Latest studies
- RecruitingPHASE2, PHASE3
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
This study looks into new treatments for a rare, inherited form of Alzheimer's disease. Researchers want to see if these drugs can stop or slow down the disease in people who are at high risk or in the very early stages, based on their family history and genes.
Alzheimers DiseaseDementiaAlzheimers Disease, FamilialNetherlands - Active not recruitingPHASE3
A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)
This study compared two oral medications, asciminib and nilotinib, for adults newly diagnosed with a type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (CML). It looked at how well people tolerated each drug.
Philadelphia Chromosome-Positive Chronic Myeloid LeukemiaNetherlands - AuthorisedTherapeutic confirmatory (Phase III)
An International, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Trial on the Effects of EA-230 on the Length of Hospital Stay Following On-Pump Coronary Artery Bypass Grafting Surgery
This study is testing a new medicine, EA-230, to see if it helps people recover faster after heart bypass surgery. Doctors want to know if it can shorten the time people need to stay in hospital after their operation.
Coronary artery diseaseNetherlands - RecruitingPHASE4
Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients
This study compares different ways to treat people who have had a severe heart attack (STEMI). It looks at whether a shorter course of anti-clotting medicine (prasugrel) followed by just one anti-clotting medicine is as safe and effective as the usual longer course.
ST Elevated Myocardial InfarctionDual Antiplatelet TherapyNetherlands - RecruitingPHASE2
Study of Olutasidenib and Temozolomide in HGG
This study is for young people aged 12-39 with a type of brain tumour called high-grade glioma (HGG) that has a specific IDH1 gene change. It tests if a new drug, olutasidenib, combined with standard treatment, can help patients live longer after radiotherapy.
High Grade GliomaAstrocytomaAstrocytoma, Grade IIIAstrocytoma, Grade IVNetherlands - RecruitingPHASE3
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
This study looks at a new medicine called etavopivat for people with sickle cell disease. It aims to see if it reduces painful crises, organ damage, and tiredness, and improves exercise. Participants will get either the medicine or a dummy pill.
Sickle Cell DiseaseNetherlands - Enrolling by invitationPHASE3
A Long-Term Study of Navenibart in Participants With Hereditary Angioedema
This study looks at a new medicine called navenibart for people with hereditary angioedema (HAE). It checks how safe and effective it is over a long time. Only people who were in a previous study with this medicine can join.
Hereditary Angioedema (HAE)Netherlands - Active not recruitingPHASE3
Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab
This study looks at the long-term safety and effects of a medicine called apitegromab for people with Spinal Muscular Atrophy (SMA) types 2 and 3. It's for those who have already completed earlier studies with this drug.
Spinal Muscular AtrophySpinal Muscular Atrophy Type 3Spinal Muscular Atrophy Type 2SMANetherlands - RecruitingPHASE2
A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF
This study is testing a new inhaled medicine, RCT2100, for cystic fibrosis. It will first check if it's safe for healthy people, then for people with CF, sometimes alongside other CF treatments. We aim to understand its safety and how the body handles it.
Cystic FibrosisNetherlands - Active not recruitingPHASE3
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
This study compares a new treatment, Belantamab Mafodotin, with a common combination treatment (Pomalidomide and Dexamethasone) for Multiple Myeloma that has returned or not responded well to past treatments. It aims to see which treatment works better and is safer.
Multiple MyelomaNetherlands - Active not recruiting
ADH1 and ADH2 Disease Monitoring Study (DMS)
This study looks at how Autosomal Dominant Hypocalcemia (ADH types 1 and 2) affects people over time. It aims to understand the condition and how current treatments are used in real life for both children and adults.
Autosomal Dominant HypocalcemiaNetherlands - Active not recruitingNA
Clinical Study to Predict the Risk of Bone Fractures With the POROUS Ultrasound Device
This study looks at a new ultrasound scanner, called POROUS, to see if it can better predict bone breaks, especially in older adults. It compares POROUS with the usual X-ray scan (DXA) to help improve how we find and treat weak bones.
HealthyOsteopeniaOsteoporosisNetherlands - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
This study looks at a new drug, divarasib, for advanced lung cancer with a specific genetic change (KRAS G12C). It compares divarasib to existing treatments, sotorasib or adagrasib, to see how well they work and if they are safe.
Non-Small Cell Lung CancerKRAS G12C Lung CancerNetherlands - Active not recruitingPHASE3
Efficacy and Safety Study of bb2121 Versus Standard Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
This study looks at a new treatment, bb2121, for multiple myeloma that has come back or isn't responding to common medicines. It compares bb2121 with standard treatments to see which works best and is safest for patients aged 18 and over.
Multiple MyelomaNetherlands - Active not recruitingPHASE3
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
This study looks at new treatments for ovarian cancer that has come back and is resistant to platinum-based chemotherapy. It combines existing drugs like paclitaxel and bevacizumab with a new drug called pembrolizumab, hoping to stop the cancer from growing for longer.
Ovarian CancerCarcinoma, Ovarian EpithelialFallopian Tube NeoplasmsNetherlands - Active not recruitingPHASE3
A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids
This study is for adults with a blood condition called ITP who haven't improved with steroid treatment. It's testing a new drug called ianalumab, given with another drug called eltrombopag, to see if it can help keep blood platelet levels stable and safe for longer.
Primary Immune ThrombocytopeniaNetherlands - Enrolling by invitationNA
PIECES - Towards Large-Scale Adaptation and Tailored Implementation of Primary Cancer Prevention Programs
This study is testing an online toolkit to help groups better deliver programmes that stop cancer before it starts. It aims to make these prevention programmes more effective and reach more people across different countries.
Focus of Study: Tailored ImplementationNetherlands - RecruitingPhase I/II
A 2-part, randomized, double-blind, placebo-controlled study in participants with Duchenne muscular dystrophy amenable to exon 45 skipping to evaluate the safety and efficacy of ENTR-601-45 (ELEVATE-45)
This study, ELEVATE-45, is testing a new medicine called ENTR-601-45 for Duchenne muscular dystrophy (DMD). It aims to see if it's safe, what side effects it has, and if it helps by increasing a muscle-building protein called dystrophin in boys and young men aged 4-20.
Duchenne muscular dystrophyNetherlands - RecruitingPhase II
A study of JNJ-90301900 in combination with chemoradiation followed by consolidation immunotherapy for non-small cell lung cancer (NSCLC)
This study is testing a new drug, JNJ-90301900, for a type of advanced lung cancer that can't be removed by surgery. It aims to see if adding this drug, along with standard chemotherapy and radiation, can improve treatment results and is safe for patients.
Locally advanced and unresectable Stage III non-small cell lung cancerNetherlands - Active not recruitingPHASE3
A Study to Test the Long-term Treatment of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa
This study looks at the long-term safety of a treatment called bimekizumab for people with moderate to severe hidradenitis suppurativa (HS). It builds on earlier studies to see how well the treatment works and if it's safe over a longer period.
Hidradenitis SuppurativaNetherlands - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseNetherlands - AuthorisedHuman Pharmacology (Phase I)- Other
Mass Balance and Absolute Oral Bioavailability of [14C]VH4524184
This early-stage study is looking at a new medicine called VH4524184 for people with HIV. It checks how the body takes in, uses, and gets rid of the medicine to understand it better. This helps scientists develop safer and more effective treatments for HIV.
human immunodeficiency virus (HIV)Netherlands - Active not recruitingPHASE1
A Study Evaluating the Safety and Tolerability of QRL-201 in ALS
This study is looking at a new medicine called QRL-201 for people with Amyotrophic Lateral Sclerosis (ALS). Researchers want to see if it's safe and how well people tolerate different doses. It's an early-stage study to understand the medicine better.
Amyotrophic Lateral SclerosisNetherlands - Active not recruitingPHASE1, PHASE2
Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant Recipients
This study looks at a new treatment called TX200-TR101 for people getting a kidney transplant from a living donor. It aims to help the body accept the new kidney and prevent it from being rejected. Researchers want to check if it's safe and how well it works.
Kidney Transplant RejectionEnd Stage Renal DiseaseNetherlands - RecruitingPHASE2
Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder
This study is looking at a new medicine called inebilizumab for children and teenagers aged 2-17 with a rare condition called Neuromyelitis Optica Spectrum Disorder (NMOSD). It will check how the medicine works, how safe it is, and what effects it has on the body.
Neuromyelitis Optica Spectrum DisorderNetherlands - Not yet recruitingPHASE3
A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia
This study is looking at how a new medicine, Xanomeline/Trospium (XT), affects thinking and memory in adults with schizophrenia over one year. XT is already approved for treating other symptoms but this study focuses on cognitive benefits.
Schizophrenia; PsychosisCognitive ImpairmentNetherlands - Active not recruitingPHASE2
A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis
This study looks at new drug combinations for a serious condition called AL amyloidosis, which affects the heart. We want to see how safe these treatments are for the heart and how they work in different people, especially those from diverse backgrounds.
AmyloidosisNetherlands - RecruitingPHASE2
A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
This study is testing a new medicine, LY4005130, for severe alopecia areata (hair loss). We want to see how well it helps hair grow back compared to a dummy treatment, and what side effects it might have.
Alopecia AreataNetherlands - Recruiting
E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
The E²-RADIatE study is collecting information from cancer patients across Europe who are having radiotherapy. This helps researchers better understand how radiotherapy is used and how it works alongside other treatments to improve care for people with cancer.
CancerNetherlands - RecruitingPHASE1
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
This study is testing a new drug, PF-08046054/SGN-PDL1V, alone and with an existing medicine called pembrolizumab, for various advanced cancers. Researchers want to see how safe it is and if it has any effect on the cancer. It's a very early stage study.
Carcinoma, Non-Small-Cell LungSquamous Cell Carcinoma of the Head and NeckEsophageal Squamous Cell CarcinomaTriple Negative Breast NeoplasmsNetherlands - Recruiting
A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older
This study looks at how well a computer program, called Osteo Signal, can spot signs of osteoporosis (weak bones) using old chest X-rays. It compares the results from the program to usual bone density scans (DXA). No new tests or procedures are needed for this study; it uses existing patient information.
Osteoporosis, OsteopeniaNetherlands - RecruitingPHASE1
First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)
This study tests a new treatment, BAY3563254, for advanced prostate cancer that has spread and no longer responds to usual hormone therapy. It aims to find a safe dose and see how well it works by targeting cancer cells with radiation.
Advanced Metastatic Castration-resistant Prostate CancerProstate Specific Membrane Antigen (PSMA) ExpressionNetherlands - Active not recruitingPHASE2
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)
This study is looking into a new treatment called sotatercept for pulmonary arterial hypertension (PAH). It's an extension of a previous study. The main aim is to see if sotatercept, given in doses based on weight groups, is safe and can be tolerated by people with PAH over a longer time.
Pulmonary Arterial HypertensionNetherlands - RecruitingPHASE2
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
This study is looking into a new medicine, Tovorafenib, for children and young adults aged 6 months to 25 years in the UK. It focuses on those with specific types of brain tumours (low-grade glioma) or advanced solid tumours that have come back or gotten worse, especially if they have certain genetic changes.
Low-grade GliomaAdvanced Solid TumorNetherlands - RecruitingPHASE2
A Study With CIT-013 in HS Patients
This study is testing a new medicine called CIT-013 for adults with Hidradenitis Suppurativa (HS), a skin condition. Researchers want to see if CIT-013 helps reduce HS symptoms and if it's safe. It's a Phase 2 trial comparing different doses of CIT-013 to a dummy medicine.
Hidradenitis Suppurativa (HS)Netherlands - Active not recruitingPHASE1, PHASE2
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia
This study is testing a new medicine called Bosutinib for children and teenagers (1-17 years old) with a type of blood cancer called Philadelphia chromosome-positive Chronic Myeloid Leukemia (CML). It aims to find the right dose and see how safe and effective it is.
Philadelphia Chromosome Positive CMLAccelerated Phase Chronic Myelogenous LeukemiaBlastic Phase Chronic Myelogenous LeukemiaChronic Phase Chronic Myelogenous LeukemiaNetherlands - Active not recruitingPHASE1
A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies
This study is looking into a new treatment called KQB198 for blood cancers in adults. Researchers want to see if KQB198 is safe and if it can help shrink tumours, either by itself or with another medicine. They are also trying to find the best dose.
Hematologic MalignanciesAdultNetherlands - Enrolling by invitationPHASE3
Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older
This study is looking at a new medicine called VNZ/TEZ/D-IVA for people with cystic fibrosis, aged one year and older. It wants to see how safe and effective it is over a long time for those who have already been in a related study.
Cystic FibrosisNetherlands - AuthorisedTherapeutic exploratory (Phase II)
A phase II, multicenter, open-label, single arm study to evaluate the safety and efficacy of asciminib in pediatric participants newly diagnosed or previously treated with Philadelphia positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP) with or without known T315I mutation
This study is looking at a new medicine, asciminib, for children and young people with a specific type of blood cancer called Philadelphia positive Chronic Myeloid Leukaemia (CML). It aims to see how safe and effective it is in helping their leukaemia go into remission.
Philadelphia positive Chronic Myeloid leukemia in Chronic Phase with newly diagnosed and resistant/intolerant to previous TKIs, with or without the T315I mutationNetherlands - RecruitingPHASE1, PHASE2
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed
This study is testing a new medicine, GSK5764227, for advanced bowel or pancreatic cancer that can't be removed by surgery. It will check how safe and effective it is, and how the body handles it in people who have already had other treatments.
Gastrointestinal NeoplasmsNetherlands - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Efficacy and Safety Study Comparing Orelabrutinib to Placebo in Patients With Primary Progressive Multiple Sclerosis
This study is testing a new medicine, orelabrutinib, for people with a type of multiple sclerosis called Primary Progressive MS (PPMS). We want to see if it can slow down the worsening of symptoms compared to a dummy pill (placebo).
Primary Progressive Multiple Sclerosis (PPMS)Netherlands - RecruitingPHASE2
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
This study looks at new treatments for advanced stomach or oesophageal cancer with a specific protein called HER2. We're testing a new drug, trastuzumab deruxtecan, by itself or with other common cancer medicines to see if it's safe and effective.
Gastric CancerNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A two part, randomized, participant and investigator-blinded, 2-arm, parallel-design, placebo-controlled study to evaluate the safety, tolerability and preliminary efficacy of NGI226 microparticles on tendon regeneration in patients with Achilles tendinopathy
This study is looking into a new treatment called NGI226 for Achilles tendinopathy, a painful heel condition. We want to see if it's safe, how well people tolerate it, and if it helps regenerate tendons. It's an early-stage study.
Achilles TendinopathyNetherlands - RecruitingPHASE3
Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)
This study, called NIAGARA-2, is looking at a new way to treat bladder cancer that has grown into the muscle. It combines a drug called durvalumab with standard chemotherapy, given before and after surgery. The aim is to see if this combination improves treatment.
Urinary Bladder NeoplasmsImmune Checkpoint InhibitorsMethotrexateVinblastineNetherlands - Completed
Studying how lomitapide treatment affects the risk of serious heart problems in people with a rare inherited high cholesterol condition
This study looks at how a medicine called lomitapide affects serious heart problems in adults with a rare inherited high cholesterol condition called HoFH. It uses existing health records and follows patients for three years to understand its long-term effects.
MACE in patients with familial hypercholesterolemiaNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Effects of NT-0796 in Healthy Volunteers and Patients with Parkinson’s Disease
This study is looking for healthy volunteers and people with Parkinson's disease. Researchers want to see how a new medicine, called NT-0796, works in the body and if it's safe. It's an early-stage study to understand the medicine better.
Parkinson's DiseaseNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A single and multiple ascending dose study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZP-3813, a growth hormone antagonist, in healthy subjects
This early-stage study is looking at a new medicine called AZP-3813 for a condition called acromegaly. Researchers want to see if it's safe, how the body handles it, and if it has the desired effects in healthy people who don't have acromegaly yet. It's the first time it’s been given to humans.
AcromegalyNetherlands - Ongoing, recruitingPhase III and phase IV (Integrated)
L-NAC for reversal of opioid-induced respiratory depression
This study is looking at a medicine called L-NAC to see if it can help people who have breathing problems after receiving strong pain medication like fentanyl. It aims to find out if L-NAC can help them breathe more easily and safely. Participants will be healthy volunteers.
none, healthy subjects onlyNetherlands - RecruitingPhase III
European preparedness platform to treat and prevent respiratory syncytial virus infections in pregnant women and infants
This study looks at new ways to protect babies from a common chest infection called RSV. We're testing if giving a vaccine to pregnant mothers, or an injection to their baby, or both, works best. This helps ensure new medicines are safe and effective for mums and babies.
Respiratory syncytial virus (RSV) in infantsNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Single-Blind, Placebo-Controlled, Fixed-Sequence Design Trial to Evaluate the Photoparoxysmal Electroencephalogram Response, Safety, Tolerability, and Pharmacokinetics of PRAX-628 in Participants with Epilepsy and a Photoparoxysmal Electroencephalogram Response to Intermittent Photic Stimulation
This study is testing a new medicine, PRAX-628, for people with epilepsy whose brains show certain changes when exposed to flashing lights. We want to see if the medicine can stop these brain changes and if it's safe to use.
IPS induced photoparoxysmal electroencephalogram response (IPS-induced PPR) in participants with epilepsy and IPS-induced PPRNetherlands