Heart health research
Cardiovascular disease, heart failure, blood pressure and stroke prevention.
762 indexed studies · 359 currently recruiting
Top conditions in this hub
- Heart failure95
- Cardiovascular Diseases59
- Coronary Artery Disease48
- Stroke42
- Atrial Fibrillation41
- Hypertension31
- Pulmonary Arterial Hypertension24
- Atrial Fibrillation (AF)17
- Heart Diseases14
- Pulmonary Hypertension13
- Acute ischemic stroke13
- Cardiovascular disease13
- Obesity12
- Heart Failure with Preserved Ejection Fraction11
- Chronic Kidney disease10
- Heart failure with reduced ejection fraction10
Recent studies
- Recruiting
Characteristics, Phenotypes, and TRAITS of Heart Failure With Preserved Ejection Fraction (TRAITS-HFpEF)
This study, called TRAITS-HFpEF, wants to understand a type of heart failure called HFpEF. We don't fully know why people get it or how best to treat it. By collecting information from patients, researchers hope to find new ways to diagnose and treat this condition, and learn more about how it affects people's lives.
United Kingdom - Ongoing, recruitingTherapeutic use (Phase IV)
Escalated single Platelet Inhibition for one month plus Direct oral anticoagulation in patients with Atrial fibrillation and acUte coRonary syndrome undergoing percutaneoUS coronary intervention (EPIDAURUS)
This study looks at different ways to treat people who have both an irregular heartbeat (atrial fibrillation) and have recently had a heart attack. It compares how well different medicines prevent further heart problems like strokes, while also checking for any serious bleeding.
Austria · Germany - Ongoing, recruitingPhase II and Phase III (Integrated)
A multicenter, randomized, double-blind, placebo-controlled TRial evaluating Immunosuppressive treatment in patients with chronic virus-Negative Inflammatory cardiomyopaThY (TRINITY trial)
This study looks at new treatments for a heart problem called inflammatory cardiomyopathy. It tests if certain medicines, prednisolone and Mowel, can improve heart function in people whose hearts aren't getting better with usual treatments. It's a key step in finding better ways to help your heart.
Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIa, Open Label, Proof of Concept Study to Evaluate the Safety of Aqueous Afamelanotide Solution in Patients with acute Arterial Ischaemic Stroke (AIS) who are ineligible for Intravenous Thrombolysis (IVT) or Endovascular Thrombectomy (EVT)
This study is looking at a new treatment called PRENUMBRA for people who have had a certain type of stroke. It wants to check if the treatment is safe for patients who can't have other common stroke treatments. The main goal is to see if there are any side effects.
Spain - Ongoing, recruitingTherapeutic use (Phase IV)
DECISION; Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands
This study, called DECISION, is looking at digoxin, a common medicine, for people with heart failure in the Netherlands. It wants to see if digoxin helps reduce hospital visits for heart failure and prevent heart-related deaths in patients who are not in the hospital.
Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomised placebo controlled clinical trial of efficacy of MYOcardial protection in postacute inFLAMmatory cardiac involvEment due to COVID-19 (MYOFLAME-19)
This study looks at new ways to protect the heart after inflammation caused by COVID-19. Researchers are testing two existing medicines to see if they can help improve heart function and reduce long-term problems. It aims to find better treatments for your heart post-COVID.
Austria · Germany - AuthorisedTherapeutic use (Phase IV)
The effect of corticosteroids on early recovery after major surgery in eldery patients: CORTERAS study
This study looks at whether a steroid medicine, methylprednisolone, can help older patients recover better after major surgery. Researchers are checking if it improves muscle strength and other aspects of recovery like breathing and thinking clearly after operations such as heart, lung, or prostate surgery.
Belgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
Effects of DAPAgliflozin on cardiopulmonary exercise capacity and hemodynamics in Pulmonary Arterial Hypertension: A double blind randomized trial. (DAPAH-trial)
This study is looking at a medicine called Forxiga (dapagliflozin) for people with high blood pressure in their lungs (pulmonary hypertension). We want to see if it helps improve how well people can exercise and how their heart and lungs work.
Denmark - AuthorisedTherapeutic confirmatory (Phase III)
SPironolactONe for the maintenance of Sinus Rhythm in hypertensive patients with atrial fibrillation and preserved left ventricular ejection fraction: a Prospective Randomized Open Blinded End-point (PROBE) multicenter study (SPONSoR study).
This study looks at whether a medicine called spironolactone can help people with high blood pressure and an irregular heartbeat (atrial fibrillation) stay in a normal heart rhythm. It checks how well spironolactone works over 12 months in preventing their irregular heartbeat from coming back.
France - AuthorisedPhase III and phase IV (Integrated)
Stabilization of vulnerable atherosclerotic carotid plaques by Rivaroxaban as evaluated by 3D contrast enhanced ultrasound (CEUS)
This study looks at whether a medicine called rivaroxaban can help stabilise fatty plaques in the neck arteries of people with existing circulation problems. Researchers are using special ultrasound scans to see if the medicine makes these plaques less likely to cause strokes or other serious issues.
Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2, Multicenter, Randomized, Parallel, 3-arm, Placebo-controlled Study to Assess Efficacy and Safety of CDR132L in Patients with Reduced Left Ventricular Ejection Fraction (≤ 45%) After Myocardial Infarction (HF-REVERT)
This study looks at a new treatment (CDR132L) for people who have had a heart attack and now have weakened heart pumping. It aims to see if the treatment helps the heart recover and is safe to use. Patients will either get the new treatment or a dummy treatment.
Poland · Spain · Czechia - AuthorisedTherapeutic exploratory (Phase II)
Reduction of SystemiC Inflammation after ischemic stroke by intravenous DNase administration (ReSCInD)
This study looks at whether a drug called DNase can help reduce swelling and damage in the brain after a stroke. Researchers are testing if it lowers a chemical called IL-1β in the blood, which is linked to inflammation.
Germany - AuthorisedTherapeutic use (Phase IV)
The effect of Oxygen sUppleTion on vascular resistance and FLOW: the OUTFLOW study
This study, called OUTFLOW, is looking at how pure oxygen affects blood flow and pressure in people with certain heart and lung conditions. It focuses on conditions like high blood pressure in the lungs and problems with tiny blood vessels in the heart. Researchers will measure how much blood the heart pumps after giving oxygen.
Netherlands - AuthorisedTherapeutic exploratory (Phase II)
Upper-limb Active Function and Botulinum Toxin A
This study looks at how a medicine called Dysport, similar to Botox, might help people who have had a stroke and have stiff or tight arm muscles. Researchers want to see if it improves arm movement and reduces muscle co-contraction (muscles working against each other).
France - AuthorisedHuman Pharmacology (Phase I)- First administration to humans
Regenerative Stem Cell Therapy for Stroke in Europe 1
This study is looking at a new type of treatment using special cells, called stem cells, for people who have had a stroke. It's an early stage trial to see if the treatment is safe for humans and how it works. Adults of any age can take part.
France - AuthorisedTherapeutic exploratory (Phase II)
Randomized, controlled, double-blind trial to investigate the effect of colchicin on the endothelial function in patients with CHIP mutations and chronic heart failure with reduced left ventricular function (CHIP-HF)
This study looks at whether a medicine called colchicine can help people with a specific type of heart failure. It compares colchicine to a dummy pill to see impacts on blood vessel health, especially in those with certain genetic changes.
Germany - RecruitingPHASE3
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
This study is looking into a new medicine, finerenone, for children aged 6 months to 17 years with heart failure. It aims to see if finerenone, when added to their usual treatment, can help their heart pump better and if it is safe to use.
United States · Argentina · Austria - Ongoing, recruitingTherapeutic exploratory (Phase II)
IMPACT-CTEPH Initial dual oral coMbination therapy versus standard-of-care initial oral monotherapy Prior to balloon pulmonary Angioplasty in patients with inoperable Chronic thromboembolic pulmonary hyperTension”
This study looks at new ways to treat a serious lung condition called Chronic Thromboembolic Pulmonary Hypertension (CTEPH). We're testing if two medicines together work better than one for people who can't have surgery, before a procedure called balloon pulmonary angioplasty.
France - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
FIRST-IN-HUMAN OPEN-LABEL MULTICENTRE CLINICAL TRIAL TO EVALUATE THE SAFETY AND EFFICACY OF EPICARDIAL IMPLANTATION OF COLLAGEN MEMBRANES WITH ALLOGENEIC ADIPOSE-DERIVED STEM CELLS IN PATIENTS WITH ISCHAEMIC LEFT VENTRICULAR DYSFUNCTION SCHEDULED TO UNDERGO CORONARY REVASCULARISATION SURGERY
This early-stage study is testing a new treatment for severe heart failure in people having heart bypass surgery. It involves placing a special patch with stem cells on the heart to see if it's safe and helps the heart pump better.
Poland - Ongoing, recruitingTherapeutic use (Phase IV)
A randomized trial on Hemodynamic Optimization of cerebral Perfusion after Endovascular therapy in patients with acute ischemic stroke (HOPE study)
This study looks at different ways to control blood pressure in people who have had a stroke and treatment to unblock a brain blood vessel. Researchers want to find the best approach to help patients recover well, focusing on how their brain receives blood after treatment.
Spain - AuthorisedTherapeutic use (Phase IV)
Anticoagulant medicines for Balloon Pulmonary Angioplasty
This study looks at how safe different blood-thinning medicines are during a procedure called Balloon Pulmonary Angioplasty (BPA). It focuses on patients with specific lung conditions to see if these medicines cause issues like bleeding or lung problems.
Netherlands - Ongoing, recruitingPhase III and phase IV (Integrated)
A Multicenter, Randomized, Double-Blind, Parallel Group, Placebo-Controlled Trial to Evaluate the Effect of In-Hospital Initiation of Dapagliflozin on Clinical Outcomes in Patients Who Have Been Stabilized During Hospitalization for Acute Heart Failure
This study looks at whether a medicine called dapagliflozin, started in hospital, can help patients who have been treated for sudden heart failure. It aims to see if the medicine can prevent future heart problems or hospital stays.
Poland · Hungary · Czechia - AuthorisedTherapeutic confirmatory (Phase III)
The effect of phoSPHocreatine on mEdical emergency team (met) tREated patients: a randomized clinical trial protocol – SPHERE
This study is looking at a medicine called Neoton to see if it helps very sick patients treated by a special emergency team. It's for adults aged 18 and over who have serious breathing or heart problems, or a sudden change in their awareness.
Italy - AuthorisedTherapeutic confirmatory (Phase III)
"MetCool ACS"- Metformin "Cooling" Effect on metformin-naive Patients Treated with PCI because of Acute Coronary Syndrome
This study looks at whether metformin, a common diabetes drug, can help patients who have had a heart attack and recently had a procedure to clear their blood vessels. Researchers want to see if it reduces the need for more heart-clearing procedures later on.
Poland - Ongoing, recruitingTherapeutic use (Phase IV)
The Optimal Anticoagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
This study looks at how well different blood thinners work to prevent strokes in people who've had a procedure called 'catheter ablation' for a wobbly heart rhythm (atrial fibrillation). It aims to find the best way to stop strokes while keeping side effects low.
Germany · Belgium - AuthorisedTherapeutic confirmatory (Phase III)
Extending the time window for Tenecteplase by Effective RecanalizatioN of bAsilar artery occLusion in patients with POSTerior circulation stroke (POST ETERNAL)
This study looks at treating a severe type of stroke affecting the back of the brain. It's testing if a clot-busting medicine, Tenecteplase, can be given effectively over a wider time window to prevent disability or death and improve recovery.
France - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Evaluation of safety and efficacy of two ticagrelorbased de-escalation antiplatelet strategies in acute coronary syndrome: the randomized, multicenter, double-blind ELECTRA RCT study.
This study looks at safer ways to give blood-thinning medicines like Brilique and Aspirin after a heart attack. It compares different doses of ticagrelor to see which causes less serious bleeding while still preventing new heart problems.
Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Dual Antithrombotic Therapy with Dabigatran and Ticagrelor in Patients with Acute Coronary Syndrome and Non-valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention (ADONIS-PCI)
This study looks at a new way to prevent blood clots and bleeding in people who have had a heart attack or similar heart problem and also have an irregular heartbeat, after having a heart procedure. It compares different doses of a blood-thinning medicine.
Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
Prospective, monocentric, exploratory phase II study for the evaluation of the diagnostic use of the tracer PET (18F) -Flutemetamol (Vizamyl®) in patients with cardiac amyloidosis
This study is looking at a special scan called a PET scan to see how a new tracer (a tiny amount of a radioactive substance) called Vizamyl works. We want to see how much of it is taken up by the heart in people with different types of cardiac amyloidosis.
Italy - Ongoing, recruitingPhase III and phase IV (Integrated)
RE-DUAL TICLO PCI: Dual Therapy with dabigatran/ticagrelor versus Dual Therapy with dabigatran/clopidogrel in ACS patients with indication for NOAC undergoing PCI.
This study looks at two different ways to combine medicines for people who have had a heart attack and need a procedure to unblock their heart arteries. It aims to find out which combination is safer in terms of causing less bleeding, while still preventing blood clots.
Netherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Single-blinded, Randomized Study to Evaluate the Pharmacokinetics and Safety of Sotatercept (MK-7962) Administered Using Either a Weight-based or Weight-banded Approach in Participants With Pulmonary Arterial Hypertension (PAH) on Standard of Care
This study is looking at a new medicine called sotatercept for people with pulmonary arterial hypertension (PAH). Researchers want to see how the body handles the medicine and check for any side effects. It’s a randomised study, meaning some people will get different doses.
Czechia · Poland · Spain - Ongoing, recruitingTherapeutic use (Phase IV)
PROgnostic value of precision medicine in patients with Myocardial Infarction and non-obStructive coronary artEries: the PROMISE study
The PROMISE study looks at improving care for people who've had a heart attack but don't have blocked arteries. It checks how different treatments affect their angina (chest pain) and quality of life over a year.
Italy - AuthorisedHuman Pharmacology (Phase I)- First administration to humans
A randomized, placebo-controlled, double-blind, single-ascending-dose, Phase 1a/b study to assess the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of intravenous NTR-641 in healthy adults and patients with acute ischemic stroke
This study is testing a new medicine called NTR-641 for people who have recently had a stroke caused by a blood clot. We want to see if it's safe, how it works in the body, and if it causes an immune reaction, starting with healthy volunteers.
Austria - AuthorisedPhase III and phase IV (Integrated)
LEVOMEMS: Comparison of the Hemodynamic Profile of Dobutamine and Levosimendan in the Current Therapeutic Context
This study compares two common heart failure medicines, dobutamine and levosimendan, to see which works better for certain patients. Doctors will measure heart and lung pressure and how well the heart pumps blood after three months to understand their effects.
Spain - AuthorisedTherapeutic confirmatory (Phase III)
Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.
This study looks at whether a widely used medicine called colchicine can slow down the hardening of the heart's aortic valve. Researchers will compare people taking colchicine with those taking a dummy pill, to see if it helps keep the valve working better for longer. It's a big study to find out if this treatment could be useful.
Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
The effect of sertraline on anxiety-depressive symptoms, endothelial dysfunction and biomarkers in heart failure patients with preserved ejection fraction
This study is looking at whether a common medicine called sertraline can help people with heart failure who also feel anxious or down. It aims to see if sertraline can improve their well-being and reduce the chances of them needing to go to the hospital or having other serious health problems.
Poland - AuthorisedTherapeutic use (Phase IV)
Optimal Antiplatelet Treatment to Achieve Stroke Avoidance and Fall in Bleeding Events following Left Atrial Appendage Closure – Chronic Kidney Disease (SAFE LAAC CKD). Comparative Health Effectiveness Ancillary Study – PILOT
Researchers are comparing two common medicines, aspirin and clopidogrel, after a procedure to help people with an irregular heartbeat and kidney disease. They want to find the best way to prevent strokes while also reducing bleeding risks.
Poland - Ongoing, recruitingTherapeutic use (Phase IV)
Glucagone Like Peptide-1 Receptor (GLP-1R) Analogue Assisted Rapid Weight Loss Program as treatment of Idiopathic Intracranial Hypertension
This study looks at whether certain weight-loss medications (Wegovy, Ozempic) can help people with a condition called Idiopathic Intracranial Hypertension (IIH). Researchers want to see if losing weight quickly with these medicines can improve brain pressure and other symptoms over 8 weeks and then 10 months.
Denmark - Ongoing, recruitingTherapeutic use (Phase IV)
ACAV: EFFICACY AND SAFETY OF ALIROCUMAB TO PREVENT EARLY CARDIAC ALLOGRAFT VASCULOPATHY IN RECENT HEART TRANSPLANT RECIPIENTS
This study looks at a new drug, Alirocumab, to see if it can help prevent arteries in transplanted hearts from narrowing soon after surgery. Researchers will compare it to a dummy drug (placebo) and measure cholesterol levels in patients who have recently had a heart transplant.
Czechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multi-Center, Randomized, Single-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral TTI-0102 for Treatment of Patients with Mitochondrial encephalomyopathy, lactic acidosis and strokelike episodes (MELAS).
This study is testing a new medicine, TTI-0102, for people with MELAS. Researchers want to see if it helps improve how well people can move and feel, and if it's safe to take. It's a type of research where some people get the medicine and others get a dummy pill.
France · Netherlands