Diabetes research
Type 1 and type 2 diabetes, prediabetes and related metabolic research.
453 indexed studies · 209 currently recruiting
Top conditions in this hub
Recent studies
- Recruiting
Evaluation of Security and Efficacy of Medtrum Hybrid Closed Loop System
This study looks at a new 'artificial pancreas' system (Medtrum Hybrid Closed Loop) for people with Type 1 diabetes aged 7 to 75. It compares how well it helps keep blood sugar levels stable at home compared to standard insulin pump use.
France - Ongoing, recruitingTherapeutic use (Phase IV)
Pan-European proof-of-concept study comparing Decentralised Clinical Trial (DCT) and hybrid approaches to conventional clinical trial approaches in patients with Type 2 diabetes mellitus treated with Toujeo®
This study is looking at new ways to run clinical trials for people with Type 2 diabetes who use Toujeo insulin. It compares traditional trial methods with more flexible approaches to see which works best for patients.
Denmark · Italy · Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, randomized, double-blind, placebo-controlled, four-way cross-over study to evaluate the analgesic effects of TRV045 in healthy adults
This study is testing a new medicine, TRV045, to see if it can help with pain. It's a very early study in healthy adults, not patients, to understand how the medicine works in the body and if it's safe. Researchers are using a special light to create a small, temporary sunburn to measure pain.
Netherlands - Ongoing, recruitingTherapeutic use (Phase IV)
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
This study is looking at how well a new medicine, Tirzepatide, works for adults with type 2 diabetes when they switch from another medicine called Dulaglutide. Researchers want to see if the new medicine helps lower blood sugar and improve other health markers like weight.
Romania · Germany · Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic Pain due to Diabetic Polyneuropathy
This study is looking for new ways to help people with ongoing pain caused by diabetes affecting their nerves. It's testing a new spray treatment to see if it reduces pain and if it's safe compared to a dummy spray.
Austria · Germany - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of a proposed biosimilar insulin glargine U300 with Toujeo®
This study is testing a new version of insulin for people with Type 1 diabetes. It wants to see if this new insulin works in the same way as an existing insulin called Toujeo®. This is an early-stage study to check if they are similar.
Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J1I-MC-GZBK: A Master Protocol to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants with Type 2 Diabetes Mellitus Who Have Obesity or Overweight: A Randomized Double-Blind, Placebo-Controlled Trial (TRIUMPH-2)
This study is looking into a new weekly injection called Retatrutide. It's for people with type 2 diabetes who are also overweight or obese. The main goal is to see how well it helps with weight loss compared to a dummy injection (placebo).
Spain · Romania - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study comparing the effect of different dosing conditions on blood levels of semaglutide in a new tablet composition in healthy participants
This study is looking at a new tablet for type 2 diabetes. It aims to see how different amounts of the medicine, semaglutide, affect its levels in the blood of healthy male volunteers.
Germany - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3 Double-masked, Randomized, 2-stage, Multicenter Study of the Efficacy and Safety of OCS-01 Eye Drops in Subjects With Diabetic Macular Edema
This study looks at eye drops for diabetic macular edema (DME), a common eye problem caused by diabetes. Researchers want to see if the eye drops can help improve vision and reduce swelling in the back of the eye.
Spain · Hungary - Ongoing, recruitingTherapeutic confirmatory (Phase III)
(22267) A parallel-group, randomized, prospective, interventional, double-blind, multicenter global Phase 3 study to investigate the efficacy and safety of finerenone versus placebo, in addition to standard of care, in participants with chronic kidney disease and type 1 diabetes
This study is looking into a new medication called finerenone for people with long-term kidney disease caused by type 1 diabetes. We want to see if it works better than a dummy medicine (placebo) to slow down kidney damage over 6 months, alongside their usual care.
Italy · Germany · Denmark - Active not recruiting
Gestational Diabetes Monitoring and Management
This study looks at information from pregnant women with gestational diabetes to predict potential problems for mum and baby, and to work out the best way to monitor blood sugar. It uses existing data to help improve care and reduce the number of blood tests needed.
United Kingdom - RecruitingNA
Is Community Based Monitoring of Diabetic Maculopathy and Pre-proliferative Diabetic Retinopathy Safe?
This study looks at whether opticians in your local area can help check for eye problems caused by diabetes, using special scans. It aims to make it easier to get checked and reduce hospital visits, while making sure it's safe and effective.
United Kingdom - Recruiting
Early Versus Late Monitoring Among Pregnant Women With a History of Gestational Diabetes
This study looks at pregnant women who had gestational diabetes before. We want to see if checking blood sugar early in pregnancy leads to better health for mum and baby, compared to a later check-up. The goal is to improve care for mums with this history.
United Kingdom - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - Not yet recruitingPHASE2
Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
This study looks at a new drug, sotagliflozin, to see if it can protect kidneys in people with type 1 diabetes. Researchers want to understand how it affects kidney oxygen levels and overall kidney health over 12 weeks.
Denmark · United Kingdom - RecruitingPHASE2
Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
This study is looking into a new medicine called Rezpegaldesleukin for people recently diagnosed with Type 1 Diabetes. It aims to see if the medicine can help their bodies make more insulin. Participants will receive the medicine or a dummy treatment over six months.
United States · Canada - Not yet recruitingPHASE2
A Probiotic Based Intervention in Pregnancies Complicated by GDM
This study looks at whether a special probiotic and prebiotic supplement can help pregnant people with gestational diabetes manage their blood sugar and improve their gut health. It's hoped this might be a new way to help mothers and babies.
Canada - Not yet recruitingNA
Small Steps for Big Changes - Recipe for Health
This study looks at how a 6-week healthy living program helps people with prediabetes. It checks if changes in diet and activity lead to better blood sugar, weight, and waist size over two years. The goal is to understand how these small steps make a big difference.
Canada - Active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - Recruiting
Visceral Adipose Tissue and Liver Changes Associated With Semaglutide in CKD
This study looks at how a drug called semaglutide affects body fat and the liver in people with type 2 diabetes and kidney disease. It aims to understand how this medication helps improve health by looking closely at fat tissue.
Canada - Active not recruiting
Preoperative Optimization of Diabetic Patients
This study looks back at records of adults with diabetes having surgery in Alberta, Canada. It aims to understand how many surgical patients have diabetes, how well their diabetes is managed before surgery (using a blood test called HbA1C), and if this management affects their recovery and hospital stay.
Canada - RecruitingEARLY_PHASE1
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
This study looks at whether apple cider vinegar can increase beneficial gut bacteria in men with prostate cancer starting hormone therapy. Researchers want to see if this helps reduce side effects like weight gain and diabetes, which can be linked to their treatment.
Canada - RecruitingNA
Healthy Outcomes for Muscle with Exercise in T1D
This study looks at how exercise affects muscles and blood vessels in people with Type 1 Diabetes (T1D). Researchers want to understand if exercise can help prevent health problems linked to T1D and if men and women respond differently to exercise.
Canada - RecruitingNA
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
This study looks at how omega-3 from fish oil might help prevent type 2 diabetes. Researchers are exploring if lowering 'bad cholesterol' in a certain way can increase diabetes risk, and if omega-3 can help counteract this in some people.
Canada - Active not recruitingNA
The CanDo (Canadian Donor Milk) Trial
This study looks at whether giving donor breast milk or formula to certain babies in hospital helps them with breastfeeding and their health. It focuses on babies who might need extra milk, like those born to diabetic mothers, or who are smaller or a little early.
Canada - Active not recruitingPHASE1
Safety of ENC-201-CED ENCRT
This study is looking at a new treatment called ENC-201-CED for people with Type 1 diabetes. We want to see if it's safe and if people can tolerate it well when placed under the skin. This is an early-stage study to understand how it works.
Canada - Active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - RecruitingPHASE2, PHASE3
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
This study looks into whether a weekly injection, Semaglutide, combined with an 'artificial pancreas' system, can help people with Type 1 Diabetes manage their blood sugar without needing to count carbohydrates every meal.
Canada - Recruiting
Canadian Bone Strength Development Study
This study looks at how bones develop differently in children aged 10-12 with and without type-1 diabetes. Researchers want to understand why differences happen and track bone growth, strength, and activity for up to four years.
Canada - RecruitingNA
Improving Insulin Sensitivity in Patients With Type 2 Diabetes Via Repeated Cold-induced Shivering Thermogenesis
This study looks at whether getting a little cold and shivery could help people with Type 2 Diabetes manage their blood sugar and heart health better. Researchers believe regular, mild shivering might improve how the body uses insulin, offering a new way to support health alongside diet and exercise.
Canada - RecruitingNA
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
This study looks at how a genetic test predicting heart and kidney problems in people with type 2 diabetes affects treatment. It compares people who know their risk score with those who don't, to see if knowing this information helps them reach their health goals better.
Canada - RecruitingNA
Effect of Chronic Exposure to Nextida GC-B on Glycemic Control in Adults With Normoglycemia or Prediabetes
This study looks at a new product, Nextida GC-B, to see if it helps manage blood sugar levels in adults who have normal blood sugar or are at risk of developing type 2 diabetes. We want to find out if it's safe and effective.
Canada - RecruitingPHASE3
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
This study is testing a new medicine, Ribupatide, for people who are overweight or have obesity and also have type 2 diabetes. It aims to see if Ribupatide helps with weight loss and improves blood sugar levels compared to a dummy medicine.
United States · Argentina · Australia - AuthorisedTherapeutic confirmatory (Phase III)
LIBRETTO: Stimulan™ Local Antibiotic Delivery System Versus 4-Week Systemic Antibiotic Therapy for Diabetic Foot Osteomyelitis – A Prospective, Randomized, Controlled Trial
This study is looking at better ways to treat a serious foot infection called diabetic foot osteomyelitis. It compares a new local antibiotic treatment system with standard antibiotic pills or injections to see which is more effective at healing the infection and preventing its return.
Finland - AuthorisedTherapeutic exploratory (Phase II)
Open-label, safety, tolerability and proof of concept study to evaluate the use of ANXV (recombinant human Annexin A5 protein) in the treatment of patients with either Diabetic Retinopathy or recent onset Retinal Vein Occlusion
This study is testing a new medicine, ANXV, for people with certain eye conditions like diabetic eye disease or recent blood clots in the eye, to see if it's safe and how well it works. It's an early stage trial to understand the medicine better.
Germany - Active not recruitingNA
Evaluation of Pharmacist Intervention for Individuals With Uncontrolled Type 2 Diabetes
This study looks at how pharmacists can help people with uncontrolled Type 2 diabetes manage their condition better. It checks if their help improves blood sugar levels and how confident people feel about looking after their diabetes.
Canada - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 Open-Label, Single Ascending Dose, First-In-Human Study to Assess Safety and Tolerability of Endoscopic Ultrasound-Guided Pancreatic Infusion of RJVA-001 in Adults With Inadequately Controlled Type 2 Diabetes on Multiple Glucose-Lowering Agents.
This study is testing a new treatment, RJVA-001, for adults with Type 2 diabetes that isn't well-controlled. It's the first time this treatment is being given to people. Doctors want to see if it's safe, what dose works best, and how it affects blood sugar.
Netherlands - Recruiting
Heidelberg Study on Diabetes and Complications
This study in Heidelberg looks at how diabetes affects the body over time. Researchers want to understand why some people with type 1, type 2, or pre-diabetes get complications, while others don't. They're also comparing them to people without diabetes to find new ways to prevent these problems.
Germany - RecruitingNA
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
This study looks at how 5 days of bed rest affects young, healthy adults. We want to understand changes in muscle size, strength, and how the body uses sugar. This helps us learn more about muscle loss during illness or injury.
Canada - RecruitingPHASE3
Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis
This study is looking at a new medicine called tradipitant for people with gastroparesis (when your stomach empties too slowly). It aims to check how safe the medicine is over three months for people with gastroparesis caused by diabetes or for no clear reason.
Belgium · Germany