Latest studies
- Ongoing, recruitingTherapeutic exploratory (Phase II)
Multicenter, double-blind, randomized, placebo-controlled, dose-response trial with the full-spectrum Cannabis Extract VER-01 in patients with chronic non-specific low back pain
This study is testing a new cannabis-based medicine, VER-01, for people with ongoing lower back pain. It will compare VER-01 to a dummy pill (placebo) to see if it helps reduce pain when other pain medicines haven't worked or can't be used. We want to know if it's safe and effective.
For the treatment of patients with chronic non-specific low back pain when drug treatment is indicated and previous optimised treatments with non-opioid analgesics have not led to sufficient pain relief or were unsuitable due to contraindications or intolerance.Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study to test the safety (any good or bad effects) of CC-90011 in combination with standard of care (cisplatin and etoposide), on how long the drug can stay in the body and if it can control the disease of people diagnosed with extensive small cell lung cancer and have not had any previous treatment for the disease. CC-90011, single agent, will be also given in consolidation after completion of the 4 to 6 cycles of chemotherapy
This study looks at a new drug, CC-90011, for extensive small cell lung cancer in people who haven't had treatment before. It checks if the drug is safe, how long it stays in the body, and if it helps control the cancer when given with standard chemotherapy and afterwards on its own.
extensive stage small cell lung cancerSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity and type 2 diabetes. We want to see if it helps with weight loss and is safe to use over about 1.5 years, compared to a dummy medicine.
ObesityDiabetes mellitus type IISpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
J3E-MC-EZDB: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3540378 in Adults with Worsening Chronic Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called LY3540378 for people with a type of heart failure where the heart struggles to relax properly. Researchers want to see if this new medicine can help improve how the heart works and if it's safe to use.
Heart Failure with Preserved Ejection FractionHeart FailureSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
KEYMAKER-U01 Master Study: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) KEYMAKER-U01 Substudy 3: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents in Combination with Pembrolizumab in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Previously Treated with anti-PD-(L)1 Therapy
This study is looking for better ways to treat advanced lung cancer that has not responded to previous treatments. It checks how well new medicines work with or without standard therapy, hoping to shrink tumours.
Non-small Cell Lung CancerSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 First-in-human Study of BMS-986288 Alone and in Combination with Nivolumab in Advanced Malignant Tumors
This study is testing a new medicine, BMS-986288, alone and with another drug, nivolumab. It's for people with various advanced cancers. The main goals are to check for side effects and how well the new medicine works against the cancer.
Advanced solid tumors (squamous cell carcinoma of the head and neck (SCCHN)non-small cell lung cancer (NSCLC)cutaneous melanomatriple-negative breast cancer (TNBC)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb, Multicenter, Randomized, Parallel-group, Double- blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AZD0780 in Participants with Dyslipidemia
This study looks at a new medicine called AZD0780 for people with high cholesterol. We want to see if it safely lowers bad cholesterol and other fats in the blood, which can help prevent heart problems. Participants will take the medicine or a dummy pill.
Dyslipidemia Dyslipidemias are alterations to the plasma lipid profile associated often with clinical condition. A common form of dyslipidemia is Hypercholesterolemia due to high level of LDL-cholesterolwhich is a major risk factor for Cardiovascular Disease (CVD)such as Ischemic Heart Disease and Ischemic Stroke. CVD is a leading cause of global mortality and a contributor to disability.Spain - Ongoing, recruitingTherapeutic use (Phase IV)
I4V-MC-JAJA (RA-BRIDGE): A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
This study looks at how safe and effective a medicine called baricitinib is for people with rheumatoid arthritis, compared to other common treatments. It will see how long it takes for a blood clot to happen. This is a long-term study that will last over five years.
Rheumatoid ArthritisSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02D
This study, called KEYMAKER-U02, is for adults with advanced melanoma, a type of skin cancer, that has spread to the brain. It's looking at new ways to treat this cancer, sometimes using a drug called pembrolizumab (Keytruda) alone, or in combination with other medicines like Lenvatinib or MK-1308A.
Advanced melanoma with brain metastasesPD-1 refractory or PD-1 naiveSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
(20289) A Phase 2 Basket Study of the Oral TRK Inhibitor larotrectinib in Subjects with NTRK Fusion-Positive Tumors
This study is testing a new medicine, larotrectinib, for adult patients with certain types of cancer that have a specific genetic change called an 'NTRK fusion'. Doctors want to see how well the medicine shrinks these tumours and if it's safe.
Solid tumors harboring NTRK fusionSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
INCB 18424-320: A phase 3, double-blind, randomised, vehicle-controlled, efficacy and safety study of ruxolitinib cream in participants with Prurigo Nodularis. Topical ruxolitinib evaluation in Prurigo Nodularis (TRuE-PN2)
This study is testing a new cream for people with very itchy skin lumps called Prurigo Nodularis. It wants to see if the cream, called ruxolitinib, can reduce itching compared to a cream without any medicine in it. The study aims to find out how well it works and if it's safe.
Prurigo NodularisSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase II, Randomized, Partially Blinded Study to Assess the Safety, Tolerability and Immunogenicity of Meningococcal Combined ABCWY Vaccine when Administered to Healthy Infants
This study is testing a new vaccine that aims to protect babies from serious illnesses like meningitis. The main goals are to see if it's safe, how well babies tolerate it, and if it helps their bodies build protection against these infections.
InfectionsMeningococcalSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Open-Label, Multiple Ascending Dose, Multicenter Study of VRG50635 in Participants With Sporadic and Familial Amyotrophic Lateral Sclerosis Followed by Long-Term Treatment
This study is testing a new medicine called VRG50635 for people with Amyotrophic Lateral Sclerosis (ALS). It's an early-stage study to see how the medicine works, how much to give, and if it's safe. Both common and inherited forms of ALS are included.
Amyotrophic Lateral SclerosisSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase 1/2 Open-label Study of BMS-986466 in Combination with Adagrasib with or without Cetuximab in Participants with KRAS G12C-mutant Advanced Solid Tumors
This study is testing new combinations of medicines for advanced cancers that have a specific genetic change called KRAS G12C. It's looking at how safe the new medicines are and if they can shrink tumours in people with lung or bowel cancer.
OncologyNSCLC and CRCSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Phase II Study of BMS-986315 and Nivolumab in Combination with Chemotherapy Versus Nivolumab in Combination with Chemotherapy as First-line Treatment for Participants with Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC)
This study is looking at new ways to treat advanced lung cancer. It combines standard chemotherapy with two different drug approaches to see which works best and if there are side effects. Doctors want to find better treatments for non-small cell lung cancer.
Non-small Cell Lung CancerSpain - AuthorisedTherapeutic confirmatory (Phase III)
Impact of Intraoperative Arteriography with Indocyanine Green in Preserving the Parathyroid Glands During Total Thyroidectomy With or Without Central Cervical Lymph Node Dissection. A Multicenter Prospective Randomized Trial.
This study looks at a special dye, indocyanine green, used during thyroid surgery. Doctors want to see if using this dye helps protect tiny glands called parathyroid glands, which are important for keeping your calcium levels healthy. They are comparing surgery with and without the dye.
HypothyroidismSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of TAK-280 in Patients With Unresectable Locally Advanced or Metastatic Cancer
This study is testing a new medicine, TAK-280, for people with advanced cancer that can't be removed by surgery. It's an early-stage study looking at how safe the drug is, what side effects it might cause, and how the body handles it. We also want to see if it helps shrink tumours.
Unresectable Locally Advanced or Metastatic CancerSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Phase 3 Multicenter, Randomized, Double-Blind, Study to Assess the Efficacy and Safety of Treatment with Bepirovirsen in Nucleos(t)ide Analogue-treated Participants with Chronic Hepatitis B Virus (B-Well 2)
This study is looking into a new treatment called Bepirovirsen for people with long-term Hepatitis B. It's hoped this treatment could help some people stop all their Hepatitis B medicines. Researchers want to see if it works well and is safe.
Hepatitis BChronicSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Open-Label, Multicenter, Phase II Study of Multiple Doses of RO7247669 in Participants with Previously Untreated Unresectable or Metastatic Melanoma
This study is testing a new medicine called RO7247669 for advanced skin cancer (melanoma) that has spread or can't be removed by surgery. It's an early-stage trial looking at how safe the medicine is and if it can help slow down or stop the cancer from growing.
Unresectable or Metastatic MelanomaSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Open-Label Extension Study of PRX012 in Subjects with Alzheimer’s Disease Who Were Enrolled in Study PRX012-101 or PRX012-102
This study is an open-label extension, meaning everyone gets the study drug. It's for people with Alzheimer's disease who have already taken part in previous PRX012 studies (PRX012-101 or PRX012-102) to see how the treatment works long-term.
Alzheimer’s DiseaseSpain - Ongoing, recruitingPhase III and phase IV (Integrated)
A phase 3b, interventional, adaptive, clinical trial to evaluate the efficacy and safety of tralokinumab 300 mg every second week monotherapy compared with placebo in subjects with moderate-to-severe atopic hand eczema who are candidates for systemic therapy (ADHAND)
This study is looking into a new treatment called tralokinumab for adults with moderate to severe eczema on their hands. It wants to see how well it works and if it's safe compared to a dummy treatment. The goal is to see if the medicine can clear up or significantly improve hand eczema in a few months.
Atopic dermatitis and moderate-to severe atopic hand eczemaSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
Subcutaneous Methotrexate, Oral Dexamethasone or Oral Montelukast for the Prevention of Infusion Related Reaction Associated with Amivantamab, an EGFR-MET bispecific antibody, Among Post-osimertinib Treated EGFRm NSCLC; SKIPPirr, a Phase 2 Study
This study looks at ways to prevent infusion reactions in people with advanced lung cancer receiving a new combination of medicines. Researchers are testing different medications given before treatment to see if they can reduce side effects when the main cancer drug is given through a drip.
EGFR-mutated Advanced or Metastatic Non-small Cell Lung CancerSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A first-in-human, Phase 1, Dose Escalation Study of SGR-2921 as Monotherapy in subjects with relapsed/refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
This study is testing a new medicine, SGR-2921, for the first time in people. It's for adults with certain blood cancers, Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndrome (MDS), who haven't responded to previous treatments. Researchers want to find a safe dose.
Myelodysplastic syndrome (MDS)Acute Myeloid Leukemia (AML)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Study to Evaluate the Efficacy and Safety of Pembrolizumab plus Investigational Agents in Combination with Etoposide and Cisplatin or Carboplatin for the First-Line Treatment of Participants with Extensive-Stage Small Cell Lung Cancer (KEYNOTE-B99)
This study is looking at new ways to treat advanced small cell lung cancer for the first time. It combines Pembrolizumab with other medications to see how well they work together and if they are safe.
First-line treatment of participants with extensive-stage small cell lung cancerSpain - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Multicenter, Randomized, Double-blind Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Oral Ozanimod (RPC1063) in Pediatric Participants with Moderately to Severely Active Crohn’s Disease with an Inadequate Response to Conventional Therapy
This study is looking at a new medicine called Zeposia for children and young people with Crohn's disease that hasn't responded well to other treatments. Researchers want to see if Zeposia can help improve symptoms and how safe it is over time.
Moderately to Severely Active Crohn's DiseaseSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
Rheumatoid arthritisSpain - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study is looking into a new medicine, efgartigimod, for people with bullous pemphigoid (BP). It compares efgartigimod to a dummy drug (placebo) to see if it can help patients achieve clear skin without needing steroid tablets for a long time.
Bullous Pemphigoid (BP)Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess the effect of CC-95251 alone and in combination with anti-cancer drugs in subjects with Acute Myeloid Leukemia and Myelodysplastic Syndromes
This study is looking at a new medicine called CC-95251 for people with acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Researchers want to see how safe it is and if it works well, both on its own and with other cancer drugs.
Acute Myeloid Leukemia and Myelodysplastic SyndromesSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, single arm, multicenter open label trial to determine the efficacy and safety of tisagenlecleucel (CTL019) in adult patients with refractory or relapsed follicular lymphoma
This study is for adults in the UK with a type of cancer called follicular lymphoma that has come back or not responded to previous treatments. It investigates a new cell therapy called tisagenlecleucel to see how well it works and if it's safe.
Adult patients with refractory or relapsed follicular lymphomaSpain - AuthorisedTherapeutic confirmatory (Phase III)
Is antibiotic prophylaxis necessary in inguinal or femoral hernia repair for the prevention of surgical site infection in our environment?
This study is looking at whether giving antibiotics before surgery for a groin hernia (inguinal or femoral hernia) is truly needed to stop infections. Researchers want to see if patients still heal well without them.
Inguinal or femoral herniaSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
This study is testing a new medicine, tozorakimab, for people with lung disease called COPD. It wants to see if this medicine can help reduce flare-ups of COPD. Some people will get the new medicine, and others will get a dummy medicine, alongside their usual care.
Chronic Obstructive Pulmonary Disease (COPD)Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test a medicine (fitusiran) for preventing bleeds in people with severe hemophilia who previously received preventive treatment with emicizumab
This study is testing a new medicine, fitusiran, for severe haemophilia A. It's for adult men who have bleeding episodes despite taking another preventative treatment called emicizumab. The aim is to see if fitusiran can help reduce these bleeding events.
Hemophilia ASpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 1/2 Multicenter, Open-label Study to Assess the Safety, Pharmacokinetics and Efficacy of CC-92480 Monotherapy and in Combination with Dexamethasone in Subjects with Relapsed and Refractory Multiple Myeloma
This study is looking at a new drug, CC-92480, for people with multiple myeloma that has come back or not responded to previous treatments. It aims to see how safe the drug is, how it moves through the body, and how well it works, both on its own and with another medicine called dexamethasone.
Relapsed and refractory multiple myeloma (RRMM)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
This study is looking into a new tablet called brensocatib for adults with long-term sinus problems that don't involve growths (nasal polyps). It wants to see if this new medicine can help reduce symptoms like stuffy nose and improve how people feel, compared to a dummy pill.
Chronic Rhinosinusitis without Nasal Polyps (CRSsNP)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicenter, Open-label, Phase 2 Basket Study of MK‑7684A, a Co formation of Vibostolimab (MK‑7684) With Pembrolizumab (MK‑3475), With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (KEYVIBE 005)
This study, called KEYVIBE 005, is testing a new combination of medicines (MK-7684A, which includes vibostolimab and pembrolizumab) for people with advanced solid tumours. Researchers want to see how well this new treatment shrinks tumours and stops them from growing, either alone or with other cancer therapies.
Advanced solid tumorsSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma
This study looks at a new combination of medicines (A+AVD) compared to a standard treatment (ABVD) for advanced Hodgkin Lymphoma. It aims to see if the new combination can better control the cancer and help people live longer.
Advanced Classical Hodgkin LymphomaSpain - Ongoing, recruitingPhase III and phase IV (Integrated)
MEMENTO-A Phase 3b/4 Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy to assess the impact on Myocardial Structure with Cardiac Magnetic Resonance Imaging (CMR)
This study is looking at a new medicine called mavacamten for adults with a heart condition called obstructive hypertrophic cardiomyopathy (HCM). It aims to see if the medicine can reduce the thickness of the heart walls and the size of the heart's upper chambers.
Symptomatic Obstructive Hypertrophic CardiomyopathySpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Multicenter, Phase 3 Study of Venetoclax and Azacitidine as Maintenance Therapy for Patients with Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M)
This study is looking at two medicines, venetoclax and azacitidine, to see if they can help people with a type of blood cancer called acute myeloid leukemia (AML) stay well after their first round of treatment. It's a key stage of research to check their safety and how well they work.
Acute Myeloid Leukemia in First RemissionSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
An open-label, multicenter Phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and as a combination therapy in adult subjects with advanced or metastatic solid tumors
This study is testing a new medicine, THOR-707, for people with advanced cancer. It aims to find the safest and most effective dose, and see how well it works alone or with other treatments to shrink tumours and improve health.
CancerSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Month, Randomized, Controlled, Open-Label, Dose Escalation Study Evaluating Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of an Anti-CD2 Monoclonal Antibody, TCD601(siplizumab) Compared to Anti-Thymocyte Globulin (rATG), as Induction Therapy in de novo Renal Transplant Recipients
This study looks at a new medicine called TCD601 (siplizumab) for people who have recently had a kidney transplant. It compares TCD601 to a standard treatment to see if it's safe and how well it helps prevent the body from rejecting the new kidney.
Renal TransplantationSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa)
This study looks at a new gene treatment called Pariglasgene brecaparvovec for adults with a rare liver condition called Glycogen Storage Disease Type Ia (GSDIa). It aims to see how safe it is and if it helps control blood sugar levels long-term.
Glycogen storage disease type IaSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
BelieveIT-201: A Randomized, Phase 2, Open-label Trial of TransCon TLR7/8 Agonist in Combination with Pembrolizumab, TransCon TLR7/8 Agonist in Combination with TransCon IL-2 β/γ, or Pembrolizumab Monotherapy as Neoadjuvant Therapy in Participants with Stage III-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)
This study looks at new ways to treat a type of head and neck cancer before surgery. It's testing new medicines, alone or together, to see if they can shrink the cancer effectively. This could help improve treatment for people with this specific cancer.
Stage III-IVA Resectable Locoregionall Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Randomised, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of AZD4604 Twice Daily for Twelve Weeks in Adult Patients with Moderate to Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA
This study is testing a new medicine, AZD4604, for adults with asthma that isn't well controlled, even with their usual inhalers. We want to see if it helps reduce asthma flare-ups and improve breathing, comparing it to a dummy medicine.
Adult Patients with Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABASpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Patient- and Investigator-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Study Participants With Prodromal to Mild Alzheimer’s Disease (AD), Followed by an Open-Label Extension Period
This study is testing a new medicine called Bepranemab for people with early Alzheimer's disease. Researchers want to see if it's safe and helps with memory and thinking, compared to a dummy drug. It's a key step in understanding if this treatment could work.
Alzheimer’s DiseaseSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy with Nivolumab + Relatlimab Fixed-dose Combination versus Nivolumab Monotherapy after Complete Resection of Stage III-IV Melanoma
This study looks at a new combination treatment for advanced melanoma that has been removed by surgery. It compares two drugs given together (nivolumab and relatlimab) against nivolumab alone, to see if the combination can help prevent the cancer from coming back.
Participants with completely resected Stage III or Stage IV melanomaSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An open-label, prospective Phase III clinical study to compare polatuzumab vedotin plus rituximab, ifosfamide, carboplatin and etoposide (Pola-R-ICE) with rituximab, ifosfamide, carboplatin and etoposide (R-ICE) alone as salvage therapy in patients with primary refractory or relapsed diffuse large B-cell lymphoma (DLBCL)
This study is for adults with a type of lymphoma called DLBCL that has come back or not responded to earlier treatment. It compares two treatments: a standard one (R-ICE) and a new one (Pola-R-ICE) to see which is better at stopping the cancer from growing.
Adult patients with relapsed or primary refractory DLBCLSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2, Umbrella Study of the Efficacy and Safety of Pembrolizumab plus Enfortumab vedotin +/- Investigational Agents in First-Line metastatic urothelial carcinoma
This study is looking at new treatments for advanced bladder cancer that has spread. It combines pembrolizumab and enfortumab vedotin, sometimes with other new medicines, to see if they are safe and work well as a first treatment.
Advanced Urothelial CarcinomaSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Phase 2, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of KER-012 in Combination with Background Therapy in Adult Participants with Pulmonary Arterial Hypertension (TROPOS-Study)
This study is testing a new medicine, cibotercept (also known as KER-012), for adults with pulmonary arterial hypertension (high blood pressure in the lungs). Researchers want to see if it's safe and helps improve lung blood vessel function when added to existing treatments.
Pulmonary Arterial HypertensionSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
OPAL Master Protocol: A Phase 1B/2 Multicohort Umbrella Study to Evaluate the Safety and Efficacy of Novel Treatments and/or Combinations of Treatments in Participants with Ovarian Cancer (OPAL) (PR-3000-02-005/213357) Cohort C: Open-label Phase 2, Randomized, Controlled Multicenter Study Comparing Niraparib Versus Platinum-Taxane Doublet Chemotherapy as Neoadjuvant Treatment in Participants with Homologous Recombination- Deficient Stage III/IV Ovarian Cancer
This study looks at new ways to treat advanced ovarian cancer before surgery. It compares a drug called niraparib with standard chemotherapy. Researchers want to see if the new approach is safer and works better for certain types of ovarian cancer.
Ovarian NeoplasmsSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeSpain