Digestive health research
IBS, IBD, Crohn's, coeliac disease and other gut and liver conditions.
576 indexed studies · 263 currently recruiting
Top conditions in this hub
- Ulcerative Colitis78
- Crohn's disease49
- Crohn Disease37
- Inflammatory Bowel Diseases23
- Colitis, Ulcerative17
- Non-alcoholic Fatty Liver Disease15
- Ulcerative Colitis (UC)15
- Liver Cirrhosis14
- Moderately to Severely Active Ulcerative Colitis12
- Non-alcoholic Steatohepatitis10
- Inflammatory bowel disease10
- Liver transplantation9
- Crohn Disease (CD)9
- Irritable Bowel Syndrome8
- Chronic hepatitis B8
- Hepatocellular Carcinoma8
Recent studies
- RecruitingPHASE3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
This study looks at new medicines, retatrutide and tirzepatide, for adults with a type of fatty liver disease called MASLD. It aims to see if these drugs can help prevent serious liver problems. Some participants will receive a dummy drug (placebo) to compare.
United States · Argentina · Australia - RecruitingNA
Time-restricted Feeding in MASLD
This study looks at how a special eating plan called 5:2 time-restricted feeding affects a liver condition called MASLD. Participants will eat normally for five days and have very low calories on two days. We want to see if this helps improve the liver and overall health.
Germany - Active not recruitingPHASE2
A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection
This study is testing new medicines, Tobevibart and Elebsiran, against an existing treatment, Bulevirtide. It's for people in the UK who have long-lasting hepatitis delta virus (HDV) infection to see which treatment works best to control the virus and improve liver health.
Belgium · Bulgaria · France - Recruiting
Global Research Initiative for Patients Screening on MASH
This study aims to improve how doctors find serious liver conditions like MASH in people with health problems like diabetes or obesity. It brings together healthcare providers across Europe to use new care guidelines and raise awareness about these liver diseases.
Belgium · Czechia · France - RecruitingPHASE3
A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)
This study compares two new treatments, brelovitug and bulevirtide, for chronic Hepatitis Delta. It aims to see which is more effective for people with this liver condition, helping us find better long-term solutions.
Austria · Czechia · France - RecruitingPHASE2, PHASE3
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
This study looks at switching from one existing medicine, Bulevirtide, to a new one, Brelovitug, for people with long-term Hepatitis D. Researchers want to see if the new medicine is safe and works better.
Austria · Czechia · France - Not yet recruiting
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
This study looks at how the body's immune system reacts to severe liver failure and serious infections (sepsis). We want to understand what makes inflammation spread and find new ways to treat these conditions, hopefully reducing the need for liver transplants.
United Kingdom - RecruitingPHASE3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
This study looks at combining two medicines, mirikizumab and tirzepatide, for adults with ulcerative colitis (UC) who are also overweight or obese. The goal is to see if this combination helps UC symptoms improve and also leads to significant weight loss.
United States · Austria · Belgium - RecruitingPHASE4
Phase 4 Paediatric Study to Evaluate Sonazoid Safety and Efficacy for Contrast-Enhanced Ultrasound Liver Imaging
This study looks at a special ultrasound scan using a contrast dye called Sonazoid for children with liver growths. It aims to see how well this scan helps doctors tell if these growths are harmless or serious, helping them make the best treatment plans.
Germany · Italy · United Kingdom - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine, Afimkibart, for people with moderate to severe Crohn's disease. We want to see if it helps reduce symptoms and if it's safe to use. Half the people will get the new medicine, and half will get a dummy medicine.
United States · Argentina · Australia - Active not recruitingNA
Stereotactic Body Radiation Therapy (SBRT) Efficiency and Toxicity in Liver Cancer
This study looks at a special type of radiation called SBRT for treating liver cancer or cancer that has spread to the liver. It checks how well it works and if it causes side effects in many different patients across the UK.
France - RecruitingPHASE1
Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
This study is looking into a new treatment called sacituzumab govitecan for people with advanced cancer and some liver problems. It aims to find the safest dose and understand its effects in this group of patients.
United States · France · Italy - RecruitingPHASE2
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
This study looks at new medications for adults with moderate to severe Crohn's disease. Researchers want to see how well these 'targeted therapies' work and if they cause side effects, to find better ways to manage the condition.
United States · Austria · Belgium - RecruitingPHASE4
Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
This study looks at how certain medicines for ulcerative colitis affect your heart and blood vessels. Researchers want to see if drugs like anti-TNF, vedolizumab, and tofacitinib change things like blood vessel stiffness or thickness over time.
France - RecruitingPHASE1
First in Human Safety and Ease of Use Assessment of 400mg Progesterone Callavid in Women With Luteal Phase Insufficiency
This study is testing a new way to deliver progesterone, called Callavid, for women with luteal phase insufficiency who have experienced miscarriage. It checks if it's safe, easy to use, and how well it gets progesterone into the body, compared to existing treatments.
United Kingdom - RecruitingNA
Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
This study looks at a blood test for organ transplant patients with Cytomegalovirus (CMV) infection. It aims to see if this test can help doctors decide who really needs antiviral medicine, to avoid unnecessary treatment and its side effects.
France - Active not recruiting
Evaluation of the Impact of Rotating Posterior and Transverse Presentations At 2 Hours of Full Dilation
This study looks at a gentle way to help babies turn during labor if they're not in the best position. It aims to see if waiting a little longer before helping them turn by hand makes for better deliveries for mums and babies.
France - Active not recruitingPHASE1
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
This study looks at new treatments for advanced bowel cancer that has spread. It tests a new vaccine (ATP128), a drug called BI 754091, and sometimes another vaccine (VSV-GP128), both alone and in combinations, to see if they are safe and how well people tolerate them.
United States · Belgium · Germany - RecruitingPHASE2
Safety of Atezolizumab-Bevacizumab in Liver Transplanted Patients With Advanced Hepatocellular Carcinoma
This study looks at a new combination treatment, Atezolizumab-Bevacizumab, for liver transplant patients in the UK with advanced liver cancer that has come back. It aims to see if this treatment is safe and effective when used with special medicines to prevent organ rejection.
France - Active not recruitingNA
Formula Diet Treatment for NASH Patients.
This study looks at how a special diet, called a formula diet, might help people with a liver condition called NASH, or fatty liver. It aims to see if changing your diet can improve this condition, for which there isn't a standard treatment yet.
Germany - RecruitingNA
KONO-S Anastomosis Compared to Conventional Ileocolonic Anastomosis to Reduce Recurrence in Crohn's Disease
This study compares two surgical techniques for Crohn's disease: the Kono-S method and a standard method. It aims to see which is better at preventing the disease from returning after surgery.
France - RecruitingNA
Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
This study looks at the best way to remove liver tumours from bowel cancer patients with a specific genetic change (RAS mutation). It compares two types of surgery to see which helps patients live longer without the cancer returning in the liver.
Germany - Recruiting
Analysis of Therapeutic Management Strategies for Anal Suppurations of Crohn's Disease
This study looks at the best ways to treat anal Crohn's disease, specifically focusing on infections and abscesses. We want to find out which treatments, combining medication and surgery, work best to completely heal these problems and keep them away for a long time.
France - RecruitingPHASE1, PHASE2
Dose Escalation of Allogeneic Adipose Derived Stroma/Stem Cells for the Treatment of Crohn's Fistula
This study is testing a new cell treatment, called CellReady®, for difficult-to-treat Crohn's fistulas. It aims to see if different doses of these special cells can help heal fistulas when usual treatments haven't worked.
France - RecruitingPHASE3
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
This study compares two medicines, guselkumab and risankizumab, for people with moderate to severe Crohn's disease. Researchers want to see which one works better to reduce inflammation in the gut and improve symptoms.
United States · Canada · China - Recruiting
Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells
This study compares two treatments for anal fistulas in people with Crohn's disease: a new cell therapy called Alofisel and a treatment using your own body fat (fat stem cells). It aims to see which is more effective for these complex fistulas.
France - Recruiting
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
This study looks at how heart attacks affect people with and without diabetes. We want to understand more about metabolism, how bodies use energy, and their link to heart health to help improve treatments for people who've had a heart attack.
Germany - Active not recruitingPHASE2, PHASE3
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called guselkumab for people with ulcerative colitis that isn't well-controlled. We want to see if it helps reduce symptoms and if it's safe to use for those with moderate to severe forms of the condition.
United States · Argentina · Australia - Active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
This study is looking into a new treatment called Rosnilimab for people in the UK with moderate to severe ulcerative colitis. It aims to see how safe and effective it is compared to a dummy treatment.
United States · Austria · Bulgaria - RecruitingPHASE2
Soluble Fibre Supplementation in NAFLD
This study, called FIND, is looking at whether a special fibre supplement can help children aged 8-17 with fatty liver disease. Participants will take either the fibre or a dummy pill, and doctors will check their liver fat, diet, and do blood tests.
Canada - Recruiting
Functional Digestive Disorders Observatory
This study looks at common gut problems like IBS, constipation, and tummy pain. Researchers are collecting health information and samples (like blood) from adults already getting care. The aim is to understand these conditions better and find new ways to diagnose or treat them.
France - Recruiting
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease
This study looks at how genetics affect severe liver damage caused by alcohol. Researchers want to understand more about alcoholic hepatitis, its impact on people, and how to diagnose it. They're collecting information and samples to help improve care for those with alcohol-related liver diseases.
France - Recruiting
Pathogenic Study of Adult Immune Enteropathies
This study looks into why certain gut conditions, like coeliac disease and inflammatory bowel diseases, happen. Researchers want to understand how the immune system in the gut goes wrong and how it might lead to other problems, including those affecting the liver.
France - Not yet recruiting
Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance
This study looks at how new imaging technology helps treat cancers in the liver, lung, and bone. It collects information from patients already receiving these treatments to see if the advanced scans can improve planning and results in the future.
France · Netherlands - RecruitingNA
Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcifications
This study looks at how liver problems, especially scarring, might affect the hardening of arteries. Researchers want to see if liver transplants can help by bringing a natural body chemical back to normal levels, potentially slowing down artery changes. They'll use blood and urine tests.
France - Active not recruiting
Observational Study, to Assess Treatment Retention of an Adalimumab Biosimilar (Hyrimoz®) in IBD Patients in Real Life Setting
This study looks at how well people with Inflammatory Bowel Disease (IBD) stay on a medicine called Hyrimoz® for up to six months. It helps us understand how the medicine works in real life.
Belgium · France - Enrolling by invitationPHASE1, PHASE2
TherVacB - A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine Candidate
This study is testing a new hepatitis B vaccine called TherVacB. It aims to see if it's safe and helps the body fight the hepatitis B virus in people who are already taking medication for it.
Germany - Active not recruitingPHASE3
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
This study looks at the long-term safety of a medicine called filgotinib for adults with ulcerative colitis. It's for people who have already been in another filgotinib study. The main goal is to see if taking filgotinib over a longer time is safe.
United States · Argentina · Australia - Active not recruitingNA
Interventions to Curb Hepatitis C Reinfections Among Men Who Have Sex With Men
This study looks at new ways to help men who have sex with men (MSM) avoid getting hepatitis C again after they’ve been cured. We're testing online advice, home-based testing, or a combination of both to see if these can prevent reinfection and stop the spread of the virus.
France · Netherlands - RecruitingPHASE2
Safety and Efficacy of OD-07656 and of Subsequent Vedolizumab Therapy in Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, OD-07656, for people with moderate to severe ulcerative colitis. It also looks at whether OD-07656 can improve the effects of another medicine called vedolizumab when used afterwards. The main goal is to check how well the medicines work and if they are safe.
Australia · Austria · Canada