
Unresectable metastatic non-small cell lung cancerPoland - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaPoland - RecruitingPhase II
A Phase Ib/II, open-label study of amivantamab monotherapy and amivantamab in addition to other therapeutic agents in participants with head and neck squamous cell carcinoma
This study tests a targeted drug called amivantamab for head and neck cancer. Doctors want to see if giving amivantamab on its own or alongside other cancer drugs works well to shrink tumours and is safe for patients whose cancer has spread, returned, or requires surgery.
Head and neck squamous cell carcinomaPoland - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseasePoland - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaPoland - CompletedPhase III
A randomized, open-label phase 3 study of amivantamab + FOLFIRI versus cetuximab/bevacizumab + FOLFIRI in participants with KRAS/NRAS and BRAF wildtype recurrent, unresectable or metastatic colorectal cancer who have received prior chemotherapy
This clinical trial is testing a new targeted drug, amivantamab, combined with chemotherapy for people with advanced bowel cancer. Researchers want to see if this combination works better at slowing cancer growth and helping people live longer than current standard targeted treatments after their first chemotherapy has stopped working.
Recurrent, unresectable or metastatic colorectal cancerPoland - RecruitingNot Applicable
Safety and performance of the Nurotron CS-30A cochlear implant system in adults with hearing loss
This study looks at how safe and effective the Nurotron CS-30A cochlear implant is for adults with severe hearing loss in both ears. It aims to see how well the device helps people hear and understand speech when ordinary hearing aids are no longer enough.
Post-lingual severe-to-profound bilateral sensorineural hearing loss in adultsPoland - RecruitingPHASE2, PHASE3
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
This study looks at a new medicine called ponsegromab for advanced pancreatic cancer that has spread, especially when patients have lost a lot of weight and feel very tired. It aims to see if adding ponsegromab to standard chemotherapy helps more than chemotherapy alone.
CachexiaMetastatic Pancreatic Ductal AdenocarcinomaPoland - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
This study looks at new ways to treat type 2 diabetes by testing two medicines, Elecoglipron and Dapagliflozin, both on their own and together. Researchers want to see how well they work and if they are safe for adults with type 2 diabetes.
Type 2 Diabetes MellitusPoland - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
This study looks at a new medicine called enicepatide for people who are overweight or have obesity and also have type 2 diabetes. We want to see if it helps with weight loss and if it's safe to use.
Obesity or OverweightType 2 Diabetes MellitusPoland - RecruitingPHASE3
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
This study compares a new medicine, Elecoglipron, to an existing one, Semaglutide, for adults with Type 2 Diabetes. It aims to see if the new drug is safe and effective for people whose diabetes isn't well-controlled and who have a higher risk of heart problems.
Type 2 Diabetes MellitusPoland - RecruitingPHASE3
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
This study, called DLLEVATE, is looking at a new treatment, ZL-1310, for people with small cell lung cancer that has come back. It compares ZL-1310 to other standard treatments to see if it's safe and works well. You might be eligible if you're over 18 and have had previous treatments.
Small-cell Lung CancerPoland - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
Obesity or OverweightPoland - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
MyelofibrosisAnemiaPoland - Completed
Multi-centre European study of major infectious disease syndromes (MERMAIDS) – Acute respiratory infections
This study looks at acute chest and throat infections to understand why some people get much sicker than others. Researchers from the University of Oxford are collecting blood and swab samples from adults treated at GP surgeries or hospitals to help develop better, more personalised treatments for future infections.
Acute respiratory infectionsPoland - Completed
Vitamin D and lifestyle Intervention for gestational diabetes mellitus (GDM) prevention
This study looks at ways to prevent gestational diabetes, which is high blood sugar during pregnancy. Researchers are testing whether vitamin D supplements, healthy eating advice, regular physical activity, or combinations of these can help pregnant women with a higher body mass index stay healthy throughout their pregnancy.
Gestational diabetesPoland - RecruitingPHASE3
INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)
This study is testing a new medicine called sapablursen for people with Polycythemia Vera (PV). It aims to see if adding sapablursen to usual treatment is safe and helps control the condition better. Participants will be involved for up to three years, comparing the new medicine to a dummy treatment.
Polycythemia VeraPoland - RecruitingPhase III
Phase 3, randomised, double-blind, placebo- controlled, 3-arm study to investigate the safety and efficacy of efimosfermin alfa in participants with biopsy-confirmed F2- or F3-stage metabolic dysfunction-associated steatohepatitis (MASH) (ZENITH-1)
This clinical trial is testing a new injection called efimosfermin alfa for people with metabolic dysfunction-associated steatohepatitis (MASH), an inflamed fatty liver condition. Researchers want to see if monthly injections over four years can safely reduce liver fat, ease inflammation, and improve liver scarring compared to a dummy treatment.
Medical condition: Metabolic Dysfunction-Associated Steatohepatitis (MASH) Medical condition in lay language: Metabolic Fatty Liver Inflamation Therapeutic areas: Diseases [C] - Nutritional and Metabolic Diseases [C18]Poland - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Poland - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseasePoland - RecruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomized, Double-Blind, Parallel-Group, Placebo Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fexlamose (AER 01) Inhalation Solution in the Treatment of Adults with Moderate to Severe Chronic Obstructive Pulmonary Disease
This clinical trial is testing a new inhaled medicine called Fexlamose for adults with moderate to severe chronic obstructive pulmonary disease (COPD). Researchers want to see if breathing in this liquid medicine for four weeks improves lung function, clears mucus from the airways, and helps people breathe more easily.
Chronic Obstructive Pulmonary DiseasePoland - RecruitingTherapeutic exploratory (Phase II)
C1071003 - MAGNETISMM-3, An Open-Label, Multicenter, Non-Randomized Phase 2 Study of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One Proteasome Inhibitor, One Immunomodulatory Drug and One Anti-CD38 Antibody
This clinical trial is testing a new medicine called elranatamab for adults with multiple myeloma. It is designed for people whose cancer has returned or stopped responding after trying three standard types of treatment. The aim is to find out how well the drug works on its own.
Multiple myelomaPoland - RecruitingTherapeutic exploratory (Phase II)
A Phase 2 Study to Investigate the Safety and Efficacy of Petosemtamab in Adults with Non-Small Cell Lung Cancer in Combination with Pembrolizumab.
This clinical trial is testing a new drug called petosemtamab combined with an established immunotherapy called pembrolizumab (Keytruda). It aims to find out if this combination is safe and effective at shrinking tumours in adults diagnosed with non-small cell lung cancer.
Non Small Cell Lung CancerPoland - CompletedPhase III
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
This clinical trial looks at whether giving common medicines right after a stroke can prevent complications like fever, sickness, and chest infections before they start. Researchers want to see if treating older adults early with paracetamol, antibiotics, or anti-sickness medicine helps them recover better and stay independent.
Acute ischaemic stroke or intracerebral haemorrhagePoland - AuthorisedHuman Pharmacology (Phase I)- First administration to humans
A Study to Learn How Different Amounts of the Study Intervention Called PF-07832837 are Tolerated and Act in the Body in Healthy Adults and Patients
Researchers are testing an experimental medicine called PF-07832837 to see how safe it is and how it behaves in the human body. This early-stage study is open to healthy adults and people living with atopic dermatitis (eczema) who are aged 18 and older.
Atopic DermatitisPoland - AuthorisedTherapeutic confirmatory (Phase III)
A Long-term Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder for Treatment of Pulmonary Hypertension Associated with Interstitial Lung Disease
This study tests an inhaled dry powder medicine called treprostinil palmitil for adults with high blood pressure in the lungs linked to lung scarring. The trial lasts up to two years to see if the medicine is safe and helps improve breathing, walking ability, and overall quality of life.
Pulmonary Hypertension Associated with Interstitial Lung DiseasePoland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-Controlled Study to Assess the Safety and Efficacy of MTX-474 in the Treatment of Participants with Diffuse Cutaneous Systemic Sclerosis (dcSSc)
This study tests a new medicine called MTX-474 for adults with diffuse cutaneous systemic sclerosis. This rare condition causes skin thickening and hardening across the body. Researchers want to see if MTX-474 is safe and if it helps soften the skin over 24 weeks compared to a dummy treatment.
Diffuse Cutaneous Systemic Sclerosis (dcSSc)Poland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Surovatamig in Adults with Antibody-mediated Kidney Disease
This study tests a new medicine called surovatamig for adults with kidney disease caused by the immune system. Doctors want to see if it is safe and can lower protein leaking into the urine, which helps protect kidney function. Everyone in the trial receives the active study medicine.
Antibody-mediated Kidney DiseasePoland - AuthorisedTherapeutic confirmatory (Phase III)
Phase 3 Randomized Study of Teclistamab and Talquetamab (Tec-Tal) Versus Daratumumab and Lenalidomide (DR) in Minimal Residual Disease (MRD) Positive Patients With Newly Diagnosed Multiple Myeloma After Autologous Hematopoietic Stem Cell Transplantation (TiTan)
This phase 3 trial is for adults with multiple myeloma who have had a stem cell transplant but still have tiny traces of cancer left. It compares a new combination of two targeted medicines against the standard treatment to see which is better at clearing the remaining cancer cells.
Multiple myelomaPoland - AuthorisedTherapeutic confirmatory (Phase III)
An Open-Label, Phase 3 Study to Evaluate the Efficacy and Safety of Salanersen (BIIB115) in Participants Aged 15-60 Years With Spinal Muscular Atrophy Who Are Either Treatment-Naïve or Have Previously Been Treated With Risdiplam
This phase 3 study tests an investigational medicine called salanersen (BIIB115) for people aged 15 to 60 with spinal muscular atrophy (SMA). Researchers want to see if it helps improve physical movement, arm strength, and walking ability over time in people new to treatment or previously treated with risdiplam.
Spinal Muscular AtrophyPoland - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase I/II, randomized, placebo-controlled, multi-arm, dose-finding study to evaluate the safety, efficacy and immunogenicity of an Acne mRNA vaccine candidate in adults with moderate to severe acne 18 to 45 years of age
This clinical trial is testing a new mRNA vaccine for adults aged 18 to 45 with moderate to severe acne. Researchers want to find out if the vaccine is safe, how the immune system responds to it, and whether it helps reduce spots on the face.
AcnePoland - AuthorisedPhase II and Phase III (Integrated)
Prognostic value assessment of PSMA-T4 examination in the group of patients with triple-negative breast cancer (TNBC) qualified to radical therapy
This study tests a new imaging scan called PSMA-T4 in women with triple-negative breast cancer. Doctors want to see if this scan can highlight cancer cells clearly before surgery. The goal is to find out if it helps predict how the cancer behaves and guide better future care.
triple-negative breast cancerPoland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF)
This study is testing a new tablet called CRD-4730 for adults with heart failure. Researchers want to see if the medicine can help the heart pump blood better, ease everyday symptoms, and improve quality of life. Participants will take either the study drug or a dummy pill for 24 weeks.
heart failurePoland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rozanolixizumab in adult participants with ocular myasthenia gravis
This clinical trial is testing a medicine called rozanolixizumab (Rystiggo) for adults with ocular myasthenia gravis. This condition causes eye muscle weakness, leading to droopy eyelids and double vision. Researchers want to see if this injection reduces eye symptoms and improves daily life compared to a dummy treatment (placebo).
Ocular Myasthenia GravisPoland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Open-Label Study of Linvoseltamab Versus Daratumumab in Participants with Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma
This study looks at adults with high-risk smoldering multiple myeloma, an early form of blood cancer. Researchers are comparing a newer medicine called linvoseltamab against an established treatment called daratumumab. The goal is to see which medicine is better at delaying or stopping the condition from turning into active cancer.
High Risk Smoldering Multiple Myeloma (HR-SMM)Poland - AuthorisedTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Phase 2 Trial Evaluating the Efficacy, Safety and Tolerability of Primary Cardioprotection with Dapagliflozin in Patients with Newly Diagnosed Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation
This trial looks at whether a daily tablet called dapagliflozin can protect the heart in people having stem cell treatment for multiple myeloma. Patients will take either the real tablet or a dummy pill to see if it reduces the risk of heart complications during cancer therapy.
Multiple MyelomaPoland - AuthorisedTherapeutic confirmatory (Phase III)
A Randomized, Open-Label Phase 3 Study of Azenosertib Versus Investigator’s Choice of Chemotherapy in Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression
This study is testing a new targeted cancer drug called azenosertib. It is for women with advanced ovarian, fallopian tube, or peritoneal cancer that has returned after standard platinum chemotherapy. Researchers want to see if azenosertib works better than standard chemotherapy options at keeping the cancer under control.
High-Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal CancerPoland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, open-label extension study to evaluate the long-term safety and efficacy of rozanolixizumab in adult participants with ocular myasthenia gravis
This clinical trial tests a medicine called rozanolixizumab (Rystiggo) for adults with ocular myasthenia gravis. This condition causes eye muscle weakness, leading to drooping eyelids and double vision. Researchers want to find out how safe and effective this medicine is when used over a longer period.
Ocular Myasthenia GravisPoland - AuthorisedTherapeutic exploratory (Phase II)
Randomized, Double blind, Phase II Trial of Vortosiran to Evaluate Safety, Tolerability, and Pharmacodynamic Efficacy in Participants with Prior Venous Thromboembolism After Completion of Initial Anticoagulant Therapy (Cohort A) and in Cancer Patients at High Risk of Venous Thromboembolism (Cohort B)
This study tests a new injection called vortosiran to see if it can safely prevent blood clots. It is for adults who have had a blood clot in the past, or people with cancer who have a high risk of getting one. Researchers want to see how it affects clotting proteins.
Venous ThromboembolismPoland - AuthorisedHuman Pharmacology (Phase I)- Other
A trial to learn how safe anifrolumab is, how it moves throughout the body over time, and how it affects the body of adults with systemic lupus erythematosus
This clinical study looks at a medicine called anifrolumab in adults with systemic lupus erythematosus (lupus). Researchers want to see how safe the drug is, how it moves through the bloodstream, and how it affects the body. The goal is to improve future treatment options for people with lupus.
Systemic Lupus ErythematosusPoland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blinded, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Participants with Sjogren’s Disease-Associated Sensorimotor or Sensory Polyneuropathy
This study tests a medicine called Vyvgart in adults with Sjögren's disease who have nerve damage in their hands, legs, or feet. Researchers want to see if regular injections under the skin can ease nerve symptoms, reduce fatigue, and be used safely compared with a dummy treatment.
Sjogren’s Disease-Associated Sensorimotor Polyneuropathy (SMPN) or Sensory Polyneuropathy (SPN)Poland - AuthorisedHuman Pharmacology (Phase I)- First administration to humans
A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers
This early-stage clinical trial tests a new medicine, LY4584180, for adults with certain blood cancers, such as non-Hodgkin lymphoma. It is for people whose cancer has returned or continued to grow after previous treatments. Researchers want to find a safe dose and understand how the body handles the drug.
Lymphoma, Non-Hodgkin's Lymphoma, Diffuse Large B-Cell Follicular LymphomaPoland - AuthorisedTherapeutic exploratory (Phase II)
A Multicenter, Open-Label, Long-Term Extension Study to Evaluate the Long Term Safety and Tolerability of KT-621 in Participants With Asthma Previously Enrolled in a KT-621 Asthma Study
This study looks at the long-term safety of a new medicine called KT-621 for adults with moderate to severe eosinophilic asthma. It is an extension study for people who already took part in an earlier KT-621 trial, checking how well the body tolerates the treatment over 52 weeks.
Uncontrolled Moderate to Severe Eosinophilic AsthmaPoland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study to Evaluate the Efficacy and Safety of ENV-294 in Adult Participants with Moderate-to-Severe Atopic Dermatitis
This study is testing a new tablet called ENV-294 for adults living with moderate-to-severe atopic dermatitis, also known as eczema. Researchers want to see if different doses of this medicine can calm inflamed skin, reduce itching, and remain safe and gentle for people to take.
Atopic DermatitisPoland - AuthorisedTherapeutic confirmatory (Phase III)
An Open-label, Multi-Center, Single-arm Prospective Clinical Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Gamunex®-C plus Standard Medical Treatment to Prevent Infections in Participants with Secondary Antibody Deficiency Associated with Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin Lymphoma (Sigma).
Certain blood cancers can weaken your immune system, leaving you at higher risk of serious infections. This study tests whether an antibody drip called Gamunex-C, given alongside your usual medical care, can safely prevent severe bacterial infections and keep you out of hospital.
Secondary Antibody Deficiency Associated with Chronic Lymphocytic Leukemia, Multiple Myeloma, or Non-Hodgkin LymphomaPoland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination with the Modified Gemcitabine and nab-Paclitaxel Regimen Versus the Standard Gemcitabine and nab-Paclitaxel Regimen for the Treatment of Patients with Metastatic Pancreatic Ductal Adenocarcinoma Cancer (MAPKeeper 301)
This clinical trial is testing a new targeted medicine called atebimetinib for advanced pancreatic cancer. Doctors want to see if adding this drug to standard chemotherapy helps people live longer and improves their quality of life compared to standard chemotherapy alone.
Metastatic Pancreatic Ductal AdenocarcinomaPoland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Soquelitinib in Moderate to Severe Atopic Dermatitis (SIERRA1)
This clinical study tests an experimental tablet called soquelitinib for adults with moderate to severe atopic dermatitis, also known as eczema. Researchers want to see if the medicine is safe, easy to take, and able to reduce skin redness, dry patches, and itchy symptoms compared to a dummy tablet.
Atopic dermatitis (AD)Poland - AuthorisedTherapeutic exploratory (Phase II)
Randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the safety and efficacy of 2 dose levels of the oral ghrelin receptor agonist AC01 over 12 weeks in patients with chronic advanced heart failure with reduced ejection fraction (HFrEF)
This study tests a new daily tablet called AC01 for people with long-term heart failure. Researchers want to see if this medicine can help the heart pump blood more effectively. Participants take either the real medicine or a dummy tablet for 12 weeks while doctors monitor their heart health.
chronic advanced heart failure with reduced ejection fraction (HFrEF)Poland - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2b, randomized, placebo-controlled, observer-blind study in adults 60 years and older to evaluate the efficacy, safety, and immunogenicity of a bivalent protein vaccine candidate against Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (HMPV)
This clinical trial is testing a new combination vaccine designed to protect older adults against two common chest viruses: RSV and HMPV. Researchers want to find out how well the vaccine prevents lung infections, how safe it is, and whether it helps the immune system build strong protective defences.
Infections and infestationsPoland