Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess the Efficacy of PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy in Adult Subjects with Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite (HDM) Allergy
This study is testing a new injection called PURETHAL Mites to see if it can help adults with hay fever-like symptoms or asthma caused by house dust mites. It compares the injection to a dummy treatment (placebo) to see if it reduces their allergy symptoms.
Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite (HDM) AllergyPoland - Ongoing, recruitingTherapeutic use (Phase IV)
Impact of trimetazidine on endothelial function and biomarkers correlating with the prognosis of heart failure with preserved ejection fraction
This study is looking at a medicine called Trimeductan MR for people with a type of heart failure where the heart still pumps blood well. It wants to see if the medicine can reduce hospital stays for heart failure or prevent death, and how it affects heart health.
Heart failure with preserved ejection fractionPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
Multicenter, double-blind, randomized, placebo-controlled, dose-response trial with the full-spectrum Cannabis Extract VER-01 in patients with chronic non-specific low back pain
This study is testing a new cannabis-based medicine, VER-01, for people with ongoing lower back pain. It will compare VER-01 to a dummy pill (placebo) to see if it helps reduce pain when other pain medicines haven't worked or can't be used. We want to know if it's safe and effective.
For the treatment of patients with chronic non-specific low back pain when drug treatment is indicated and previous optimised treatments with non-opioid analgesics have not led to sufficient pain relief or were unsuitable due to contraindications or intolerance.Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I6T-MC-AMBA - A Multicenter, Phase 3, Open-Label Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mirikizumab in Participants 2 Years to Less Than 18 Years of Age with Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine, Mirikizumab (also called Omvoh), for children and teenagers aged 2 to under 18 who have moderate to severe ulcerative colitis. We want to see how well it works and if it's safe to help them feel better.
Moderately to Severely Active Ulcerative ColitisPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity without type 2 diabetes
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity. It wants to see if the medicine helps with weight loss and if it's safe. Participants will get either the real medicine or a dummy injection.
ObesityPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity and type 2 diabetes. We want to see if it helps with weight loss and is safe to use over about 1.5 years, compared to a dummy medicine.
ObesityDiabetes mellitus type IIPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
J3E-MC-EZDB: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3540378 in Adults with Worsening Chronic Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called LY3540378 for people with a type of heart failure where the heart struggles to relax properly. Researchers want to see if this new medicine can help improve how the heart works and if it's safe to use.
Heart Failure with Preserved Ejection FractionHeart FailurePoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
KEYMAKER-U01 Master Study: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) KEYMAKER-U01 Substudy 3: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents in Combination with Pembrolizumab in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Previously Treated with anti-PD-(L)1 Therapy
This study is looking for better ways to treat advanced lung cancer that has not responded to previous treatments. It checks how well new medicines work with or without standard therapy, hoping to shrink tumours.
Non-small Cell Lung CancerPoland - Ongoing, recruitingPhase III and phase IV (Integrated)
Effects of single-pill combination of telmisartan/amlodipine and telmisartan/amlodipine/hydrochlorothiazide on 24-hour blood pressure (BP) reduction, 24-h BP variability and office BP control in patients with arterial hypertension – SATELLITE
This study looks at how new combination medicines affect high blood pressure over 24 hours. Researchers want to see how well these pills lower blood pressure and keep it steady throughout the day in people with high blood pressure.
Arterial hypertensionPoland - Ongoing, recruitingTherapeutic use (Phase IV)
I4V-MC-JAJA (RA-BRIDGE): A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
This study looks at how safe and effective a medicine called baricitinib is for people with rheumatoid arthritis, compared to other common treatments. It will see how long it takes for a blood clot to happen. This is a long-term study that will last over five years.
Rheumatoid ArthritisPoland - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02D
This study, called KEYMAKER-U02, is for adults with advanced melanoma, a type of skin cancer, that has spread to the brain. It's looking at new ways to treat this cancer, sometimes using a drug called pembrolizumab (Keytruda) alone, or in combination with other medicines like Lenvatinib or MK-1308A.
Advanced melanoma with brain metastasesPD-1 refractory or PD-1 naivePoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
INCB 18424-320: A phase 3, double-blind, randomised, vehicle-controlled, efficacy and safety study of ruxolitinib cream in participants with Prurigo Nodularis. Topical ruxolitinib evaluation in Prurigo Nodularis (TRuE-PN2)
This study is testing a new cream for people with very itchy skin lumps called Prurigo Nodularis. It wants to see if the cream, called ruxolitinib, can reduce itching compared to a cream without any medicine in it. The study aims to find out how well it works and if it's safe.
Prurigo NodularisPoland - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase II, Randomized, Partially Blinded Study to Assess the Safety, Tolerability and Immunogenicity of Meningococcal Combined ABCWY Vaccine when Administered to Healthy Infants
This study is testing a new vaccine that aims to protect babies from serious illnesses like meningitis. The main goals are to see if it's safe, how well babies tolerate it, and if it helps their bodies build protection against these infections.
InfectionsMeningococcalPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Clinical Study to Evaluate the Safety and Efficacy of Topical Administration of Bacteriophage Therapy TP-102 in Patients with Diabetic Foot Infection
This study looks at a new gel treatment, TP-102, for diabetic foot infections. It aims to see if TP-102 can safely and effectively help heal wounds caused by specific bacteria, compared to a dummy gel and standard care.
Diabetic foot ulcers infected by Acinetobacter baumanniiPseudomonas aeruginosa and /or Staphylococcus aureusPoland - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Study of Imvotamab in Severe Systemic Lupus Erythematosus
This study is looking at a new medicine called Imvotamab for people with severe lupus. It's an early-stage study to check if the medicine is safe and how it works in the body. If you are 18 or older and have severe lupus, you might be able to take part.
Systemic Lupus ErythematosusPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Phase II Study of BMS-986315 and Nivolumab in Combination with Chemotherapy Versus Nivolumab in Combination with Chemotherapy as First-line Treatment for Participants with Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC)
This study is looking at new ways to treat advanced lung cancer. It combines standard chemotherapy with two different drug approaches to see which works best and if there are side effects. Doctors want to find better treatments for non-small cell lung cancer.
Non-small Cell Lung CancerPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Phase 3 Multicenter, Randomized, Double-Blind, Study to Assess the Efficacy and Safety of Treatment with Bepirovirsen in Nucleos(t)ide Analogue-treated Participants with Chronic Hepatitis B Virus (B-Well 2)
This study is looking into a new treatment called Bepirovirsen for people with long-term Hepatitis B. It's hoped this treatment could help some people stop all their Hepatitis B medicines. Researchers want to see if it works well and is safe.
Hepatitis BChronicPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Open-Label, Multicenter, Phase II Study of Multiple Doses of RO7247669 in Participants with Previously Untreated Unresectable or Metastatic Melanoma
This study is testing a new medicine called RO7247669 for advanced skin cancer (melanoma) that has spread or can't be removed by surgery. It's an early-stage trial looking at how safe the medicine is and if it can help slow down or stop the cancer from growing.
Unresectable or Metastatic MelanomaPoland - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Open-Label Extension Study of PRX012 in Subjects with Alzheimer’s Disease Who Were Enrolled in Study PRX012-101 or PRX012-102
This study is an open-label extension, meaning everyone gets the study drug. It's for people with Alzheimer's disease who have already taken part in previous PRX012 studies (PRX012-101 or PRX012-102) to see how the treatment works long-term.
Alzheimer’s DiseasePoland - Ongoing, recruitingPhase III and phase IV (Integrated)
A phase 3b, interventional, adaptive, clinical trial to evaluate the efficacy and safety of tralokinumab 300 mg every second week monotherapy compared with placebo in subjects with moderate-to-severe atopic hand eczema who are candidates for systemic therapy (ADHAND)
This study is looking into a new treatment called tralokinumab for adults with moderate to severe eczema on their hands. It wants to see how well it works and if it's safe compared to a dummy treatment. The goal is to see if the medicine can clear up or significantly improve hand eczema in a few months.
Atopic dermatitis and moderate-to severe atopic hand eczemaPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multi-Center, Open-Label Study of the Human Anti-TNF Monoclonal Antibody Adalimumab to Evaluate Long-Term Safety and Tolerability of Repeated Administration of Adalimumab in Pediatric Subjects with Ulcerative Colitis Who Completed the Study M11-290
This study looks at the long-term safety of a treatment called Humira for children and teens with ulcerative colitis. It's for those who have already been on Humira in a previous study. We want to see how well they continue to do.
Ulcerative ColitisPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Study to Evaluate the Efficacy and Safety of Pembrolizumab plus Investigational Agents in Combination with Etoposide and Cisplatin or Carboplatin for the First-Line Treatment of Participants with Extensive-Stage Small Cell Lung Cancer (KEYNOTE-B99)
This study is looking at new ways to treat advanced small cell lung cancer for the first time. It combines Pembrolizumab with other medications to see how well they work together and if they are safe.
First-line treatment of participants with extensive-stage small cell lung cancerPoland - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Multicenter, Randomized, Double-blind Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Oral Ozanimod (RPC1063) in Pediatric Participants with Moderately to Severely Active Crohn’s Disease with an Inadequate Response to Conventional Therapy
This study is looking at a new medicine called Zeposia for children and young people with Crohn's disease that hasn't responded well to other treatments. Researchers want to see if Zeposia can help improve symptoms and how safe it is over time.
Moderately to Severely Active Crohn's DiseasePoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
Rheumatoid arthritisPoland - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study is looking into a new medicine, efgartigimod, for people with bullous pemphigoid (BP). It compares efgartigimod to a dummy drug (placebo) to see if it can help patients achieve clear skin without needing steroid tablets for a long time.
Bullous Pemphigoid (BP)Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of SCD-044 in the Treatment of Moderate to Severe Plaque Psoriasis
This study is looking into a new tablet called SCD-044 for people aged 18 and over with moderate to severe plaque psoriasis. It wants to see if different doses of this tablet can improve skin more than a dummy pill (placebo) after 16 weeks, and if it's safe to use.
moderate to severe plaque psoriasisPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), Compared to a SoC Treated Control Arm, in Prevention of Post Abdominal Surgery Incisional Infection.
This study is testing if a treatment called D-PLEX can help prevent infections after tummy surgery. It compares D-PLEX plus usual care to just usual care, to see if it reduces surgical wound infections.
Prevention of post abdominal surgery incisional infection.Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
This study is testing a new medicine, tozorakimab, for people with lung disease called COPD. It wants to see if this medicine can help reduce flare-ups of COPD. Some people will get the new medicine, and others will get a dummy medicine, alongside their usual care.
Chronic Obstructive Pulmonary Disease (COPD)Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
This study is looking into a new tablet called brensocatib for adults with long-term sinus problems that don't involve growths (nasal polyps). It wants to see if this new medicine can help reduce symptoms like stuffy nose and improve how people feel, compared to a dummy pill.
Chronic Rhinosinusitis without Nasal Polyps (CRSsNP)Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicenter, Open-label, Phase 2 Basket Study of MK‑7684A, a Co formation of Vibostolimab (MK‑7684) With Pembrolizumab (MK‑3475), With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (KEYVIBE 005)
This study, called KEYVIBE 005, is testing a new combination of medicines (MK-7684A, which includes vibostolimab and pembrolizumab) for people with advanced solid tumours. Researchers want to see how well this new treatment shrinks tumours and stops them from growing, either alone or with other cancer therapies.
Advanced solid tumorsPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma
This study looks at a new combination of medicines (A+AVD) compared to a standard treatment (ABVD) for advanced Hodgkin Lymphoma. It aims to see if the new combination can better control the cancer and help people live longer.
Advanced Classical Hodgkin LymphomaPoland - Ongoing, recruitingPhase III and phase IV (Integrated)
MEMENTO-A Phase 3b/4 Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy to assess the impact on Myocardial Structure with Cardiac Magnetic Resonance Imaging (CMR)
This study is looking at a new medicine called mavacamten for adults with a heart condition called obstructive hypertrophic cardiomyopathy (HCM). It aims to see if the medicine can reduce the thickness of the heart walls and the size of the heart's upper chambers.
Symptomatic Obstructive Hypertrophic CardiomyopathyPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
BelieveIT-201: A Randomized, Phase 2, Open-label Trial of TransCon TLR7/8 Agonist in Combination with Pembrolizumab, TransCon TLR7/8 Agonist in Combination with TransCon IL-2 β/γ, or Pembrolizumab Monotherapy as Neoadjuvant Therapy in Participants with Stage III-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)
This study looks at new ways to treat a type of head and neck cancer before surgery. It's testing new medicines, alone or together, to see if they can shrink the cancer effectively. This could help improve treatment for people with this specific cancer.
Stage III-IVA Resectable Locoregionall Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Patient- and Investigator-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Study Participants With Prodromal to Mild Alzheimer’s Disease (AD), Followed by an Open-Label Extension Period
This study is testing a new medicine called Bepranemab for people with early Alzheimer's disease. Researchers want to see if it's safe and helps with memory and thinking, compared to a dummy drug. It's a key step in understanding if this treatment could work.
Alzheimer’s DiseasePoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Phase 2, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of KER-012 in Combination with Background Therapy in Adult Participants with Pulmonary Arterial Hypertension (TROPOS-Study)
This study is testing a new medicine, cibotercept (also known as KER-012), for adults with pulmonary arterial hypertension (high blood pressure in the lungs). Researchers want to see if it's safe and helps improve lung blood vessel function when added to existing treatments.
Pulmonary Arterial HypertensionPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typePoland - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Clinical Activity of RO7276389 Alone and in Combination with Cobimetinib in Participants with BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRAF-V600 Mutation-Positive Melanoma with Central Nervous System Metastases
This study is looking at a new drug, RO7276389, by itself and with another medicine, cobimetinib. It's for adults with advanced cancers that have a specific change (BRAF-V600 mutation), especially melanoma that has spread to the brain. We want to see if it's safe and how it works.
BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRAF-V600 Mutation-Positive Melanoma with or without Central Nervous System MetastasesPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Global Multicenter, Randomized, Double-blinded, Propofol-controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of HSK3486 Injectable Emulsion for Induction of General Anesthesia in Adults Undergoing Elective Surgery
This study is testing a new medicine, given through a drip, to help people go to sleep before surgery. It's comparing this new medicine to a common anaesthetic to see if it works well and is safe for adults having an operation.
General anaesthesiaPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease has Remained Stable or Responded to First-Line Platinum Based Chemotherapy with Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL 1L)
This study looks at a new combination treatment for advanced lung cancer (non-small cell lung cancer). It compares two medicines, Niraparib and Pembrolizumab, with Pembrolizumab alone, to see if the combination helps people live longer or keeps their cancer from growing for longer.
Lung CancerNon-Small CellPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A parallel-group, prevention, Phase III, modified double-blind, 2-arm, study to investigate the immunogenicity and describe the safety of a quadrivalent meningococcal conjugate vaccine (MenACYW conjugate vaccine) compared with Nimenrix® when administered in a 1+1 schedule in healthy infants and toddlers at 6 and 12 months of age
This study is looking at a new vaccine to protect babies and young children from meningococcal disease. We are comparing how well this new vaccine works and its safety compared to a current vaccine, Nimenrix, in healthy infants and toddlers in the UK.
Healthy volunteers (Meningococcal infection)Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® pressurised MDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (KALOS)
This study is testing a new inhaler for adults with asthma that isn't well controlled. It compares a new triple-medicine inhaler to existing ones to see if it works better at preventing asthma attacks and improving breathing over 24-52 weeks.
Severe and inadequately controlled asthmaPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGV: A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared with Dapagliflozin in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Metformin (ACHIEVE-2)
This study looks at a new drug, orforglipron, for people with type 2 diabetes whose blood sugar isn't well controlled with metformin. It compares orforglipron with an existing drug, dapagliflozin, to see how well they lower blood sugar and if they're safe.
Type 2 DiabetesPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicentre, Randomised, Double-Blind, Parallel-Group, Placebo- Controlled Phase 3 Efficacy and Safety Study of Benralizumab in Patients with Eosinophilic Chronic Rhinosinusitis with Nasal Polyps (ORCHID)
This study looks at a new medicine called benralizumab for adults with severe nose polyps and asthma. It aims to see if it can shrink polyps and reduce stuffy noses better than a dummy treatment, using standard nasal sprays alongside.
Severe CRSwNP patients with asthma.Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A multi-centre, single arm, open-label extension study to evaluate the long-term safety of GSK3511294 (Depemokimab) in adult and adolescent participants with severe asthma with an eosinophilic phenotype from studies 206713 or 213744
This study looks at the long-term safety of a new medicine, GSK3511294 (Depemokimab), for adults and teenagers with severe asthma. Participants have already taken part in earlier studies of this medicine. We'll check for side effects and how their asthma is doing over a year.
Severe asthma with an eosinophilic phenotypePoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A prospective, randomized, double-blind placebo-controlled multicentre study with mannan-conjugated birch pollen allergoids administered subcutaneously to adolescent and adult patients with birch pollen-induced allergic rhinitis or rhinoconjunctivitis.
This study is looking for people aged 18 and over with birch pollen allergies. It compares a new treatment with a dummy treatment (placebo) to see if it reduces allergy symptoms like a runny nose or itchy eyes during birch pollen season.
Birch pollen induced allergic rhinitis or rhinoconjunctivitisPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A phase 3, prospective, open-label, multisite, extension of phase 3 studies to assess the long-term safety and tolerability of soticlestat as adjunctive therapy in subjects with Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2)
This study looks at the long-term safety and how well a medicine called soticlestat works for people with Dravet Syndrome or Lennox-Gastaut Syndrome. It's for those already in a previous study and focuses on side effects and overall health.
Dravet and Lennox-Gastaut SyndromesPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A RANDOMIZED, PHASE 2, DOUBLE-BLIND STUDY TO EVALUATE THE EFFICACY OF DOSTARLIMAB PLUS CHEMOTHERAPY VERSUS PEMBROLIZUMAB PLUS CHEMOTHERAPY IN METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
This study looks at new treatments for a type of lung cancer that has spread. It compares two different drug combinations, both including chemotherapy, to see which works better at shrinking tumours and helping people live longer. It's a key step in finding improved care.
Lung CancerNon-Small CellPoland - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizuma Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02B
This study is looking at new treatments for melanoma, a type of skin cancer, that has not responded to previous therapies. Researchers want to see how safe these new treatments are, especially when given with or without a common cancer drug called pembrolizumab (Keytruda).
PD-1 refractory melanomaPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Baxdrostat in Participants with Uncontrolled Hypertension on Two or More Medications including Participants with Resistant Hypertension
This study is testing a new drug called Baxdrostat for people whose high blood pressure isn't controlled by their current medicines. It aims to see if Baxdrostat helps lower blood pressure and if it's safe to use, compared to a dummy pill.
Uncontrolled hypertension (uTHN) defined as blood pressure that remains higher than goal levels despite patients being treated with 2 anti-hypertensive agentsincluding a diuretic. Resistant hypertension (rHTN) defined as blood pressure that remains higher than goal levels despite the use of at least 3 anti hypertensive drugs of different classes at maximum tolerated doseincluding a diuretic.Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)
This study is looking at a new tablet, semaglutide, to see if it can help people with early Alzheimer's disease. Researchers want to know if it's safe and if it can slow down changes in memory and thinking over about two years.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typePoland