Latest studies
- RecruitingNot Applicable
Vagus nerve stimulation for epilepsy in children and adults: assessment of longer term clinical and cost effectiveness in a randomised controlled trial
This study looks at how well a treatment called Vagus Nerve Stimulation (VNS) works for children and adults with epilepsy that hasn't responded to other medicines. We want to understand its long-term benefits and if it helps people with learning difficulties.
EpilepsyScotland - Recruiting
Protein engineering to design better enzyme replacement therapies for Fabry disease
Researchers are developing new treatments for Fabry disease using AI. This study aims to test these new enzymes in blood and urine samples to see if they cause fewer immune reactions than current treatments. It’s for people with Fabry disease over 16.
Fabry diseaseScotland - Recruiting
Specimen collection study for diagnostic test development
This study collects blood samples to help develop new, faster diagnostic tests for various health conditions like heart disease, diabetes, and infections. It aims to make future medical tests better and more efficient for patients and the NHS.
Patients presenting with symptoms of the areas of interest embolisms, infection or inflammation, cardiometabolic (includes heart failure, cardiovascular disease, myocardial infarction, diabetes) and renal cohortsScotland - Recruiting
A study to see if earlier and more hormonal testing can detect problems sooner in patients who have had radiotherapy treatment for brain tumours
This study checks hormone levels more often after brain tumour radiotherapy. By testing every four months, doctors hope to spot and treat hormone problems earlier, which could improve long-term health. It's for people aged 25 or under who've had specific brain radiotherapy.
Tumour of the central nervous system where 10Gy or more radiotherapy has been received to the hypothalamus or pituitary glandScotland - Recruiting
Genicular embolisation for knee osteoarthritis
This study explores a new treatment called genicular artery embolisation (GAE) for ongoing knee pain from osteoarthritis. It aims to see if blocking small blood vessels in the knee can reduce pain for people who haven't found relief from other treatments but aren't ready for surgery.
Knee osteoarthritisScotland - Recruiting
Drug-coated balloon (Sequent Please Neo) vs drug-eluting stent treatment for acute ST-elevation myocardial infarction: a randomised trial
This study compares two ways to treat a heart attack: a special balloon (drug-coated balloon) or a small tube (drug-eluting stent). Both aim to keep the heart artery open. We want to see if the balloon treatment is just as good, or even better, over several years.
Acute ST-elevation myocardial infarctionScotland - Recruiting
Assessing airway twitchiness in patients with severe asthma on biologics as they reduce their inhaled corticosteriod dose
This study looks at whether people with severe asthma using new biologic medicines (dupilumab or tezepelumab) can safely lower their steroid inhaler dose. We want to see if the biologic can control asthma twitchiness well enough to reduce steroid use and its side effects.
Severe asthma patient on either dupilumab or tezepelumabScotland - Completed
Promoting personhood in social care
This study looks at how people with learning disabilities feel seen and supported in social care. It involves talking to people with learning disabilities, their carers, and staff to find ways to make support better and more personal. The goal is to improve how social care helps people feel valued as individuals.
Person-centred support and people with learning disabilitiesScotland - CompletedPhase I
A healthy volunteer study of MOS-118 nasal spray
This study is testing a new nasal spray, called MOS-118, for obstructive sleep apnoea. It's a first-stage study in healthy volunteers to check how safe it is, how well the body handles it, and how it moves through the nose and throat. The aim is to find a new way to treat sleep apnoea.
Obstructive sleep apnoeaScotland - Completed
How do we define and identify high-risk surgical patients
This study looks at how patients and doctors view the idea of being 'high-risk' for planned surgery. It wants to improve how we identify and care for patients before operations like bowel or pancreas surgery, making sure their experiences and concerns are better understood.
Patients' and clinicians' perceptions of label of 'high-risk' in context of elective general surgery.Scotland - Recruiting
DRAGON: Are reusable surgical drapes and gowns as good as disposable surgical drapes and gowns at increasing days alive and at home after surgery?
This study compares reusable and disposable surgical drapes and gowns to see if reusable options are just as safe and effective, aiming to make operations more environmentally friendly. It's part of a bigger effort to reduce the NHS's carbon footprint.
Patients (adults) undergoing elective or emergency surgery with at least one incision ≥5 cm in adults and a clean-contaminated, contaminated or dirty wound, in NHS hospitals where there is equipoise to use either disposable or reusable drapes and gowns.Scotland - Recruiting
Testing a digital, comprehensive, standardised assessment approach to improve the management of people with cancer
This study is testing a new digital tool called MyPath to help people with cancer. It lets patients record their symptoms on a phone or tablet, so doctors can better understand how they are feeling and give more personalised care. The aim is to make cancer treatment better for everyone.
CancerScotland - Completed
Imaging technologies for the detection of breathing infection in patients on breathing machines in the intensive care unit
This study looks at new cameras and liquids to find lung infections quickly in very sick patients on breathing machines. It aims to help doctors give the right treatment sooner.
Characterisation of pulmonary infiltrates in medically ventilated participants in the Intensive Care UnitScotland - CompletedNot Applicable
Identifying lung disease by using novel imaging techniques
This study is testing new camera tools, Eyes on Target (EoT1) and KronoScan (KC.02), to help doctors see deeper inside the lungs during routine lung exams. The goal is to improve how doctors find and sample lung problems, especially lung cancer, to get a quicker and more accurate diagnosis.
Lung cancerScotland - RecruitingPhase II
Research study for people who have cerebral small vessel disease (cSVD, damaged small blood vessels in the brain) and a stroke, which may lead to impaired memory and thinking and then dementia
This study looks for new ways to treat people who've had a stroke and also have damaged tiny blood vessels in their brain. We're testing two existing drugs, cilostazol and isosorbide mononitrate, to see if they can help prevent memory and thinking problems that can sometimes lead to dementia after a stroke.
Clinical syndrome of cortical or large subcortical stroke or TIA (TACS, PACS or cerebellar POCS)Scotland - Completed
Sex workers evaluate reporting violence
This study looks at how National Ugly Mugs (NUM), a service for sex workers, helps improve safety and mental health. It explores how NUM's alerts and support services work to prevent violence and assist survivors, with sex workers closely involved in the research.
Violence prevention and survivor support for and by sex workersScotland - Recruiting
Safety and autonomy for everyone at Home. Understanding safety, risks and harm-benefit balances arising from home-based care.
This study wants to make care at home safer for older people. Researchers will review existing information and talk to care workers and people receiving care to understand how to improve home care and find out what works best. It aims to help make home care better for everyone.
Care received at home, focusing on older adults (>60 years old).Scotland - RecruitingPhase III
Evaluation of intravenous therapy (i.e. injection into the vein) in asthma
This study looks at which injection works best for children and young people with severe asthma attacks. Doctors want to find out if aminophylline, magnesium sulphate, or salbutamol is the most effective and acceptable treatment to help them breathe better.
Severe acute asthmaScotland - Recruiting
PCN-CRP: a programme for improving the prediction and prevention of preterm birth and women’s experience of care
This study aims to understand and prevent premature births. It's collecting health information from pregnant women at risk, combining it with other studies to find better ways to predict, stop, and improve care around early births for families in the future.
Prediction and prevention of preterm birthScotland - Recruiting
A study to see whether the lungs of very sick patients on an artificial lung machine heal more quickly with slower, deeper breathing
This study looks at how different breathing settings on a ventilator help very unwell patients with severe lung problems (ARDS) while they are supported by a special machine called ECMO. We want to see if letting the lungs rest more helps them heal faster.
Acute respiratory distress syndrome (ARDS)Scotland - Recruiting
Can eye imaging in pregnancy help predict stillbirth?
This study looks at whether pictures of blood vessels at the back of the eye during pregnancy could help identify babies at risk of stillbirth. Researchers want to better understand stillbirth and improve early detection methods to help pregnant women and their babies.
Stillbirth and pregnancy complications linked to stillbirth risk (pre-eclampsia and fetal growth restriction)Scotland - Recruiting
Preventing miscarriage through platform testing of multiple novel interventions
This study looks at whether taking omega-3 (DHA) supplements can help prevent miscarriage in women who have had two or more miscarriages. Researchers want to see if different doses of DHA can increase the chance of a baby being born healthy and later in pregnancy.
Medical condition: Miscarriage Medical condition in lay language: Miscarriage Therapeutic areas: Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]Scotland - RecruitingPhase III
STEPFORWARD: A comparison between usual care “rigid” prosthetic feet and hydraulic “flexible” feet for quality of life in patients with a below-knee amputation who have limited mobility
This study compares standard prosthetic feet with newer flexible feet for people with a below-knee amputation and limited mobility. It aims to see if the flexible feet improve comfort, safety, and quality of life, helping the NHS decide if they should be offered more widely.
Patients with a below-knee amputation categorised as having limited mobilityScotland - Recruiting
Care of people at the end of their lives in the rural and coastal communities of the South West Peninsula of England
This study aims to improve end-of-life care in rural and coastal areas of Devon, Cornwall, and Somerset. It involves talking to patients, families, and professionals to understand current care and find ways to make it better for everyone involved.
People at the end of life, family members and professionalsScotland - Recruiting
Understanding visual processing differences using short video tasks in adults with cerebral visual impairment
This study looks at how adults with a vision condition called Cerebral Visual Impairment (CVI) see and understand short everyday videos. We want to compare this to people with typical vision to better understand CVI and find ways to help in the future.
Cerebral visual impairment (CVI)Scotland - Recruiting
Fix or replace enhancing distal humerus fracture outcomes
This study compares two common surgeries for broken elbows in people over 60: elbow replacement or fixing the break with plates and screws. It aims to find which treatment works best to help people recover and use their arm normally again.
Intra-articular fracture of the distal humerus AO type B or CScotland - Completed
Exploring biomarkers of mucosal inflammation in paediatric Crohn’s disease (Mini-MUSIC)
The Mini-MUSIC study looks at children and young people (6-17) in Scotland with Inflammatory Bowel Disease (IBD). We're trying to find new ways to check gut inflammation using blood, stool, and saliva tests, hoping to avoid frequent endoscopies.
Paediatric inflammatory bowel diseaseScotland - Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthScotland - Recruiting
Pelvic floor muscle exercises plus pessary for treatment of prolapse versus pelvic floor muscle exercises alone
This study looks at combining pelvic floor exercises with a vaginal pessary for women with pelvic organ prolapse. It wants to see if this combined approach works better at reducing symptoms than just doing the exercises alone, helping to improve women's daily lives.
Pelvic organ prolapseScotland - CompletedPhase II
The purpose of the trial is to test the safety, tolerability and efficacy of the drug tildacerfont, that is being developed for the treatment of major depressive disorder
This study is testing a new drug called tildacerfont for moderate to severe depression. It aims to see if it's safe and helps people who haven't found enough relief from current treatments. Participants will take either the drug or a dummy pill for 15 weeks.
Major depressive disorder (MDD)Scotland - Recruiting
What do people who are at high risk of dying from street-drug overdose say is needed to reduce the chance of drug death?
This study wants to hear from people experiencing homelessness in Scotland who use drugs, especially those who inject or have overdosed. Researchers want to understand what they think is needed to reduce harm and improve their lives, helping to make future support better.
Homelessness and illicit drug use (especially injecting drug use and/or history of overdose)Scotland - CompletedPhase IV
Evaluating the accuracy of remote monitoring technology in capturing how patients respond to treatments for pulmonary arterial hypertension
This study is using small, implanted devices to check how well new and existing lung treatments work for people with Pulmonary Arterial Hypertension (PAH) from their own homes. It aims to help doctors find the best treatments faster and reduce hospital visits.
Pulmonary arterial hypertension (PAH)Scotland - Recruiting
Do patient information animations enhance patient understanding compared to patient information leaflets alone for a clinical trial investigating CT coronary angiography to guide treatment of heart attack (myocardial infarction)?
This study wants to know if a cartoon video helps people understand information about a future heart attack study better than just reading. It's for people in the hospital with a certain type of heart attack, aged 16 and over.
Patients with non-ST elevation myocardial infarctionScotland - CompletedPhase II
Exploratory effect of long-term Verapamil therapy in adults with Type 1 diabetes mellitus (Ver-A-Long)
This study looks at whether a blood pressure medicine called Verapamil can help adults with Type 1 diabetes. It explores if taking it long-term helps the body make more insulin and checks its safety. This is for people already in a related Verapamil study.
Type 1 DiabetesScotland - RecruitingPhase IV
Optimising the use of azithromycin antibiotic to reduce Bronchiectasis flare-ups
This study looks at whether people with a lung condition called bronchiectasis can safely stop taking azithromycin, an antibiotic, after their condition has settled down. We want to see if stopping the medicine still keeps flare-ups away and improves their quality of life.
Medical condition: Bronchiectasis Medical condition in lay language: Bronchiectasis Therapeutic areas: Diseases [C] - Respiratory Tract Diseases [C08]Scotland - RecruitingPhase I/II
A study to learn how the study medicine called PF-07868489 is tolerated and acts in people with pulmonary arterial hypertension
This study is looking into a new medicine, PF-07868489, for pulmonary arterial hypertension (PAH). Researchers want to see if it's safe and how it works in people with this lung condition. It's an early-stage study to understand the medicine better.
Pulmonary arterial hypertensionScotland - RecruitingNot Specified
Developing genetic tests to diagnose, monitor and guide treatment decisions for children and young people whose cancer has returned
This study looks at the genes in children and young people whose cancer has come back or not responded to treatment. We compare genes in healthy cells with cancer cells to find changes. This helps doctors personalise treatments and find new ways to fight cancer based on genetic information.
Relapsed/refractory solid tumours (including lymphomas) or leukaemiaScotland - Recruiting
Reconstruction after advanced pelvic cancer surgery
This study looks at how repairing the body after major cancer surgery in the pelvis affects a person's life. It compares different ways of reconstruction to see which works best for quality of life, complications, and costs.
Advanced pelvic cancersScotland - Recruiting
Treatment of retinal detachment in people who have not had cataract surgery and are not very short-sighted with either vitrectomy surgery alone or with vitrectomy and removal of the cataract at the same time
This study looks at the best way to fix a detached retina, a problem at the back of your eye. It compares having a single eye surgery called vitrectomy to having vitrectomy and cataract surgery at the same time. The goal is to see which option works better for your vision and overall eye health.
Rhegmatogenous retinal detachmentScotland - Completed
Fusion surgery for bunions gives improvement in pain and function
This study looks at how well a specific surgery called 'fusion' works for bunions (hallux valgus). It checks if fusing the big toe joint reduces pain and improves function for people in NHS Tayside.
Hallux valgusScotland - Recruiting
Patient expectations and experiences of current and new gout management
This study wants to learn about your experiences with gout. We'll ask about how you manage it and what you think about new ways to control it, like apps. Your thoughts could help doctors better understand and treat gout in the future.
Adults (aged 18 or older) with goutScotland - Completed
Examining heart and blood vessel health in women with a history of high blood pressure during pregnancy using ultrasound and eye scans
This study looks at heart and blood vessel health in women who had high blood pressure during pregnancy. Researchers use eye and neck scans, plus blood tests, to find out who might be at risk of heart problems later. This could help doctors identify risks earlier.
Future cardiovascular diseases in women with gestation hypertensionScotland - Completed
A pilot and feasibility study comparing vaginal continence devices and pelvic floor muscle training (PFMT) versus PFMT only for female stress urinary incontinence
This study looks at new ways to help women with bladder leakage when they cough, sneeze, or laugh. It compares pelvic floor muscle exercises alone with these exercises plus a small device worn inside the vagina, aiming to find the best way to improve quality of life.
Female stress urinary incontinenceScotland - Not yet recruitingNot Applicable
Project COMFORT Study- Understanding how new blood sampling devices for use at home compare with standard hospital vein blood tests
The Project COMFORT Study is looking at new ways to collect blood samples at home for people with, or at risk of, heart conditions. We want to see if these new methods work as well as traditional hospital blood tests and how easy they are for patients to use.
Cardiovascular disease (CVD) or elevated cardiovascular riskScotland - RecruitingPhase I
Using light-based imaging to check where a feeding tube is placed in the stomach
This study is testing a new device that uses light to help doctors accurately place feeding tubes into the stomach. It aims to make the process safer and quicker by avoiding X-rays. We're looking for healthy volunteers and patients needing a feeding tube.
Prevention of misplacement of nasogastric tubes in patientsScotland - Recruiting
The LITE study: shining LIGHT on Parkinson’s disease
The LITE study is looking into Parkinson's disease (PD) to better understand its causes and how it affects people. We need volunteers, with and without PD, to help us collect important information that could lead to new treatments.
Parkinson's diseaseScotland - Completed
Development of guidelines for treating patients with cancer-related blockages in the upper urinary tract
This study aims to create clear guidelines for doctors treating cancer patients who have blockages in their urinary tubes. These blockages can cause serious problems, and currently, there aren't agreed-upon ways to treat them. Experts will share their knowledge to help improve patient care.
Clinical guidelines for the management of malignant upper urinary tract obstruction (MUUTO), in cancer patients.Scotland - Completed
Understanding the role of community pharmacy in the support of people with long COVID
This study looks at how local chemists (community pharmacies) can better support people in the UK living with "long COVID." Researchers will talk to people with long COVID and pharmacy staff to create a useful online training course for pharmacists to help them understand and assist those with ongoing symptoms.
Long COVIDScotland - RecruitingPhase IV
DEsogestrel for Bleeding on the Implant (DEBI)
This study looks at treating annoying bleeding caused by the contraceptive implant. We're comparing two hormonal treatments, desogestrel and the combined pill, to see which works best to settle periods and offer a safer, easier option for implant users.
Self-reported problem bleeding on the contraceptive implantScotland - Recruiting
Coronary artery stents in heart failure with preserved ejection fraction
This study looks at whether fitting small tubes called stents in the heart's blood vessels can help people with a type of heart failure called HFpEF. We want to see if it improves their quality of life and blood flow.
Heart failure with preserved ejection fraction (HFpEF) and coronary artery diseaseScotland