Digestive health research
IBS, IBD, Crohn's, coeliac disease and other gut and liver conditions.
588 indexed studies · 271 currently recruiting
Top conditions in this hub
- Ulcerative Colitis79
- Crohn's Disease51
- Crohn Disease37
- Inflammatory Bowel Diseases23
- Colitis, Ulcerative19
- Ulcerative Colitis (UC)16
- Non-Alcoholic Fatty Liver Disease15
- Liver Cirrhosis15
- Moderately to severely active ulcerative colitis12
- Liver Transplantation10
- Non-alcoholic steatohepatitis10
- Inflammatory bowel disease.10
- Crohn Disease (CD)9
- Irritable Bowel Syndrome9
- Chronic hepatitis B8
- Hepatocellular Carcinoma8
Recent studies
- RecruitingPHASE2
Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions
This study is testing a new medicine, AHB-137, for people with long-term hepatitis B. It aims to see how well it works and if it's safe when added to their current treatment. It's for adults already taking medicine for hepatitis B.
United States · Canada · France - Active not recruitingPHASE3
A Long-term Extension Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
This study is looking into the long-term effects and safety of a medicine called mirikizumab for people with Crohn's disease. Participants have already taken part in a related study, and this new study will help us understand how the medicine works over a longer period.
United States · Argentina · Australia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
United States · Australia · Austria - Active not recruitingPHASE3
A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
This study looks at a new medicine called risankizumab for Crohn's disease. We're checking how well it works and if it's safe for people who have already started treatment. It's like a follow-up to see how different doses work and how people feel over time.
United States · Argentina · Australia - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
United States · Australia · Austria - RecruitingPHASE2, PHASE3
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine, icotrokinra, for people in the UK with moderately to severely active Crohn's disease. Researchers want to see if it helps reduce symptoms and if it's safe to use, compared to a dummy medicine.
United States · Argentina · Australia - Active not recruitingPHASE3
Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
This study compares two treatments, risankizumab and ustekinumab, for adults with moderate to severe Crohn's disease. Researchers want to see which treatment works best to reduce Crohn's symptoms. Both treatments are given initially by IV, then by injection.
United States · Argentina · Australia - Active not recruitingPHASE3
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
This study looks at a new medicine called upadacitinib for adults with Crohn's disease. It checks how well it works and if it's safe over a long time for people who have already started treatment in previous studies. The aim is to see if it can help manage Crohn's.
United States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
United States · Argentina · Australia - RecruitingPHASE2
FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis
The FARGO trial is investigating if a 'healthy gut bacteria transplant' (Faecal Microbiota Transplant, or FMT) can help people in the UK with the liver condition Primary Sclerosing Cholangitis (PSC) who also have Inflammatory Bowel Disease (IBD). Half of the participants will receive FMT, and the other half a dummy treatment, to see if it improves their condition.
United Kingdom - Active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase IIa, open label, Single-centre study to assess the initial antifibrotic efficacy, safety, tolerability, pharmacokinetic and pharmacodynamic profile of MBF-118 in Crohn’s disease patients with stenosis.
This study is testing a new medicine, MBF-118, for people with Crohn's disease whose gut has narrowed (stenosis). Researchers want to see if it's safe and if it helps reduce the narrowing and inflammation, over about two months.
Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, 2-part, placebo-controlled study to evaluate the efficacy, safety, and PK of PF-07054894 in participants with mild to severe UC.
This study is testing a new medicine called PF-07054894 for people with ulcerative colitis. It will check if the medicine is safe, how well it works, and how the body uses it, compared to a dummy pill.
Germany · Poland - Ongoing, recruitingTherapeutic use (Phase IV)
Phase IV comparative, randomized, open-label pilot study to evaluate the efficacy and safety of a rilpivirine-based antiretroviral treatment regimen in HIV-infected patients with metabolic liver disease who maintain undetectable HIV viral load
This study looks at how well a specific HIV treatment helps people with both HIV and liver problems. It compares a new medicine combination to standard treatments to see if it improves liver health over 18 months.
Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 0 Open Label Positron Emission Tomography Study to Assess the Biodistribution and Binding Characteristics of [11C]AZ14132516 Following Administration to Healthy Participants
This early-stage study uses special scans to see how a new experimental substance called [11C]AZ14132516 moves and attaches in the body of healthy volunteers. It helps scientists understand if it could eventually be used to study Crohn's disease.
Sweden - RecruitingPHASE2
Target Engagement of EXL01 in the Prevention of Post-operative Recurrence of Crohn's Disease
This study looks at a new medicine called EXL01 to see if it can stop Crohn's disease from coming back after surgery. Patients will be given either EXL01 or a dummy pill for about six months to see if it helps.
France - Ongoing, recruitingTherapeutic exploratory (Phase II)
Focus Green: Fluorescence-guided resection Of Colorectal liver metastases Using SGM-101 and Indocyanine GREEN
This study looks at new ways to find and remove bowel cancer that has spread to the liver. It uses special dyes and imaging during surgery to help surgeons see cancer cells more clearly and make sure all of them are removed, improving treatment.
Netherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Learn How Different Amounts and Forms of the Study Intervention Called PF-07899895 are Tolerated and Act in the Body of Healthy Adults
This study is looking at a new medicine called PF-07899895 to see how well healthy adults tolerate it and how it works in their bodies. This is the first time it's being given to people.
Belgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Multicenter, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, JNJ-77242113, for people in the UK with moderate to severe ulcerative colitis. We want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
Czechia · Spain · Poland - Not yet recruitingNA
Supporting Children and Young People to Live Well With Coeliac Disease: A RCT
This study looks at a new online resource for parents of children aged 7-11 with coeliac disease. It aims to help families manage their child's special diet better and improve everyone's wellbeing. Half of the families will get the resource straight away, and half will get it later.
United Kingdom - RecruitingPHASE3
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
This study is testing a new medicine, efruxifermin, for people with a serious liver condition called NASH/MASH cirrhosis. It's to see if the medicine helps improve liver health in those with scarring that hasn't yet caused severe problems.
United States · Argentina · Australia - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called Afimkibart for people with moderately to severely active Crohn's disease. It's a Phase 3 study, which means it's a big step before the medicine might become widely available, looking at how well it works and if it's safe.
United States · Argentina · Australia - Active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new combination treatment, JNJ-78934804, for people aged 18-65 with Crohn's disease that is moderate to severe. It compares this new treatment to existing medicines, guselkumab and golimumab, to see how well it works over 48 weeks.
United States · Australia · Austria - Active not recruiting
A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)
This study looks at the long-term effects of a medicine called Humira for adults with a bowel condition called ulcerative colitis. It aims to see how well Humira works and if it's safe over a long time when used as doctors usually prescribe it.
United States · Australia · Austria - Enrolling by invitation
European TIF2.0 Registry
This study looks at a keyhole procedure called TIF to treat reflux (heartburn and sickness). Doctors want to see how safe and effective it is for people experiencing symptoms like stomach acid coming up and a sore throat, sometimes combined with a small hernia repair.
Austria · Italy · Serbia - Active not recruiting
A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)
This study looks at how well a medicine called Humira works and how safe it is for children aged 6 to 17 with Crohn's disease. It also compares Humira to other common treatments like azathioprine, 6-mercaptopurine, or methotrexate, watching patients over a long time.
United States · Bosnia and Herzegovina · Bulgaria - Recruiting
Endoscopic Severity Image Recognition to Advance Research and Training in Inflammatory Bowel Disease (EVEREST - IBD)
This study aims to improve how doctors check inflammatory bowel disease (IBD) using a camera test called an endoscopy. We're training computers to understand these images better, hoping to lead to more accurate checks, earlier detection of issues, and improved care for people with IBD.
United Kingdom - Active not recruitingPHASE2
A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver
This study looks at a new drug, QBECO, for bowel cancer that has spread to the liver. It aims to see if QBECO, given before and after surgery, can reduce the chance of the cancer growing or coming back, compared to a dummy drug.
Canada - RecruitingNA
AIRE-2 Device for Study of Breath Analysis in IBD
This study looks at how diet, gut bugs, and symptoms affect people with Inflammatory Bowel Diseases (IBD) and their household members. It uses a device called AIRE-2 and a phone app to track breath, symptoms, and food. The aim is to understand these links better.
Canada - Active not recruiting
HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B
This study looks at how your body's defence system, called the immune system, works in people with long-term hepatitis B. Researchers want to understand the balance between parts of the immune system that control the virus and those that fight it, to learn why some people get sicker than others.
United States · Canada - RecruitingPHASE4
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
This study looks at how a treatment called anti-TNF works for children aged 6-17 with newly diagnosed Crohn's disease. Researchers want to understand why some children get better and others don't, helping doctors offer more tailored care.
United States · Canada - Active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - Recruiting
Quantitative Ultrasound Techniques for Diagnosis of Nonalcoholic Steatohepatitis
This study is testing new, safe ultrasound scans to diagnose advanced fatty liver disease (NASH). These scans could replace painful liver biopsies, making it easier to check for liver fat, inflammation, and scarring.
Canada - AuthorisedTherapeutic use (Phase IV)
Phase IV, single-center, randomized, crossover clinical trial to validate the use of gadopiclenol versus gadobutrol in the evaluation of magnetic resonance imaging (MRI) diagnosis of perianal fistula associated with Crohn's disease
This study compares two special dyes used in MRI scans for Crohn's disease patients with perianal fistulas. It checks which dye helps doctors see the fistulas more clearly to give better treatment.
Spain - RecruitingPHASE2
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
This study is looking at a new medicine called tenofovir alafenamide (TAF) for children and teenagers aged 2-17 with long-term hepatitis B. It aims to see if TAF is safe and works better than a dummy medicine (placebo) and to find the right dose for different age groups.
United States · Belgium · Canada - Active not recruitingNA
The CanDo (Canadian Donor Milk) Trial
This study looks at whether giving donor breast milk or formula to certain babies in hospital helps them with breastfeeding and their health. It focuses on babies who might need extra milk, like those born to diabetic mothers, or who are smaller or a little early.
Canada - RecruitingNA
APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor
This study looks at a special technique during liver transplants for when donor livers aren't perfect. We want to see if a temporary bypass, called a porto-caval shunt, helps protect the new liver and makes it work better by reducing stress during the operation.
France - RecruitingNA
The DRAGON 2 Trial
The DRAGON 2 study looks at treating advanced bowel cancer that has spread to the liver. It compares a standard procedure called PVE with a newer one, PVE/HVE, to help the liver grow before surgery. This aims to make liver surgery safer for more people.
United States · Australia · Austria - RecruitingPHASE4
Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations
This study compares two forms of medicine called tacrolimus, given after a liver transplant. It aims to see which one causes fewer shaky hands (tremors), a common side effect, to help patients recover better.
Canada - Active not recruitingPHASE3
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
This study is looking at a medicine called tofacitinib for children aged 2-17 with a bowel condition called ulcerative colitis. It aims to see how well it works, how safe it is, and how the body uses it, especially if other treatments haven't worked.
United States · Australia · Belgium