Infectious diseases research
Vaccines, antivirals and trials for COVID-19, HIV, flu and more.
614 indexed studies · 232 currently recruiting
Top conditions in this hub
Recent studies
- RecruitingPHASE2
Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions
This study is testing a new medicine, AHB-137, for people with long-term hepatitis B. It aims to see how well it works and if it's safe when added to their current treatment. It's for adults already taking medicine for hepatitis B.
United States · Canada · France - RecruitingPHASE1
Development of a Controlled Human Infection Model for Assessment of SARS-CoV-2 Omicron Subvariants
This study is looking into how a specific type of COVID-19 (Omicron EG.5.1) affects healthy, vaccinated adults. Volunteers will be given a small amount of the virus in their nose to help scientists understand the infection and immune response, and to test future vaccines and treatments.
United Kingdom - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 4-week double-blind, randomized, placebo-controlled, phase II study evaluating the effects of oral pamapimod 150 mg with pioglitazone 10 mg daily on COVID-19 evolution and recovery in non-hospitalized patients infected with SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2)
This study looks at how two medicines, pamapimod and pioglitazone, might help people with COVID-19 who don't need to be in hospital. It aims to see if they can help people get better faster and reduce their symptoms. Participants will take one of the study medicines or a dummy pill for 4 weeks.
Germany - Ongoing, recruitingTherapeutic use (Phase IV)
A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs. Standard-Dose Quadrivalent Influenza Vaccine in Older Adults
This study is looking at whether a high-dose flu vaccine works better than the standard flu vaccine for older adults. It aims to see if the high-dose vaccine helps prevent hospital stays due to flu or pneumonia.
Denmark - Ongoing, recruitingTherapeutic use (Phase IV)
Phase IV comparative, randomized, open-label pilot study to evaluate the efficacy and safety of a rilpivirine-based antiretroviral treatment regimen in HIV-infected patients with metabolic liver disease who maintain undetectable HIV viral load
This study looks at how well a specific HIV treatment helps people with both HIV and liver problems. It compares a new medicine combination to standard treatments to see if it improves liver health over 18 months.
Spain - Ongoing, recruitingPhase III and phase IV (Integrated)
Prospective Randomized trial of Everolimus replacing MMF/MP Acid by the RECOVAC consortium to increase VACcine response in kidney transplant patients
This study looks at how well kidney transplant patients respond to COVID-19 and shingles vaccines when their anti-rejection medication is changed. It compares two different drug treatment plans to see which one helps the body make more protective antibodies.
Netherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase II, randomized, double-blind, multi-centre trial to evaluate the safety and immunogenicity of BIMERVAX® when coadministered with seasonal surface antigen, inactivated, adjuvanted influenza vaccine (SIIV) in adults older than 65 years of age fully vaccinated against COVID-19.
This study is testing a new COVID-19 vaccine, BIMERVAX®, when given at the same time as a regular flu jab. We want to see if it's safe and how well it helps your body fight off viruses in people over 65.
Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
Open-label, Multi-centre, Non-Inferiority study of safety and immunogenicity of BIMERVAX as heterologous booster for the prevention of coronavirus disease 2019 (COVID-19) in adolescents from 12 years to less than 18 years of age.
This study is looking at a new COVID-19 booster vaccine called BIMERVAX for teenagers aged 12 to 17. It aims to see if BIMERVAX is as safe and effective as another vaccine, HIPRA-HH-2, in boosting protection against the Omicron variant of COVID-19.
Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2a, double-blind, randomized, placebo-controlled trial of methylprednisolone versus placebo in patients with cognitive deficits in post-COVID-19 syndrome (PCS) - PoCoVIT
This study is looking at whether a medicine called methylprednisolone can help people with memory problems and 'brain fog' after having COVID-19. It compares this medicine to a dummy pill to see if it improves how satisfied people are with their memory.
Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Bemnifosbuvir in High-Risk Outpatients with COVID-19
This study is testing new treatments for COVID-19 in people who are at higher risk of becoming very unwell. It compares a new medicine called Bemnifosbuvir with usual care and Paxlovid to see if it helps prevent serious illness or hospital stays.
Latvia · Netherlands · Sweden - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy
This study looks at two different daily pill combinations for adults newly diagnosed with HIV. It compares a two-drug treatment with a three-drug treatment to see which is safer and works better for controlling the virus.
Argentina · Belgium · Denmark - RecruitingPHASE3
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
This study is testing a new medicine, efruxifermin, for people with a serious liver condition called NASH/MASH cirrhosis. It's to see if the medicine helps improve liver health in those with scarring that hasn't yet caused severe problems.
United States · Argentina · Australia - RecruitingPHASE3
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
This study looks at a new medicine called Tozorakimab. We want to see if it can help people in hospital with lung infections who need extra oxygen. The goal is to stop them from getting sicker, like needing a breathing machine, or even dying.
United States · Argentina · Australia - Not yet recruitingPHASE2
Phase 2a Study of the Efficacy and Safety of TRX-100 in a Human Influenza A Challenge Model
This study is looking into a new medicine, TRX-100, to see if it can help prevent flu (influenza A). We want to find out if it's safe and effective in healthy adults by giving them the medicine and then a small amount of the flu virus.
United Kingdom - Not yet recruiting
TB Stigma in the UK: Patients Experiences and Everyday Responses
This study looks at how people in the UK feel about having tuberculosis (TB). It explores their experiences with stigma, which is when people feel negatively judged or treated differently because of their illness. The aim is to understand common challenges and improve support for patients.
United Kingdom - Active not recruitingPHASE3
Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
This study looks at whether switching from daily tablets to monthly injections can keep HIV under control in adults. It's for people whose HIV is already well-managed with current medication, testing a new long-acting injectable treatment.
United States · Canada · France - Active not recruitingPHASE2
Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study
This study is looking into a new way to treat COVID-19 in hospital. We're testing if breathing in a medicine called Interferon Beta 1b through a nebuliser can help patients who need oxygen. This might reduce the need for oxygen and help people recover faster.
France - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
efficacy and safety of the use of regulatory T cells in immune hyperactivation in patients with COVID-19 and/or acute respiratory distress syndrome
This study is looking at a new treatment involving special immune cells for people very sick with COVID-19 or a severe lung problem called ARDS. It aims to see if this treatment is safe and helps calm down an overactive immune system, which can make these illnesses worse.
Spain - Ongoing, recruitingTherapeutic use (Phase IV)
(The Lion Trial) LAIV induced Immune respOnse in the Nasopharynx
This study, called 'The Lion Trial,' is looking at how the Fluenz nasal spray flu vaccine works. Researchers want to understand if the vaccine virus is found in the nose after vaccination and how the body’s immune system reacts to it.
Netherlands - Not yet recruitingEARLY_PHASE1
Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission
This study looks at treating donated kidneys with a special medicine called SYN002 before transplant. The aim is to remove a common virus (CMV) from the kidney, which can cause problems after transplant, making the transplant safer for the patient.
Canada - Active not recruiting
HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B
This study looks at how your body's defence system, called the immune system, works in people with long-term hepatitis B. Researchers want to understand the balance between parts of the immune system that control the virus and those that fight it, to learn why some people get sicker than others.
United States · Canada - RecruitingPHASE2, PHASE3
Secondary Prevention of Clostridioides Difficile Using Vancomycin
This study looks at whether a medicine called vancomycin, given after a C. difficile infection, can stop it from coming back, especially when you need to take other antibiotics. We want to see if this helps prevent repeat infections.
Canada - Recruiting
Quantitative Ultrasound Techniques for Diagnosis of Nonalcoholic Steatohepatitis
This study is testing new, safe ultrasound scans to diagnose advanced fatty liver disease (NASH). These scans could replace painful liver biopsies, making it easier to check for liver fat, inflammation, and scarring.
Canada - Ongoing, recruitingTherapeutic use (Phase IV)
Impact of influenza vaccination on nasal resident memory immune responses and respiratory peripheral memory immune responses - MUCOVAC 2
This study, MUCOVAC 2, is looking at how flu vaccines protect against the flu. Specifically, it's exploring how the vaccine affects the body's immune cells in the nose and blood, aiming to understand better how our bodies learn to fight off the flu.
France - Recruiting
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
This study looks at how donor and medical choices affect lung transplant success. Researchers will collect information and blood samples from patients, donors, and those waiting for a transplant. The goal is to improve care and understand complications like infection or rejection.
United States · Canada - RecruitingPHASE2
Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
This study is looking at a new medicine called tenofovir alafenamide (TAF) for children and teenagers aged 2-17 with long-term hepatitis B. It aims to see if TAF is safe and works better than a dummy medicine (placebo) and to find the right dose for different age groups.
United States · Belgium · Canada - RecruitingPHASE3
A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1
This study looks at a new long-acting medicine for people with HIV whose current treatment isn't fully controlling the virus. It checks how well it works and if it's safe. We also want to know what patients think about it.
United States · Argentina · Belgium - Not yet recruitingPHASE4
The Antiretroviral Speed Access Program Switch (ASAP-Switch) Study
This study for people living with HIV who have recently moved to Quebec looks at how easy and helpful it is to switch to a new, single-pill HIV treatment called B/F/TAF. We want to understand their experiences with this new medicine and their journey with HIV care in Canada.
Canada - AuthorisedTherapeutic use (Phase IV)
Randomized, multicenter, open-label clinical trial to evaluate the clinical and microbiological impact of methenamine hippurate as an alternative prophylaxis to antibiotics in the management of recurrent urinary tract infections in women
This study is looking at new ways to prevent repeat urine infections in women. It compares a non-antibiotic treatment called methenamine hippurate with standard antibiotics to see which works best and if it helps reduce antibiotic resistance.
Spain - Active not recruitingNA
Barrier-Protect Study
This study looks at a special plaster with iodine to see if it can stop infections after heart device operations. We want to know if putting it on early helps keep the surgery area clean.
Canada - RecruitingPHASE2
Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID
This study looks at a new treatment called PNMR for Long COVID. We want to see if PNMR, along with care and lifestyle advice, can help people feel better. It involves comparing PNMR with standard care over six weeks.
Canada - AuthorisedTherapeutic use (Phase IV)
Application of radiomics in molecular imaging (18F-FDG-PET/CT) for diagnosis and follow-up of cardiovascular device infections: PREDICT study
This study looks at new ways to spot heart device infections and track their treatment using special scans. It compares advanced computer analysis with standard methods to see which is best at finding these infections and predicting if treatments are working.
Spain - Recruiting
COVID Infection in Pediatric Surgical Patient
This study looks at how common COVID-19 is in children having surgery. It uses a quick test to see if they have the virus. Most children with COVID-19 don't show many symptoms, but understanding how it spreads is important for everyone's safety.
Canada - AuthorisedTherapeutic exploratory (Phase II)
Curing HIV: proof of concept randomized clinical trial with Pyrimethamine, Lenalidomide, TOpiramate (PLUTO)
This study, called PLUTO, is investigating if a combination of three existing medicines (lenalidomide, pyrimethamine, and topiramate) can help us find a cure for HIV. It's an early-stage trial looking at how these drugs affect the HIV virus in people and how safe they are.
Netherlands - Active not recruitingPHASE2, PHASE3
Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance
This study is testing a new medicine called lenacapavir for people with HIV-1 who haven't responded well to other treatments. It aims to see if adding lenacapavir to their current treatment helps reduce the amount of virus in their body.
United States · Canada · Dominican Republic - Active not recruitingNA
Pharmacy-based Testing and Treatment for Gonorrhea and Chlamydia
This study in Nova Scotia, Canada, explores whether pharmacies can help test and treat common sexually transmitted infections (STIs) called chlamydia and gonorrhoea. It aims to make testing and treatment easier to access for more people, using self-swabs or urine samples.
Canada - RecruitingPHASE1, PHASE2
Phase 1/2 Study of a Plant-Based Seasonal Recombinant Trivalent VLP Influenza Vaccine
This study is testing a new plant-based flu vaccine that uses different parts of the flu virus to see if it's safe and works well. It's for adults 18 and older, and we want to find the best dose.
Canada - AuthorisedPhase I and Phase II (Integrated)- Other
LAMP-COVID: Locating Amyloid-containing Microclots with total-body PET in post-COVID syndrome
This study is looking for tiny blood clots, called microclots, in people with long COVID. We're using a special scan called a PET scan with a tracer called FLUTEMETAMOL to see if these microclots are linked to long COVID symptoms and if they can be measured throughout the body.
Netherlands - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Panzyga for Prevention of Major Infections in Patients with Hypogammaglobulinemia and Autoimmune or Rheumatic Conditions Receiving Treatment with B-cell Depletion Therapy ("PROTECT")
This study looks at a medicine called Panzyga to see if it can prevent serious infections in people with certain autoimmune conditions. Participants receive either Panzyga or a salt solution to see if the medicine helps keep them healthier.
Czechia · Lithuania · Greece - RecruitingNA
Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients
This study looks at whether cold water treatments, called Kneipp hydrotherapy, can help people with long COVID feel better. Researchers will compare how people using this therapy feel compared to those receiving usual care, focusing on their quality of life.
Germany