Latest studies
- RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseGeorgia - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseGeorgia - RecruitingPHASE3
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
This study is testing a new drug, rilvegostomig, against a standard treatment, pembrolizumab, for advanced lung cancer. It's for people whose cancer has spread and has high levels of a specific marker called PD-L1. The aim is to see which treatment works better and is safer.
Carcinoma, Non-Small Cell LungGeorgia - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
Ulcerative ColitisGeorgia - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
This study looks at a new combination of drugs, cabozantinib and atezolizumab, for men with prostate cancer that has spread and is no longer responding to hormone therapy. It compares this new combination with standard hormone treatments to see if it works better.
Metastatic Prostate CancerProstate AdenocarcinomaGeorgia - RecruitingPHASE2
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
This study is looking at a new medicine called AZD0901 for people with certain advanced cancers like stomach or pancreatic cancer. We want to see how safe it is, if it works, and how the body handles it, sometimes on its own and sometimes with other cancer drugs.
Gastric CancerGastroesophageal Junction CancerBiliary Tract CancerPancreatic Ductal AdenocarcinomaGeorgia - Active not recruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
Prostate CancerGeorgia - Active not recruitingPHASE3
Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma
This study is comparing two drug combinations for advanced melanoma skin cancer: fianlimab plus cemiplimab, and pembrolizumab. It aims to see which is more effective, what side effects occur, and how they affect adults and teenagers.
MelanomaGeorgia - Active not recruitingPHASE2
A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma
This study is looking at a new treatment called tislelizumab, sometimes combined with other medicines, for head and neck cancer that has come back or spread. The aim is to see if it can shrink tumours and if it's safe for patients.
Head and Neck Squamous Cell CarcinomaHead and Neck CancerGeorgia - Active not recruitingPHASE2
Study With Various Immunotherapy Treatments in Participants With Lung Cancer
This study is looking at new combinations of medicines for advanced lung cancer. It aims to see how well different immunotherapy treatments work together and how safe they are for patients. The goal is to find better ways to treat this type of lung cancer.
Advanced Non-Small Cell Lung CancerGeorgia - Active not recruitingPHASE3
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.
This study looks at the everyday safety and how well a drug called tolebrutinib is tolerated over a long time. It's for adults with different types of multiple sclerosis (MS) who have already been in earlier tolebrutinib studies.
Relapsing Multiple SclerosisSecondary Progressive Multiple SclerosisProgressive Relapsing Multiple SclerosisGeorgia - Enrolling by invitationPHASE3
Long-term Safety and Tolerability of Cenerimod in Adults With Systemic Lupus Erythematosus
This study looks at how safe and well a medication called cenerimod works over a long time (up to 3 years) for adults with lupus. Participants have already been in another study and will now receive cenerimod alongside their usual lupus treatments.
Lupus Erythematosus, SystemicGeorgia - RecruitingPHASE1, PHASE2
A Platform Study in Non-Small Cell Lung Cancer (NSCLC)
This study looks at new and existing treatments for advanced lung cancer (non-small cell type). Researchers are testing different drug combinations to see how safe and effective they are. It aims to find better ways to treat this condition.
Advanced or Metastatic Non-small Cell Lung CancerGeorgia - Active not recruitingPHASE3
Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis
This study is looking at a new medicine called batoclimab for adults with a condition called generalized Myasthenia Gravis (gMG). It wants to see how well it works and if it's safe. Participants will receive batoclimab or a dummy medicine (placebo) to see if it helps relieve their symptoms.
Generalized Myasthenia GravisGeorgia - Active not recruitingPHASE3
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
This study is testing a new medicine, barzolvolimab, for people with chronic spontaneous urticaria (CSU), also known as chronic hives. It aims to see if the medicine is safe and helps reduce hives better than a dummy medicine (placebo) for those whose current treatments aren't enough.
Chronic Spontaneous UrticariaGeorgia - Enrolling by invitationPHASE1
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
This study helps us understand the long-term safety of new treatments for certain cancers like leukemia and lymphoma. People who have already been in an earlier drug trial for these conditions will continue to be monitored to see how they respond over time.
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Non-HodgkinMyelodysplastic SyndromesGeorgia - Active not recruitingPHASE3
A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults
This study is testing a medicine called Dysport® for people who get chronic migraines. It aims to see if Dysport® can reduce how often and how bad migraines are, and if it's safe to use, compared to a dummy medicine.
Chronic MigraineGeorgia - RecruitingPHASE3
Study of OCTAPLEX in Patients With Acute Major Bleeding on DOAC Therapy With Factor Xa Inhibitor
This study is testing a medicine called OCTAPLEX for people experiencing serious bleeding while taking a specific type of blood thinner (Factor Xa inhibitor). Researchers want to see if OCTAPLEX can effectively stop the bleeding and if it's safe, comparing two different doses.
Acute Major BleedingGeorgia - RecruitingPHASE2
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
The APEX study is looking at a new medicine called TX000045 for people with high blood pressure in their lungs caused by a certain type of heart failure. It will compare two doses of the medicine against a dummy treatment to see if it helps.
Pulmonary HypertensionHeart Failure With Preserved Ejection FractionGeorgia - RecruitingPHASE3
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
This study looks at a new medicine called Mavorixafor for people with a blood condition called neutropenia. It aims to see if the drug can help reduce infections and increase white blood cells called neutrophils, which fight infections.
NeutropeniaGeorgia - Active not recruitingPHASE3
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
This study looks at the long-term safety of a medicine called filgotinib for adults with ulcerative colitis. It's for people who have already been in another filgotinib study. The main goal is to see if taking filgotinib over a longer time is safe.
Ulcerative ColitisGeorgia - Active not recruitingPHASE3
Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis
This study is looking at a new medicine called nemolizumab for people with moderate to severe eczema. It aims to understand how safe and effective the medicine is over a long period. Participants would have been in a previous nemolizumab study.
Moderate-to-Severe Atopic DermatitisGeorgia - RecruitingPHASE3
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
This study is testing a new combination of two medicines, calderasib and pembrolizumab, for a specific type of lung cancer. We want to see if this combination works better than current treatments for people with advanced non-small cell lung cancer that has a particular genetic change.
Non-small Cell Lung CancerGeorgia - RecruitingPHASE3
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
This study is testing a new medicine, Molnupiravir, to see if it can stop people at high risk of severe COVID-19 from becoming very ill. It's for people who can't take other COVID-19 treatments. We want to find out if it works better than a dummy treatment.
Coronavirus Disease (COVID-19)Georgia - RecruitingPHASE3
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
This study looks at a new inhaled medicine, called TPIP, for people with high blood pressure in the lungs due to scarring (PH-ILD). It wants to see if the medicine helps them walk further over 24 weeks compared to a dummy medicine.
Pulmonary HypertensionInterstitial Lung DiseaseGeorgia - RecruitingPHASE3
Study to Evaluate Subcutaneous (SC) VGA039 in Patients With Von Willebrand Disease (VWD)
This study is looking into a new medication called VGA039 for people with Von Willebrand Disease (VWD). It's a Phase 3 trial, meaning it's a later stage of research, testing if this medicine can safely and effectively reduce bleeding when given as an injection under the skin.
Von Willebrand Disease (VWD)Georgia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
This study is looking at a new medication, sotagliflozin, to see if it can help people with a heart condition called hypertrophic cardiomyopathy (HCM). It aims to find out if the drug improves symptoms and daily activities compared to a dummy pill.
Obstructive Cardiomyopathy, HypertrophicNon-obstructive Hypertrophic CardiomyopathyGeorgia - RecruitingPHASE3
Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)
This study is looking at new treatments for a type of lung cancer called limited-stage small cell lung cancer. It tests two new drugs, toripalimab and tifcemalimab, alone or together, after standard chemotherapy and radiation, to see if they can help stop the cancer from coming back.
Limited-stage Small Cell Lung Cancer (LS-SCLC)Georgia - Active not recruitingPHASE3
A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
This study is testing a new combination of medicines with chemotherapy for some upper gut cancers that have spread and can't be removed by surgery. It aims to see if the new combination works better than current treatments.
Advanced Upper Gastrointestinal Tract AdenocarcinomaGeorgia - RecruitingPHASE1
A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD)
This study is testing a new medicine called AIR-001 for adults with a genetic lung condition called Alpha-1 Antitrypsin Deficiency (AATD). Doctors want to see how safe it is and how the body handles different doses.
Alpha 1 Antitrypsin DeficiencyGeorgia - RecruitingPHASE3
A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer
This study looks at a new medicine called HLX22, combined with standard treatments, for people newly diagnosed with a certain type of stomach and food pipe cancer. It aims to see how well it works and if it's safe compared to current treatments.
Gastroesophageal-junction CancerMonoclonal AntibodyGastric CancerHER2-positive Gastric CancerGeorgia - RecruitingPHASE3
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
This study looks at adding a new medicine, navtemadlin, to an existing treatment, ruxolitinib, for people with myelofibrosis. It aims to see if this combination works better for those whose myelofibrosis isn't fully controlled by ruxolitinib alone.
MyelofibrosisPost-PV MFPost-ET MyelofibrosisPrimary MyelofibrosisGeorgia - RecruitingPHASE3
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
This study looks at a new medicine called survodutide for adults with a liver condition called NASH or MASH and scarring (cirrhosis). Participants will get either the medicine or a dummy treatment, along with diet and exercise advice, to see if it helps their liver.
Metabolic Dysfunction Associated SteatohepatitisGeorgia - RecruitingPHASE3
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
This study looks at a long-term treatment called nerandomilast for people with pulmonary fibrosis. It's for those who've used it in a past study. We'll see how safe and effective it is over time, checking if it helps lung function and slows down the disease.
Idiopathic Pulmonary FibrosisProgressive Pulmonary FibrosisGeorgia - Active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
This study is looking into a new treatment called Rosnilimab for people in the UK with moderate to severe ulcerative colitis. It aims to see how safe and effective it is compared to a dummy treatment.
Ulcerative ColitisGeorgia - Active not recruitingPHASE3
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis Naive to Biologic Disease-Modifying Antirheumatic Drug
This study is looking at a new medicine called sonelokimab for people with psoriatic arthritis who haven't tried powerful biologic drugs before. It wants to see if sonelokimab is safe and helps improve their arthritis and skin.
Arthritis, PsoriaticGeorgia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
This study is looking at a new medicine called fenebrutinib for people with relapsing multiple sclerosis (RMS). It wants to see if fenebrutinib is safe and works better than an existing medicine, teriflunomide, at slowing down the disease and reducing flare-ups.
Relapsing Multiple SclerosisGeorgia - Not yet recruitingPHASE2
A Study to Assess the Safety, Pharmacokinetics, and Efficacy of ABI-6250 in Participants With Chronic Hepatitis D Virus Infection
This study is looking at a new medicine called ABI-6250 for people with chronic hepatitis D (HDV) infection. Researchers want to see if it's safe, how it works in the body, and if it helps treat the infection. It's a Phase 2 trial, meaning it's still in the earlier stages of testing.
Chronic Hepatitis D InfectionGeorgia - RecruitingPHASE2, PHASE3
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
This study is testing a new drug called pumitamig, combined with usual chemotherapy and other drugs, for people with a type of lung cancer called non-small cell lung cancer. It aims to see if this new combination is safe and works well.
Non-small Cell Lung CancerGeorgia - RecruitingPHASE2
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus
This study is testing a new medicine, VENT-03, for adults with a skin condition called cutaneous lupus (CLE), who may also have systemic lupus (SLE). Researchers want to see if VENT-03 helps reduce symptoms and if it's safe.
Cutaneous Lupus Erythematosus (CLE)Systemic Lupus ErythematosusSLESLE (Systemic Lupus)Georgia - Active not recruitingPHASE3
Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)
This study compares a new medicine, ABP 692, with an existing one, Ocrevus, for people with a type of multiple sclerosis (RRMS). It checks if special brain scans and how the medicines act in the body are similar, aiming to offer another treatment option.
Relapsing-remitting Multiple Sclerosis (RRMS)Georgia - RecruitingPHASE3
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
This study is looking into a new medication called EPX-100 (clemizole hydrochloride) for children and adults with Dravet syndrome. It aims to see if this medicine can help control seizures and is safe to use alongside their current treatments.
Dravet SyndromeGeorgia - RecruitingPHASE1
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies
This study is testing a new medicine called EXS73565 for people with certain types of B-cell cancers that have come back or not responded to usual treatments. We want to find a safe dose and see how it works.
Relapsed or Refractory B-cell MalignanciesChronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)Follicular Lymphoma (FL)Marginal Zone Lymphoma (MZL)Georgia - Active not recruitingPHASE2
A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
This study is looking at a new drug combination for lung cancer that can be removed by surgery. It aims to see if adding Fianlimab to standard treatment (Cemiplimab and chemotherapy) works better and is safe for adults with certain types of non-small cell lung cancer.
Resectable Non-small Cell Lung CancerGeorgia - RecruitingPHASE3
Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis
This study is testing a new medicine, IMVT-1402, for adults with a condition called myasthenia gravis. The aim is to see if it's safe and helps improve daily life for those with mild to severe symptoms.
Generalized Myasthenia GravisGeorgia - Active not recruitingPHASE1
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This study is testing new ways to give medicines called niraparib and abiraterone acetate for men with advanced prostate cancer. Researchers want to see how well different forms of these drugs are absorbed by the body to help patients get the best treatment.
Prostatic NeoplasmsGeorgia - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
This study is testing a new medicine called empasiprubart for adults with a nerve condition called CIDP. It wants to see if the medicine is safe and helps people feel better. Participants will get the study medicine or a dummy medicine first, then everyone will get the study medicine.
Chronic Inflammatory Demyelinating PolyneuropathyCIDPChronic Inflammatory Demyelinating PolyradiculoneuropathyGeorgia - Active not recruitingPHASE3
RZ358 Treatment for Congenital Hyperinsulinism
This study is testing a new medicine, RZ358, for children and adults with congenital hyperinsulinism (CHI). This condition causes very low blood sugar. The study will see how well RZ358 works to control blood sugar and if it's safe, compared to current treatments alone.
Congenital HyperinsulinismGeorgia - Active not recruitingPHASE3
A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
This study looks at a new injection called efgartigimod for adults with primary immune thrombocytopenia (ITP). It aims to see how safe and effective it is. If you've been in a previous study for this treatment, you might be able to continue.
Primary Immune ThrombocytopeniaGeorgia - RecruitingPHASE3
Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)
This study is testing a new medicine, cladribine, in pill form for people with a muscle weakening condition called myasthenia gravis. We want to see if it helps and if it's safe compared to a dummy pill. We're also looking at its long-term effects and how the body uses the medicine.
Generalized Myasthenia GravisGeorgia