Diabetes research
Type 1 and type 2 diabetes, prediabetes and related metabolic research.
445 indexed studies · 205 currently recruiting
Top conditions in this hub
- Type 2 diabetes70
- Diabetes Mellitus Type 238
- Diabetes mellitus35
- Obesity31
- Diabetes31
- Type 1 diabetes26
- Diabetes Mellitus, Type 122
- Type 2 Diabetes Mellitus21
- Type 1 Diabetes Mellitus14
- Hypertension13
- Cardiovascular Diseases13
- PreDiabetes11
- Diabetic Foot Ulcer10
- Heart Failure10
- Gestational diabetes9
- Insulin Resistance9
Recent studies
- AuthorisedHuman Pharmacology (Phase I)- First administration to humans
A three-part first-in-human trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of GUB-UCN2 in healthy lean and obese participants and participants with T2D
This early-stage study is testing a new medicine called GUB-UCN2. It's looking at how safe it is and what it does in the body. We're testing it in healthy people, those with obesity, and people with type 2 diabetes. We want to see how the body handles the medicine.
Germany - RecruitingNA
The Poor Responders Study
This study aims to understand why some people don't lose as much weight as expected after weight-loss surgery, despite having the same operation. Researchers want to identify factors that predict who will lose the most weight and who might struggle, before the surgery takes place.
United Kingdom - RecruitingNA
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
This study will look at whether a daily probiotic can help overweight young adults with slightly high blood sugar. We want to see if it improves memory and other brain functions, as well as blood sugar, cholesterol, and general health over 12 weeks.
United Kingdom - RecruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - Active not recruitingPHASE3
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
This study investigates how a medicine called semaglutide affects eye problems in people with type 2 diabetes over five years. Participants will get either semaglutide or a dummy medicine, injected once a week, along with their usual diabetes treatments.
United States · Brazil · Bulgaria - Recruiting
A nationwide clinical trial for patients with the eye condition vitreous haemorrhage due to proliferative diabetic retinopathy investigating whether early eye surgery and laser treatment is a safe and better option for improving visual outcomes than the current standard of care
This study looks at a new way to treat blurry vision caused by diabetes, called vitreous haemorrhage. We compare early eye surgery and laser treatment to the usual care to see if it improves sight quicker and is safer for people with diabetes.
United Kingdom · England - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Clinical Study to Evaluate the Safety and Efficacy of Ertugliflozin (MK-8835/PF-04971729) in Pediatric Participants (ages 10 to 17 years, inclusive) with Type 2 Diabetes Mellitus (MK-8835-059/B1521066)
This study is looking at a new medicine called ertugliflozin for young people aged 10 to 17 with type 2 diabetes. We want to see if it helps control blood sugar and if it's safe compared to a dummy pill.
Poland · Italy · Hungary - Completed
Exploring engagement and implementation of a digital self-management programme designed for people living with early-onset type 2 diabetes
This study looks at a new online programme (EOT2D MyDESMOND) for younger adults (18-45) with type 2 diabetes. It aims to help them manage their condition, feel better, and improve their health, specifically focusing on how well people use the programme and its availability.
United Kingdom · England - RecruitingNot Applicable
Can pocket-sized ultrasound devices be used safely and acceptably in routine pregnancy care?
This study looks at using small, hand-held ultrasound devices in pregnancy care at Liverpool Women's Hospital. It aims to see if they are easy to use and if pregnant people are happy with them, potentially improving future pregnancy scans.
United Kingdom · England - Recruiting
The Sunnybrook Type 2 Diabetes Study
This study looks at how Type 2 Diabetes and prediabetes affect mood, thinking, and overall health. It examines lifestyle, genes, and brain scans to understand these links better. The goal is to improve care for people living with these conditions.
Canada - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Effect of mesenchymal stem cells on healing of foot ulcers in diabetes patients. A phase I pilot study.
This study is looking at how a special type of cell, called mesenchymal stem cells, might help diabetic foot ulcers heal. It's an early-stage study to see if this treatment is safe and if it works for people with a common complication of diabetes.
Denmark - RecruitingNA
The Purpose of This Study is to Assess Clinical Efficacy and Safety of Berovenal® Intended to Promote Treatment and to Expedite Chronic Diabetic Foot Ulcer Healing
This study is looking at a new gel called Berovenal® for healing stubborn foot sores often linked to diabetes. Researchers want to see if it helps these sores heal faster and safer compared to another standard treatment. It involves applying the gel and regular check-ups.
Germany · Poland - Completed
Improving uptake of screening for type 2 diabetes after a diagnosis of gestational diabetes in pregnancy: is a home blood test the answer?
This study is testing if a home blood test kit can help more women with a history of diabetes in pregnancy (gestational diabetes) get their follow-up blood sugar check. This check is important as it helps to spot if they are at risk of developing type 2 diabetes later on.
United Kingdom · Scotland - Not yet recruiting
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion
This study looks at how type 2 diabetes affects special cells in your blood that help repair blood vessels. Researchers want to see if these repair cells work differently in people with type 2 diabetes compared to those without it, using a simple blood test.
Canada - Recruiting
The Sarcopenia Study
This study looks at muscle weakness, called sarcopenia, in people with heart failure. Researchers want to see if different types of heart failure affect how common sarcopenia is, comparing heart failure patients to healthy people and those with type 2 diabetes.
United Kingdom - RecruitingNA
The DAPA-MEMRI Trial
This study looks at how a drug called dapagliflozin (Farxiga) helps people with heart failure, with or without diabetes. We're using a special heart scan to understand how it affects chemicals in the heart muscle.
United Kingdom - RecruitingNA
Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents With Type 1 Diabetes
This study looks at a new automated insulin system for children and teenagers recently diagnosed with Type 1 diabetes. It compares this system to standard treatments to see if it helps manage blood sugar levels better and makes living with diabetes easier for families.
France - Recruiting
Paraoxonase and HDL Qualities in Glycaemia and Inflammation
This study looks at how weight loss surgery and diabetes affect 'good' cholesterol (HDL), inflammation, and blood sugar. We want to understand how HDL works to protect your heart and how this changes with diabetes or after weight loss surgery to reduce heart disease risk.
United Kingdom - Active not recruitingNA
Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living With Diabetes Using Continuous Glucose Monitoring ( GAP OUEST )
This study looks at how a measurement called Hemoglobin Glycation Index (HGI) changes over time in people with diabetes. Researchers will use continuous glucose monitors to track this, helping us understand diabetes management better.
France - Recruiting
Impact of Smart Connected Insulin Pens on Quality of Life in Dependent Patients with Diabetes Using Continuous Glucose Measurement
This study looks at how smart insulin pens and continuous glucose monitors can help improve diabetes care for adults who need help managing their insulin. It aims to see if guiding caregivers on using these tools can lead to better health and fewer problems for patients.
France - RecruitingNA
Driving with Neuropathy
This study looks at how training with visual feedback can help drivers with diabetes and nerve damage (neuropathy) to use their accelerator pedal safely. It aims to see if this training can reduce how much they press the pedal, making driving safer.
United Kingdom - Recruiting
Vascular Complications in Children From T1D Diagnosis
This study looks at how Type 1 diabetes affects the heart and blood vessels in children and teenagers (8-18). Researchers want to find out when and how these problems might start in the first two years after diagnosis. It's hoped this will help doctors understand and manage the condition better.
Canada - Recruiting
Cohort Study to Refine the Positioning of Closed-loop Therapy Versus Islet Transplantation in the Management of Patients With Unstable Type 1 Diabetes
This study looks at how well an 'artificial pancreas' system works for people with unstable Type 1 diabetes. It compares it to another treatment called islet transplantation to understand which might be best for particular patients.
France - Ongoing, recruitingTherapeutic use (Phase IV)
Does Increasing Oxygen Nurture Your Symptomatic Ischemic Ulcer Sufficiently?
This study is looking at whether giving extra oxygen can help people with leg ulcers caused by diabetes and poor blood flow. It wants to see if this treatment can reduce the need for major amputations over 12 months.
Netherlands · Spain - Not yet recruitingNA
The REmission of Diabetes Using a PlAnt-based Weight Loss InteRvention (REPAIR) Trial
This study, called REPAIR, explores if a plant-based diet and exercise can help people with type 2 diabetes achieve remission and significant weight loss. It compares this approach to standard diabetes care.
Canada - Not yet recruitingNA
Feasibility Testing of Plant-Based Meal Replacement Products Made With Manitoba Crop Ingredients for Weight Loss and Diabetes Remission
This study looks at whether plant-based meal replacements (like shakes or bars) can help people in a weight loss clinic lose weight and potentially reverse pre-diabetes or diabetes. Researchers want to see if these meal replacements are easy to use and effective when added to a standard weight loss program.
Canada - AuthorisedTherapeutic exploratory (Phase II)
Visualizing beta cells in patients with a history of gestational diabetes.
This study looks at how a special scan can help us understand cells in the pancreas of women who have had diabetes during pregnancy. It aims to see if a new way of scanning can show how these cells are working and if it links to how well their bodies manage sugar.
Netherlands - Active not recruitingNA
Children's Hospital Academic Medical Organization (CHAMO) MyChart Study
This study looks at how a new online form (MyChart Questionnaire) used before appointments could improve care for children with Type 1 Diabetes. It aims to make clinic visits more helpful by letting families share information ahead of time.
Canada - RecruitingPHASE2, PHASE3
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This study looks at whether a weekly medicine, tirzepatide, can help adults with type 1 diabetes manage their blood sugar more easily with an insulin pump, especially by reducing or removing the need to count carbs at meals.
Canada · Switzerland - RecruitingNA
Fetal Cell Receptors Repertoire
This study looks at special cells from pregnancy that stay in a mother's body. We want to see how these cells help heal skin wounds like leg ulcers after childbirth. We'll compare cells from women with ulcers to those without, to understand how healing works.
France - Active not recruiting
Pathogenicity Factors of Staphylococcus Pettenkoferi in Foot Wounds and Osteitis in Diabetic Patients
This study looks at a specific germ called Staphylococcus pettenkoferi, commonly found in foot wounds and bone infections in people with diabetes. We want to understand what makes this germ harmful and how it causes problems, hoping to find better ways to treat these infections.
France - RecruitingNA
Home-based Heat Therapy for Type 2 Diabetes
This study is exploring if warm water soaks at home can help people with type 2 diabetes. Researchers want to see if regular heat treatment improves how the body handles sugar and fats, and if it helps blood vessels work better. It focuses on finding new, easy ways to support heart health.
Canada - RecruitingNA
Effects of Cranberry on Gut and Metabolic Health
This study looks at how cranberry drinks affect health in overweight people. We want to see if cranberries can help with blood sugar, fats, and gut bacteria. Participants will drink cranberry or a dummy drink for 12 weeks to see the effects.
Canada - Active not recruiting
Observational Study of Adult Participants With Diabetic Macular Edema and Suboptimal Response to Anti-Vascular Endothelial Growth Factor Treated With Dexamethasone Intravitreal Implant
This study looks at how a medicine called a dexamethasone implant works for adults with blurry vision from diabetes (Diabetic Macular Edema) whose previous treatment didn't work well enough. It's an observational study, meaning researchers will just watch how patients do with the implant as part of their regular care. About 327 people globally will take part.
Belgium · China · Germany - RecruitingPHASE3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
This study looks at new and existing medicines (CagriSema and Semaglutide) to help people with obesity, sometimes with type 2 diabetes, lose weight. Researchers want to see how safe and effective these medicines are. It lasts about 83 weeks.
United States · Argentina · Australia - RecruitingNA
The Use of Ultrasound Detection of Lipohypertrophy to Improve Glycemic Control
This study looks at how injecting insulin into certain fatty areas under the skin, called lipohypertrophy, affects blood sugar control in people with diabetes. It uses ultrasound to find these areas and aims to see if avoiding them can improve health.
Canada - RecruitingNA
iCARE 2.0: A Pilot Intervention of Dialectical Behavioural Therapy for Youth With Type 2 Diabetes.
This study, iCARE 2.0, is exploring if a special talking therapy called Dialectical Behavioural Therapy (DBT) can help young people (14-22) in the UK with Type 2 Diabetes manage their health better. It also looks at including traditional Indigenous medicine.
Canada - Ongoing, recruitingTherapeutic use (Phase IV)
Transfer of metformin into human breast milk and the plasma of breastfeeding children - A low intervention trial with biobanking of breast milk and plasma in Västra Götalandsregionen and Region Örebro
This study looks at how much metformin, a diabetes medicine, passes into breast milk and then into a baby's blood. It's for breastfeeding mothers with type 2 or gestational diabetes who take metformin, to see if the medicine affects their baby.
Sweden - RecruitingNA
Closed Loop and Education for Hypoglycemia Awareness Restoration
This study looks at new ways to help people with type 1 diabetes better recognise when their blood sugar is going too low. It tests special insulin pumps and educational programmes to see which ones work best to improve awareness and reduce dangerous low blood sugar episodes.
United States · Australia · United Kingdom - Active not recruiting
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
This study looks at the long-term safety of a treatment called teplizumab for young people with recent Type 1 diabetes. It follows participants from a previous study, PROTECT, for an extra 42 months to see how they're doing without giving new medication.
United States · Belgium · Canada