Latest studies
- Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthScotland - Recruiting
Pelvic floor muscle exercises plus pessary for treatment of prolapse versus pelvic floor muscle exercises alone
This study looks at combining pelvic floor exercises with a vaginal pessary for women with pelvic organ prolapse. It wants to see if this combined approach works better at reducing symptoms than just doing the exercises alone, helping to improve women's daily lives.
Pelvic organ prolapseScotland - CompletedPhase II
The purpose of the trial is to test the safety, tolerability and efficacy of the drug tildacerfont, that is being developed for the treatment of major depressive disorder
This study is testing a new drug called tildacerfont for moderate to severe depression. It aims to see if it's safe and helps people who haven't found enough relief from current treatments. Participants will take either the drug or a dummy pill for 15 weeks.
Major depressive disorder (MDD)Scotland - Recruiting
What do people who are at high risk of dying from street-drug overdose say is needed to reduce the chance of drug death?
This study wants to hear from people experiencing homelessness in Scotland who use drugs, especially those who inject or have overdosed. Researchers want to understand what they think is needed to reduce harm and improve their lives, helping to make future support better.
Homelessness and illicit drug use (especially injecting drug use and/or history of overdose)Scotland - Completed
Exploring biomarkers of mucosal inflammation in paediatric Crohn’s disease (Mini-MUSIC)
The Mini-MUSIC study looks at children and young people (6-17) in Scotland with Inflammatory Bowel Disease (IBD). We're trying to find new ways to check gut inflammation using blood, stool, and saliva tests, hoping to avoid frequent endoscopies.
Paediatric inflammatory bowel diseaseScotland - CompletedPhase IV
Evaluating the accuracy of remote monitoring technology in capturing how patients respond to treatments for pulmonary arterial hypertension
This study is using small, implanted devices to check how well new and existing lung treatments work for people with Pulmonary Arterial Hypertension (PAH) from their own homes. It aims to help doctors find the best treatments faster and reduce hospital visits.
Pulmonary arterial hypertension (PAH)Scotland - Recruiting
Do patient information animations enhance patient understanding compared to patient information leaflets alone for a clinical trial investigating CT coronary angiography to guide treatment of heart attack (myocardial infarction)?
This study wants to know if a cartoon video helps people understand information about a future heart attack study better than just reading. It's for people in the hospital with a certain type of heart attack, aged 16 and over.
Patients with non-ST elevation myocardial infarctionScotland - CompletedPhase II
Exploratory effect of long-term Verapamil therapy in adults with Type 1 diabetes mellitus (Ver-A-Long)
This study looks at whether a blood pressure medicine called Verapamil can help adults with Type 1 diabetes. It explores if taking it long-term helps the body make more insulin and checks its safety. This is for people already in a related Verapamil study.
Type 1 DiabetesScotland - RecruitingPhase IV
Optimising the use of azithromycin antibiotic to reduce Bronchiectasis flare-ups
This study looks at whether people with a lung condition called bronchiectasis can safely stop taking azithromycin, an antibiotic, after their condition has settled down. We want to see if stopping the medicine still keeps flare-ups away and improves their quality of life.
Medical condition: Bronchiectasis Medical condition in lay language: Bronchiectasis Therapeutic areas: Diseases [C] - Respiratory Tract Diseases [C08]Scotland - Recruiting
Fix or replace enhancing distal humerus fracture outcomes
This study compares two common surgeries for broken elbows in people over 60: elbow replacement or fixing the break with plates and screws. It aims to find which treatment works best to help people recover and use their arm normally again.
Intra-articular fracture of the distal humerus AO type B or CScotland - RecruitingPhase I/II
A study to learn how the study medicine called PF-07868489 is tolerated and acts in people with pulmonary arterial hypertension
This study is looking into a new medicine, PF-07868489, for pulmonary arterial hypertension (PAH). Researchers want to see if it's safe and how it works in people with this lung condition. It's an early-stage study to understand the medicine better.
Pulmonary arterial hypertensionScotland - RecruitingNot Specified
Developing genetic tests to diagnose, monitor and guide treatment decisions for children and young people whose cancer has returned
This study looks at the genes in children and young people whose cancer has come back or not responded to treatment. We compare genes in healthy cells with cancer cells to find changes. This helps doctors personalise treatments and find new ways to fight cancer based on genetic information.
Relapsed/refractory solid tumours (including lymphomas) or leukaemiaScotland - Recruiting
Reconstruction after advanced pelvic cancer surgery
This study looks at how repairing the body after major cancer surgery in the pelvis affects a person's life. It compares different ways of reconstruction to see which works best for quality of life, complications, and costs.
Advanced pelvic cancersScotland - Recruiting
Treatment of retinal detachment in people who have not had cataract surgery and are not very short-sighted with either vitrectomy surgery alone or with vitrectomy and removal of the cataract at the same time
This study looks at the best way to fix a detached retina, a problem at the back of your eye. It compares having a single eye surgery called vitrectomy to having vitrectomy and cataract surgery at the same time. The goal is to see which option works better for your vision and overall eye health.
Rhegmatogenous retinal detachmentScotland - Completed
Fusion surgery for bunions gives improvement in pain and function
This study looks at how well a specific surgery called 'fusion' works for bunions (hallux valgus). It checks if fusing the big toe joint reduces pain and improves function for people in NHS Tayside.
Hallux valgusScotland - Completed
A pilot and feasibility study comparing vaginal continence devices and pelvic floor muscle training (PFMT) versus PFMT only for female stress urinary incontinence
This study looks at new ways to help women with bladder leakage when they cough, sneeze, or laugh. It compares pelvic floor muscle exercises alone with these exercises plus a small device worn inside the vagina, aiming to find the best way to improve quality of life.
Female stress urinary incontinenceScotland - Not yet recruitingNot Applicable
Project COMFORT Study- Understanding how new blood sampling devices for use at home compare with standard hospital vein blood tests
The Project COMFORT Study is looking at new ways to collect blood samples at home for people with, or at risk of, heart conditions. We want to see if these new methods work as well as traditional hospital blood tests and how easy they are for patients to use.
Cardiovascular disease (CVD) or elevated cardiovascular riskScotland - Recruiting
Patient expectations and experiences of current and new gout management
This study wants to learn about your experiences with gout. We'll ask about how you manage it and what you think about new ways to control it, like apps. Your thoughts could help doctors better understand and treat gout in the future.
Adults (aged 18 or older) with goutScotland - Completed
Understanding the role of community pharmacy in the support of people with long COVID
This study looks at how local chemists (community pharmacies) can better support people in the UK living with "long COVID." Researchers will talk to people with long COVID and pharmacy staff to create a useful online training course for pharmacists to help them understand and assist those with ongoing symptoms.
Long COVIDScotland - RecruitingPhase IV
DEsogestrel for Bleeding on the Implant (DEBI)
This study looks at treating annoying bleeding caused by the contraceptive implant. We're comparing two hormonal treatments, desogestrel and the combined pill, to see which works best to settle periods and offer a safer, easier option for implant users.
Self-reported problem bleeding on the contraceptive implantScotland - Recruiting
Coronary artery stents in heart failure with preserved ejection fraction
This study looks at whether fitting small tubes called stents in the heart's blood vessels can help people with a type of heart failure called HFpEF. We want to see if it improves their quality of life and blood flow.
Heart failure with preserved ejection fraction (HFpEF) and coronary artery diseaseScotland - Completed
Examining heart and blood vessel health in women with high blood pressure during pregnancy using ultrasound and eye scans
This study looks at how high blood pressure during pregnancy affects women’s hearts and blood vessels. Using eye scans and ultrasound, researchers hope to find early signs of future health problems, particularly focusing on small blood vessels. It aims to improve care for pregnant women.
Cardiovascular diseases in women with gestational hypertensionScotland - Completed
Examining heart and blood vessel health in women with a history of high blood pressure during pregnancy using ultrasound and eye scans
This study looks at heart and blood vessel health in women who had high blood pressure during pregnancy. Researchers use eye and neck scans, plus blood tests, to find out who might be at risk of heart problems later. This could help doctors identify risks earlier.
Future cardiovascular diseases in women with gestation hypertensionScotland - RecruitingPhase I
Using light-based imaging to check where a feeding tube is placed in the stomach
This study is testing a new device that uses light to help doctors accurately place feeding tubes into the stomach. It aims to make the process safer and quicker by avoiding X-rays. We're looking for healthy volunteers and patients needing a feeding tube.
Prevention of misplacement of nasogastric tubes in patientsScotland - Completed
An evaluation of a cognitive-behavioural intervention for medical students
This study looks at a special support program called Thumos for UK medical students. It aims to help them cope with stress, feel more confident, and reduce burnout and depression during their clinical placements. We want to see if Thumos works better than usual support.
Improvement of psychological resilience in UK medical studentsScotland - Completed
Feasibility of an aquatic exercise therapy intervention for falls prevention in older adults
This study looks into whether water-based exercises (aquatic therapy) can help prevent falls in older people. Many older adults fall, and this can cause serious problems. The study compares water exercises with land-based exercises to see which might work best and if people are willing to take part.
Prevention of falls in older adults who have a high risk of fallsScotland - Recruiting
The LITE study: shining LIGHT on Parkinson’s disease
The LITE study is looking into Parkinson's disease (PD) to better understand its causes and how it affects people. We need volunteers, with and without PD, to help us collect important information that could lead to new treatments.
Parkinson's diseaseScotland - Completed
Development of guidelines for treating patients with cancer-related blockages in the upper urinary tract
This study aims to create clear guidelines for doctors treating cancer patients who have blockages in their urinary tubes. These blockages can cause serious problems, and currently, there aren't agreed-upon ways to treat them. Experts will share their knowledge to help improve patient care.
Clinical guidelines for the management of malignant upper urinary tract obstruction (MUUTO), in cancer patients.Scotland - RecruitingPhase III
Treatment to prevent the narrowing of the oesophagus in a condition called oesophageal atresia (a disorder present at birth in which the oesophagus, the tube that carries food from the mouth to the stomach, does not develop properly)
This study looks at whether a common medicine given to babies after surgery for a birth condition called oesophageal atresia (OA) really helps. It aims to find out if giving this medicine routinely prevents problems like narrowing of the food pipe and if it has any downsides.
Infants born with oesophageal artesia (OA) with distal-oesophageal fistula (TOF) who have undergone primary repairScotland - Recruiting
The effect of football heading on blood biomarkers of brain injury
This study looks at how heading a football affects your brain. We're checking blood for tiny signs of brain changes after heading. It helps us understand if heading could be linked to brain health problems later in life and how to make sports safer.
Risk-factors for long-term neurodegenerative disease associated with repeated subconcussive head impact exposureScotland - CompletedPhase II
Evaluation of a smartphone app to support low mood and worry in female armed forces veterans in Great Britain
This study looks at a smartphone app to help female UK military veterans with low mood and worry. It's online and checks if a larger study might work. Participants use the app daily for six weeks, with some getting the special app and others a simple meditation app.
Mild to moderate depression and anxietyScotland - Recruiting
Mentalization-based therapy for individuals with probable complex post-traumatic stress disorder
This study looks into a new talking therapy called Mentalization-Based Treatment - Trauma Focused (MT-TF) for adults with Complex Post-Traumatic Stress Disorder (CPTSD). It compares MT-TF to usual care to see if it helps reduce symptoms and improve well-being.
Complex post-traumatic stress disorder (CPTSD)Scotland - Recruiting
The evaluation of a meeting centre in a hospital
This study looks at how a special 'Meeting Centre' within a Dundee hospital helps people with dementia, their families, and staff. It aims to see if it makes hospital stays better and if similar centres could work elsewhere in the UK.
Supporting people living with dementia during their hospital stayScotland - Recruiting
Could giving someone who smokes help to quit through a financial advice service make them more likely to quit than someone who does not get any support?
This study looks at whether people trying to quit smoking, who are also getting financial advice, are more likely to stop if offered extra support like vapes and counselling, compared to those who don't get any extra help from the study.
Tobacco addictionScotland - RecruitingPhase II
Prevention of childhood asthma using house dust mite allergen tablets
This study looks at whether a daily tablet can help stop babies at risk of asthma from developing it. We’re testing a treatment that aims to make children less sensitive to house dust mites, a common cause of asthma. It's for babies aged 5-12 months with a family history of allergies.
Paediatric asthmaScotland - Completed
Improving uptake of screening for type 2 diabetes after a diagnosis of gestational diabetes in pregnancy: is a home blood test the answer?
This study is testing if a home blood test kit can help more women with a history of diabetes in pregnancy (gestational diabetes) get their follow-up blood sugar check. This check is important as it helps to spot if they are at risk of developing type 2 diabetes later on.
Screening for type 2 diabetes in patients with a history of gestational diabetesScotland - Recruiting
A multicomponent evaluation of new restrictions on marketing of less healthy foods in England
This study looks at how new UK rules on advertising unhealthy food and drinks affect what people buy, how companies sell products, and overall health. It also checks what people think about these new rules, which aim to encourage healthier eating.
Unhealthy dietsScotland - Recruiting
The investigation of eye tear film proteins to see if there is an association with the stage of an eye condition called Retinopathy of Prematurity (ROP) which can occur in some premature babies; and the investigation of eye nerve development in these babies
This study looks for early signs of an eye condition called Retinopathy of Prematurity (ROP) in premature babies. Researchers will check proteins in tears and how babies' eyes respond to light to find new ways to detect ROP and prevent vision problems early on.
Retinopathy of prematurityScotland - Completed
Predictors of disease activity in multiple sclerosis
This study aims to better predict how Multiple Sclerosis (MS) will affect individuals. It uses routine NHS blood tests and scans to help doctors make more personalised treatment choices earlier. This could lead to better long-term results for people with MS.
Development of “disease activity” prediction tools based on next-generation biomarkers in people with multiple sclerosis to inform prospective decisions about the personalised risk/benefit relationship of available treatmentsScotland - RecruitingPhase II
Radiotherapy (miBG) in neuroblastoma combined with chemotherapy (talazoparib)
This study for children and young people with high-risk neuroblastoma tests a new combination of treatments: a targeted radiation therapy (131I-mIBG) and a chemotherapy drug (talazoparib). The goal is to see if this combination works better, especially for patients with certain gene changes.
Relapsed and refractory high-risk neuroblastomaScotland - Recruiting
Diet-driven gut microbiome and outcome in patients with early-stage triple-negative breast cancer undergoing neoadjuvant chemotherapy and immunotherapy
This study looks at how the 'good' bacteria in our gut might affect treatment for a type of breast cancer called triple-negative breast cancer. Researchers want to see if changes in diet could help improve how well chemotherapy and immunotherapy work.
Stage I-III Triple Negative Breast CancerScotland - Recruiting
How treatments affect people recently diagnosed with follicular lymphoma. A study over time
This study looks at how treatments affect people newly diagnosed with follicular lymphoma. It will collect information during your usual hospital visits, helping us understand the illness better and hopefully improve future care for patients in the UK and worldwide. You won't have extra tests or treatments.
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissueScotland - Recruiting
Supermarket voluntary price promotion ban: a public health study
This study looks at what happens when two UK supermarkets stop using special offers on unhealthy foods. Researchers want to see how this affects what people buy, their health, and the businesses involved. It aims to understand if stopping these deals helps people eat better.
The main focus of this work is the prevention of obesity and risk of chronic non-communicable diseases through reduction of consumption of high fat salt sugar foods.Scotland - RecruitingPhase III
Benzodiazepine intervention in adults receiving opioid agonist treatment
This study looks at whether providing a steady supply of prescribed diazepam, along with extra support, can help people on opioid addiction treatment reduce their use of street benzodiazepines. Street versions of these drugs can be very dangerous.
Medical condition: Adults enrolled in OAT (Opioid Agonist Treatment) with DSM-5-diagnosed substance (benzodiazepine) use disorder with toxicologically verified non-prescription benzodiazepine use in the previous month. Medical condition in lay language: Adults who are enrolled in Opioid Agonist Treatment programme (methadone or buprenorphine) who are using non-prescribed (street) benzodiazepine. Therapeutic areas: Psychiatry and Psychology [F] - Behaviours [F01]Scotland - RecruitingPhase III
Study evaluating the efficacy of icotrokinra in ulcerative colitis
This study is testing a new medicine, icotrokinra, for ulcerative colitis (UC) in adults and teenagers. It aims to see if icotrokinra can help reduce UC symptoms and keep the disease under control by targeting inflammation.
Ulcerative colitisScotland - RecruitingNot Applicable
A multi-centre study testing a new imaging app to help diagnose systemic sclerosis using nailfold capillaroscopy
This study tests a new app called CapilyticsAcquisition to help doctors diagnose conditions like Raynaud's and systemic sclerosis. It takes pictures of tiny blood vessels near fingernails to assist with earlier and more accurate diagnosis. Participants are adults and children aged 6+.
Systemic sclerosis spectrum disordersScotland - Recruiting
SMILE: Supporting mental health in young people: integrated methodology for clinical decisions and evidence-based interventions
The SMILE study helps young people (10-24) with anxiety or depression. It uses a fun online game and activities to build resilience and improve mental health. The study runs from February 2025 to July 2026 across seven countries, including the UK.
Depression and anxiety in children and young peopleScotland - CompletedPhase III
A study to assess the safety of using 100 mg methotrexate for the treatment of an unruptured ectopic pregnancy
This study aims to see if a standard 100mg dose of methotrexate is safe and effective for women with a stable ectopic pregnancy. This could help make treatment quicker and simpler, avoiding individual dose calculations and long waiting times.
Ectopic pregnancyScotland - Completed
Understanding corridor care in UK emergency departments
This study looks at how many patients are cared for in places like hospital corridors when emergency departments are busy. It wants to understand who these patients are and why they're there, to help improve emergency care across the UK.
UK Emergency Department use of escalation areasScotland - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionScotland