Latest studies
- RecruitingPhase IV
Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with rheumatoid arthritis predictive of response to drug treatments?
This UK clinical study tests whether examining a small sample of joint tissue can help doctors pick the best medicine for rheumatoid arthritis. Adults with active arthritis will have a minor joint biopsy and receive one of two standard biologic medicines to see if tissue tests improve treatment success.
Rheumatoid arthritisSpain - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaSpain - Completed
Barriers and facilitators to deprescribing antithrombotic therapy in advanced cancer patients: A qualitative interview study of patients’, companions’ and clinicians’ experiences and perspectives
This study looks at how people with advanced cancer feel about taking blood-thinning medicines. Researchers want to understand patients' and carers' views on whether and when to stop these treatments. Taking part involves a single 30 to 60-minute interview. The findings will help build a new decision-making app for future patients.
Cancer and deprescribing antithrombotic therapy at end-of-lifeSpain - RecruitingTherapeutic use (Phase IV)
Prospective, randomized, blinded, comparative study between botulinum toxin and topical capsaicin in the treatment of postmastectomy syndrome. Pilot study
This study looks at two different treatments for persistent pain after breast cancer surgery (mastectomy). Researchers want to compare Xeomin injections (botulinum toxin) with Qutenza skin patches (capsaicin, from chilli peppers) to see which one works better at easing nerve pain and improving everyday comfort for women.
Postmastectomy SyndromeSpain - RecruitingPhase II
A Phase Ib/II, open-label study of amivantamab monotherapy and amivantamab in addition to other therapeutic agents in participants with head and neck squamous cell carcinoma
This study tests a targeted drug called amivantamab for head and neck cancer. Doctors want to see if giving amivantamab on its own or alongside other cancer drugs works well to shrink tumours and is safe for patients whose cancer has spread, returned, or requires surgery.
Head and neck squamous cell carcinomaSpain - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseSpain - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaSpain - CompletedPhase III
A randomized, open-label phase 3 study of amivantamab + FOLFIRI versus cetuximab/bevacizumab + FOLFIRI in participants with KRAS/NRAS and BRAF wildtype recurrent, unresectable or metastatic colorectal cancer who have received prior chemotherapy
This clinical trial is testing a new targeted drug, amivantamab, combined with chemotherapy for people with advanced bowel cancer. Researchers want to see if this combination works better at slowing cancer growth and helping people live longer than current standard targeted treatments after their first chemotherapy has stopped working.
Recurrent, unresectable or metastatic colorectal cancerSpain - RecruitingPhase IV
The 3TR-PARTNER-RA study: Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with early Rheumatoid Arthritis (symptoms <12 months) predictive of response to biologic drug treatments?
This UK clinical study investigates whether testing a tiny sample of joint tissue can help doctors choose the most effective treatment for early rheumatoid arthritis. Researchers want to see if specific biological markers can predict whether a modern medicine called abatacept works well for newly diagnosed patients.
Rheumatoid arthritisSpain - RecruitingPhase I
A study of JNJ-95804306 for relapsed or refractory hematological malignancies
This early-stage clinical trial is testing a new medicine called JNJ-95804306 for adults with blood cancers that have returned or stopped responding to standard treatments. Doctors want to find safe doses and check how well the body handles the drug when given alone or with other cancer therapies.
Hematologic neoplasms, blood cancerSpain - CompletedPhase II
Testing new medicine for adults with Cystic Fibrosis who do not have access to the currently available CFTR-modulating drugs due to genetic mutations
This clinical trial tests a new three-in-one medicine for adults with cystic fibrosis who have rare genetic mutations. These patients cannot access currently approved treatments. Researchers are checking whether this daily combination of capsules can safely improve lung health after promising results in laboratory tests using patient cell samples.
Treatment of Cystic Fibrosis (CF) in patients with CFTR mutations who are responders in the organoid assaySpain - RecruitingNot Applicable
Safety and performance of the Nurotron CS-30A cochlear implant system in adults with hearing loss
This study looks at how safe and effective the Nurotron CS-30A cochlear implant is for adults with severe hearing loss in both ears. It aims to see how well the device helps people hear and understand speech when ordinary hearing aids are no longer enough.
Post-lingual severe-to-profound bilateral sensorineural hearing loss in adultsSpain - RecruitingPHASE2, PHASE3
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
This study looks at a new medicine called ponsegromab for advanced pancreatic cancer that has spread, especially when patients have lost a lot of weight and feel very tired. It aims to see if adding ponsegromab to standard chemotherapy helps more than chemotherapy alone.
CachexiaMetastatic Pancreatic Ductal AdenocarcinomaSpain - Active not recruitingPHASE2
A Study of Olaparib Prior to Surgery and Chemotherapy in Ovarian, Primary Peritoneal, and Fallopian Tube Cancer
This study looks at giving olaparib, a new drug, before surgery and chemotherapy for recurrent ovarian, primary peritoneal, or fallopian tube cancer. It aims to see if it can shrink tumours and improve outcomes.
Ovarian CancerFallopian Tube CancerNeoadjuvant TreatmentDebulking Surgical ProceduresSpain - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
This study looks at a new medicine called enicepatide for people who are overweight or have obesity and also have type 2 diabetes. We want to see if it helps with weight loss and if it's safe to use.
Obesity or OverweightType 2 Diabetes MellitusSpain - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
This study is testing a new medicine, Elecoglipron, for adults with type 2 diabetes and kidney problems. It compares Elecoglipron to a dummy pill (placebo) to see if it's safe and effective when taken with other usual diabetes medicines, including dapagliflozin.
Type 2 Diabetes MellitusType 2 Diabetes With Chronic Kidney DiseaseSpain - RecruitingPHASE3
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
This study, called DLLEVATE, is looking at a new treatment, ZL-1310, for people with small cell lung cancer that has come back. It compares ZL-1310 to other standard treatments to see if it's safe and works well. You might be eligible if you're over 18 and have had previous treatments.
Small-cell Lung CancerSpain - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
Obesity or OverweightSpain - RecruitingPHASE3
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
This study looks at combining two medicines, Finerenone and Empagliflozin, for people in the hospital with heart failure. We want to see if this combination works better and is safe compared to usual care for managing their condition.
Heart FailureSpain - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
MyelofibrosisAnemiaSpain - Completed
Multi-centre European study of major infectious disease syndromes (MERMAIDS) – Acute respiratory infections
This study looks at acute chest and throat infections to understand why some people get much sicker than others. Researchers from the University of Oxford are collecting blood and swab samples from adults treated at GP surgeries or hospitals to help develop better, more personalised treatments for future infections.
Acute respiratory infectionsSpain - CompletedPhase I
A modular, multi-part, multi-arm, open-label, phase I/II study to evaluate the safety and tolerability of GRWD5769 alone and in combination with anticancer treatments in patients with solid malignancies
This early-stage clinical trial is testing a new cancer medicine called GRWD5769. It looks at how safe the drug is when taken alone or alongside another cancer drug, cemiplimab. It aims to help the body's immune system recognise and fight advanced solid tumours that have spread or cannot be cured.
Advanced or metastatic solid malignancySpain - Completed
Vitamin D and lifestyle Intervention for gestational diabetes mellitus (GDM) prevention
This study looks at ways to prevent gestational diabetes, which is high blood sugar during pregnancy. Researchers are testing whether vitamin D supplements, healthy eating advice, regular physical activity, or combinations of these can help pregnant women with a higher body mass index stay healthy throughout their pregnancy.
Gestational diabetesSpain - CompletedPhase II
A Phase II study to understand the safety and effects of inhaled SNG001, the study medication, in patients who are mechanically ventilated due to a respiratory viral infection in the lungs
This study tests an inhaled medicine called SNG001 for people in intensive care with severe chest infections caused by viruses like flu or COVID-19. Researchers want to see if breathing in this natural virus-fighting protein helps patients recover faster and spend less time on a breathing machine.
Respiratory viral infectionsSpain - Recruiting
Development and Multi-Centre Validation of a Novel Non-Invasive Melanoma Molecular Diagnostic Test
Researchers are testing a gentle sticky-tape test to detect melanoma, a serious skin cancer. Currently, doctors must cut away suspicious moles to test them. This study investigates whether simple skin tape can accurately collect cells and spot cancer markers, potentially saving many patients from having unnecessary minor surgery in the future.
MelanomaSpain - RecruitingPHASE1, PHASE2
A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003).
This study looks at new ways to treat ovarian cancer that has come back after earlier treatments. It tests a new drug called Raludotatug deruxtecan (R-DXd) by itself or with other standard treatments, to see if it's safe and helps shrink the cancer.
Ovarian Cancer RecurrentSpain - RecruitingPHASE1
Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer
This study is looking at a new medicine, VIR-5500, for prostate cancer that has spread and isn't responding to standard hormone therapy. It will check if the medicine is safe, how it works in the body, and if it helps shrink the cancer, both alone and with other medicines.
Hormone-refractory Prostate CancerSpain - Recruiting
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This study looks at how the quality of CPR given to children during a cardiac arrest affects their recovery. Researchers are observing children in hospitals to see if better CPR techniques and after-care improve survival and brain function.
Cardiac ArrestCardiopulmonary ArrestSpain - RecruitingPHASE2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
This study is testing a new medicine called belzutifan for certain types of advanced cancers, including rare adrenal gland, gut, and kidney cancers. We want to see how well it works and if it's safe for people aged 12 and over.
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorSpain - RecruitingPHASE3
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
This study looks at a new treatment called AAA617 for men with early-stage prostate cancer that has spread a little (oligometastatic). It compares AAA617 to careful watching, to see if it can stop the cancer from growing and help men live better for longer.
Oligometastatic Prostate Cancer (OMPC)Spain - RecruitingPHASE2, PHASE3
A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients
This study is testing a new treatment called hu14.18K322A, given with chemotherapy, for children and young people with a type of cancer called high-risk neuroblastoma. It aims to see if this combination treatment is safe and effective in fighting the cancer.
High-Risk NeuroblastomaSpain - RecruitingPhase III
Tranexamic acid (and Desmopressin) for very early bleeds in the brain
This clinical trial tests whether an affordable medicine called tranexamic acid can stop bleeding in the brain after a stroke. Doctors want to see if giving this injection quickly in the emergency room helps people survive with less long-term disability, improving recovery and everyday life six months later.
Hyperacute primary intracerebral haemorrhage (stroke)Spain - RecruitingPhase III
Phase 3, randomised, double-blind, placebo- controlled, 3-arm study to investigate the safety and efficacy of efimosfermin alfa in participants with biopsy-confirmed F2- or F3-stage metabolic dysfunction-associated steatohepatitis (MASH) (ZENITH-1)
This clinical trial is testing a new injection called efimosfermin alfa for people with metabolic dysfunction-associated steatohepatitis (MASH), an inflamed fatty liver condition. Researchers want to see if monthly injections over four years can safely reduce liver fat, ease inflammation, and improve liver scarring compared to a dummy treatment.
Medical condition: Metabolic Dysfunction-Associated Steatohepatitis (MASH) Medical condition in lay language: Metabolic Fatty Liver Inflamation Therapeutic areas: Diseases [C] - Nutritional and Metabolic Diseases [C18]Spain - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Spain - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseSpain - Not yet recruiting
Phase 3a and 3b update of the gastric cancer module, EORTC QLQ-STO22
Researchers are updating a widely used questionnaire that measures how stomach cancer and modern treatments affect daily life and well-being. If you have stomach cancer, you can help by completing the draft survey and sharing your feedback during a single, one-off chat lasting up to an hour.
Gastric adenocarcinomaSpain - RecruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomized, Double-Blind, Parallel-Group, Placebo Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fexlamose (AER 01) Inhalation Solution in the Treatment of Adults with Moderate to Severe Chronic Obstructive Pulmonary Disease
This clinical trial is testing a new inhaled medicine called Fexlamose for adults with moderate to severe chronic obstructive pulmonary disease (COPD). Researchers want to see if breathing in this liquid medicine for four weeks improves lung function, clears mucus from the airways, and helps people breathe more easily.
Chronic Obstructive Pulmonary DiseaseSpain - RecruitingTherapeutic exploratory (Phase II)
C1071003 - MAGNETISMM-3, An Open-Label, Multicenter, Non-Randomized Phase 2 Study of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One Proteasome Inhibitor, One Immunomodulatory Drug and One Anti-CD38 Antibody
This clinical trial is testing a new medicine called elranatamab for adults with multiple myeloma. It is designed for people whose cancer has returned or stopped responding after trying three standard types of treatment. The aim is to find out how well the drug works on its own.
Multiple myelomaSpain - RecruitingHuman Pharmacology (Phase I)- Other
Phase 1, Randomized, Open-label, Single center study to evaluate Pharmacokinetic and Bioequivalence of Levonorgestrel Vaginal Delivery System in Healthy Female Volunteers after different days of use
This early-stage study looks at a new vaginal device that releases levonorgestrel, a common hormone used in contraception. Researchers want to see how healthy women absorb the hormone into their blood after using the device for different numbers of days. It will check how safe and effective the device is.
No medical conditionSpain - RecruitingTherapeutic exploratory (Phase II)
A Phase 2 Study to Investigate the Safety and Efficacy of Petosemtamab in Adults with Non-Small Cell Lung Cancer in Combination with Pembrolizumab.
This clinical trial is testing a new drug called petosemtamab combined with an established immunotherapy called pembrolizumab (Keytruda). It aims to find out if this combination is safe and effective at shrinking tumours in adults diagnosed with non-small cell lung cancer.
Non Small Cell Lung CancerSpain - RecruitingTherapeutic confirmatory (Phase III)
KontRASt-02: A randomized, controlled, open label, phase III study evaluating the efficacy and safety of JDQ443 versus docetaxel in previously treated subjects with locally advanced or metastatic KRAS G12C mutant non-small cell lung cancer.
This clinical trial compares a new targeted drug called JDQ443 with standard chemotherapy (docetaxel). It is for adults with advanced non-small cell lung cancer that carries a specific genetic change called KRAS G12C. Researchers want to find out which treatment keeps cancer from growing for longer.
Advanced non-small cell lung cancer harboring the KRAS G12C mutationSpain - AuthorisedTherapeutic exploratory (Phase II)
A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Safety, Tolerability, and Efficacy of TAK-360 for the Treatment of Narcolepsy with Cataplexy (Narcolepsy Type 1)
This clinical trial is testing an experimental medicine called TAK-360 for adults with narcolepsy type 1. Researchers want to see if the medicine is safe and helps reduce daytime sleepiness and sudden muscle weakness (cataplexy). Participants will receive either the study medicine or a dummy pill for comparison.
Narcolepsy with Cataplexy (NT1)Spain - Completed
A multi-site observational study looking at the risk factors associated with tooth sensitivity, receding gums and tooth wear
This study looks into why adults develop sensitive teeth, receding gums, and worn tooth enamel. Researchers are studying how diet, brushing, and lifestyle affect oral health across Europe. Taking part is simple: it involves completing a short lifestyle survey and having a gentle mouth check-up during a single dental appointment.
Dentine hypersensitivity Tooth wear Recession Clinical loss of attachment Oral hygiene habits Dietary habitsSpain - RecruitingHuman Pharmacology (Phase I)- Other
M9466 Alone or in Combination in Advanced Solid Tumors (DDRiver 501)
This early-stage clinical trial is testing a new drug called M9466 for adults with advanced solid tumours. Researchers want to find out how safe the medicine is, what dose works best, and how it behaves when given either on its own or with other cancer treatments.
Advanced solid tumorsSpain - AuthorisedTherapeutic exploratory (Phase II)
A Master Protocol of a Phase II, Open-label, Multicenter, Global Platform Study to Evaluate the Safety and Efficacy of Immunotherapy With or Without Other Anticancer Drugs in Participants with Unresectable Stage III Non-small Cell Lung Cancer Planning to Undergo Concurrent Chemoradiotherapy (AQUARIUS)
This clinical study tests a new immunotherapy drug called rilvegostomig for adults with stage 3 non-small cell lung cancer that cannot be removed by surgery. Researchers want to see if adding it to standard chemotherapy and radiotherapy is safe and helps control the cancer better.
Non-small Cell Lung CancerSpain - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
Phase 1-2, Open-Label, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION337 in Patients with Dravet Syndrome
This early clinical trial is testing an experimental medicine called ION337 for people with Dravet syndrome. Researchers want to find out if the drug is safe, how the body handles it, and whether it can help reduce the number of major seizures patients experience.
Dravet SyndromeSpain - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3 Multicenter Double-blind Randomized Study of Taletrectinib Versus Placebo in Patients With ROS1-Fusion Positive Stage IB-IIIA Non-Small Cell Lung Cancer Who Have Undergone Complete Tumor Resection
This clinical trial looks at whether a targeted medicine called taletrectinib can stop lung cancer from returning. It is for adults who have had surgery to completely remove non-small cell lung cancer with a specific gene change known as ROS1. Participants take either taletrectinib capsules or dummy capsules.
Non Small Cell Lung Cancer (NSCLC)Spain - AuthorisedTherapeutic confirmatory (Phase III)
A Long-term Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder for Treatment of Pulmonary Hypertension Associated with Interstitial Lung Disease
This study tests an inhaled dry powder medicine called treprostinil palmitil for adults with high blood pressure in the lungs linked to lung scarring. The trial lasts up to two years to see if the medicine is safe and helps improve breathing, walking ability, and overall quality of life.
Pulmonary Hypertension Associated with Interstitial Lung DiseaseSpain - AuthorisedTherapeutic confirmatory (Phase III)
AugmENtation witH cAnnabidiol iN first episode psyChosis: a doublE blind randomised controlled trial (STEP-ENHANCE Trial)
This clinical trial looks at whether cannabidiol (CBD) can help people experiencing psychosis for the first time. Participants take either CBD liquid or a harmless dummy medicine alongside their standard care for six weeks. Researchers want to see if adding CBD helps reduce symptoms and improves overall recovery.
First Episode Psychosis (FEP)Spain - CompletedPhase II/III
Comparing a two-drug fixed dose combination containing dolutegravir and lamivudine to the usual three-drug combination for maintenance treatment in children aged 2-14 years with HIV infection living in Europe, Thailand and Africa
This trial looks at whether a simpler two-in-one daily tablet works just as well as standard three-drug treatments for children aged 2 to 14 living with HIV. Researchers want to see if taking fewer medicines keeps HIV controlled while causing fewer side effects as children grow.
HIV infection in childrenSpain