Latest studies
- Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase 1 study to evaluate the dose, safety and tolerability of a radionuclide therapy (Radspherin®) in patients with platinum sensitive recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma with peritoneal carcinomatosis following complete surgical resection
This study is testing a new treatment called Radspherin® for women with certain types of ovarian, fallopian tube, or peritoneal cancer that has come back. It's looking at the right dose and how safe it is after surgery.
Platinum Sensitive Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma With Peritoneal CarcinomatosisSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of ezetimibe/atorvastatin
This study is looking at how well two different versions of a medicine called ezetimibe/atorvastatin are absorbed by the body. This medicine is used to help lower cholesterol. We need healthy volunteers to take part and help us understand if the new version works the same as the established one.
Healthy volunteersSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
AKTive-001: A Phase 1/1b Multiple Cohort Trial of ALTA2618 in Patients with Advanced Solid Tumors with AKT1 E17K Mutation
This study is testing a new medicine, ALTA2618, for people with advanced cancers. It's for those whose cancer has a specific change called an AKT1 E17K mutation. This is a very early study to see if the medicine is safe and how it works.
Advanced Solid Tumors with AKT1 E17K MutationSpain - Active not recruitingNA
Pediatric Expansion Study of the Sentio System
This study is looking at how a hearing system, called Sentio, works for children aged 3 to 11. It's already used by adults and older children, and this research aims to check its safety and how well it helps younger children hear better.
Hearing Loss, ConductiveHearing Loss, MixedSingle Sided DeafnessSpain - Recruiting
Atypical Hemolytic-Uremic Syndrome (aHUS) Registry
This study is gathering important information about a rare kidney disease called atypical Hemolytic-Uremic Syndrome (aHUS). It looks at how the disease progresses and how safe new treatments like eculizumab and ravulizumab are for patients of all ages.
Atypical Hemolytic-Uremic SyndromeSpain - AuthorisedPhase II and Phase III (Integrated)
An Operationally Seamless Phase 2/3, Randomized, Active -Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of GS-1720 in Combination With GS-4182 Versus Biktarvy in Virologically Suppressed People With HIV-1
This study is testing a new weekly pill for HIV to see if it's as good as a daily pill people already take. It's for adults whose HIV is already under control. We want to check how safe and effective the new weekly treatment is.
HIV-1 InfectionSpain - Active not recruitingPHASE3
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
This study looks at a new drug, zanidatamab, combined with chemotherapy, and sometimes another drug called tislelizumab. It aims to see if this treatment works better and is safer than standard chemotherapy for advanced stomach and gullet cancers that have HER2.
Gastric NeoplasmsGastroesophageal AdenocarcinomaEsophageal AdenocarcinomaSpain - RecruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
Heart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection FractionObesitySpain - AuthorisedTherapeutic use (Phase IV)
NT-proBNP Selected PreventiOn of cardiac eveNts in a populaTion of dIabetic patients without A history of Cardiac disease; a prospective randomized trial
This study looks at how certain blood pressure and heart medications might help people with type 2 diabetes, who haven't had heart problems before, to avoid future heart issues. It focuses on a specific blood marker (NT-proBNP) to guide treatment.
Diabetes mellitus Type 2Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase IB, Randomized, Placebo-Controlled Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso‑Occlusive Episodes (VOE) in Patients With Sickle Cell Disease (SCD)
This study is testing a new medicine, crovalimab, for people with sickle cell disease who are having a pain crisis (called a vaso-occlusive episode). We want to see if it's safe, how it works in the body, and if it helps reduce pain and other problems.
Sickle Cell DiseaseSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Double-Masked, Randomized, Placebo-Controlled, Parallel-Group, 12 Week Administration With Two-Week Gradual Dose Taper Phase and 38-Week Follow-Up Phase, Phase 3 Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Subjects with Fuchs Endothelial Corneal Dystrophy
This study is looking at new eye drops for people with an eye condition called Fuchs Endothelial Corneal Dystrophy. It checks if the drops help people see better after cataract surgery and another eye procedure. The study lasts about a year.
Fuchs Endothelial Corneal DystrophySpain - RecruitingPHASE3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
This study looks at a new medicine, abelacimab, for people with an irregular heartbeat (atrial fibrillation) who can't take usual blood thinners. It compares abelacimab to a dummy medicine to see if it can prevent strokes.
Atrial Fibrillation (AF)Spain - Active not recruitingPHASE2
Rezafungin for Treatment of Chronic Pulmonary Aspergillosis (CPA) in Adults With Limited Treatment Options
This study is testing a new weekly drug called rezafungin for adults with a serious lung infection called Chronic Pulmonary Aspergillosis (CPA). It's for people who haven't found other treatments effective or can't take them. We want to see if it's safe and helps improve their health over six months.
Chronic Pulmonary AspergillosisSpain - Active not recruitingPHASE1
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
This study looks at a new drug called XL092 for advanced solid tumours like kidney, breast, prostate, or bowel cancer. Researchers are testing it alone and with other drugs (Atezolizumab, Avelumab) to see if it's safe, how it works, and if it can help slow down or shrink tumours.
Neoplasm MalignantRenal Cell CarcinomaHormone Receptor Positive Breast CarcinomaMetastatic Castration-resistant Prostate CancerSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 Study of JNJ-70218902, a T Cell Redirecting Agent, in Advanced Stage Solid Tumors
This early-stage study is testing a new drug, JNJ-70218902, for men with advanced prostate cancer that has spread and no longer responds to standard hormone treatments. It aims to see if the drug is safe and how it works in the body.
Metastatic Castration-Resistant Prostate CancerSpain - RecruitingPHASE2
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
This study is testing a new medicine, GSK4532990, for people aged 18-70 with liver damage caused by alcohol. We want to see if it's safe and if it helps the liver. Some people will get the medicine, others a dummy pill.
Liver Diseases, AlcoholicSpain - RecruitingPHASE2
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
This study is testing a new medicine, ensifentrine, for people with a lung condition called non-cystic fibrosis bronchiectasis. We want to see if it helps reduce flare-ups, improve breathing, and make people feel better, compared to a dummy medicine.
Non-cystic Fibrosis BronchiectasisSpain - AuthorisedPhase II and Phase III (Integrated)
A Randomized, Phase 2/3, Open-Label Study to Investigate the Efficacy and Safety of RP2 in Combination with Nivolumab versus Ipilimumab in Combination with Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients with Metastatic Uveal Melanoma
This study looks at new ways to treat a type of skin cancer in the eye that has spread (metastatic uveal melanoma). It compares two drug combinations, RP2 with Nivolumab, against Ipilimumab with Nivolumab, to see which is safer and more effective.
metastatic uveal melanomaSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
Study 1002-041: An Open-Label Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Bempedoic Acid in Pediatric Patients (6 to 17 Years of Age) with Heterozygous Familial Hypercholesterolemia
This study is looking at a medicine called bempedoic acid for children and teenagers aged 6 to 17 who have a genetic condition called heterozygous familial hypercholesterolemia. We want to see how the medicine works in their bodies and if it's safe.
Heterozygous familial hypercholesterolemia, Heterozygous Familial HypercholesterolemiaSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase I clinical trial to evaluate the pharmacokinetics, safety and tolerability of repeated topical application of PARENTIDE in healthy volunteers
This study is testing a new cream called PARENTIDE on healthy people. We want to see how the cream is absorbed, if it's safe, and if people can tolerate it when used repeatedly. It's an early-stage study to understand the new treatment better.
Healthy volunteersSpain - RecruitingPHASE1
First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors
This study is testing a new experimental medicine, CDR404, for hard-to-treat solid cancers that have a specific marker called MAGE-A4. It's the first time CDR404 is being used in people, and doctors want to see if it's safe and if it can help fight the cancer.
Select Advanced Solid TumorsSpain - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
LeukemiaSpain - RecruitingPHASE3
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
This study is testing a new medicine, volrustomig, for people with a type of head and neck cancer that hasn't spread and wasn't removed by surgery. It aims to see if volrustomig helps prevent the cancer from coming back after standard treatment like chemotherapy and radiotherapy.
Locally Advanced Head and Neck Squamous Cell CarcinomaSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase I/Ib Dose Escalation and Cohort Expansion Study of OMX-0407 a Salt-inducible Kinase inhibitor in patients with previously treated unresectable solid tumours
This study is testing a new medicine, OMX-0407, for people with advanced cancers that can't be removed by surgery and have been treated before. It's an early-stage study to find a safe dose and see how well it works.
Previously treated unresectable solid tumoursSpain - AuthorisedTherapeutic use (Phase IV)
EFFICACY OF INFILTRATED MEPIVACAINE AS A LOCAL ANESTHETIC PRIOR TO ARTERIAL PUNCTURE: A RANDOMIZED CONTROLLED CLINICAL TRIAL
This study looks at how well a pain-numbing medicine called Mepivacaine works to reduce discomfort during a blood test called an arterial puncture. It compares Mepivacaine to a dummy treatment or no treatment at all for patients with breathing problems.
Respiratory disease.Prescripcion o indicación de gasometría.Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efgartigimod PH20 SC Administered by Prefilled Syringe in Adult Participants With Thyroid Eye Disease
This study is looking at a new medicine called Vyvgart for people with Thyroid Eye Disease. It aims to see if the medicine can help reduce bulging eyes and improve eye health, compared to a dummy medicine, over 24 weeks.
Thyroid Eye Disease (TED)Spain - AuthorisedPhase I and Phase II (Integrated)- Other
Phase I/II randomized clinical trial of selinexor plus gemcitabine in selected advanced soft-tissue sarcomas
This study is looking into a new treatment for certain advanced soft-tissue sarcomas (a type of cancer). It combines two medicines, selinexor and gemcitabine, to see if it's safe and helps control the cancer for longer.
Patients with advanced soft-tissue sarcoma (leiomyosarcoma or malignant peripheral nerve sheath tumor) will receive selinexor in combination with gemcitabine.Spain - Enrolling by invitationNA
Optical Coherence Tomography in Acute Vessel Evaluation
This study compares two ways to help people having a heart attack: one uses standard X-rays, the other uses a special camera called OCT. We want to see if the OCT camera leads to better results for patients.
Ischemic Heart DiseaseIschemic Coronary Artery DiseaseACS (Acute Coronary Syndrome)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
EORTC 2120-HNCG: Radiotherapy plus xevinapant or placebo in older patients with locally advanced head and neck squamous cell carcinoma: a randomized phase II study (Ravina)
This study looks at a new drug, xevinapant, given with radiotherapy for older patients with advanced head and neck cancer. We want to see if this combination helps more people live longer without their cancer coming back. It's a Phase II study, meaning we're testing its effectiveness and safety.
Squamous cell carcinoma of head and neckSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Quadruple Masked, Dose-Finding Study to Evaluate the Efficacy and Safety of Intranasal BPL-003, with Open Label Extension, in Patients with Treatment Resistant Depression
This study is testing a new nasal spray, BPL-003, for people with depression that hasn't responded to other treatments. Researchers are looking at different doses to see how well it works and if it's safe.
Treatment-Resistant Depression (TRD)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Global, Open-label, Adaptive Design Study to Investigate the Efficacy and Safety of SerpinPC in Subjects With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B (PRESent-2)
This study is looking into a new medicine called SerpinPC for severe haemophilia A or B. It wants to see if SerpinPC can reduce bleeding in adults with these conditions, especially those who currently treat bleeds as they happen. Researchers will also check how safe the new medicine is.
Severe Hemophilia A or Moderately Severe to Severe Hemophilia BSpain - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-blind, Parallel-group, Placebo-controlled, Flexible-dose, Multicenter Study to Evaluate the Efficacy and Safety of SEP 363856 in the Treatment of Adults with Generalized Anxiety Disorder
This study is looking at a new medicine called Ulotaront for adults with generalised anxiety disorder. We want to see if it helps reduce anxiety and if it's safe to use. Some people will get the new medicine, and others will get a dummy pill.
generalised anxiety disorderSpain - Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
This study is gathering information on a rare genetic condition called LAL Deficiency. It aims to understand the disease better and improve care for affected individuals, from babies to adults. It's a worldwide effort to collect health data over time.
Lysosomal Acid Lipase DeficiencyCholesterol Ester Storage DiseaseWolman DiseaseAcid Cholesteryl Ester Hydrolase Deficiency, Type 2Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study in people with advanced cancer to test whether the amount of BI 907828 in the blood is influenced by taking an OATP inhibitor or a CYP3 inhibitor
This study looks at how a new medicine, BI 907828, behaves in the body of people with advanced cancer. Researchers want to see if other common medicines change how much BI 907828 is in the blood.
Solid cancer tumorsSpain - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathySpain - Active not recruitingPHASE2
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
This study looks at a new drug, tulisokibart, for people with a lung condition called interstitial lung disease (ILD) linked to scleroderma. We want to see if it's safe and helps improve the condition.
Diffuse Cutaneous Systemic SclerosisInterstitial Lung DiseaseSpain - RecruitingPHASE2
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
This study looks at new treatments for stomach or food pipe cancer that can be removed by surgery. It aims to see how safe and effective these new drugs or drug combinations are before and after the operation.
Gastroesophageal AdenocarcinomaSpain - Ongoing, recruitingPhase III and phase IV (Integrated)
A Phase 3b/4, Double-masked, Randomized, International, Parallel-assignment, Multicenter Trial in Patients with Thyroid Eye Disease to Evaluate the Safety and Tolerability of Different Dosing Durations of Teprotumumab
This study is looking at a new treatment called teprotumumab for Thyroid Eye Disease. It aims to safely see if different lengths of taking the medicine affect how well it works and if people need further treatment later.
Thyroid Eye DiseaseSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-label, Multinational, Multicenter, Intravenous Infusion Study of the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Avalglucosidase Alfa in Treatment-naïve Pediatric Participants with Infantile-Onset Pompe Disease (IOPD)
This study is testing a new medicine, Nexviadyme, for babies with a rare genetic condition called Pompe disease. It aims to see if the medicine helps them breathe better and grow, and if it's safe, especially for those who haven't tried other treatments.
Glycogen storage disease type IISpain - Active not recruitingPHASE3
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
This study is testing a new medicine, selumetinib, for adults with a condition called Neurofibromatosis Type 1 (NF1). It focuses on people who have painful, non-removable growths called plexiform neurofibromas. We want to see if this medicine can help reduce symptoms and safely shrink these growths.
Neurofibromatosis 1Plexiform Neurofibroma (PN)Spain - Active not recruitingPHASE3
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
This study looks at a medicine called atezolizumab for people with a type of bladder cancer that has spread into the muscle. It checks if this medicine, given after surgery, can stop the cancer from coming back in those who show signs of tiny cancer cells in their blood.
Muscle-invasive Bladder CancerSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efgartigimod PH20 SC Administered by Prefilled Syringe in Adult Participants With Thyroid Eye Disease
This study is looking into a new treatment called Efgartigimod for Thyroid Eye Disease (TED). Researchers want to see how well it works, if it's safe, and if it causes any side effects. It's a big study involving many people, with some receiving the new drug and others a dummy treatment.
Thyroid Eye Disease (TED)Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 14-week, multicentre, double-blind, randomised, placebo-controlled phase II study with an 8-week treatment period to assess the efficacy and tolerability of a fixed dose of BH-200 (250 mg BID) in outpatients with Major Depressive Disorder (MDD)
This study looks at a new medicine called BH-200 for adults with severe depression. It compares BH-200 to a dummy pill to see if it helps improve mood and daily life better, and if it's safe.
Major Depressive DisorderSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGS: A Phase 3, Open-Label Study of Once Daily Orforglipron Compared with Insulin Glargine in Adult Participants with Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk (ACHIEVE-4)
This study is testing a new medicine, Orforglipron, for adults with type 2 diabetes and who are overweight or obese. It's looking at how well it works compared to an insulin called Glargine to protect against heart problems.
Obesity, Chronic Kidney disease, Type 2 Diabetes, Cardiovascular Diseases, Overweight or Obesity, OverweightSpain - Active not recruitingPHASE3
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
This study looks at treating muscle-invasive bladder cancer. It compares standard chemotherapy with chemotherapy plus a new immunotherapy drug called nivolumab, given before and after surgery. The aim is to see if adding nivolumab helps more people.
Urinary Bladder NeoplasmsMuscle-Invasive Bladder CancerSpain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1/2 Multi-Center Study Evaluating the Safety and Efficacy of KTE-X19 in Pediatric and Adolescent Subjects with Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia or Relapsed/Refractory BCell Non Hodgkin Lymphoma (ZUMA-4)
This study is testing a new treatment called Tecartus for children and teenagers with certain types of blood cancer (leukaemia and lymphoma) that have come back after treatment. We want to see how safe it is and how well it works to help patients get better.
Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) Relapsed/Refractory B-cell non-Hodgkin lymphoma (r/r NHL)Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A randomised, multi-centre, intra-patient imaging and dosimetry crossover study of lutetium (177Lu) rhPSMA-10.1 and lutetium (177Lu) vipivotide tetraxetan (Pluvicto®) in patients with non-curative metastatic prostate cancer
This study compares two treatments, Lutetium-177 rhPSMA-10.1 and Pluvicto, for men with advanced prostate cancer that has spread. Researchers want to see which treatment delivers more helpful radiation to the cancer and less to healthy body parts like the kidneys.
PSMA-positive non-curative metastatic castration-resistant prostate cancerSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer: ENZARAD
This study is looking at how a new treatment for prostate cancer, called enzalutamide, works when used with standard hormone therapy and radiation. It's for men with prostate cancer that hasn't spread but is considered high-risk. We want to see if this combination stops the cancer from spreading.
Localised prostate cancer at high risk of recurrenceSpain - Active not recruitingPHASE3
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A
This study is looking at a new medicine called efanesoctocog alfa (BIVV001) for people with haemophilia A. It aims to see if it's safe and effective over a long time in preventing and treating bleeds, improving joint health and quality of life.
Hemophilia ASpain - Active not recruitingPHASE3
A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)
This study is looking at a new medicine called baricitinib for children aged 1 to 17 with a type of arthritis called systemic juvenile idiopathic arthritis (sJIA). It aims to see if baricitinib is safe and helps to reduce their symptoms.
Systemic Juvenile Idiopathic ArthritisSpain