Latest studies
- Recruiting
Cerebrospinal fluid shunting or dural venous sinus stenting to preserve vision in idiopathic intracranial hypertension (IIH Intervention)
Idiopathic intracranial hypertension (IIH) causes high pressure around the brain that can threaten your sight. This UK study compares two standard operations: inserting a small drainage tube (shunt) or a tiny mesh tube (stent). The aim is to discover which treatment best protects your vision and helps the NHS.
Idiopathic intracranial hypertensionScotland - Completed
The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care
Premature babies fed through a tube often have their stomach contents checked regularly to see how they digest milk. The neoGASTRIC study looks at whether stopping these routine checks helps premature babies reach full milk feeds more quickly and safely. It compares two standard care approaches already used in hospitals.
Preterm birthScotland - Recruiting
Treating people with a lung collapse (pneumothorax) without inserting a needle into the chest. Is it safe and effective?
This UK clinical trial is looking at whether a collapsed lung can heal safely on its own without needing a chest drain. Researchers want to see if simply resting and being monitored allows patients aged 16 to 50 to recover well at home, avoiding invasive hospital procedures.
Primary spontaneous pneumothoraxScotland - Completed
No routine measurement of gastric residual volume in paediatric critical care
Children in intensive care need good nutrition through a feeding tube to help them heal. Doctors usually use a syringe to check fluid in the stomach every six hours, which can pause feeding. This study looks at whether stopping these routine checks safely allows children to get more of their required food.
Oral and GastrointestinalScotland - Recruiting
Pilot study of safety and efficacy of unilateral MRI-guided focused ultrasound thalamotomy in tremor-dominant Parkinson’s disease
This Scottish study tests a non-invasive treatment for Parkinson’s tremors. Using sound waves guided by an MRI scanner, doctors create a tiny heat spot in the brain to calm shaking. The trial checks whether this single-session treatment is safe and effective for people whose tremors do not improve with medicine.
Parkinson's diseaseScotland - RecruitingPhase II
Assessing if stopping and starting standard of care medication for later stage melanoma can reduce the body's resistance to the treatment
This clinical trial tests a new way of taking standard medicines for advanced skin cancer (melanoma). Instead of taking pills every day, some patients take planned breaks guided by regular blood tests. Researchers want to see if pausing and restarting treatment stops cancer cells from becoming resistant, helping the medicine work longer.
Cutaneous melanomaScotland - Completed
Effectiveness of a maternity improvement programme to reduce excess bleeding and need for transfusion after childbirth: the Obstetric Bleeding Study UK (OBS UK)
Heavy bleeding is a common complication after giving birth. The OBS UK study tests a new maternity care package across 36 NHS hospitals to help staff spot and treat heavy bleeding faster. By measuring blood loss accurately and acting early, researchers hope to reduce blood transfusions and improve safety.
Obstetric bleedingScotland - CompletedNot Applicable
Engagement and acceptability of a digital programme for anxiety
Researchers are testing a new smartphone app designed to help adults manage worry and stress. The app uses short, interactive text chats, videos, and worksheets based on talking therapy. This study looks at how easy and helpful people find the six-week programme from home to improve future digital mental healthcare.
Anxiety symptoms in adultsScotland - CompletedNot Applicable
Ambulatory ECG monitor versus standard care in acute unexplained syncope (sudden loss of consciousness also known as blackout or fainting)
Fainting and sudden blackouts are common reasons people visit hospital, but finding the cause can be tricky once you feel better. This UK trial tests whether wearing a small, stick-on heart monitor for two weeks helps doctors spot hidden heart rhythm problems faster than standard NHS care alone.
Early diagnosis of patients presenting to Emergency Departments with undiagnosed syncope (blackouts).Scotland - RecruitingPhase III
Investigating the clinical and cost-effectiveness of two different drugs (amiodarone and beta blockers) to treat patients with new-onset atrial fibrillation whilst in the intensive care unit
This UK study looks at two standard NHS medicines for an irregular heartbeat that can start during a stay in intensive care. Researchers want to find out whether drugs called beta-blockers or a drug called amiodarone work best to return the heart to a normal rhythm safely.
New onset atrial fibrillation (NOAF)Scotland - CompletedPhase III
Pain relief after instrumented spinal surgery trial
Having lower back surgery can cause significant pain, which can slow down recovery. The PRAISE study compares three different ways to relieve pain after spinal surgery: standard pain tablets and drips, a targeted spinal injection, or a nerve block in the back muscles, to see which helps patients heal best.
Patients scheduled for elective, posterior lumbar-instrumented spinal surgery +/- decompression.Scotland - Recruiting
CONNECT: using electronic devices (e.g. smartphones, smartwatches) to predict relapse of psychosis
The CONNECT study explores whether everyday smartwatches and mobile phones can help spot early warning signs of a psychosis relapse. By monitoring daily activity, sleep, and brief mood check-ins over 12 months, researchers hope to help NHS teams step in earlier to keep people well.
PsychosisScotland - Recruiting
Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) in the management of cancers of the bowel, ovary and stomach: a randomised controlled trial of efficacy in peritoneal metastases
This UK clinical trial is testing a new way to deliver chemotherapy called PIPAC for people whose bowel, ovarian, or stomach cancer has spread to the lining of the abdomen. It aims to see if spraying chemotherapy directly into the tummy during keyhole surgery works better than standard chemotherapy alone.
Colorectal, ovarian and stomach cancer with peritoneal metastasisScotland - RecruitingPhase IV
A shorter duration of antibiotic treatment versus a longer duration of antibiotic treatment for patients with a flare-up of their chronic lung condition requiring intravenous antibiotics
This UK trial looks at whether a 7-day course of intravenous (IV) antibiotics works just as well as the standard 14-day course for bronchiectasis flare-ups. Researchers want to see if shorter treatment helps people stay well for longer, reduces side effects, and cuts the risk of antibiotic resistance.
BronchiectasisScotland - RecruitingPhase II
SOPRANO - Stereotactic radiotherapy alone or stereotactic radiotherapy follow by niraparib treatment for ovarian cancer with progressive disease in three or less lesions, or recurrence of 3 or less metastatic lesions that had previously achieved complete response.
This trial tests whether targeted, pinpoint radiotherapy can help control ovarian cancer that has grown in just a few small spots after drug treatment. Patients receive radiotherapy to the growing tumours, either on its own or followed by a daily targeted tablet called niraparib, to delay further cancer progression.
Oligometastatic or oligoprogressive ovarian, fallopian tube or primary peritoneal carcinomaScotland - RecruitingPhase II
EXPErimental medicine Route To Success in Amyotrophic Lateral Sclerosis (EXPERTS-ALS)
EXPERTS-ALS is a UK clinical trial testing whether existing, widely used medications can help slow down amyotrophic lateral sclerosis (ALS). Researchers check blood samples for a nerve protein called NFL to see if a drug protects nerve cells. There is no dummy pill, so every participant receives an active treatment.
Amyotrophic lateral sclerosis (ALS)Scotland - Completed
COBIx: Multi-site validation study of the COBIx reporting tool
This UK study tests a computer program called COBIx to help doctors examine bowel tissue samples (biopsies). COBIx spots healthy samples and flags serious conditions like bowel cancer. Researchers are testing 10,000 routine NHS samples to see if the tool can safely speed up diagnoses and reduce hospital backlogs.
Colon and rectal endoscopic biopsyScotland - Completed
Developing and testing a way to correctly identify people with chronic pain from their primary care records
Researchers in Scotland are testing a computer tool to identify people living with chronic pain using GP records. By comparing medical files with patient surveys and interviews, the study aims to give the NHS accurate figures, helping planners design better pain services and improve everyday care across the country.
Chronic painScotland - RecruitingPhase II
Sotagliflozin in patients with heart failure symptoms and type 1 diabetes
This UK trial looks at whether a daily tablet called sotagliflozin can help people living with both type 1 diabetes and heart failure. Researchers want to see if the medication improves everyday symptoms, boosts quality of life, and is safe to use alongside standard daily insulin routines.
Type 1 Diabetes, Heart FailureScotland - RecruitingPhase III
MiTiGate trial: Is Botox more effective than lidocaine and treatment as usual in myalgia temporomandibular disorder (TMD)?
The MiTiGate trial looks at treatments for ongoing jaw muscle pain (M-TMD). Researchers are comparing standard daily pain tablets (amitriptyline or gabapentin) with injections of either Botox or a numbing medicine called lidocaine. The aim is to find out which option provides the safest, most effective, and best-value relief.
Myalgia temporomandibular disorder (M TMD)Scotland - CompletedNot Applicable
Post-market clinical follow-up for stenfilcon A sphere and toric lenses
This study looks at how well stenfilcon A contact lenses work in everyday life. Researchers want to confirm their real-world safety and comfort in people who already wear them. If you are aged 8 to 75 and already use these soft lenses, you may be invited for a single routine check-up.
Myopia, astigmatism, hyperopiaScotland - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseScotland - Completed
Developing a checklist to allow accurate diagnosis of vulval lichen sclerosus
This UK study tests a simple checklist to help doctors diagnose vulval lichen sclerosus more quickly and accurately. Researchers want to see if this new tool helps non-specialists spot the skin condition sooner. Women aged 18 and over attending a specialist clinic for vulval symptoms can take part during one appointment.
Vulval lichen sclerosusScotland - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaScotland - Recruiting
Randomised evaluation of rehabilitation after acute proximal humerus (shoulder) fracture: the REACH study
The REACH study looks at the best way to help adults recover from a broken shoulder that does not need surgery. It compares doing exercises at home using a guidebook and videos against attending regular hospital physiotherapy appointments, to see if home recovery works just as well.
Proximal humerus fractureScotland - Completed
Quality of life after radiotherapy treatment for patients with non-small cell lung cancer
The QUARTZ LUNG trial is looking at whether gentle, low-dose radiotherapy to the chest helps people with advanced (stage 4) non-small cell lung cancer feel better. Researchers want to see if this treatment improves day-to-day quality of life and eases chest symptoms compared to standard supportive care alone.
Stage IV non-small cell lung cancerScotland - Recruiting
Personalised exercise rehabilitation for people with multiple long-term conditions: Main Trial
This UK study tests whether a personalised exercise programme, called PERFORM, helps people living with two or more long-term health conditions. Researchers want to see if tailored exercise improves fitness, quality of life, and day-to-day well-being compared to standard NHS care.
Multiple long-term conditionsScotland - Recruiting
Operative or non-surgical treatment of Perthes’ disease
Perthes’ disease affects the hip joint in children, causing the top of the thigh bone to soften and flatten. This UK study compares two usual NHS treatments: physiotherapy and guided exercises without surgery, versus an operation to realign the hip bone. The aim is to see which approach works best.
Perthes’ diseaseScotland - RecruitingPhase II
AIR-NET- Testing anti-inflammatories for the treatment of bronchiectasis
The AIR-NET study tests whether three existing medicines can calm lung inflammation in adults with bronchiectasis. Researchers want to find out if repurposing these safe, well-known drugs can help ease daily symptoms, reduce chest damage, and offer better treatment options alongside usual care for people living with this lung condition.
BronchiectasisScotland - Recruiting
Lifestyle in Perimenopause: Exploring a Community Intervention
This Edinburgh-based study explores whether a friendly community group can help people manage perimenopause and menopause symptoms. By taking part in weekly walks, educational talks, and creative group discussions, researchers hope to learn if peer support and lifestyle changes can help protect bone health and lower stress.
People who are having difficulty managing symptoms of perimenopause and menopause.Scotland - RecruitingNot Applicable
Diabetic foot ulcer infection prevention study
Diabetic foot ulcers can easily become infected, leading to serious medical complications. This UK study looks at whether a special wound dressing called Cutimed Sorbact can help stop infections before they start. Researchers are comparing this dressing alongside routine NHS wound care against standard care alone over 12 weeks.
Non-infected superficial diabetes-related foot ulcersScotland - Recruiting
A feasibility study of a combined mental health and neurodevelopmental assessment for young people in crisis services
This study tests a new approach for young people aged 12 to 17 in mental health crisis. It combines urgent mental health support with a quick assessment for conditions like autism and ADHD. The goal is to see if this combined check helps teens get the right support much faster.
Neurodivergence. Mental health, suicidality, self harmScotland - RecruitingPhase II
NOVEL: A Clinical Trial of the Oxygen-carrying Substance NanO2 to Protect the Brain after Stroke
This UK clinical trial tests a new medicine called NanO2 for people who have had a severe stroke caused by a blood clot. NanO2 carries extra oxygen to brain tissue to keep it alive while doctors work to open the blocked blood vessel and restore normal blood flow.
Large vessel occlusion strokeScotland - Recruiting
Co-development of a web-app for young people with attention deficit hyperactivity disorder
Researchers in the UK are developing a new web app to support young people aged 16 to 30 who have ADHD or are waiting for an assessment. By testing the app in friendly workshops, participants help design useful tools and trusted information to improve everyday life and future NHS care.
Attention deficit hyperactivity disorder (ADHD)Scotland - RecruitingPhase I
Deferred registration: Phase I Trial: MAC code 'MAC215'
MAC215 is an early-stage (Phase 1) clinical study for adults aged 50 to 85. The UK Health Research Authority has agreed that specific study details can remain private for now. Full information about the treatment and health condition will be published after the study has ended.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry date.Scotland - Completed
Investigating the clinical and cost-effectiveness of children’s early self-care support in children with neurodisability
This UK study tests a programme called CHESS, which helps young children with disabilities learn everyday skills like eating, dressing, and washing. Researchers want to find out if CHESS works better and provides better value for money than the usual care NHS therapists currently provide.
Investigating the clinical and cost-effectiveness of self-care support in children with neurodisabilityScotland - Recruiting
Can a digital self-help tool, created together with autistic people, support them in managing headaches?
Headaches are common in autistic people, but most health apps are not built with their needs in mind. This UK study works alongside autistic people to adapt a headache self-help app. Researchers want to see if the new app is easy, practical, and helpful to use in daily life.
Self reported persistent or chronic headache in autistic individualsScotland - RecruitingPhase III
Better outcomes in babies with bacterial meningitis
This study looks at whether giving a steroid medicine called dexamethasone helps babies under three months recover from bacterial meningitis. Bacterial meningitis is a serious infection around the brain. Steroids help older children, but we do not know if they help young babies. The trial aims to improve survival and prevent disabilities.
Bacterial meningitis (BM)Scotland - CompletedNot Applicable
Spinal cord magnetic resonance imaging in multiple sclerosis
This study looks at how multiple sclerosis affects the spinal cord in its early stages. Researchers in Edinburgh are using advanced MRI scans to take detailed pictures of the spine. The aim is to help doctors better understand the disease, predict how it progresses, and develop better future treatments.
Establishing spinal cord imaging biomarkers in people with recently diagnosed multiple sclerosisScotland - RecruitingPhase II
Finding the best treatment for lung disease from infection with Mycobacterium abscessus
This clinical trial is testing different combinations of antibiotics to find the best way to treat lung infections caused by Mycobacterium abscessus. The goal is to discover which medicines work best to clear the bacteria while causing the fewest and least severe side effects for patients.
Mycobacterium abscessus pulmonary diseaseScotland - CompletedNot Applicable
Evaluating the use of a lower blood pressure target to guide drug treatment in critically ill children with low blood pressure
This UK study looks at critically ill children in intensive care who have low blood pressure. Doctors want to see if aiming for a slightly lower, safe blood pressure target reduces the amount of strong medicine needed. This could help children recover better and avoid unwanted side effects from intensive treatments.
Critically ill children with hypotensionScotland - Completed
R&R: A trial for moral injury related mental health difficulties
This study tests a new talking therapy called Restore & Rebuild (R&R) for UK military veterans. It aims to help veterans who are struggling with difficult feelings or mental health issues caused by moral injury from their service, comparing R&R to standard care provided by Combat Stress.
Moral injury related mental health difficulties in UK military veterans.Scotland - CompletedPhase I
A modular, multi-part, multi-arm, open-label, phase I/II study to evaluate the safety and tolerability of GRWD5769 alone and in combination with anticancer treatments in patients with solid malignancies
This early-stage clinical trial is testing a new cancer medicine called GRWD5769. It looks at how safe the drug is when taken alone or alongside another cancer drug, cemiplimab. It aims to help the body's immune system recognise and fight advanced solid tumours that have spread or cannot be cured.
Advanced or metastatic solid malignancyScotland - Completed
A randomised controlled trial comparing surgery with watchful waiting for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones
This UK trial looks at the best way to treat painful gallstones. It compares keyhole surgery to remove the gallbladder with a 'watch and wait' approach using pain relief and lifestyle advice. Researchers want to see which option offers patients better quality of life and provides better value for the NHS.
GallstonesScotland - CompletedPhase III
Remote ischaemic Conditioning After Stroke Trial - 3
This UK study tests whether gently squeezing both arms with blood pressure cuffs can help protect the brain after a stroke. Known as remote ischaemic conditioning, it aims to reduce long-term disability. Around 1,300 patients will receive either this cuff treatment or a dummy version alongside their standard NHS care.
Adults with acute ischaemic stroke presenting in Emergency Departments and Stroke Units in the UKScotland - Completed
A clinical trial of blood flow optimisation for patients who have emergency bowel surgery
Emergency bowel surgery is a major operation. Doctors give fluids through a drip to protect vital organs, but getting the amount right can be difficult. This UK trial tests whether using an extra heart monitor helps doctors give the best fluid amounts, helping patients recover faster and return home sooner.
Surgery - emergency laparotomyScotland - CompletedPhase II
A Phase II study to understand the safety and effects of inhaled SNG001, the study medication, in patients who are mechanically ventilated due to a respiratory viral infection in the lungs
This study tests an inhaled medicine called SNG001 for people in intensive care with severe chest infections caused by viruses like flu or COVID-19. Researchers want to see if breathing in this natural virus-fighting protein helps patients recover faster and spend less time on a breathing machine.
Respiratory viral infectionsScotland - RecruitingPhase III
Metoclopramide for avoiding pneumonia after stroke
Pneumonia is a serious risk for people who struggle to swallow after a stroke. This UK trial investigates whether an everyday anti-sickness medicine, metoclopramide, can prevent chest infections. By helping to empty the stomach, researchers hope to stop fluids entering the lungs, protecting patients and aiding recovery.
Prevention of pneumonia caused by dysphagia after an acute strokeScotland - Completed
Personalised treatment packages for adults with a learning disability
The PETAL study tests a personalised support programme for adults with learning disabilities who show aggressive behaviour. By tailoring care to each person's unique needs, researchers hope to help individuals and their carers better manage distress, improve everyday quality of life, and reduce the need for strong medications or hospital stays.
Intellectual disabilityScotland - CompletedPhase II
A two-part study to assess the effectiveness, safety, and blood levels of repeat doses of inhaled ETD001 in people with cystic fibrosis
This study looks at a new inhaled medicine called ETD001 for adults with cystic fibrosis. The treatment aims to loosen sticky lung mucus to help make breathing easier. Researchers want to see if the medicine is safe, well tolerated, and improves lung function when taken alongside usual daily care.
Cystic fibrosisScotland