Latest studies
- RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
This study is looking into a new medication called remibrutinib for people with a type of multiple sclerosis (MS) called Secondary Progressive MS (SPMS). It will check if the medicine is safe and helps slow down the disease.
Secondary Progressive Multiple Sclerosis (SPMS)India - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
This study is looking at a new medicine called AZ-3102 for children and young people with rare conditions like Niemann-Pick Type C, GM1 Gangliosidosis, or GM2 Gangliosidosis. It aims to see if the medicine is safe and if it helps improve their health over 18 months.
Niemann-Pick Type C DiseaseGM1 GangliosidosisGM2 GangliosidosisIndia - Active not recruitingPHASE3
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
This study looks at a new drug, astegolimab, for people with COPD who have flare-ups often. It compares the new drug to a dummy treatment (placebo) to see if it's safe and helps improve their breathing and reduce flare-ups.
Chronic Obstructive Pulmonary Disease (COPD)India - Active not recruitingPHASE3
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia With Inhibitors
This study looks at a new medicine called concizumab for haemophilia A or B with inhibitors. It aims to see if it can prevent bleeding and is safe. Some people will get the new medicine straight away, others later, all through daily injections at home.
Haemophilia A With InhibitorsHaemophilia B With InhibitorsIndia - Active not recruitingPHASE3
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
This study is looking into a new combination treatment for a type of breast cancer called triple-negative breast cancer (TNBC) that has spread or is advanced. It combines a new drug, Capivasertib, with a common chemotherapy, Paclitaxel, to see if it works better than just Paclitaxel alone.
Triple Negative Breast NeoplasmsIndia - Active not recruitingPHASE3
A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
This study is looking into a new combination of medicines for people in the UK with multiple myeloma that has come back or not responded to previous treatments. It compares a new medicine combination with a standard one to see if the new option works better.
Relapsed or Refractory Multiple MyelomaIndia - RecruitingPHASE2
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
This study is looking at a new medicine called iptacopan for people with active lupus nephritis, a kidney problem caused by lupus. It aims to see how well it works and if it's safe when added to standard treatments.
Lupus NephritisIndia - RecruitingPHASE3
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
This study looks at a new medicine called ziltivekimab for people with heart failure and inflammation. It aims to see if monthly injections of ziltivekimab can help, compared to a dummy medicine, over a few years.
Heart FailureIndia - Recruiting
Fabry Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Fabry disease over time, including pregnant women. It helps doctors better understand the disease and improve care, without giving any new treatments. It's about observing, not experimenting.
Fabry DiseaseIndia - Active not recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (PATHFNDR-2)
This study is testing a new medicine, paltusotine, for people with acromegaly, a rare condition causing too much growth hormone. It's a pill being compared to a dummy pill to see if it's safe and helps improve symptoms.
AcromegalyIndia - RecruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
ObesityOverweightIndia - Active not recruitingPHASE3
A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
This study looks at a new combination of drugs, ceralasertib and durvalumab, for people with advanced lung cancer that has grown after previous treatments. It compares this new combination to a standard chemotherapy drug, docetaxel, to see which works better and is safer.
Advanced or Metastatic Non-Small Cell Lung CancerIndia - RecruitingPHASE3
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
This study looks at a new drug, Surovatamig, combined with rituximab, for people with previously untreated follicular lymphoma. It compares this new combination therapy with standard treatments to see if it works better and is safe.
Untreated Follicular LymphomaIndia - Active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new combination treatment, JNJ-78934804, for people aged 18-65 with Crohn's disease that is moderate to severe. It compares this new treatment to existing medicines, guselkumab and golimumab, to see how well it works over 48 weeks.
Crohn's DiseaseIndia - Active not recruitingPHASE3
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This study is looking at two new drug combinations, amivantamab and lazertinib, compared to a standard drug, osimertinib, for people in the UK with advanced non-small cell lung cancer that has a specific genetic change (EGFR mutation).
Carcinoma, Non-Small-Cell LungIndia - Active not recruitingPHASE2
Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus
This study is looking into a new medication called ESK-001 for adults with an active form of lupus (SLE). We want to see if it's safe and helps improve symptoms compared to a dummy drug (placebo).
SLEIndia - RecruitingNA
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
This study looks at different ways of giving blood transfusions to younger patients (under 66) having heart surgery. It compares two common approaches to see which one is safer and more effective. The goal is to improve care for people undergoing these operations.
DisorderHeartPostoperativeCardiac SurgeryIndia - Active not recruitingPHASE3
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
This study is comparing a new medication called remibrutinib with an existing treatment, teriflunomide, for people with relapsing multiple sclerosis (RMS). It aims to see how well remibrutinib works and if it's safe to use in managing RMS symptoms.
Relapsing Multiple SclerosisIndia - Active not recruitingPHASE3
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
This study looks at new drug combinations for advanced bowel cancer that has spread and has a specific gene change (BRAF). It compares these new combinations with standard chemotherapy to see which works best for people who haven't had treatment for their spread cancer.
NeoplasmsIndia - RecruitingPHASE3
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
This study is looking at two different treatments, pumitamig and durvalumab, for people with a type of lung cancer called non-small cell lung cancer (NSCLC) that can't be removed by surgery. It's for patients who have already had chemotherapy and radiation.
Non-small Cell Lung Cancer (NSCLC)India - Active not recruitingPHASE3
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
This study is testing a new drug called ianalumab for people with lupus (SLE). It aims to see if ianalumab, given alongside usual lupus treatments, is safe and helps improve symptoms. It's for adults and some teenagers with active lupus.
Systemic Lupus ErythematosusIndia - Active not recruitingNA
PROSpect: Prone and Oscillation Pediatric Clinical Trial
This study looks at the best ways to help children with severe breathing problems (PARDS). It compares lying on the back or front, and two types of breathing machines, to see which helps children recover faster and spend less time on a ventilator.
Acute Respiratory Distress Syndrome in ChildrenIndia - Enrolling by invitationPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
This study is for cancer patients who have already been in another durvalumab drug trial and are still benefiting from the treatment. It lets them continue receiving the drug to see if it keeps helping them.
CancerIndia - Active not recruitingPHASE3
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
This study is testing a new medicine called BLU-5937 for adults with a stubborn, long-lasting cough that hasn't responded to other treatments. It aims to see if the medicine can reduce how often people cough, compared to a dummy pill.
CoughRefractory Chronic CoughIndia - Active not recruitingPHASE3
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
This study is looking at a medicine called semaglutide for a liver condition called non-alcoholic steatohepatitis (NASH). Participants will receive either semaglutide or a dummy medicine. It's a long study, lasting about 5 years, with regular clinic visits.
Non-alcoholic SteatohepatitisIndia - RecruitingPHASE3
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
This study looks at a new treatment called Pumitamig for advanced non-small cell lung cancer that hasn't been treated before. It compares Pumitamig to an existing treatment, Pembrolizumab, in people whose cancer cells have a high level of a specific marker called PD-L1.
Non-Small Cell Lung Cancer (NSCLC)India - RecruitingPHASE3
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
This study is testing a new drug, AZD2265, for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapy. We want to see if AZD2265 works better than current treatments at slowing down cancer growth and helping men live longer.
Metastatic Castration-resistant Prostate CancerIndia - Enrolling by invitationPHASE2, PHASE3
Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials
This study looks at a medicine called amlitelimab for moderate to severe eczema in people who've already tried it in other studies. We want to see how safe and effective it is over a long time, and if it continues to help.
Dermatitis AtopicIndia - Active not recruitingNA
SyncAV Post-Market Trial
This study looks at a special heart device for people with heart failure. We're testing if a new setting, called SyncAV ON, helps the device work better and improve the heart's function more than the usual settings.
Congestive Heart FailureIndia - RecruitingPHASE2
Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow
This study is for children and adults with a type of high-risk neuroblastoma that hasn't fully responded to previous treatments. It investigates a new approach using two medicines, Naxitamab and GM-CSF, to see if they can help manage the condition.
NeuroblastomaIndia - Active not recruitingPHASE3
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
This study looks at a new medicine called asciminib for adults with a type of blood cancer called CML. Researchers want to see if it works better than other standard CML treatments. It's for people recently diagnosed who haven't had treatment yet.
Chronic Myeloid Leukemia (CML) Philadelphia Chromosome PositiveIndia - Active not recruitingPHASE1, PHASE2
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
This study is looking at new combinations of medicines for HER2-positive breast cancer that has spread. It aims to see how safe and effective these combinations are in patients whose advanced breast cancer has come back or spread.
Metastatic Breast CancerIndia - Active not recruitingPHASE2, PHASE3
A Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma With Homozygous MTAP Deletion (MountainTAP-30)
This study is looking at a new drug, Navlimetostat, combined with standard treatment (Nab-paclitaxel and Gemcitabine) for pancreatic cancer that has spread. It's for people whose cancer has a specific genetic change called MTAP deletion, which the new drug targets.
Pancreatic Ductal AdenocarcinomaIndia - Recruiting
European and North Indian Cohort of KaWasaki dIsease
This study looks at Kawasaki disease in children across Europe and North India. Researchers want to better predict which children might not respond to standard treatment, aiming to improve how we care for their hearts and prevent serious heart problems later on.
Kawasaki DiseaseIndia - RecruitingPHASE3
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
This study is looking into a new medication called efruxifermin for people with a kind of liver disease called NASH/MASH and scarring (fibrosis). It's a large study where some people get the medication, and others get a dummy treatment, to see if it's safe and helps improve the liver condition.
NASH With FibrosisMASH With FibrosisIndia - Active not recruitingPHASE3
Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome
This study is testing a new medicine, ianalumab, for people with active Sjögren's syndrome. Researchers want to see if it's safe and helps improve symptoms. Participants will receive either the new medicine or a dummy medicine called a placebo.
Sjogren SyndromeIndia - Recruiting
Pompe Disease Registry Protocol
This registry tracks people with Pompe disease globally. It helps us understand the condition better, how it changes over time, and the effects of treatments. The goal is to improve care for everyone with Pompe disease.
Glycogen Storage Disease Type IIPompe DiseaseIndia - Active not recruitingPHASE3
A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)
This study looks at new treatments for a type of bladder cancer that hasn't spread into the muscle. It compares new drugs, TAR-200 (alone or with Cetrelimab), against the usual treatment, BCG, to see which works best and is safest.
Bladder CancerIndia - Active not recruitingPHASE3
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
This study looks at a new medicine called concizumab for people with haemophilia A or B without inhibitors. It aims to see how well it prevents bleeding and if it's safe. Participants will take the medicine daily, usually by injection under the skin, for up to 8 years.
Haemophilia A Without InhibitorsHaemophilia B Without InhibitorsIndia - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
This study is testing a new medicine, tezepelumab, for adults with moderate to very severe COPD. It wants to see if the medicine helps improve their breathing and overall health, and if it's safe to use.
Chronic Obstructive Pulmonary Disease (COPD)India - RecruitingPHASE3
A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
This study compares Elritercept with Epoetin Alfa for adults with a certain type of Myelodysplastic Syndrome (MDS) and anaemia. It checks if Elritercept reduces the need for blood transfusions and improves tiredness, while also looking at safety.
Myelodysplastic SyndromeAnemiaIndia - Active not recruitingPHASE3
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
This study is looking at a new medicine called Dato-DXd for advanced triple-negative breast cancer. It compares Dato-DXd with standard chemotherapy in patients who cannot have a specific type of immunotherapy. The aim is to see if Dato-DXd is better at shrinking tumours and helping people live longer.
Breast CancerIndia - Active not recruitingPHASE3
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
This study is looking into the long-term effects and safety of a medicine called mirikizumab for people with Crohn's disease. Participants have already taken part in a related study, and this new study will help us understand how the medicine works over a longer period.
Crohn's DiseaseIndia - RecruitingPHASE3
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is looking into a new medicine, BI 1291583, for people with bronchiectasis. It aims to see if this medicine can help reduce flare-ups, which are common with the condition. Participants will take a tablet daily and be monitored for up to 1 year and 8 months.
BronchiectasisIndia - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseIndia - Recruiting
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
This study looks at how well a stomach-shrinking procedure called Endoscopic Sleeve Gastroplasty (ESG) helps people lose weight and keep it off for five years or more. It aims to understand the long-term success of this treatment for obesity.
Obesity and Obesity-related Medical ConditionsWeight LossIndia - RecruitingPHASE4
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
This study looks at how different sodium levels in dialysis fluid affect people with advanced kidney disease. It compares two common sodium levels (137mmol/l and 140mmol/l) to see which might be better for preventing serious heart problems or death.
End-Stage Kidney DiseaseIndia - RecruitingPHASE3
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
This study is looking into a new medicine called ziltivekimab for people with heart failure and inflammation. It compares ziltivekimab to a dummy medicine (placebo) to see if it can help. The treatment you receive is chosen by chance, and the study will last up to 1 year and 4 months.
Heart FailureSystemic InflammationIndia - RecruitingPHASE3
An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia
This study looks at the long-term safety of a new medicine, KarXT, for people with schizophrenia whose current treatment isn't working well enough. It's for those who have already started in a previous related study.
SchizophreniaIndia - RecruitingPHASE2, PHASE3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
This study is looking at a new treatment called pumitamig, combined with chemotherapy, for people with advanced bowel cancer that hasn't been treated before. It's being compared to a standard treatment, bevacizumab with chemotherapy, to see which is safer and more effective.
Untreated, Unresectable, or Metastatic Colorectal CancerIndia