Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind Study to Evaluate Perioperative Pembrolizumab (MK-3475) + Neoadjuvant Chemotherapy versus Perioperative Placebo + Neoadjuvant Chemotherapy in Cisplatin-eligible Participants with Muscle-invasive Bladder Cancer (KEYNOTE-866)
This study is testing if adding a new drug, pembrolizumab (Keytruda), to standard chemotherapy before and after surgery can help people with a type of bladder cancer. Researchers want to see if this combination works better than chemotherapy alone to keep the cancer away.
Cis-eligible Muscle-invasive bladder cancer.Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity without type 2 diabetes
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity. It wants to see if the medicine helps with weight loss and if it's safe. Participants will get either the real medicine or a dummy injection.
ObesitySweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity and type 2 diabetes. We want to see if it helps with weight loss and is safe to use over about 1.5 years, compared to a dummy medicine.
ObesityDiabetes mellitus type IISweden - Ongoing, recruitingTherapeutic use (Phase IV)
Brain effects of hormonal contraceptives. A randomized, double-blind, longitudinal study comparing two combined oral contraceptives (Estetrol/drospirenone vs ethinylestradiol/levonorgestrel).
This study looks at how different hormone birth control pills affect the brain in women. Researchers want to see if specific brain areas change when taking one of two common contraceptive pills, and how this might relate to mood.
ContraceptionSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
(20289) A Phase 2 Basket Study of the Oral TRK Inhibitor larotrectinib in Subjects with NTRK Fusion-Positive Tumors
This study is testing a new medicine, larotrectinib, for adult patients with certain types of cancer that have a specific genetic change called an 'NTRK fusion'. Doctors want to see how well the medicine shrinks these tumours and if it's safe.
Solid tumors harboring NTRK fusionSweden - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
An open-label first-in-human single ascending dose study to explore the safety, tolerability and efficacy of subretinal administration of CPK850 gene therapy in patients with retinitis pigmentosa caused by mutations in the RLBP1 gene
This study is testing a new gene therapy, CPK850, for a serious eye condition called retinitis pigmentosa caused by specific gene changes. It's the first time this treatment is being given to people, checking if it's safe, how well it's tolerated, and if it helps improve vision.
Retinitis pigmentosa caused by biallelic mutations in the RLBP1 geneSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Open-Label, Multiple Ascending Dose, Multicenter Study of VRG50635 in Participants With Sporadic and Familial Amyotrophic Lateral Sclerosis Followed by Long-Term Treatment
This study is testing a new medicine called VRG50635 for people with Amyotrophic Lateral Sclerosis (ALS). It's an early-stage study to see how the medicine works, how much to give, and if it's safe. Both common and inherited forms of ALS are included.
Amyotrophic Lateral SclerosisSweden - Ongoing, recruitingTherapeutic use (Phase IV)
Transfer of metformin into human breast milk and the plasma of breastfeeding children - A low intervention trial with biobanking of breast milk and plasma in Västra Götalandsregionen and Region Örebro
This study looks at how much metformin, a diabetes medicine, passes into breast milk and then into a baby's blood. It's for breastfeeding mothers with type 2 or gestational diabetes who take metformin, to see if the medicine affects their baby.
type 2 diabetes mellitus and gestational diabetes mellitusSweden - Ongoing, recruitingPhase III and phase IV (Integrated)
A phase 3b, interventional, adaptive, clinical trial to evaluate the efficacy and safety of tralokinumab 300 mg every second week monotherapy compared with placebo in subjects with moderate-to-severe atopic hand eczema who are candidates for systemic therapy (ADHAND)
This study is looking into a new treatment called tralokinumab for adults with moderate to severe eczema on their hands. It wants to see how well it works and if it's safe compared to a dummy treatment. The goal is to see if the medicine can clear up or significantly improve hand eczema in a few months.
Atopic dermatitis and moderate-to severe atopic hand eczemaSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess the effect of CC-95251 alone and in combination with anti-cancer drugs in subjects with Acute Myeloid Leukemia and Myelodysplastic Syndromes
This study is looking at a new medicine called CC-95251 for people with acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Researchers want to see how safe it is and if it works well, both on its own and with other cancer drugs.
Acute Myeloid Leukemia and Myelodysplastic SyndromesSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase 2, randomised, double-blind, placebo-controlled trial to evaluate safety and local tolerability of four weekly administrations of A24110He in subjects with elevated triglyceride plasma concentrations
This study is testing a new medicine called A24110He for people with very high levels of a type of fat (triglycerides) in their blood. We want to see if it's safe and how the body handles it. Participants will receive either the new medicine or a dummy treatment (placebo).
Moderate to severe hypertriglyceridemiaSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Month, Randomized, Controlled, Open-Label, Dose Escalation Study Evaluating Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of an Anti-CD2 Monoclonal Antibody, TCD601(siplizumab) Compared to Anti-Thymocyte Globulin (rATG), as Induction Therapy in de novo Renal Transplant Recipients
This study looks at a new medicine called TCD601 (siplizumab) for people who have recently had a kidney transplant. It compares TCD601 to a standard treatment to see if it's safe and how well it helps prevent the body from rejecting the new kidney.
Renal TransplantationSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Randomised, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of AZD4604 Twice Daily for Twelve Weeks in Adult Patients with Moderate to Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA
This study is testing a new medicine, AZD4604, for adults with asthma that isn't well controlled, even with their usual inhalers. We want to see if it helps reduce asthma flare-ups and improve breathing, comparing it to a dummy medicine.
Adult Patients with Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABASweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy with Nivolumab + Relatlimab Fixed-dose Combination versus Nivolumab Monotherapy after Complete Resection of Stage III-IV Melanoma
This study looks at a new combination treatment for advanced melanoma that has been removed by surgery. It compares two drugs given together (nivolumab and relatlimab) against nivolumab alone, to see if the combination can help prevent the cancer from coming back.
Participants with completely resected Stage III or Stage IV melanomaSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Randomized, Double-blind, Placebo‑controlled Study with Deferred Active Treatment to Investigate the Efficacy, Safety, and Pharmacokinetics of JNJ‑73763989 + Nucleos(t)ide Analog in Participants Co‑infected with Hepatitis B and Hepatitis D Virus
This study is looking into a new treatment, JNJ-73763989, for people who have both Hepatitis B and Hepatitis D. It aims to see how well it works, if it's safe, and how the body handles it, compared to a dummy treatment.
Hepatitis B and Hepatitis D Viral Co-infectionSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease has Remained Stable or Responded to First-Line Platinum Based Chemotherapy with Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL 1L)
This study looks at a new combination treatment for advanced lung cancer (non-small cell lung cancer). It compares two medicines, Niraparib and Pembrolizumab, with Pembrolizumab alone, to see if the combination helps people live longer or keeps their cancer from growing for longer.
Lung CancerNon-Small CellSweden - Ongoing, recruitingTherapeutic use (Phase IV)
A Phase IV Longitudinal Study of SUBLOCADE (SUBUTEX Prolonged Release) Clinical Outcomes in Adults with Opioid Use Disorder (Opioid Dependence)
This study looks at how well SUBLOCADE, a long-acting injection, helps adults with opioid use disorder. It aims to see if people achieve and maintain recovery over 3 years while using this treatment, checking for symptom improvement and other important health outcomes.
Opioid Use DisorderSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Baxdrostat in Participants with Uncontrolled Hypertension on Two or More Medications including Participants with Resistant Hypertension
This study is testing a new drug called Baxdrostat for people whose high blood pressure isn't controlled by their current medicines. It aims to see if Baxdrostat helps lower blood pressure and if it's safe to use, compared to a dummy pill.
Uncontrolled hypertension (uTHN) defined as blood pressure that remains higher than goal levels despite patients being treated with 2 anti-hypertensive agentsincluding a diuretic. Resistant hypertension (rHTN) defined as blood pressure that remains higher than goal levels despite the use of at least 3 anti hypertensive drugs of different classes at maximum tolerated doseincluding a diuretic.Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)
This study is looking at a new tablet, semaglutide, to see if it can help people with early Alzheimer's disease. Researchers want to know if it's safe and if it can slow down changes in memory and thinking over about two years.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase I Study of INCB099280 in Combination With Ipilimumab in Participants With Selected Solid Tumors
This early-stage study is testing a new drug, INCB099280, combined with an existing cancer treatment, YERVOY, for solid tumours. Researchers want to see if this combination causes any serious side effects and how much of the new drug stays in the body. It's a first step to understand safety.
Solid tumorSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multi-center, Double-blind, Placebo-controlled Phase 3 Study of Bemarituzumab plus Chemotherapy versus Placebo plus Chemotherapy in Subjects with Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b Overexpression FORTITUDE-101)
This study looks at a new drug, bemarituzumab, for advanced stomach or gullet cancer that hasn't been treated before. It aims to see if adding bemarituzumab to standard chemotherapy helps people live longer and improves their quality of life compared to chemotherapy alone.
Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b overexpressionSweden - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
An adaptive open-label multicentre phase 1/2 trial, to determine the recommended phase 2 dose of CCTx-001, and to assess safety, tolerability, and clinical activity in patients with relapsed/refractory acute myeloid leukaemia (RESOLVE AML 001)
This study is testing a new treatment (CCTx-001) for adults with acute myeloid leukaemia (AML) that has returned or not responded to previous treatments. It aims to find the right dose and check how safe and effective it is.
Relapsed/Refractory Acute Myeloid Leukemia (AML)Sweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
The Attractive 2 trial – An open-label, randomised, 2-period cross-over trial to assess the pharmacokinetics of ATR-258 oral capsule vs. oral solution formulations in healthy volunteers
This study is testing a new medicine, ATR-258, for people with type 2 diabetes. We want to see how two different forms of the medicine (a capsule and a liquid) move through the body in healthy adult volunteers.
Type 2 diabetes (T2D)Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Double-Blinded, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Neoadjuvant Treatment with Atezolizumab or Placebo in Combination with Platinum-Based Chemotherapy in Patients With resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer
This study is testing a new way to treat early-stage lung cancer before surgery. It combines standard chemotherapy with a new drug called Tecentriq, or a dummy drug, to see if it helps patients live longer and stay cancer-free.
Early-Stage Resectable Non-small cell lung cancer (NSCLC)Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
This study is looking at a new medicine called Tozorakimab for people with COPD. It aims to see if it can reduce severe flare-ups and if it's safe. Participants will be compared to those taking a dummy medicine.
Chronic Obstructive Pulmonary Disease (COPD)Sweden - Ongoing, recruitingPhase II and Phase III (Integrated)
IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH)
This study is looking into a new treatment, AV-101, for Pulmonary Arterial Hypertension (PAH), a condition affecting the lungs and heart. It aims to see if the treatment is safe and effective by comparing it to a dummy medicine.
Pulmonary Arterial Hypertension (PAH)Sweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Parallel Group, Randomized, Double-Blind, Placebo-Controlled, 3-Arm, Multicenter Treatment Study to Evaluate the Efficacy and Safety of GSK4527226 [AL101] Intravenous Infusion Compared with Placebo in Patients with Early Alzheimer’s Disease
This study is testing a new medicine called GSK4527226 (also known as AL101) for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and if it can help improve memory and thinking compared to a dummy treatment.
Alzheimer's DiseaseSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Ravulizumab in Adult and Adolescent Participants who have Thrombotic Microangiopathy (TMA) after Hematopoietic Stem Cell Transplant (HSCT)
This study is testing a new medicine called Ultomiris to see if it can help adults who get a serious side effect called TMA after a stem cell transplant. It's comparing Ultomiris to a dummy treatment.
Hematopoietic stem cell transplant-associated thrombotic microangiopathySweden - Ongoing, recruitingTherapeutic use (Phase IV)
Transfer of prednisolone into human breast milk and plasma of breastfeeding children - A low intervention cohort study with biobanking of breast milk and plasma
This study looks at how much prednisolone medication, taken by breastfeeding mums, passes into their breast milk and then into their baby's blood. We want to understand if babies are exposed to the medicine and how much.
Reumatoid ArthritisSLEmyositispsoriatric arthritisSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants With Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)
This study is testing a new medicine, Ultomiris, for adults with kidney diseases called Lupus Nephritis or IgA Nephropathy. Doctors want to see if it reduces protein in their urine and helps their kidneys work better, compared to a dummy medicine.
Lupus Nephritis (LN) Immunoglobulin A Nephropathy (IgAN)Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Single-arm, Open-label Extension of the Vericiguat VALOR Study in Pediatric Participants with Heart Failure due to Systemic Left Ventricular Systolic Dysfunction (VALOR EXT)
This study looks at a medicine called Vericiguat for children with a type of heart failure. It checks how safe the medicine is and if it causes any unwanted effects. This is a follow-up study for those already taking part.
Heart Failure due to Systemic Left Ventricular Systolic DysfunctionSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
IMPAHCT-FUL: A Long-Term Extension, Multi-Center Safety Study of AV-101 in Subjects With Pulmonary Arterial Hypertension (PAH) Who Have Completed Study AV-101-002
This study looks at the long-term safety of a new medicine, AV-101, for people with pulmonary arterial hypertension (PAH). It's for those who have already tried AV-101 in a previous study and aims to learn more about how well it's tolerated over time.
Pulmonary Arterial Hypertension (PAH)Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 2b/3 Study of Safety and Efficacy of AMX0035 in Progressive Supranuclear Palsy (ORION)
This study, called ORION, is testing a new drug called AMX0035 for Progressive Supranuclear Palsy (PSP). Researchers want to see if the drug is safe and helps slow down the disease's progression. It's a late-stage trial, hoping to show clear benefits.
Progressive Supranuclear PalsySweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Children and Adolescents With Increased Risk of Pneumococcal Disease.
This study is testing a new vaccine (V116) to see how well it works and if it's safe for children and teens who are more likely to get sick from certain bacteria called pneumococcus. It compares the new vaccine to existing ones.
Pneumococcal diseaseSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to learn how much [11C]savolitinib enters the brains of healthy participants
This study looks at how a new medicine, called [11C]savolitinib, gets into the brains of healthy adults. It's a very early stage of research to understand how the medicine works in the body.
Healthy VolunteersSweden - Ongoing, recruitingTherapeutic use (Phase IV)
COMPIS - Congenital myopathy intervention study. An open-label, cross over, randomized, controlled study using salbutamol
This study looks at a common asthma medicine, salbutamol (Ventolin), for people with congenital myopathy. It aims to see if salbutamol can improve muscle strength and daily activities over six months compared to not taking the medicine.
Congenital myopathySweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Astegolimab in Patients with Chronic Obstructive Pulmonary Disease
This study is testing a new medicine, astegolimab, for people with lung disease called COPD. It wants to see if this medicine can reduce flare-ups (exacerbations) and improve how people feel and breathe. They are also looking at how safe it is.
Chronic Obstructive Pulmonary Disease (COPD)Sweden - Ongoing, recruitingTherapeutic use (Phase IV)
Interventional, randomized, double-blind, parallel-group, placebo-controlled study of add-on eptinezumab treatment to brief education intervention, for the preventive treatment of migraine in patients with a dual diagnosis of migraine and Medication Overuse Headache.
This study looks at a medicine called VYEPTI for people who get frequent migraines and also over-use headache pain relievers. It compares VYEPTI plus headache education to a dummy treatment plus education, to see if VYEPTI helps reduce headache days.
Chronic MigraneMigraneMedication Overuse HeadacheSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study to evaluate the addition of an experimental drug, CC-90010, to the usual treatment of brain cancer after surgery
This study is testing a new experimental drug, CC-90010, alongside standard treatments for a type of brain cancer called glioblastoma. It's for adults whose brain tumour has been recently diagnosed and surgically removed, either fully or in part, to see if the new drug can help.
Subjects with newly diagnosed WHO Grade IV glioblastoma (ndGBM) who have undergone complete or partial tumor resectionSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-Label, Multi-Center Extension Study to Characterize the Long-Term Safety and Efficacy of BMS-986165 in Subjects with Moderate-to-Severe Plaque Psoriasis
This study looks at a new medicine called deucravacitinib for people with moderate to severe plaque psoriasis. It aims to see if it's safe and effective over a long period. This is a follow-up study for people who have already tried the medicine.
Moderate-to-Severe Plaque PsoriasisSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
This study looks at a new medicine called Evolocumab to see if it can lower the chance of serious heart problems like heart attacks or strokes in people at high risk who haven't had them before. It compares Evolocumab to a dummy medicine.
Adults at high risk of cardiovascular events without prior MI or stroke.Sweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Assess the Efficacy, Safety, Tolerability, PK, and Biomarker Effects of PTC857 in Adult Subjects With Amyotrophic Lateral Sclerosis (CARDINALS)
This study is testing a new medicine, PTC857, for people with Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neurone Disease. We want to see if it helps improve daily activities and how safe it is compared to a dummy medicine.
Amyotrophic Lateral SclerosisSweden - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, randomised, open label, multicentre study to evaluate efficacy and safety of an intraperitoneal α-emitting radionuclide therapy (Radspherin®) in patients with peritoneal carcinomatosis from colorectal carcinoma following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)
This study is testing a new treatment for bowel cancer that has spread to the tummy lining. It's for people who have already had surgery and chemotherapy. Researchers want to see if the new treatment, called Radspherin, can stop the cancer from growing back and if it's safe.
Carcinomatosis of peritoneal cavitySweden - AuthorisedTherapeutic use (Phase IV)
Studies to gain insight how the drugs PCSK9-inhibitors and statins affect cholesterol and bile acid metabolism
This study looks at how medicines like statins and PCSK9 inhibitors affect cholesterol and digestion in healthy men over 18. Doctors want to understand better how these drugs work to help treat high cholesterol.
Healthy volunteersSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants with Relapsed or Refractory Multiple Myeloma (RRMM) - ALUMMINATE RRMM
This study is testing a new medicine, Alnuctamab, for people in the UK with multiple myeloma whose cancer has come back or isn't responding to other treatments. Researchers want to see if Alnuctamab works better and is safer than current treatments, aiming to stop the cancer from growing for longer.
Relapsed and/or Refractory Multiple MyelomaSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Double-blind, Randomized, Active-control, Parallel Group Study to Assess the Pharmacokinetics, Pharmacodynamics, Immunogenicity, and safety of SAR447537 (INBRX-101) Compared to Plasma Derived Apha1-Proteinase Inhibitor (A1PI) Augmentation Therapy in Adults with Alpha-1 Antitrypsin Deficiency (AATD) Emphysema
This study compares a new medicine, INBRX-101, with standard treatment for Alpha-1 Antitrypsin Deficiency (AATD) emphysema. It looks at how the medicines work in the body, their effects, and if they are safe, to help people with this lung condition.
Alpha-1 Antitrypsin Deficiency (AATD) EmphysemaSweden - AuthorisedTherapeutic confirmatory (Phase III)
A randomized phase III study comparing trastuzumab, pertuzumab plus docetaxel (TPD) followed by 3 cycles of chemotherapy to the current standard regimen as the treatments of early HER2-positive breast cancer
This study looks at a new way to treat early breast cancer that is HER2-positive. It compares a combination of medicines (trastuzumab, pertuzumab, and docetaxel) to the usual treatment to see which is better at preventing the cancer from coming back.
breast cancerSweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 study to assess the efficacy and safety of 2 dosage regimens of oral fidrisertib (IPN60130) for the treatment of fibrodysplasia ossificans progressiva in male and female paediatric and adult participants.
This study is testing a new medicine, fidrisertib, for children and adults with Fibrodysplasia Ossificans Progressiva (FOP). We want to see if it can slow down the new bone growth and reduce flare-ups, and if it's safe to use. Some participants will receive a dummy pill (placebo).
Fibrodysplasia Ossificans ProgressivaSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled, parallel-group, 3-arm, multinational, multicenter study to evaluate the efficacy and safety of amlitelimab monotherapy by subcutaneous injection in participants aged 12 years and older with moderate-to-severe atopic dermatitis.
This study is testing a new medicine, amlitelimab, for moderate-to-severe eczema in people aged 12 and over. It compares amlitelimab to a dummy medicine (placebo) to see if it improves eczema symptoms like itching and skin clearing.
Dermatitis atopicSweden