Heart health research
Cardiovascular disease, heart failure, blood pressure and stroke prevention.
1,286 indexed studies · 734 currently recruiting
Top conditions in this hub
- Heart Failure136
- Stroke92
- Cardiovascular Diseases81
- Atrial Fibrillation76
- Coronary Artery Disease71
- Hypertension47
- Atrial Fibrillation (AF)33
- Pulmonary Arterial Hypertension26
- Ischemic Stroke23
- Pulmonary Hypertension22
- Acute Ischemic Stroke21
- Heart Diseases21
- Obesity17
- Heart Failure With Preserved Ejection Fraction16
- Cardiovascular Disease15
- Stroke Acute15
Recent studies
- Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to learn how safe the study treatment BAY2701250 is, how it affects the body and how it moves into, through and out of the body in healthy male participants when a single amount is given as an injection into the vein (intravenous infusion) or under the skin (subcutaneous injection).
This study is looking at a new medicine called BAY2701250 for a heart and lung condition. We want to see how safe it is and how it works in the body. Healthy men will receive a single dose, either as an injection into a vein or under the skin.
Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomized double-blind trial to study the benefit of Colchicine in Patients with Acutely Decompensated Heart Failure
This study is looking at whether a medicine called Colchicine can help people who have heart failure that has suddenly gotten worse. Researchers want to see if it can improve how the heart works and help people feel better. It involves comparing Colchicine to a dummy pill to see the real effects.
Spain · Italy - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
(21751) First-in-human single dose escalation study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of BAY 3018250 in healthy men in a randomized, placebo-controlled, single-blind, group-comparison design
This early-stage study is looking at a new medicine called BAY 3018250 for treating strokes. It's the very first time this medicine is being given to people. We want to check if it's safe and how the body handles it in healthy men.
Germany - Ongoing, recruitingTherapeutic use (Phase IV)
The effect of empagliflozin on peripheral microvascular dysfunction in heart failure with preserved ejection fraction
This study for people with a type of heart failure called 'heart failure with preserved ejection fraction' is looking at how a medicine called empagliflozin affects tiny blood vessels in the skin. We want to see if it improves blood flow.
Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
ARTEMIS: RAvulizumab to PRotect PaTients with Chronic Kidney DisEase (CKD) froM Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and Subsequent Major Adverse Kidney Events (MAKE): A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study
This study looks at a new medicine called Ultomiris to see if it can protect the kidneys of people with existing kidney problems who are having heart surgery. It aims to reduce serious kidney complications after the operation.
Italy · Germany · Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
ISIS 678354-CS9: A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) in Patients with Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), or with Severe Hypertriglyceridemia
This study is testing a new medicine, Olezarsen, for people with high 'triglycerides' (a type of fat in the blood) and heart problems. It aims to see if the medicine can lower these fats and is safe to use.
Denmark · Spain · France - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)
This study is testing a new medicine, AZD3427, for people with heart failure and high blood pressure in the lungs caused by heart problems. We want to see if it improves how the heart and lungs work together.
Denmark · Poland · Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3b Study to Evaluate the Duration of Effect of Bimatoprost SR in Participants with Open-Angle Glaucoma or Ocular Hypertension
This study looks at how long a special eye drop called Bimatoprost SR works for people with glaucoma or high eye pressure. It helps us understand if it keeps working over time to protect your eyesight.
Ireland · Denmark · Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J1I-MC-GZBM: A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants with Severe Obesity and Established Cardiovascular Disease (TRIUMPH-3)
This study is looking into a new weekly injection called Retatrutide. We want to see if it helps people with severe obesity and heart problems lose weight safely. It's compared to a dummy injection to see how well it works.
Slovakia · Hungary · Spain - Active not recruiting
Gestational Diabetes Monitoring and Management
This study looks at information from pregnant women with gestational diabetes to predict potential problems for mum and baby, and to work out the best way to monitor blood sugar. It uses existing data to help improve care and reduce the number of blood tests needed.
United Kingdom - Not yet recruitingNA
Virtual Reality in Occupational Therapy Upper Limb Stroke Rehabilitation
This study looks at using a virtual reality (VR) system called Resynk to help stroke survivors improve movement in their arm and hand. We want to see if it's practical and helpful for patients both in hospital and at home.
United Kingdom - Active not recruitingNA
REDUCE LAP-HF RANDOMIZED TRIAL I
This study looks at a new small device for people with heart failure. It aims to see if this device can lower high pressure in the heart's upper left chamber, which could help reduce symptoms.
United States · Australia · Belgium - Recruiting
Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation
This study looks at how heart valve problems, called mitral and tricuspid regurgitation, affect people with an irregular heartbeat (atrial fibrillation). Researchers want to understand these conditions better and find out what causes them to get worse.
United Kingdom - Active not recruiting
Prospective Validation of the CoDE-HF Algorithm for the Diagnosis of Acute Heart Failure
This study is testing a new computer tool called CoDE-HF that helps doctors quickly diagnose acute heart failure. This condition means your heart suddenly can't pump blood well. The tool combines a blood test result with patient information to help get the right diagnosis faster.
United Kingdom - RecruitingNA
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
This study looks at whether a special nutritional drink, 'Think Tank', can help middle-aged women aged 40-60 think more clearly after stressful experiences. Researchers will compare it to a dummy drink to see if it improves memory, attention, and overall well-being.
United Kingdom - Recruiting
Product Surveillance Registry
This study keeps track of how well Medtronic medical devices, like those for heart problems or other conditions, work in real life. It aims to make sure these devices are safe and effective for patients.
United States · Argentina · Australia - Not yet recruitingNA
Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial
This study looks at the best way to help people breathe during CPR after their heart stops. Researchers want to find out if giving a little or a lot of air makes a difference in survival and recovery for adults.
Canada - RecruitingNA
Strength and Balance Integration in Maintenance Cardiac Rehabilitation for Older Adults
This study looks at whether adding strength and balance exercises to existing heart rehabilitation classes helps older adults (aged 50+) improve their fitness, balance confidence, and reduce concerns about falling. It compares this new approach to standard classes.
United Kingdom - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Safety and Tolerability of AC01 in patients with heart failure
This study is looking at a new medicine called AC01 for people with heart failure. It's an early-stage trial checking if the medicine is safe and if people can take it without too many problems. Both men and women aged 18 and over can take part.
Sweden · Italy · Netherlands - RecruitingNA
Virtual Ward-Assisted Very earLy dIschArge of Low-rIsk STEMI patieNTs: the VALIANT-STEMI Trial
This study looks into safely sending home some heart attack patients sooner. It compares usual hospital stays with a new approach where patients go home early and are monitored remotely by a 'virtual ward' team using telephone check-ups.
United Kingdom - RecruitingNA
Real World Evaluation of Lifelight®: A Contactless Vital Signs Monitor for Self-monitoring Blood Pressure and Its Comparison to Standard of Care
This study compares a new contactless blood pressure monitor, Lifelight, with traditional cuffs for people with uncontrolled high blood pressure. It aims to see how well Lifelight works in real life and if it helps manage blood pressure.
United Kingdom - Enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - RecruitingNA
The Fourth Left Atrial Appendage Occlusion Study
This study looks at whether a 'WATCHMAN device' can prevent strokes in people with atrial fibrillation who are already taking blood thinners but still have a high stroke risk. It aims to see if blocking off a small part of the heart called the left atrial appendage helps.
United States · Belgium · Canada - RecruitingNA
GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
This study looks at a new brain implant called N1 and a robot, R1, for people with paralysis. It aims to see if they are safe and can help control devices like computers, offering a new way to interact with the world.
United Kingdom - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - Not yet recruitingPHASE2
Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
This study looks at a new drug, sotagliflozin, to see if it can protect kidneys in people with type 1 diabetes. Researchers want to understand how it affects kidney oxygen levels and overall kidney health over 12 weeks.
Denmark · United Kingdom - Active not recruitingNA
Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)
This study looks at a new way to treat hardened arteries in the heart. It uses special sound waves to gently break up calcium buildup, making it easier for doctors to open the artery and improve blood flow. The aim is to see how well this treatment works.
United States · Belgium · Denmark - Active not recruitingNA
CONVERGE Post-Approval Study (PAS)
This study looks at how well a special treatment works for a type of irregular heartbeat called long-standing persistent atrial fibrillation. It uses a device called EPi-Sense and combines outer and inner heart approaches to help patients whose condition hasn't improved with other medicines.
United States · United Kingdom - RecruitingNA
Cardiac Arrhythmia Telemetry; Conventional vs HeartWatch
This study compares a new device called HeartWatch with standard heart monitors (Holter monitors). It aims to see how well HeartWatch, worn on your upper arm, can detect common heart rhythm problems like atrial fibrillation and help understand your symptoms more effectively over a longer time.
Canada - RecruitingNA
Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation
This study looks at how different types of exercise, like moderate steady workouts or short bursts of high-intensity activity, affect people with ongoing atrial fibrillation. We want to see if exercise can improve fitness and quality of life for these patients.
Canada - Active not recruitingNA
Effects of Telemonitoring on the Outcome of Heart Failure Patients After an Incidence of Acute Decompensation
This study is looking at how a smartphone app called Medly can help people with heart failure manage their condition after leaving hospital. It aims to see if Medly improves their self-care, quality of life, and helps prevent them from needing to be readmitted to hospital soon after discharge.
Canada - Active not recruiting
Residual Inflammation and Plaque Progression Long-term Evaluation
This study looks at how inflammation in blood vessels after a heart attack might lead to future problems. We use special scans to see inflammation and track changes in blood vessels over time. The goal is to understand how to better prevent future heart issues.
United Kingdom - RecruitingNA
A Prospective Randomised Multi-centre Trial Comparing cArdiac MRI Guided CRT Versus Conventional CRT Implantation in Patients With Ischaemic Cardiomyopathy
This study looks at a new way to place special heart devices (CRT) in people with heart muscle damage from a lack of blood flow. We want to see if using MRI scans to guide the placement works better than the usual method for improving heart function.
United Kingdom - RecruitingNA
Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
This study looks into the best way to shock the heart back to a normal rhythm for people with atrial fibrillation. We're testing different pad placements on the chest and if pressing on the pads helps the treatment work better.
Canada - Not yet recruitingPHASE4
Cardiac Changes After Effective Dose Carbetocin for Elective Caesarian Section
This study looks at carbetocin, a medicine given during C-sections, to see if a lower dose (50mcg) causes fewer heart-related side effects than the usual dose (100mcg). We'll check how patients feel and changes in their heart. The goal is to find the safest dose for mothers.
Canada - RecruitingPHASE3
Clarifying the Optimal Application of SLT Therapy Trial
This study looks at a laser treatment called SLT for glaucoma and eye pressure. It compares different energy levels and how often the treatment is given to see if it can help reduce the need for daily eye drops.
United States · Canada - Recruiting
Augmented Renal Clearance in Neurocritical Care
This study looks at how certain serious brain conditions might cause kidneys to work extra fast, which can make medicines less effective. Researchers want to understand this better to help doctors give the right amount of medicine, improving care for patients.
United States · Canada - RecruitingNA
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
This study looks at how exercise or yoga helps older women who've had breast cancer and chemotherapy. It checks if these activities can improve heart and muscle health and make daily tasks easier.
Canada - Recruiting
Tracking Results of Ablations to Combat AF Registry Generation 2
This study, called TRAC-AF, aims to track the long-term safety and effectiveness of certain heart procedures for people with atrial fibrillation (an irregular heartbeat). It looks at different types of surgery that use special medical devices to help correct the heart's rhythm.
United States · Canada - RecruitingNA
Accuracy Testing of Validated and Non-validated Home BP Devices Sold on the Online Market.
This study checks if blood pressure monitors bought online, both approved and unapproved, give correct readings. Researchers compare them to a special 24-hour blood pressure test to see how accurate they are, aiming to help people with high blood pressure.
Canada